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Cell. Infect. Microbiol."],"abstract":"<jats:p>Many Gram-negative bacterial pathogens employ translocated virulence factors, termed effector proteins, to facilitate their parasitism of host cells and evade host anti-microbial defenses. However, eukaryotes have evolved to detect effector-mediated virulence strategies through a phenomenon termed effector-triggered immunity (ETI). Although ETI was discovered in plants, a growing body of literature demonstrates that metazoans also utilize effector-mediated immunity to detect and clear bacterial pathogens. This mini review is focused on mechanisms of effector-mediated immune responses by the accidental human pathogen <jats:italic>Legionella pneumophila<\/jats:italic>. We highlight recent advancements in the field and discuss the future prospects of harnessing effectors for the development of novel therapeutics, a critical need due to the prevalence and rapid spread of antibiotic resistance.<\/jats:p>","DOI":"10.3389\/fcimb.2020.593823","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T05:51:50Z","timestamp":1612331510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Mechanisms of Effector-Mediated Immunity Revealed by the Accidental Human Pathogen Legionella pneumophila"],"prefix":"10.3389","volume":"10","author":[{"given":"Tshegofatso","family":"Ngwaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie R.","family":"Shames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e1006088","DOI":"10.1371\/journal.ppat.1006088","article-title":"MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis","volume":"12","author":"Abshire","year":"2016","journal-title":"PLoS Pathog."},{"key":"B2","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s00018-006-6391-1","article-title":"Legionella pneumophila \u2014 a human pathogen that co-evolved with fresh water protozoa","volume":"64","author":"Albert-Weissenberger","year":"2006","journal-title":"Cell Mol. 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