{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:31:51Z","timestamp":1792024311090,"version":"4.4.0"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA022443"],"award-info":[{"award-number":["P01 CA022443"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Epstein\u2013Barr Virus (EBV) can transform B cells and contributes to the development of Burkitt lymphoma and other cancers. Through decades of study, we now recognize that many of the viral genes required to transform cells are not expressed in EBV-positive Burkitt lymphoma (BL) tumors, likely due to the immune pressure exerted on infected cells. This recognition has led to the hypothesis that the loss of expression of these viral genes must be compensated through some mechanisms. Recent progress in genome-wide mutational analysis of tumors provides a wealth of data about the cellular mutations found in EBV-positive BLs. Here, we review common cellular mutations found in these tumors and consider how they may compensate for the viral genes that are no longer expressed. Understanding these mutations and how they may substitute for EBV\u2019s genes and contribute to lymphomagenesis can serve as a launchpad for more mechanistic studies, which will help us navigate the sea of genomic data available today, and direct the discoveries necessary to improve the treatment of EBV-positive BLs.<\/jats:p>","DOI":"10.3389\/fcimb.2020.606412","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T21:56:17Z","timestamp":1610488577000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Burkitt Lymphomas Evolve to Escape Dependencies on Epstein-Barr Virus"],"prefix":"10.3389","volume":"10","author":[{"given":"Rebecca L.","family":"Hutcheson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adityarup","family":"Chakravorty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Sugden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1005158","article-title":"Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma","volume":"11","author":"Abate","year":"2015","journal-title":"PloS Pathog."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1073\/pnas.72.4.1477","article-title":"Epstein Barr Virus Genomes with Properties of Circular DNA Molecules in Carrier Cells","volume":"72","author":"Adams","year":"1975","journal-title":"Proc. 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