{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:26:24Z","timestamp":1794324384393,"version":"4.9.0"},"reference-count":248,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007526","name":"Universit\u00e9 Fran\u00e7ois-Rabelais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Toxoplasmosis is a parasitic disease affecting human, livestock and cat. Prophylactic strategies would be ideal to prevent infection. In a One Health vaccination approach, the objectives would be the prevention of congenital disease in both women and livestock, prevention\/reduction of\n                    <jats:italic>T. gondii<\/jats:italic>\n                    tissue cysts in food-producing animals; and oocyst shedding in cats. Over the last few years, an explosion of strategies for vaccine development, especially due to the development of genetic-engineering technologies has emerged. The field of vaccinology has been exploring safer vaccines by the generation of recombinant immunogenic proteins, naked DNA vaccines, and viral\/bacterial recombinants vectors. These strategies based on single- or few antigens, are less efficacious than recombinant live-attenuated, mostly tachyzoite\n                    <jats:italic>T. gondii<\/jats:italic>\n                    vaccine candidates. Reflections on the development of an anti-\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    vaccine must focus not only on the appropriate route of administration, capable of inducing efficient immune response, but also on the choice of the antigen (s) of interest and the associated delivery systems. To answer these questions, the choice of the animal model is essential. If mice helped in understanding the protection mechanisms, the data obtained cannot be directly transposed to humans, livestock and cats. Moreover, effectiveness vaccines should elicit strong and protective humoral and cellular immune responses at both local and systemic levels against the different stages of the parasite. Finally, challenge protocols should use the oral route, major natural route of infection, either by feeding tissue cysts or oocysts from different\n                    <jats:italic>T. gondii<\/jats:italic>\n                    strains. Effective\n                    <jats:italic>Toxoplasma<\/jats:italic>\n                    vaccines depend on our understanding of the (1) protective host immune response during\n                    <jats:italic>T. gondii<\/jats:italic>\n                    invasion and infection in the different hosts, (2) manipulation and modulation of host immune response to ensure survival of the parasites able to evade and subvert host immunity, (3) molecular mechanisms that define specific stage development. This review presents an overview of the key limitations for the development of an effective vaccine and highlights the contributions made by recent studies on the mechanisms behind stage switching to offer interesting perspectives for vaccine development.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2020.607198","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T04:18:15Z","timestamp":1606277895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Key Limitations and New Insights Into the Toxoplasma gondii Parasite Stage Switching for Future Vaccine Development in Human, Livestock, and Cats"],"prefix":"10.3389","volume":"10","author":[{"given":"Marie-No\u00eblle","family":"M\u00e9v\u00e9lec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Lakhrif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Dimier-Poisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0173745","DOI":"10.1371\/journal.pone.0173745","article-title":"Lactate Dehydrogenase in Toxoplasma Gondii Controls Virulence, Bradyzoite Differentiation, and Chronic Infection","volume":"12","author":"Abdelbaset","year":"2017","journal-title":"PloS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/76957","article-title":"CCR5 Provides a Signal for Microbial Induced CCR5 Provides a Signal for Microbial Induced Production of IL-12 by CD8\u03b1+ Dendritic Cells","volume":"1","author":"Aliberti","year":"2000","journal-title":"Nat. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1007\/s00436-019-06229-6","article-title":"Isolation of Viable Toxoplasma Gondii from Organs and Brazilian Commercial Meat Cuts of Experimentally Infected Pigs","volume":"118","author":"Alves","year":"2019","journal-title":"Parasitol. Res."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00408","article-title":"Serotyping of Toxoplasma Gondii Infection Using Peptide Membrane Arrays","volume":"9","author":"Arranz-Sol\u00eds","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1002288","DOI":"10.1371\/journal.pbio.1002288","article-title":"Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence","volume":"13","author":"Arroyo-Olarte","year":"2015","journal-title":"PloS Biol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2019.108963","article-title":"Cell Mediated and Innate Immune Responses in Pigs Following Vaccination and Challenge with Toxoplasma Parasites","volume":"275","author":"Bartley","year":"2019","journal-title":"Vet. Parasitol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.vetpar.2017.01.026","article-title":"Experimental Toxoplasma Gondii Infections in Pigs: Humoral Immune Response, Estimation of Specific IgG Avidity and the Challenges of Reproducing Vertical Transmission in Sows","volume":"236","author":"Basso","year":"2017","journal-title":"Vet. Parasitol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/S0020-7519(01)00288-0","article-title":"Identification of a Human Immunodominant B-Cell Epitope within the GRA1 Antigen of Toxoplasma Gondii by Phage Display of CDNA Libraries","volume":"31","author":"Beghetto","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1086\/427660","article-title":"A Combination of Antigenic Regions of Toxoplasma Gondii Microneme Proteins Induces Protective Immunity against Oral Infection with Parasite Cysts","volume":"191","author":"Beghetto","year":"2005","journal-title":"J. Infect. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/jid.2014.371","article-title":"Gut Commensal Bacteria Direct a Protective Immune Response against the Human Pathogen Toxoplasma Gondii","volume":"6","author":"Benson","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00046","article-title":"From Entry to Early Dissemination-Toxoplasma Gondii\u2019sInitial Encounter with Its Host","volume":"9","author":"Betancourt","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/ni.1629","article-title":"Immunodominant, Protective Response to the Parasite Toxoplasma Gondii Requires Antigen Processing in the Endoplasmic Reticulum","volume":"9","author":"Blanchard","year":"2008","journal-title":"Physiol. Behav."},{"key":"B13","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.4049\/jimmunol.162.12.7369","article-title":"Human Polymorphonuclear Leukocytes Produce IL-12, TNF- \u03b1, and the Chemokines Macrophage-Inflammatory Protein-1 \u03b1 and -1 \u03b2 in Response to Toxoplasma Gondii Antigens","volume":"162","author":"Bliss","year":"1999","journal-title":"J. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1093\/cid\/cir667","article-title":"Unrecognized Ingestion of Toxoplasma Gondii Oocysts Leads to Congenital Toxoplasmosis and Causes Epidemics in North America","volume":"53","author":"Boyer","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1084\/jem.20130103","article-title":"A Toxoplasma Dense Granule Protein, GRA24, Modulates the Early Immune Response to Infection by Promoting a Direct and Sustained Host P38 MAPK Activation","volume":"210","author":"Braun","year":"2013","journal-title":"J. Exp. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/s41564-019-0431-8","article-title":"The Toxoplasma Effector TEEGR Promotes Parasite Persistence by Modulating NF-\u03baB Signalling via EZH2","volume":"4","author":"Braun","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/eji.201646859","article-title":"MHC I Presentation of Toxoplasma Gondii Immunodominant Antigen Does Not Require Sec22b and Is Regulated by Antigen Orientation at the Vacuole Membrane","volume":"47","author":"Buaillon","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2460\/ajvr.1995.56.06.769","article-title":"Detection of Toxoplasma Gondii-Specific IgA in the Serum of Cats","volume":"56","author":"Burney","year":"1995","journal-title":"Am. J. Vet. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13567-015-0177-0","article-title":"Vaccination of Pigs with the S48 Strain of Toxoplasma Gondii - Safer Meat for Human Consumption","volume":"46","author":"Burrells","year":"2015","journal-title":"Vet. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1136\/vr.133.13.310","article-title":"Experimental Challenge of Sheep 18 Months after Vaccination with a Live (S48) Toxoplasma Gondii Vaccine","volume":"133","author":"Buxton","year":"1993","journal-title":"Vet. Rec."},{"key":"B21","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0169-4758(93)90236-9","article-title":"Toxoplasmosis: The First Commercial Vaccine","volume":"9","author":"Buxton","year":"1993","journal-title":"Parasitol. Today"},{"key":"B22","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.ijpara.2019.11.002","article-title":"Detection of Antibodies to Toxoplasma Gondii in Oral Fluid from Pigs","volume":"50","author":"Campero","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.imbio.2015.07.009","article-title":"A Rational Approach to Select Immunogenic Peptides That Induce IFN-\u03b3 Response against Toxoplasma Gondii in Human Leukocytes","volume":"220","author":"Cardona","year":"2015","journal-title":"Immunobiology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1128\/IAI.70.2.434-443.2002","article-title":"CD8+-T-Cell Immunity against Toxoplasma Gondii Can Be Induced but Not Maintained in Mice Lacking Conventional CD4+ T Cells","volume":"70","author":"Casciotti","year":"2002","journal-title":"Infect. Immun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13567-019-0681-8","article-title":"Peripheral and Placental Immune Responses in Sheep after Experimental Infection with Toxoplasma Gondii at the Three Terms of Gestation","volume":"50","author":"Casta\u00f1o","year":"2019","journal-title":"Vet. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1084\/jem.20041672","article-title":"Synergistic Role of Micronemal Proteins in Toxoplasma Gondii Virulence","volume":"201","author":"C\u00e9r\u00e8de","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pathogens9030234","article-title":"The Bradyzoite: A Key Developmental Stage for the Persistence and Pathogenesis of Toxoplasmosis","volume":"9","author":"Cerutti","year":"2020","journal-title":"Pathogens"},{"key":"B28","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1128\/CVI.00512-12","article-title":"Enzyme-Linked Immunosorbent Assay Using Recombinant SAG1 Antigen to Detect Toxoplasma Gondii-Specific Immunoglobulin G Antibodies in Human Sera and Saliva","volume":"20","author":"Chahed Bel-Ochi","year":"2013","journal-title":"Clin. Vaccine Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1128\/iai.58.5.1240-1246.1990","article-title":"Antibody Responses to Toxoplasma Gondii in Sera, Intestinal Secretions, and Milk from Orally Infected Mice and Characterization of Target Antigens","volume":"58","author":"Chardes","year":"1990","journal-title":"Infect. Immun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e1006027","DOI":"10.1371\/journal.ppat.1006027","article-title":"K63-Linked Ubiquitination Targets Toxoplasma Gondii for Endo-Lysosomal Destruction in IFN\u03b3-Stimulated Human Cells","volume":"12","author":"Clough","year":"2016","journal-title":"PloS Pathog."},{"key":"B31","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/pim.12164","article-title":"The Gut Mucosal Immune Response to Toxoplasma Gondii","volume":"37","author":"Cohen","year":"2015","journal-title":"Parasite Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1003706","DOI":"10.1371\/journal.ppat.1003706","article-title":"CXCR3-Dependent CD4+ T Cells Are Required to Activate Inflammatory Monocytes for Defense against Intestinal Infection","volume":"9","author":"Cohen","year":"2013","journal-title":"PloS Pathog."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-7580-6-12","article-title":"Human Immunome, Bioinformatic Analyses Using HLA Supermotifs and the Parasite Genome, Binding Assays, Studies of Human T Cell Responses, and Immunization of HLA-A*1101 Transgenic Mice Including Novel Adjuvants Provide a Foundation for HLA-A03 Restricted C","volume":"6","author":"Cong","year":"2010","journal-title":"Immunome Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.vaccine.2010.11.015","article-title":"Towards an Immunosense Vaccine to Prevent Toxoplasmosis: Protective Toxoplasma Gondii Epitopes Restricted by HLA-A*0201","volume":"29","author":"Cong","year":"2011","journal-title":"Vaccine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.humimm.2011.10.006","article-title":"Toxoplasma Gondii HLA-B*0702 Restricted GRA720\u201328 Peptide with Adjuvants and an Universal Helper T Cell Epitope Elicits CD8+ T Cells Producing IFN-\u03b3 and Reduces Parasite Burden in HLA- B*0702 Mice","volume":"73","author":"Cong","year":"2012","journal-title":"Hum. Immunol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02403","article-title":"Acute Toxoplasma Gondii Infection in Cats Induced Tissue-Specific Transcriptional Response Dominated by Immune Signatures","volume":"9","author":"Cong","year":"2018","journal-title":"Front. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/j.1365-3024.2007.00982.x","article-title":"Congenital and Acquired Toxoplasmosis: Diversity and Role of Antibodies in Different Compartments of the Host","volume":"29","author":"Correa","year":"2007","journal-title":"Parasite Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.exppara.2017.11.003","article-title":"Kinetics of Parasite Distribution after Reinfection with Genetically Distinct Strains of Toxoplasma Gondii","volume":"184","author":"Costa","year":"2018","journal-title":"Exp. Parasitol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1182\/blood-2005-02-0666","article-title":"CD11c- and CD11b-Expressing Mouse Leukocytes Transport Single Toxoplasma Gondii Tachyzoites to the Brain","volume":"107","author":"Courret","year":"2006","journal-title":"Blood"},{"key":"B40","first-page":"79","article-title":"Establishment of T-Helper Type 1- and T-Helper Type 2-like Human Toxoplasma Antigen-Specific T-Cell Clones","volume":"86","author":"Daubener","year":"1995","journal-title":"Immunology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"882","DOI":"10.2307\/3284034","article-title":"Mediation of Immunity to Toxoplasma Gondii Oocyst Shedding in Cats","volume":"81","author":"Davis","year":"1995","journal-title":"J. Parasitol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1128\/IAI.73.2.1116-1128.2005","article-title":"Localized Multigene Expression Patterns Support an Evolving Th1\/Th2-like Paradigm in Response to Infections with Toxoplasma Gondii and Ascaris Suum","volume":"73","author":"Dawson","year":"2005","journal-title":"Infect. Immun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1089\/fpd.2017.2305","article-title":"Toxoplasma Gondii, a Foodborne Pathogen in the Swine Production Chain from a European Perspective","volume":"14","author":"De Berardinis","year":"2017","journal-title":"Foodborne Pathog. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"32987","DOI":"10.1074\/jbc.M304791200","article-title":"Roles of Glycosylphosphatidylinositols of Toxoplasma Gondii: Induction of Tumor Necrosis Factor-\u03b1 Production in Macrophages","volume":"278","author":"Debierre-Grockiego","year":"2003","journal-title":"J.Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12879-018-3048-2","article-title":"First Case Report of M1 Macrophage Polarization in an Untreated Symptomatic Patient with Toxoplasmosis","volume":"18","author":"De-Luca","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.micinf.2003.11.009","article-title":"The Toxoplasma Gondii Bradyzoite Antigens BAG1 and MAG1 Induce Early Humoral and Cell-Mediated Immune Responses upon Human Infection","volume":"6","author":"Di Cristina","year":"2004","journal-title":"Microbes Infect."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1128\/IAI.00254-08","article-title":"Temporal and Spatial Distribution of Toxoplasma Gondii Differentiation into Bradyzoites and Tissue Cyst Formation in Vivo","volume":"76","author":"Di Cristina","year":"2008","journal-title":"Infect. Immun."},{"key":"B48","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1046\/j.1365-2567.1998.00553.x","article-title":"Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: a role for intracellular iron","volume":"94","author":"Dimier","year":"1998","journal-title":"Immunology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s10096-018-03442-6","article-title":"A Systematic Review on Efficiency of Microneme Proteins to Induce Protective Immunity against Toxoplasma Gondii","volume":"38","author":"Dodangeh","year":"2019","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0165124","article-title":"Congenital Toxoplasmosis in Chronically Infected and Subsequently Challenged Ewes","volume":"11","author":"Dos Santos","year":"2016","journal-title":"PloS One"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e108329","DOI":"10.1371\/journal.pone.0108329","article-title":"Diagnostic Value of a Rec-ELISA Using Toxoplasma Gondii Recombinant SporoSAG, BAG1, and GRA1 Proteins in Murine Models Infected Orally with Tissue Cysts and Oocysts","volume":"9","author":"D\u00f6\u015fkaya","year":"2014","journal-title":"PloS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-018-2934-1","article-title":"Discovery of New Toxoplasma Gondii Antigenic Proteins Using a High Throughput Protein Microarray Approach Screening Sera of Murine Model Infected Orally with Oocysts and Tissue Cysts","volume":"11","author":"D\u00f6\u015fkaya","year":"2018","journal-title":"Parasites Vectors"},{"key":"B53","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nm.4023","article-title":"Killer Lymphocytes Use Granulysin, Perforin and Granzymes to Kill Intracellular Parasites","volume":"22","author":"Dotiwala","year":"2016","journal-title":"Nat. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"12578","DOI":"10.1074\/jbc.M113.544718","article-title":"Toxoplasma Gondii Virulence Factor Rop18 Inhibits the Host Nf-Kb Pathway by Promoting P65 Degradation","volume":"289","author":"Du","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1550-7408.1972.tb03431.x","article-title":"Cyst-Induced Toxoplasmosis in Cats","volume":"19","author":"Dubey","year":"1972","journal-title":"J.\u00a0Protozool."},{"key":"B56","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1177\/030098587401100407","article-title":"Immunity to Feline Toxoplasmosis: Modification by Administration of Corticosteroids","volume":"11","author":"Dubey","year":"1974","journal-title":"Vet. Pathol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"887","DOI":"10.2307\/3284035","article-title":"Long-Term Antibody Responses of Cats Fed Toxoplasma Gondii Tissue Cysts","volume":"81","author":"Dubey","year":"1995","journal-title":"J. Parasitol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"410","DOI":"10.2307\/3283823","article-title":"Duration of Immunity to Shedding of Toxoplasma Gondii Oocysts by Cats","volume":"81","author":"Dubey","year":"1995","journal-title":"J. Parasitol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","article-title":"The History of Toxoplasma Gondii - The First 100 Years","volume":"55","author":"Dubey","year":"2008","journal-title":"J.\u00a0Eukaryotic Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetpar.2009.02.026","article-title":"Toxoplasmosis in Sheep-The Last 20 Years","volume":"163","author":"Dubey","year":"2009","journal-title":"Vet. Parasitol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.vetpar.2017.05.024","article-title":"Schizogony and Gametogony of Oocyst-Deficient T-263 Strain of Toxoplasma Gondii","volume":"245","author":"Dubey","year":"2017","journal-title":"Vet. Parasitol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.02183","article-title":"Effective Nanoparticle-Based Nasal Vaccine Against Latent and Congenital Toxoplasmosis in Sheep","volume":"11","author":"Ducournau","year":"2020","journal-title":"Front Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.coi.2010.04.008","article-title":"Monocytes Mediate Mucosal Immunity to Toxoplasma Gondii","volume":"22","author":"Dunay","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e00057","DOI":"10.1128\/CMR.00057-17","article-title":"Treatment of Toxoplasmosis: Historical Perspective, Animal","volume":"31","author":"Dunay","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.85955","article-title":"Adjuvanted Multi-Epitope Vaccines Protect HLA-A*11:01 Transgenic Mice against Toxoplasma Gondii","volume":"1","author":"El Bissati","year":"2016","journal-title":"JCI Insight"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41541-017-0024-6","article-title":"Protein Nanovaccine Confers Robust Immunity against Toxoplasma","volume":"2","author":"El Bissati","year":"2017","journal-title":"NPJ Vaccines"},{"key":"B67","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1128\/IAI.01170-13","article-title":"NLRP1 Is an Inflammasome Sensor for Toxoplasma Gondii","volume":"82","author":"Ewald","year":"2014","journal-title":"Infect. Immun."},{"key":"B68","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41564-020-0674-4","article-title":"A MORC-Driven Transcriptional Switch Controls Toxoplasma Developmental Trajectories and Sexual Commitment","volume":"5","author":"Farhat","year":"2020","journal-title":"Nat. Microbiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1645\/17-85","article-title":"Feline Toxoplasmosis: Tumor Necrosis Factor, Nitric Oxide, and Free Radicals in Seropositive Cats","volume":"104","author":"Faria","year":"2018","journal-title":"J. Parasitol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cimid.2018.09.005","article-title":"Vaccination against Toxoplasma Gondii Using Rhoptry Antigens: A Systematic Review","volume":"59","author":"Faridnia","year":"2018","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1128\/CDLI.9.3.704-707.2002","article-title":"Cellular Immune Responses to Recombinant Antigens in Pregnant Women Chronically Infected with Toxoplasma Gondii","volume":"9","author":"Fatoohi","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1017\/S0031182014001978","article-title":"Identification of Toxoplasma Gondii Antigens Associated with Different Types of Infection by Serum Antibody Profiling","volume":"142","author":"Felgner","year":"2015","journal-title":"Parasitology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15252\/embj.2018100926","article-title":"Human GBP 1 Is a Microbe-specific Gatekeeper of Macrophage Apoptosis and Pyroptosis","volume":"38","author":"Fisch","year":"2019","journal-title":"EMBO J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0166-6851(96)02773-9","article-title":"The MIC1 Microneme Protein of Toxoplasma Gondii Contains a Duplicated Receptor-like Domain and Binds to Host Cell Surface","volume":"83","author":"Fourmaux","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/415926a","article-title":"De Novo Pyrimidine Biosynthesis Is Required for Virulence of Toxoplasma Gondii","volume":"415","author":"Fox","year":"2002","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1128\/IAI.00287-10","article-title":"Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5\u2032- Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma Gondii","volume":"78","author":"Fox","year":"2010","journal-title":"Infect. Immun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1128\/IAI.02756-14","article-title":"Nonreplicating, Cyst-Defective Type II Toxoplasma Gondii Vaccine Strains Stimulate Protective Immunity against Acute and Chronic Infection","volume":"83","author":"Fox","year":"2015","journal-title":"Infect. Immun."},{"key":"B78","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2460\/ajvr.1991.52.05.759","article-title":"Prospective Vaccine Prepared from a New Mutant of Toxoplasma Gondii for Use in Cats","volume":"52","author":"Frenkel","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"716","DOI":"10.2307\/3283610","article-title":"Immunization of Cats with Tissue Cysts, Bradyzoites, and Tachyzoites of the T-263 Strain of Toxoplasma Gondii","volume":"79","author":"Freyre","year":"1993","journal-title":"J. Parasitol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"e29998","DOI":"10.1371\/journal.pone.0029998","article-title":"Transcriptomic Analysis of Toxoplasma Development Reveals Many Novel Functions and Structures Specific to Sporozoites and Oocysts","volume":"7","author":"Fritz","year":"2012","journal-title":"PloS One"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1093\/intimm\/dxl099","article-title":"Roles of the Small Intestine for Induction of Toll-like Receptor 4-Mediated Innate Resistance in Naturally Acquired Murine Toxoplasmosis","volume":"18","author":"Furuta","year":"2006","journal-title":"Int. Immunol."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.fawpar.2019.e00052","article-title":"Diversity of Toxoplasma Gondii Strains at the Global Level and Its Determinants","volume":"12","author":"Galal","year":"2019","journal-title":"Food Waterborne Parasitol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.rvsc.2007.04.014","article-title":"Evaluation of IFA, MAT, ELISAs and Immunoblotting for the Detection of Anti-Toxoplasma Gondii Antibodies in Paired Serum and Aqueous Humour Samples from Experimentally Infected Pigs","volume":"84","author":"Garcia","year":"2008","journal-title":"Res. Vet. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1046\/j.1462-5822.2000.00064.x","article-title":"The Microneme Protein MIC3 of Toxoplasma Gondii Is a Secretory Adhesin That Binds to Both the Surface of the Host Cells and the Surface of the Parasite","volume":"2","author":"Garcia-R\u00e9guet","year":"2000","journal-title":"Cell. Microbiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1084\/jem.20160340","article-title":"Toxoplasma Gondii TgIST Co-Opts Host Chromatin Repressors Dampening STAT1-Dependent Gene Regulation and IFN-\u03b3-Mediated Host Defenses","volume":"213","author":"Gay","year":"2016","journal-title":"J. Exp. Med."},{"key":"B86","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4049\/jimmunol.146.1.286","article-title":"Synergistic Role of CD4+ and CD8+ T Lymphocytes in IFN-Gamma Production and Protective Immunity Induced by an Attenuated Toxoplasma Gondii Vaccine","volume":"146","author":"Gazzinelli","year":"1991","journal-title":"J. Immunol. (Baltimore Md.: 1950)"},{"key":"B87","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4049\/jimmunol.149.1.175","article-title":"Simultaneous Depletion of CD4+ and CD8+ T Lymphocytes Is Required to Reactivate Chronic Infection with Toxoplasma Gondii","volume":"149","author":"Gazzinelli","year":"1992","journal-title":"J. Immunol."},{"key":"B88","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.153.6.2533","article-title":"Parasite-Induced IL-12 Stimulates Early IFN-Gamma Synthesis and Resistance during Acute Infection with Toxoplasma Gondii","volume":"153","author":"Gazzinelli","year":"1994","journal-title":"J. Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"5380","DOI":"10.1128\/IAI.00649-09","article-title":"Long-Term Immunity to Lethal Acute or Chronic Type II Toxoplasma Gondii Infection Is Effectively Induced in Genetically Susceptible C57BL\/6 Mice by Immunization with an Attenuated Type I Vaccine Strain","volume":"77","author":"Gigley","year":"2009","journal-title":"Infect. Immun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e01117","DOI":"10.1128\/mBio.01117-13","article-title":"Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma Gondii","volume":"5","author":"Gorfu","year":"2014","journal-title":"MBio"},{"key":"B91","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.4049\/jimmunol.1700245","article-title":"NLRP3 and Potassium Efflux Drive Rapid IL-1\u03b2 Release from Primary Human Monocytes during Toxoplasma Gondii Infection","volume":"199","author":"Gov","year":"2017","journal-title":"J. Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0022936","article-title":"Subcellular Antigen Location Influences T-Cell Activation during Acute Infection with Toxoplasma Gondii","volume":"6","author":"Gregg","year":"2011","journal-title":"PloS One"},{"key":"B93","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.ajo.2015.04.005","article-title":"Ocular Toxoplasmosis: Lessons from Brazil","volume":"159","author":"Grigg","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1128\/CMR.00005-17CE","article-title":"Toxoplasma Effectors Targeting Host Signaling and Transcription","volume":"30","author":"Hakimi","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"B95","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ijpara.2009.06.009","article-title":"An Innovative Survey Underlining the Significant Level of Contamination by Toxoplasma Gondii of Ovine Meat Consumed in France","volume":"40","author":"Halos","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/icb.2014.70.Internalization","article-title":"Internalization and TLR-Dependent Type I Interferon Production by Inflammatory Monocytes to Toxoplasma Gondii","volume":"92","author":"Han","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"e39887","DOI":"10.7554\/eLife.39887","article-title":"Characterization of a Toxoplasma Effector Uncovers an Alternative GSK3\/\u03b2-Catenin-Regulatory Pathway of Inflammation","volume":"7","author":"He","year":"2018","journal-title":"ELife"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01531","article-title":"Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma Gondii-Induced Transcriptional Landscapes","volume":"10","author":"He","year":"2019","journal-title":"Front. Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1128\/IAI.00604-12","article-title":"Toxoplasma Gondii Antigens Recognized by IgG Antibodies Differ between Mice with and without Active Proliferation of Tachyzoites in the Brain during the Chronic Stage of Infection","volume":"80","author":"Hester","year":"2012","journal-title":"Infect. Immun."},{"key":"B100","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1645\/GE-2782.1","article-title":"IDENTIFICATION OF A SPOROZOITE-SPECIFIC ANTIGEN FROM TOXOPLASMA GONDII","volume":"97","author":"Hill","year":"2011","journal-title":"J. Parasitol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.ajo.2003.09.040","article-title":"Ocular Toxoplasmosis: A Global Reassessment. Part I: Epidemiology and Course of Disease","volume":"136","author":"Holland","year":"2003","journal-title":"Am. J. Ophthalmol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.mib.2011.07.002","article-title":"The IRG Protein-Based Resistance Mechanism in Mice and Its Relation to Virulence in Toxoplasma Gondii","volume":"14","author":"Howard","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrmicro2858","article-title":"Modulation of Innate Immunity by Toxoplasma Gondii Virulence Effectors","volume":"10","author":"Hunter","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"e14057","DOI":"10.1371\/journal.pone.0014057","article-title":"T. Gondii RP Promoters & Knockdown Reveal Molecular Pathways Associated with Proliferation and Cell-Cycle Arrest","volume":"5","author":"Hutson","year":"2010","journal-title":"PloS One"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e84","DOI":"10.1371\/journal.ppat.0020084","article-title":"Toxoplasma MIC2 Is a Major Determinant of Invasion and Virulence","volume":"2","author":"Huynh","year":"2006","journal-title":"PloS Pathog."},{"key":"B106","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/0169-4758(95)80210-X","article-title":"Analysis of in Vivo Immune Responses during Toxoplasma Gondii Infection Using the Technique of Lymphatic Cannulation","volume":"11","author":"Innes","year":"1995","journal-title":"Parasitol. Today"},{"key":"B107","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1365-3024.1995.tb01017.x","article-title":"Induction of CD4+ and CD8+ T Cell Responses in Efferent Lymph Responding to Toxoplasma Gondii Infection: Analysis of Phenotype and Function","volume":"17","author":"Innes","year":"1995","journal-title":"Parasite Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0021-9975(05)80074-X","article-title":"Kinetics of Interferon Gamma Production In ~vo during Infection with the $48 Vaccine Strain of Toxoplasma Gondii","volume":"113","author":"Innes","year":"1995","journal-title":"J. Comp. Path."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.fawpar.2019.e00053","article-title":"A One Health Approach to Vaccines against Toxoplasma Gondii","volume":"12","author":"Innes","year":"2019","journal-title":"Food Waterborne Parasitol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1086\/507706","article-title":"Mic1-3 Knockout of Toxoplasma Gondii Is a Successful Vaccine against Chronic and Congenital Toxoplasmosis in Mice","volume":"194","author":"Ismael","year":"2006","journal-title":"J. Infect. Dis."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00232","article-title":"Strain- and Dose-Dependent Reduction of Toxoplasma Gondii Burden in Pigs Is Associated with Interferon-Gamma Production by CD8+ Lymphocytes in a Heterologous Challenge Model","volume":"7","author":"Jennes","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e02280","DOI":"10.1128\/mBio.02280-14","article-title":"Toxoplasma Gondii Superinfection and Virulence during Secondary Infection Correlate with the Exact ROP5\/ROP18 Allelic Combination","volume":"6","author":"Jensen","year":"2015","journal-title":"MBio"},{"key":"B113","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.pt.2015.12.011","article-title":"Antigen Presentation of Vacuolated Apicomplexans - Two Gateways to a Vaccine Antigen","volume":"32","author":"Jensen","year":"2016","journal-title":"Trends Parasitol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1128\/IAI.70.1.185-191.2002","article-title":"Deficient Humoral Responses Underlie Susceptibility to Toxoplasma Gondii in CD4-Deficient Mice","volume":"70","author":"Johnson","year":"2002","journal-title":"Infect. Immun."},{"key":"B115","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.4049\/jimmunol.164.5.2629","article-title":"Decreased Resistance of B Cell-Deficient Mice to Infection with Toxoplasma Gondii Despite Unimpaired Expression of IFN-\u03b3, TNF-\u03b1, and Inducible Nitric Oxide Synthase","volume":"164","author":"Kang","year":"2000","journal-title":"J. Immunol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.vetpar.2014.07.003","article-title":"Immunization of Lambs with the S48 Strain of Toxoplasma Gondii Reduces Tissue Cyst Burden Following Oral Challenge with a Complete Strain of the Parasite","volume":"205","author":"Katzer","year":"2014","journal-title":"Vet. Parasitol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"8038","DOI":"10.4049\/jimmunol.174.12.8038","article-title":"Stage-Specific Expression of Surface Antigens by Toxoplasma Gondii as a Mechanism to Facilitate Parasite Persistence","volume":"174","author":"Kim","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"4178","DOI":"10.4049\/jimmunol.174.7.4178","article-title":"P38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection","volume":"174","author":"Kim","year":"2005","journal-title":"J. Immunol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/msphere.00045-16","article-title":"The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma Gondii Virulence and Host GBP2 Loading","volume":"1","author":"Kim","year":"2016","journal-title":"MSphere"},{"key":"B120","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"B121","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.immuni.2012.09.016","article-title":"Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma Gondii","volume":"38","author":"Koblansky","year":"2013","journal-title":"Immunity"},{"key":"B122","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1292\/jvms.61.819","article-title":"Interleukin-12, Interferon-\u03b3 and Interleukin-4 Gene Expression in Cats Infected with Toxoplasma Gondii","volume":"61","author":"Koyama","year":"1999","journal-title":"J. Vet. Med. Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"e11479","DOI":"10.7554\/elife.11479","article-title":"Guanylate Binding Proteins Directly Attack Toxoplasma Gondii via Supramolecular Complexes","volume":"5","author":"Kravets","year":"2016","journal-title":"ELife"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00366","article-title":"Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors beyond the Parasitophorous Vacuole Membrane of Tissue Cysts","volume":"8","author":"Krishnamurthy","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.chom.2020.01.002","article-title":"Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism","volume":"27","author":"Krishnan","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B126","doi-asserted-by":"publisher","first-page":"13115","DOI":"10.1038\/s41598-020-70102-1","article-title":"Treatment of Mice with S4B6 IL-2 Complex Prevents Lethal Toxoplasmosis via IL-12- and IL-18-Dependent Interferon-Gamma Production by Non-CD4 Immune Cells","volume":"10","author":"Kupz","year":"2020","journal-title":"Sci. Rep."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.4049\/jimmunol.170.4.1949","article-title":"The Induction and Kinetics of Antigen-Specific CD8 T Cells Are Defined by the Stage Specificity and Compartmentalization of the Antigen in Murine Toxoplasmosis","volume":"170","author":"Kwok","year":"2003","journal-title":"J. Immunol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1128\/IAI.02606-14","article-title":"AMA1-Deficient Toxoplasma Gondii Parasites Transiently Colonize Mice and Trigger an Innate Immune Response That Leads to Long-Lasting Protective Immunity","volume":"83","author":"Lagal","year":"2015","journal-title":"Infect. Immun."},{"key":"B129","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2460\/ajvr.1995.56.06.774","article-title":"Detection of Toxoplasma Gondii-Specific IgA in the Aqueous Humor of Cats","volume":"56","author":"Lappin","year":"1995","journal-title":"Am. J. Vet. Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.vaccine.2019.11.076","article-title":"Evaluation of Immunogenicity and Protection of the Mic1-3 Knockout Toxoplasma Gondii Live Attenuated Strain in the Feline Host","volume":"38","author":"Le Roux","year":"2020","journal-title":"Vaccine"},{"key":"B131","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.celrep.2015.09.005","article-title":"P62 Plays a Specific Role in Interferon-\u03b3-Induced Presentation of a Toxoplasma Vacuolar Antigen","volume":"13","author":"Lee","year":"2015","journal-title":"Cell Rep."},{"key":"B132","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.vetimm.2003.11.002","article-title":"Failure of FIV-Infected Cats to Control Toxoplasma Gondii Correlates with Reduced IL2, IL6, and IL12 and Elevated IL10 Expression by Lymph Node T Cells","volume":"98","author":"Levy","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1007\/s00436-020-06815-z","article-title":"Effect of Deletion of Gra17 and Gra23 Genes on the Growth, Virulence, and Immunogenicity of Type II Toxoplasma Gondii","volume":"119","author":"Li","year":"2020","journal-title":"Parasitol. Res."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/mcp.M110.006916","article-title":"Identification of Potential Serodiagnostic and Subunit Vaccine Antigens by Antibody Profiling of Toxoplasmosis Cases in Turkey","volume":"10","author":"Liang","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8030352","article-title":"RH\u0394gra17\u0394npt1 Strain of Toxoplasma Gondii Elicits Protective Immunity against Acute, Chronic and Congenital Toxoplasmosis in Mice","volume":"8","author":"Liang","year":"2020","journal-title":"Microorganisms"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00103","article-title":"Mechanisms of Human Innate Immune Evasion by Toxoplasma Gondii","volume":"9","author":"Lima","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.cvfa.2019.11.004","article-title":"Neosporosis, Toxoplasmosis, and Sarcocystosis in Ruminants: An Update","volume":"36","author":"Lindsay","year":"2020","journal-title":"Vet. Clinics North America - Food Anim. Pract."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-019-2121-4","article-title":"Toxoplasma Gondii Oocyst-Driven Infection in Pigs, Chickens and Humans in Northeastern China","volume":"15","author":"Liu","year":"2019","journal-title":"BMC Vet. Res."},{"key":"B139","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.1016\/j.vaccine.2019.05.083","article-title":"Vaccination Challenges and Strategies against Long-Lived Toxoplasma Gondii","volume":"37","author":"Loh","year":"2019","journal-title":"Vaccine"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/602803","article-title":"Aspects of Toxoplasma Infection on the Reproductive System of Experimentally Infected Rams ( Ovis Aries )","volume":"2009","author":"Lopes","year":"2009","journal-title":"J.\u00a0Parasitol. Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1016\/j.celrep.2015.11.001","article-title":"Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma Gondii Protective Antigen","volume":"13","author":"Lopez","year":"2015","journal-title":"Cell Rep."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1007872","article-title":"TLR11-Independent Inflammasome Activation Is Critical for CD4+ t Cell-Derived IFN-\u03b3 Production and Host Resistance to Toxoplasma Gondii","volume":"15","author":"L\u00f3pez-Yglesias","year":"2019","journal-title":"PloS Pathog."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/msystems.00189-20","article-title":"Selective Upregulation of Transcripts for Six Molecules Related to T Cell Costimulation and Phagocyte Recruitment and Activation among 734 Immunity-Related Genes in the Brain during Perforin-Dependent, CD8 + T Cell-Mediated Elimination of Toxoplasma Gond","volume":"5","author":"Lutshumba","year":"2020","journal-title":"MSystems"},{"key":"B144","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1128\/CVI.00119-12","article-title":"Peptide Microarray Analysis of in Silico-Predicted Epitopes for Serological Diagnosis of Toxoplasma Gondii Infection in Humans","volume":"19","author":"Maksimov","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1017\/S0950268816000960","article-title":"Salivary IgA against Sporozoite-Specific Embryogenesis-Related Protein (TgERP) in the Study of Horizontally Transmitted Toxoplasmosis via T. Gondii Oocysts in Endemic Settings","volume":"144","author":"Mangiavacchi","year":"2016","journal-title":"Epidemiol. Infect."},{"key":"B146","doi-asserted-by":"publisher","first-page":"e3000364","DOI":"10.1371\/journal.pbio.3000364","article-title":"Intestinal Delta-6-Desaturase Activity Determines Host Range for Toxoplasma Sexual Reproduction","volume":"17","author":"Martorelli Di-Genova","year":"2019","journal-title":"PloS Biol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.immuni.2011.08.008","article-title":"CD8\u03b1+ Dendritic Cells Are the Critical Source of Interleukin-12 That Controls Acute Infection by Toxoplasma Gondii Tachyzoites","volume":"35","author":"Mashayekhi","year":"2011","journal-title":"Immunity"},{"key":"B148","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2307\/3285821","article-title":"A Field Trial of the Effectiveness of a Feline Toxoplasma Gondii Vaccine in Reducing T . Gondii Exposure for Swine","volume":"85","author":"Mateus-Pinilla","year":"1999","journal-title":"J. Parasitol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"17480","DOI":"10.1073\/pnas.1904637116","article-title":"Toxoplasma Gondii Effector TgIST Blocks Type I Interferon Signaling to Promote Infection","volume":"116","author":"Matta","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. States America"},{"key":"B150","doi-asserted-by":"publisher","first-page":"e00046","DOI":"10.1128\/mBio.00046-20","article-title":"In Vitro Characterization of Protein Effector Export in the Bradyzoite Stage of Toxoplasma Gondii","volume":"11","author":"Mayoral","year":"2020","journal-title":"MBio"},{"key":"B151","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/B978-0-12-815041-2.00004-9","article-title":"Chapter 4 -Human Toxoplasma Infection","volume-title":"Toxoplasma gondii (Third Edition)","author":"McLeod","year":"2020"},{"key":"B152","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jim.2015.07.005","article-title":"Evolution of Cytokine Profile during the Treatment of Cerebral Toxoplasmosis in HIV-Infected Patients","volume":"426","author":"Meira","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"B153","doi-asserted-by":"publisher","first-page":"e1008572","DOI":"10.1371\/journal.ppat.1008572","article-title":"Toxoplasma Gondii Dense Granule Protein GRA24 Drives MyD88-Independent P38 MAPK Activation, IL-12 Production and Induction of Protective Immunity","volume":"16","author":"Mercer","year":"2020","journal-title":"PloS Pathog."},{"key":"B154","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.tim.2011.11.002","article-title":"The Pig: A Model for Human Infectious Diseases","volume":"20","author":"Meurens","year":"2012","journal-title":"Trends Microbiol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1051\/vetres\/2010021","article-title":"Mic1-3 Knockout Toxoplasma Gondii Is a Good Candidate for a Vaccine against T. Gondii -Induced Abortion in Sheep","volume":"41","author":"M\u00e9v\u00e9lec","year":"2010","journal-title":"Vet. Res."},{"key":"B156","doi-asserted-by":"publisher","first-page":"7589","DOI":"10.4049\/jimmunol.176.12.7589","article-title":"TLR9 Is Required for the Gut-Associated Lymphoid Tissue Response Following Oral Infection of Toxoplasma Gondii","volume":"176","author":"Minns","year":"2006","journal-title":"J. Immunol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s00436-019-06274-1","article-title":"Genotyping of Toxoplasma Gondii Isolated from Pigs for Human Consumption","volume":"118","author":"Miura","year":"2019","journal-title":"Parasitol. Res."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-020-3954-1","article-title":"The Global Serological Prevalence of Toxoplasma Gondii in Felids during the Last Five Decade","volume":"13","author":"Montazeri","year":"2020","journal-title":"Parasites Vectors"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.4067\/S0718-04622007000200009","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"B160","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1365-2958.2006.05538.x","article-title":"A Patatin-like Protein Protects Toxoplasma Gondii from Degradation in Activated Macrophages","volume":"63","author":"Mordue","year":"2007","journal-title":"Mol. Microbiol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1128\/IAI.01615-14","article-title":"Type II Toxoplasma Gondii Induction of CD40 on Infected Macrophages Enhances Interleukin-12 Responses","volume":"82","author":"Morgado","year":"2014","journal-title":"Infect. Immun."},{"key":"B162","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.4049\/jimmunol.134.3.1982","article-title":"Human Mononuclear Phagocyte Antiprotozoal Mechanisms: Oxygen-Dependent vs Oxygen-Independent Activity against Intracellular Toxoplasma Gondii","volume":"134","author":"Murray","year":"1985","journal-title":"J. Immunol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"e0232552","DOI":"10.1371\/journal.pone.0232552","article-title":"Proximity Biotinylation Reveals Novel Secreted Dense Granule Proteins of Toxoplasma Gondii Bradyzoites","volume":"15","author":"Nadipuram","year":"2020","journal-title":"PloS One"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3260289","article-title":"Experimental Porcine Toxoplasma Gondii Infection as a Representative Model for Human Toxoplasmosis","volume":"2017","author":"Nau","year":"2017","journal-title":"Mediators Inflammation"},{"key":"B165","doi-asserted-by":"publisher","first-page":"11496","DOI":"10.1038\/s41598-017-10675-6","article-title":"Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer","volume":"7","author":"Ng\u00f4","year":"2017","journal-title":"Sci. Rep."},{"key":"B166","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.chom.2016.06.006","article-title":"Toxoplasma Effector Recruits the Mi-2\/NuRD Complex to Repress STAT1 Transcription and Block IFN-\u03b3-Dependent Gene Expression","volume":"20","author":"Olias","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B167","doi-asserted-by":"publisher","first-page":"28731","DOI":"10.1074\/jbc.M110.112359","article-title":"Toxoplasma Rhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6","volume":"285","author":"Ong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2020.101414","article-title":"Toxoplasma Gondii Surface Antigen 1 (SAG1) as a Potential Candidate to Develop Vaccine against Toxoplasmosis: A Systematic Review","volume":"69","author":"Pagheh","year":"2020","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"B169","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1002\/eji.200425463","article-title":"A Mouse Model of Human Adaptive Immune Functions: HLA-A2.1-\/HLA-DR1-Transgenic H-2 Class I-\/Class II-Knockout Mice","volume":"34","author":"Pajot","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.micinf.2015.09.016","article-title":"Development of Dual Fluorescent Stage Specific Reporter Strain of Toxoplasma Gondii to Follow Tachyzoite and Bradyzoite Development in Vitro and in Vivo","volume":"18","author":"Paredes-Santos","year":"2016","journal-title":"Microbes Infect."},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00321","article-title":"The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability","volume":"9","author":"Paredes-Santos","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"7240","DOI":"10.1128\/IAI.72.12.7240-7246.2004","article-title":"Development of a System to Study CD4+-T-Cell Responses to Transgenic Ovalbumin-Expressing Toxoplasma Gondii during Toxoplasmosis","volume":"72","author":"Pepper","year":"2004","journal-title":"Infect. Immun."},{"key":"B173","doi-asserted-by":"publisher","first-page":"6229","DOI":"10.4049\/jimmunol.180.9.6229","article-title":"Plasmacytoid Dendritic Cells Are Activated by Toxoplasma Gondii to Present Antigen and Produce Cytokines","volume":"180","author":"Pepper","year":"2008","journal-title":"J. Immunol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1128\/IAI.00833-08","article-title":"Transmission of Toxoplasma Gondii from Infected Dendritic Cells to Natural Killer Cells","volume":"77","author":"Persson","year":"2009","journal-title":"Infect. Immun."},{"key":"B175","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1073\/pnas.81.3.908","article-title":"Interferon \u03b3 Blocks the Growth of Toxoplasma Gondii in Human Fibroblasts by Inducing the Host Cells to Degrade Tryptophan","volume":"81","author":"Pfefferkorn","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. States America"},{"key":"B176","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.pt.2019.08.001","article-title":"Toxoplasma and Dendritic Cells: An Intimate Relationship That Deserves Further Scrutiny","volume":"35","author":"Poncet","year":"2019","journal-title":"Trends Parasitol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.4049\/jimmunol.164.7.3741","article-title":"T Cell Clones Raised from Chronically Infected Healthy Humans by Stimulation with Toxoplasma Gondii Excretory-Secretory Antigens Cross-React with Live Tachyzoites: Characterization of the Fine Antigenic Specificity of the Clones and Implications for Vacc","volume":"164","author":"Prigione","year":"2000","journal-title":"J. Immunol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.micinf.2005.08.008","article-title":"T Cell Mediated Immune Responses to Toxoplasma Gondii in Pregnant Women with Primary Toxoplasmosis","volume":"8","author":"Prigione","year":"2006","journal-title":"Microbes Infect."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1007035","article-title":"Transcriptional Repression by ApiAP2 Factors Is Central to Chronic Toxoplasmosis","volume":"14","author":"Radke","year":"2018","journal-title":"PloS Pathog."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00161","article-title":"Early Kinetics of Intestinal Infection and Immune Responses to Two Toxoplasma Gondii Strains in Pigs","volume":"10","author":"Rahman","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/s41598-018-37671-8","article-title":"An Experimental Genetically Attenuated Live Vaccine to Prevent Transmission of Toxoplasma Gondii by Cats","volume":"9","author":"Ramakrishnan","year":"2019","journal-title":"Sci. Rep."},{"key":"B182","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1056\/NEJM196512092732404","article-title":"Isaolation of the Encysted Form of Toxoplasma Gondii Grom Human Skeletal Muscle and Brain","volume":"9","author":"Remington","year":"1965","journal-title":"New Engl. J. Med."},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2019.105696","article-title":"A Systematic Review on the Role of GRA Proteins of Toxoplasma Gondii in Host Immunization","volume":"165","author":"Rezaei","year":"2019","journal-title":"J. Microbiol. Methods"},{"key":"B184","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1128\/CMR.05013-11","article-title":"Epidemiology of and Diagnostic Strategies for Toxoplasmosis","volume":"25","author":"Robert-Gangneux","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02104","article-title":"Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma Gondii Infected Host Cells","volume":"10","author":"Rommereim","year":"2019","journal-title":"Front. Immunol."},{"key":"B186","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1084\/jem.20100717","article-title":"Strain-Specific Activation of the NF-\u03baB Pathway by GRA15, a Novel Toxoplasma Gondii Dense Granule Protein","volume":"208","author":"Rosowski","year":"2011","journal-title":"J. Exp. Med."},{"key":"B187","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1645\/0022-3395(2001)087[0083:aothro]2.0.co;2","article-title":"Analysis of the Humoral Responses of Toxoplasma Gondii-Infected Cats Using Immunofluorescent Assays with Tachyzoite, Bradyzoite, and Gametogenic Stages","volume":"87","author":"Rush","year":"2001","journal-title":"J. Parasitol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/BF00931632","article-title":"Human T-Cell Clones against Toxoplasma Gondii: Production of Interferon-y, Interleukin-2, and Strain Cross-Reactivity","volume":"77","author":"Saavedra","year":"1991","journal-title":"Parasitol. Res."},{"key":"B189","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1128\/iai.64.9.3858-3862.1996","article-title":"Epitopes Recognized by Human T Lymphocytes in the ROP2 Protein Antigen of Toxoplasma Gondii","volume":"64","author":"Saavedra","year":"1996","journal-title":"Infect. Immun."},{"key":"B190","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/nature05395","article-title":"Toxoplasma Co-Opts Host Gene Expression by Injection of a Polymorphic Kinase Homologue","volume":"447","author":"Saeij","year":"2007","journal-title":"Nature"},{"key":"B191","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.physbeh.2017.03.040","article-title":"Alarmin S100A11 Initiates a Chemokine Response to the Human Pathogen Toxoplasma Gondii","volume":"20","author":"Safronova","year":"2019","journal-title":"Nat"},{"key":"B192","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1016\/j.celrep.2019.05.051","article-title":"Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons","volume":"27","author":"Salvioni","year":"2019","journal-title":"Cell Rep."},{"key":"B193","doi-asserted-by":"publisher","first-page":"e00808","DOI":"10.1128\/mbio.00808-19","article-title":"Toxoplasma GRA15 Activates the NF-Kb Pathway through Interactions with TNF Receptor-Associated Factors","volume":"10","author":"Sangar\u00e9","year":"2019","journal-title":"MBio"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.01305","article-title":"CCp5A Protein from Toxoplasma Gondii as a Serological Marker of Oocyst-Driven Infections in Humans and Domestic Animals","volume":"6","author":"Santana","year":"2015","journal-title":"Front. Microbiol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"e1007871","DOI":"10.1371\/journal.ppat.1007871","article-title":"The Lectin-Specific Activity of Toxoplasma Gondii Microneme Proteins 1 and 4 Binds Toll-like Receptor 2 and 4 N-Glycans to Regulate Innate Immune Priming","volume":"15","author":"Sardinha-Silva","year":"2019","journal-title":"PloS Pathog."},{"key":"B196","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.4049\/jimmunol.168.12.5997","article-title":"Cutting Edge: MyD88 Is Required for Resistance to Toxoplasma Gondii Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells","volume":"168","author":"Scanga","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.01157-15.Invited","article-title":"A Noncanonical Autophagy Pathway Restricts Toxoplasma Gondii Growth in a Strain-Specific Manner in IFN-\u03b3-Activated Human Cells","volume":"6","author":"Selleck","year":"2015","journal-title":"MBio"},{"key":"B198","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/j.1348-0421.1994.tb01858.x","article-title":"CD8+ T Lymphocytes Are the Major Cell Population Involved in the Early Gamma Interferon Response and Resistance to Acute Primary Toxoplasma Gondii Infection in Mice","volume":"38","author":"Shirahata","year":"1994","journal-title":"Microbiol. Immunol."},{"key":"B199","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/pim.12532","article-title":"T-Cell Profiles Elicited by Toxoplasma Gondii in Acutely\/Chronically Infected Humans","volume":"40","author":"Silva-Gutierrez","year":"2018","journal-title":"Parasite Immunol."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100882","article-title":"Pathogenesis of Ocular Toxoplasmosis","volume":"100882","author":"Smith","year":"2020","journal-title":"Prog. Retinal Eye Res."},{"key":"B201","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0020-7519(00)00159-4","article-title":"Cytokine and Lymphocyte Profiles in Miniature Swine after Oral Infection with Toxoplasma Gondii Oocysts","volume":"31","author":"Solano Aguilar","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1016\/j.vaccine.2004.04.022","article-title":"Intranasal Immunisation with Toxoplasma Gondii Tachyzoite Antigen Encapsulated into PLG Microspheres Induces Humoral and Cell-Mediated Immunity in Sheep","volume":"22","author":"Stanley","year":"2004","journal-title":"Vaccine"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.fawpar.2019.e00037","article-title":"Toxoplasma Gondii Infection and Toxoplasmosis in Farm Animals: Risk Factors and Economic Impact","volume":"12","author":"Stelzer","year":"2019","journal-title":"Food Waterborne Parasitol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"10711","DOI":"10.1073\/pnas.1307868110","article-title":"TLR-Independent Neutrophil-Derived IFN-\u03b3 Is Important for Host Resistance to Intracellular Pathogens","volume":"110","author":"Sturge","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. States America"},{"key":"B205","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.4049\/jimmunol.165.3.1498","article-title":"Human Dendritic Cells Discriminate Between Viable and Killed Toxoplasma Gondii Tachyzoites: Dendritic Cell Activation After Infection with Viable Parasites Results in CD28 and CD40 Ligand Signaling That Controls IL-12-Dependent and -Independent T Cell Pro","volume":"165","author":"Subauste","year":"2000","journal-title":"J. Immunol."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.00755-16.Editor","article-title":"Is Involved in the Switch from Tachyzoite to Bradyzoite Development","volume":"7","author":"Sugi","year":"2016","journal-title":"MBio"},{"key":"B207","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.4049\/jimmunol.181.5.3464","article-title":"TLR Adaptor MyD88 Is Essential for Pathogen Control during Oral Toxoplasma Gondii Infection but Not Adaptive Immunity Induced by a Vaccine Strain of the Parasite","volume":"181","author":"Sukhumavasi","year":"2008","journal-title":"J. Immunol."},{"key":"B208","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.4049\/jimmunol.140.11.3943","article-title":"Dual Regulation of Resistance against Toxoplasma Gondii Infection by Lyt-2+ and Lyt-1+, L3T4+ T Cells in Mice","volume":"140","author":"Suzuki","year":"1988","journal-title":"J. Immunol."},{"key":"B209","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.144.5.1954","article-title":"The Effect of Anti-IFN-Gamma Antibody on the Protective Effect of Lyt-2+ Immune T Cells against Toxoplasmosis in Mice","volume":"144","author":"Suzuki","year":"1990","journal-title":"J. Immunol."},{"key":"B210","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.4049\/jimmunol.143.6.2045","article-title":"Importance of Endogenous IFN-Gamma for Prevention of Toxoplasmic Encephalitis in Mice","volume":"143","author":"Suzuki","year":"1989","journal-title":"J. Immunol."},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2019.102030","article-title":"The Immune System Utilizes Two Distinct Effector Mechanisms of T Cells Depending on Two Different Life Cycle Stages of a Single Pathogen, Toxoplasma Gondii, to Control Its Cerebral Infection","volume":"76","author":"Suzuki","year":"2020","journal-title":"Parasitol. Int."},{"key":"B212","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"Identification of T. Gondii Epitopes, Adjuvants, & Host Genetic Factors That Influence Protection of Mice & Humans","volume":"28","author":"Tan","year":"2010","journal-title":"Vaccine"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00349","article-title":"Sustained Egr-1 Response via P38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by Toxoplasma Gondii","volume":"9","author":"Ten Hoeve","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0304-4017(92)90160-B","article-title":"Development of ELISAs Based on Recombinant Antigens for the Detection of Toxoplasma Gondii-Specific Antibodies in Sheep and Cats","volume":"43","author":"Tenter","year":"1992","journal-title":"Vet. Parasitol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma Gondii: From Animals to Humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1128\/IAI.05543-11","article-title":"A Patatin-like Protein Protects Toxoplasma Gondii from Degradation in a Nitric Oxide-Dependent Manner","volume":"80","author":"Tobin","year":"2012","journal-title":"Infect. Immun."},{"key":"B217","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1128\/IAI.00444-13","article-title":"A Toxoplasma Patatin-like Protein Changes Localization and Alters the Cytokine Response during Toxoplasmic Encephalitis","volume":"82","author":"Tobin Magle","year":"2014","journal-title":"Infect. Immun."},{"key":"B218","doi-asserted-by":"publisher","first-page":"345","DOI":"10.4049\/jimmunol.1501558","article-title":"The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma Gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion","volume":"196","author":"Tosh","year":"2016","journal-title":"J. Immunol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/s0034-5288(18)31120-2","article-title":"Serodiagnosis of Ovine Toxoplasmosis: An Assessment of the Latex Agglutination Test and the Value of IgM Specific Titres after Experimental Oocyst-Induced Infections","volume":"46","author":"Trees","year":"1989","journal-title":"Res. Vet. Sci."},{"key":"B220","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.pt.2019.08.005","article-title":"CD8+ T Cell Responses to Toxoplasma Gondii: Lessons from a Successful Parasite","volume":"35","author":"Tsitsiklis","year":"2019","journal-title":"Trends Parasitol."},{"key":"B221","doi-asserted-by":"publisher","first-page":"e00469","DOI":"10.1128\/mBio.00469-19","article-title":"Enrichment and Proteomic Characterization of the Cyst Wall from in Vitro Toxoplasma Gondii Cysts","volume":"10","author":"Tu","year":"2019","journal-title":"MBio"},{"key":"B222","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.chom.2015.11.004","article-title":"Regulation of Starch Stores by a Ca2+-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma Gondii","volume":"18","author":"Uboldi","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B223","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.vetpar.2011.02.015","article-title":"IFN-\u03b3 Expression and Infectivity of Toxoplasma Infected Tissues Are Associated with an Antibody Response against GRA7 in Experimentally Infected Pigs","volume":"179","author":"Verhelst","year":"2011","journal-title":"Vet. Parasitol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12917-014-0293-5","article-title":"Parasite Distribution and Associated Immune Response during the Acute Phase of Toxoplasma Gondii Infection in Sheep","volume":"10","author":"Verhelst","year":"2014","journal-title":"BMC Vet. Res."},{"key":"B225","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.vetpar.2014.11.014","article-title":"Interferon-Gamma Expression and Infectivity of Toxoplasma Infected Tissues in Experimentally Infected Sheep in Comparison with Pigs","volume":"207","author":"Verhelst","year":"2015","journal-title":"Vet. Parasitol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.cell.2019.12.013","article-title":"Identification of a Master Regulator of Differentiation in Toxoplasma","volume":"180","author":"Waldman","year":"2020","journal-title":"Cell"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00730","article-title":"Immunization with Toxoplasma Gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Immunol."},{"key":"B228","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.pt.2019.01.005","article-title":"Advances in the Development of Anti-Toxoplasma Gondii Vaccines: Challenges, Opportunities, and Perspectives","volume":"35","author":"Wang","year":"2019","journal-title":"Trends Parasitol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1093\/infdis\/jiy211","article-title":"Live Attenuated Pru:\u0394cdpk2 Strain of Toxoplasma Gondii Protects against Acute, Chronic, and Congenital Toxoplasmosis","volume":"218","author":"Wang","year":"2018","journal-title":"J. Infect. Dis."},{"key":"B230","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.4049\/jimmunol.1900410","article-title":"Toxoplasma Gondii Tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice","volume":"204","author":"Wang","year":"2020","journal-title":"J. Immunol."},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8010016","article-title":"Toxoplasma Gondii ADSL Knockout Provides Excellent Immune Protection against a Variety of Strains","volume":"8","author":"Wang","year":"2020","journal-title":"Vaccines"},{"key":"B232","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-018-3179-8","article-title":"Transcriptomic Insights into the Early Host-Pathogen Interaction of Cat Intestine with Toxoplasma Gondii","volume":"11","author":"Wang","year":"2018","journal-title":"Parasites Vectors"},{"key":"B233","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0021-9975(05)80089-1","article-title":"Kinetics of the Local and Systemic Antibody Response to Primary and Secondary Infection with S48 Toxoplasma Gondii in Sheep","volume":"112","author":"Wastling","year":"1995","journal-title":"J. Comp. Pathol."},{"key":"B234","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1128\/IAI.00898-10","article-title":"NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate of Toxoplasma Gondii-Infected Monocytic Cells","volume":"79","author":"Witola","year":"2011","journal-title":"Infect. Immun."},{"key":"B235","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ijpara.2020.05.001","article-title":"Cell Type- and Species-Specific Host Responses to Toxoplasma Gondii and Its near Relatives","volume":"50","author":"Wong","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01814","article-title":"A Lactate Fermentation Mutant of Toxoplasma Stimulates Protective Immunity against Acute and Chronic Toxoplasmosis","volume":"9","author":"Xia","year":"2018","journal-title":"Front. Immunol."},{"key":"B237","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.54129","article-title":"A Single-Parasite Transcriptional Atlas of Toxoplasma Gondii Reveals Novel Control of Antigen Expression","volume":"9","author":"Xue","year":"2020","journal-title":"ELife"},{"key":"B238","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4161\/viru.3.1.18340","article-title":"Inhibition of ATF6\u03b2-Dependent Host Adaptive Immune Response by a Toxoplasma Virulence Factor ROP18","volume":"3","author":"Yamamoto","year":"2012","journal-title":"Virulence"},{"key":"B239","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1084\/jem.20091703","article-title":"A Single Polymorphic Amino Acid on Toxoplasma Gondii Kinase ROP16 Determines the Direct and Strain-Specific Activation of Stat3","volume":"206","author":"Yamamoto","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01875","article-title":"Immunization with a Live-Attenuated RH:\u0394NPT1 Strain of Toxoplasma Gondii Induces Strong Protective Immunity against Toxoplasmosis in Mice","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Microbiol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1006\/bbrc.1997.6904","article-title":"Correlation between Direct Binding Ability of Synthetic T. Gondii SAG1 Peptides to HLA-A2 Measured by a Sensor for Surface Plasmon Resonance and Antigenicity of the Peptides for T. Gondii-Infected Cell-Specific CTL","volume":"236","author":"Yano","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B242","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4049\/jimmunol.165.2.628","article-title":"Cutting Edge: IL-12 Is Required for the Maintenance of IFN-\u03b3 Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen, Toxoplasma Gondii","volume":"165","author":"Yap","year":"2000","journal-title":"J. Immunol."},{"key":"B243","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1126\/science.1109893","article-title":"TLR11 Activation of Dendritic Cells by a Protozoan Profilin-like Protein","volume":"308","author":"Yarovinsky","year":"2005","journal-title":"Science"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00204","article-title":"Review on the Current Trends of Toxoplasmosis Serodiagnosis in Humans","volume":"10","author":"Yba\u00f1ez","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.exppara.2015.08.015","article-title":"Early Detection of Toxoplasma Gondii-Infected Cats by Interferon-Gamma Release Assay","volume":"157","author":"Yin","year":"2015","journal-title":"Exp. Parasitol."},{"key":"B246","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1172\/JCI136226","article-title":"The Molecular Biology and Immune Control of Chronic Toxoplasma Gondii Infection","volume":"130","author":"Zhao","year":"2020","journal-title":"J. Clin. Invest."},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00899","article-title":"Strategies Developed by Toxoplasma Gondii to Survive in the Host","volume":"10","author":"Zhu","year":"2019","journal-title":"Front. Microbiol."},{"key":"B248","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.vetpar.2017.10.021","article-title":"Toxoplasma Gondii: A Study of Oocyst Re-Shedding in Domestic Cats","volume":"249","author":"Zulpo","year":"2018","journal-title":"Vet. Parasitol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2020.607198\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T20:48:46Z","timestamp":1723927726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2020.607198\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":248,"alternative-id":["10.3389\/fcimb.2020.607198"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2020.607198","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"article-number":"607198"}}