{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:56:05Z","timestamp":1793087765379,"version":"4.5.0"},"reference-count":133,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI136511, R21 AI142506-01"],"award-info":[{"award-number":["R01 AI136511, R21 AI142506-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007602","name":"University of California, Riverside","doi-asserted-by":"publisher","award":["NIFA-Hatch-225935"],"award-info":[{"award-number":["NIFA-Hatch-225935"]}],"id":[{"id":"10.13039\/100007602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Over the past decade, we have witnessed significant progresses in understanding gene regulation in Apicomplexa including the human malaria parasite,\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    . This parasite possesses the ability to convert in multiple stages in various hosts, cell types, and environments. Recent findings indicate that\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    is talented at using efficient and complementary molecular mechanisms to ensure a tight control of gene expression at each stage of its life cycle. Here, we review the current understanding on the contribution of the epigenome, atypical transcription factors, and chromatin organization to regulate stage conversion in\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    . The adjustment of these regulatory mechanisms occurring during the progression of the life cycle will be extensively discussed.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2020.618454","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T16:41:43Z","timestamp":1610037703000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium"],"prefix":"10.3389","volume":"10","author":[{"given":"Thomas","family":"Hollin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine G.","family":"Le Roch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1186\/s12864-015-2320-8","article-title":"Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1","volume":"16","author":"Adjalley","year":"2015","journal-title":"BMC Genomics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"E982","DOI":"10.1073\/pnas.1420855112","article-title":"Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum","volume":"112","author":"Amit-Avraham","year":"2015","journal-title":"Proc. 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