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However, new antimicrobial therapies are urgently needed as significant problems exist with current treatments such as drug resistance, limited options, poor efficacy, as well as toxicity. This situation is made worse by the challenges of drug discovery and development which is costly\u00a0especially for non-profitable infectious\u00a0diseases, time-consuming, and risky with a\u00a0high failure rate. Drug repurposing which involves finding new use for existing drugs may help to more rapidly identify therapeutic candidates while drastically cutting costs of drug research and development. In this perspective article, we discuss the importance of drug repurposing, review disulfiram pharmacology, and highlight emerging data that supports repurposing disulfiram as an anti-parasitic, exemplified by the major diarrhea-causing\u00a0parasite<jats:italic>Entamoeba histolytica<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fcimb.2021.633194","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T06:27:24Z","timestamp":1615444044000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent"],"prefix":"10.3389","volume":"11","author":[{"given":"Debbie-Ann","family":"Shirley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishrya","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cirle A.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Moonah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.5863\/1551-6776-24.5.445","article-title":"Disulfiram-like Reaction With Metronidazole: An Unsuspected Culprit","volume":"24","author":"Alonzo","year":"2019","journal-title":"J. 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