{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:49:39Z","timestamp":1785898179072,"version":"3.56.0"},"reference-count":111,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. <jats:italic>Ascaris suum<\/jats:italic> and <jats:italic>Trichuris muris<\/jats:italic> have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of <jats:italic>Necator americanus<\/jats:italic>, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between <jats:italic>Nippostrongylus brasiliensis<\/jats:italic>, <jats:italic>Heligmosomoides polygyrus bakeri<\/jats:italic> and <jats:italic>Trichuris muris<\/jats:italic> and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.<\/jats:p>","DOI":"10.3389\/fcimb.2021.639573","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T06:10:42Z","timestamp":1619071842000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach"],"prefix":"10.3389","volume":"11","author":[{"given":"Karen J.","family":"Monta\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cu\u00e9llar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Sotillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s13071-020-04010-8","article-title":"Twenty-five-year research progress in hookworm excretory\/secretory products","volume":"13","author":"Abuzeid","year":"2020","journal-title":"Parasit Vectors"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e78353","DOI":"10.1371\/journal.pone.0078353","article-title":"Proteomic and Immunochemical Characterization of Glutathione Transferase as a New Allergen of the Nematode Ascaris lumbricoides","volume":"8","author":"Acevedo","year":"2013","journal-title":"PloS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1365-3024.2009.01158.x","article-title":"The mucosal response to secondary infection with Ancylostoma ceylanicum in hamsters immunized by abbreviated primary infection: Ancylostoma ceylanicum in hamsters","volume":"32","author":"Alkazmi","year":"2010","journal-title":"Parasite Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1016\/j.vaccine.2006.12.055","article-title":"The effect of vaccination with a recombinant Nippostrongylus brasiliensis acetylcholinesterase on infection outcome in the rat","volume":"25","author":"Ball","year":"2007","journal-title":"Vaccine"},{"key":"B5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2307\/3283340","article-title":"The food resource of adult Heligmosomoides polygyrus in the small intestine","volume":"80","author":"Bansemir","year":"1994","journal-title":"J. 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