{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:59:21Z","timestamp":1790801961435,"version":"4.1.0"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1626072"],"award-info":[{"award-number":["1626072"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI128136, AI144856, AI110690, AI152387, AI150090, AI138551, AI153945, AI117201"],"award-info":[{"award-number":["AI128136, AI144856, AI110690, AI152387, AI150090, AI138551, AI153945, AI117201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>The close-knit group of apicomplexan parasites displays a wide variety of cell division modes, which differ between parasites as well as between different life stages within a single parasite species. The beginning and endpoint of the asexual replication cycles is a \u2018zoite\u2019 harboring the defining apical organelles required for host cell invasion. However, the number of zoites produced per division round varies dramatically and can unfold in several different ways. This plasticity of the cell division cycle originates from a combination of hard-wired developmental programs modulated by environmental triggers. Although the environmental triggers and sensors differ between species and developmental stages, widely conserved secondary messengers mediate the signal transduction pathways. These environmental and genetic input integrate in division-mode specific chromosome organization and chromatin modifications that set the stage for each division mode. Cell cycle progression is conveyed by a smorgasbord of positively and negatively acting transcription factors, often acting in concert with epigenetic reader complexes, that can vary dramatically between species as well as division modes. A unique set of cell cycle regulators with spatially distinct localization patterns insert discrete check points which permit individual control and can uncouple general cell cycle progression from nuclear amplification. Clusters of expressed genes are grouped into four functional modules seen in all division modes: 1. mother cytoskeleton disassembly; 2. DNA replication and segregation (D&amp;amp;S); 3. karyokinesis; 4. zoite assembly. A plug-and-play strategy results in the variety of extant division modes. The timing of mother cytoskeleton disassembly is hard-wired at the species level for asexual division modes: it is either the first step, or it is the last step. In the former scenario zoite assembly occurs at the plasma membrane (external budding), and in the latter scenario zoites are assembled in the cytoplasm (internal budding). The number of times each other module is repeated can vary regardless of this first decision, and defines the modes of cell division: schizogony, binary fission, endodyogeny, endopolygeny.<\/jats:p>","DOI":"10.3389\/fcimb.2021.670049","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T07:37:33Z","timestamp":1618213053000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["The Modular Circuitry of Apicomplexan Cell Division Plasticity"],"prefix":"10.3389","volume":"11","author":[{"given":"Marc-Jan","family":"Gubbels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Coppens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Zarringhalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj T.","family":"Duraisingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemens","family":"Engelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13284","article-title":"Depletion of the Mini-Chromosome Maintenance Complex Binding Protein allows the progression of cytokinesis despite abnormal karyokinesis during the asexual development of Plasmodium falciparum","volume":"23","author":"Absalon","year":"2020","journal-title":"Cell Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1111\/febs.14150","article-title":"Identification and characterization of ARS-like sequences as putative origin(s) of replication in human malaria parasite Plasmodium falciparum","volume":"284","author":"Agarwal","year":"2017","journal-title":"FEBS J."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001029","article-title":"Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B","volume":"6","author":"Agop-Nersesian","year":"2010","journal-title":"PloS Pathog."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006483","article-title":"Checkpoints of apicomplexan cell division identified in Toxoplasma gondii","volume":"13","author":"Alvarez","year":"2017","journal-title":"PloS Pathog."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004983","article-title":"Comparative Bioinformatics Analysis of Transcription Factor Genes Indicates Conservation of Key Regulatory Domains among Babesia bovis, Babesia microti, and Theileria equi","volume":"10","author":"Alzan","year":"2016","journal-title":"PloS Negl. Trop. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1462-5822.2010.01514.x","article-title":"A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii","volume":"13","author":"Anderson-White","year":"2011","journal-title":"Cell Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-394309-5.00001-8","article-title":"Cytoskeleton assembly in Toxoplasma gondii cell division","volume":"298","author":"Anderson-White","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ijpara.2010.07.012","article-title":"The progression of the intra-erythrocytic cell cycle of Plasmodium falciparum and the role of the centriolar plaques in asynchronous mitotic division during schizogony","volume":"41","author":"Arnot","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"12164","DOI":"10.1073\/pnas.1921245117","article-title":"Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis","volume":"117","author":"Back","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.1093\/nar\/gki709","article-title":"Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains","volume":"33","author":"Balaji","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56474.sa2","article-title":"A divergent cyclin\/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission","volume":"9","author":"Balestra","year":"2020","journal-title":"Elife"},{"key":"B12","doi-asserted-by":"publisher","first-page":"11567","DOI":"10.1073\/pnas.1613653113","article-title":"O-fucosylated glycoproteins form assemblies in close proximity to the nuclear pore complexes of Toxoplasma gondii","volume":"113","author":"Bandini","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007946","article-title":"Toxoplasma F-box protein 1 is required for daughter cell scaffold function during parasite replication","volume":"15","author":"Baptista","year":"2019","journal-title":"PloS Pathog."},{"key":"B14","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.chom.2020.09.011","article-title":"A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions","volume":"28","author":"Barylyuk","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001094","article-title":"A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division","volume":"6","author":"Beck","year":"2010","journal-title":"PloS Pathog."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003162","article-title":"A Toxoplasma palmitoyl acyl transferase and the palmitoylated Armadillo Repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress","volume":"9","author":"Beck","year":"2013","journal-title":"PloS Pathog."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e12354","DOI":"10.1371\/journal.pone.0012354","article-title":"Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii","volume":"5","author":"Behnke","year":"2010","journal-title":"PloS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"4417","DOI":"10.1007\/s00018-018-2889-6","article-title":"Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny","volume":"75","author":"Berry","year":"2018","journal-title":"Cell Mol. Life Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41564-018-0339-8","article-title":"Phosphatidic acid governs natural egress in Toxoplasma gondii via a guanylate cyclase receptor platform","volume":"4","author":"Bisio","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02445-14","article-title":"Systems-based analysis of the Sarcocystis neurona genome identifies pathways that contribute to a heteroxenous life cycle","volume":"6","author":"Blazejewski","year":"2015","journal-title":"mBio"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000005","article-title":"The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum","volume":"1","author":"Bozdech","year":"2003","journal-title":"PloS Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.cell.2017.10.020","article-title":"Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum","volume":"171","author":"Brancucci","year":"2017","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001806","article-title":"Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca(2)(+) signals at key decision points in the life cycle of malaria parasites","volume":"12","author":"Brochet","year":"2014","journal-title":"PloS Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1073\/pnas.1006741108","article-title":"Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle","volume":"108","author":"Brooks","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007670","article-title":"The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosiscalcium, and phosphatidic acid","volume":"15","author":"Bullen","year":"2019","journal-title":"PloS Pathog."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1038\/s41467-018-04295-5","article-title":"Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages","volume":"9","author":"Bunnik","year":"2018","journal-title":"Nat. Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1073\/pnas.1810815116","article-title":"Comparative 3D genome organization in apicomplexan parasites","volume":"116","author":"Bunnik","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01261","article-title":"Potential Sabotage of Host Cell Physiology by Apicomplexan Parasites for Their Survival Benefits","volume":"8","author":"Chakraborty","year":"2017","journal-title":"Front. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1126\/science.1171085","article-title":"Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells","volume":"324","author":"Chandramohanadas","year":"2009","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1091\/mbc.E18-10-0608","article-title":"TgCep250 is dynamically processed through the division cycle and essential for structural integrity of the Toxoplasma centrosome","volume":"30","author":"Chen","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e02357","DOI":"10.1128\/mBio.02357-14","article-title":"Novel components of the Toxoplasma inner membrane complex revealed by BioID","volume":"6","author":"Chen","year":"2015","journal-title":"MBio"},{"key":"B32","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1091\/mbc.E15-06-0437","article-title":"Compartmentalized Toxoplasma EB1 bundles spindle microtubules to secure accurate chromosome segregation","volume":"26","author":"Chen","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1007\/s00018-017-2459-3","article-title":"Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex","volume":"74","author":"Courjol","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"8393","DOI":"10.1073\/pnas.0801993105","article-title":"Specific DNA-binding by apicomplexan AP2 transcription factors","volume":"105","author":"De Silva","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/mmi.13099","article-title":"Regulation of Plasmodium falciparum Origin Recognition Complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK-like kinase PK5","volume":"98","author":"Deshmukh","year":"2015","journal-title":"Mol. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s00294-015-0562-2","article-title":"Regulation of DNA replication proteins in parasitic protozoans: possible role of CDK-like kinases","volume":"62","author":"Deshmukh","year":"2016","journal-title":"Curr. Genet."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00085-16","article-title":"A Cell Cycle-Regulated Toxoplasma Deubiquitinase, TgOTUD3A, Targets Polyubiquitins with Specific Lysine Linkages","volume":"1","author":"Dhara","year":"2016","journal-title":"mSphere"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13212","article-title":"Two palmitoyl acyltransferases involved sequentially in the biogenesis of the inner membrane complex of Toxoplasma gondii","volume":"22","author":"Dogga","year":"2020","journal-title":"Cell Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2478\/kinome-2013-0001","article-title":"An atypical cyclin-dependent kinase controls Plasmodium falciparum proliferation rate","volume":"1","author":"Dorin-Semblat","year":"2013","journal-title":"Kinome"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00409-17","article-title":"Differential Roles for Inner Membrane Complex Proteins across Toxoplasma gondii and Sarcocystis neurona Development","volume":"2","author":"Dubey","year":"2017","journal-title":"mSphere"},{"key":"B42","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1550-7408.1979.tb04639.x","article-title":"Ultrastructural study of schizogony of Eimeria bovis in cell cultures","volume":"26","author":"Dubremetz","year":"1979","journal-title":"J. Protozool."},{"key":"B41","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/S0022-5320(73)90063-4","article-title":"[Ultrastructural study of schizogonic mitosis in the coccidian, Eimeria necatrix (Johnson 1930)]","volume":"42","author":"Dubremetz","year":"1973","journal-title":"J. Ultrastruct. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-micro-090817-062722","article-title":"Epigenetic Variation and Regulation in Malaria Parasites","volume":"72","author":"Duraisingh","year":"2018","journal-title":"Annu. Rev. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-11-265","article-title":"The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes","volume":"11","author":"Eme","year":"2011","journal-title":"BMC Evol. Biol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13112","article-title":"The apical annuli of Toxoplasma gondii are composed of coiled-coil and signaling proteins embedded in the IMC sutures","volume":"22","author":"Engelberg","year":"2020","journal-title":"Cell Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s41564-020-0674-4","article-title":"A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment","volume":"5","author":"Farhat","year":"2020","journal-title":"Nat. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/cmi.12185","article-title":"The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole)","volume":"16","author":"Farrell","year":"2014","journal-title":"Cell. Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1126\/science.1210829","article-title":"A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis","volume":"335","author":"Farrell","year":"2012","journal-title":"Science"},{"key":"B49","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1128\/EC.00021-08","article-title":"MORN1 has a conserved role in asexual and sexual development across the Apicomplexa","volume":"7","author":"Ferguson","year":"2008","journal-title":"Eukaryot. Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1126\/science.aan6042","article-title":"GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing","volume":"359","author":"Filarsky","year":"2018","journal-title":"Science"},{"key":"B54","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/nrmicro3184","article-title":"Cell division in apicomplexan parasites","volume":"12","author":"Francia","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001444","article-title":"Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella","volume":"10","author":"Francia","year":"2012","journal-title":"PloS Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13630-016-0025-5","article-title":"Basal body structure and composition in the apicomplexans Toxoplasma and Plasmodium","volume":"5","author":"Francia","year":"2015","journal-title":"Cilia"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00295","article-title":"A Homolog of Structural Maintenance of Chromosome 1 Is a Persistent Centromeric Protein Which Associates With Nuclear Pore Components in Toxoplasma gondii","volume":"10","author":"Francia","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.chom.2018.01.008","article-title":"Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites","volume":"23","author":"Fraschka","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004504","article-title":"Plasticity between MyoC- and MyoA-glideosomes: an example of functional compensation in Toxoplasma gondii invasion","volume":"10","author":"Frenal","year":"2014","journal-title":"PloS Pathog."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15710","article-title":"Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii","volume":"8","author":"Frenal","year":"2017","journal-title":"Nat. Commun."},{"key":"B58","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.molbiopara.2012.05.002","article-title":"Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation","volume":"184","author":"Fung","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1365-2958.2010.07441.x","article-title":"Cell cycle-dependent, intercellular transmission of Toxoplasma gondii is accompanied by marked changes in parasite gene expression","volume":"79","author":"Gaji","year":"2011","journal-title":"Mol. Microbiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41592-018-0238-1","article-title":"Imaging cellular ultrastructures using expansion microscopy (U-ExM)","volume":"16","author":"Gambarotto","year":"2019","journal-title":"Nat. Methods"},{"key":"B61","doi-asserted-by":"publisher","first-page":"17017","DOI":"10.1038\/nmicrobiol.2017.17","article-title":"Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony","volume":"2","author":"Ganter","year":"2017","journal-title":"Nat. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1083\/jcb.200311137","article-title":"Identification of the membrane receptor of a class XIV myosin in Toxoplasma gondii","volume":"165","author":"Gaskins","year":"2004","journal-title":"J. Cell Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1128\/EC.00314-10","article-title":"Mitosis in the human malaria parasite Plasmodium falciparum","volume":"10","author":"Gerald","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"B64","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1128\/EC.00201-08","article-title":"GAP45 phosphorylation controls assembly of the Toxoplasma myosin XIV complex","volume":"8","author":"Gilk","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030077","article-title":"Epigenomic Modifications Predict Active Promoters and Gene Structure in Toxoplasma gondii","volume":"3","author":"Gissot","year":"2007","journal-title":"PloS Pathog."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032671","article-title":"Toxoplasma gondii chromodomain protein 1 binds to heterochromatin and colocalises with centromeres and telomeres at the nuclear periphery","volume":"7","author":"Gissot","year":"2012","journal-title":"PloS One"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02020-18","article-title":"Epiplasts: Membrane Skeletons and Epiplastin Proteins in Euglenids, Glaucophytes, Cryptophytes, Ciliates, Dinoflagellates, and Apicomplexans","volume":"9","author":"Goodenough","year":"2018","journal-title":"MBio"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1093\/molbev\/msn070","article-title":"Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata","volume":"25","author":"Gould","year":"2008","journal-title":"Mol. Biol. Evol."},{"key":"B70","first-page":"743","article-title":"The Toxoplasma cytoskeleton: structures, proteins, and processes","volume-title":"Toxoplasma gondii: the model apicomplexan - perspective and methods","author":"Gubbels","year":"2020"},{"key":"B72","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.molbiopara.2004.05.007","article-title":"Fluorescent protein tagging in Toxoplasma gondii: identification of a novel inner membrane complex component conserved among Apicomplexa","volume":"137","author":"Gubbels","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1242\/jcs.02949","article-title":"A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus","volume":"119","author":"Gubbels","year":"2006","journal-title":"J. Cell Sci."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00269","article-title":"Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes","volume":"10","author":"Gubbels","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.molbiopara.2005.03.020","article-title":"Biochemical and genetic analysis of the distinct proliferating cell nuclear antigens of Toxoplasma gondii","volume":"142","author":"Guerini","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ijpara.2016.10.008","article-title":"Epigenetic landscapes underlining global patterns of gene expression in the human malaria parasite, Plasmodium falciparum","volume":"47","author":"Gupta","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/j.1365-2958.2008.06316.x","article-title":"Plasmodium falciparum origin recognition complex subunit 5: functional characterization and role in DNA replication foci formation","volume":"69","author":"Gupta","year":"2008","journal-title":"Mol. Microbiol."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003170","article-title":"Dynamic epigenetic regulation of gene expression during the life cycle of malaria parasite Plasmodium falciparum","volume":"9","author":"Gupta","year":"2013","journal-title":"PloS Pathog."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2019.111203","article-title":"A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii","volume":"232","author":"Harris","year":"2019","journal-title":"Mol. Biochem. Parasitol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.molbiopara.2005.09.015","article-title":"Golgi and centrosome cycles in Toxoplasma gondii","volume":"145","author":"Hartmann","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000754","article-title":"TgMORN1 Is a Key Organizer for the Basal Complex of Toxoplasma gondii","volume":"6","author":"Heaslip","year":"2010","journal-title":"PloS Pathog."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002201","article-title":"The motility of a human parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase","volume":"7","author":"Heaslip","year":"2011","journal-title":"PloS Pathog."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1111\/j.1462-5822.2012.01803.x","article-title":"Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony","volume":"14","author":"Hoeijmakers","year":"2012","journal-title":"Cell Microbiol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"11574","DOI":"10.1093\/nar\/gkz1044","article-title":"Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum","volume":"47","author":"Hoeijmakers","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tig.2020.09.003","article-title":"Dynamic Chromatin Structure and Epigenetics Control the Fate of Malaria Parasites","volume":"37","author":"Hollin","year":"2021","journal-title":"Trends Genet."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.618454","article-title":"From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium","volume":"10","author":"Hollin","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw2619","article-title":"The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle","volume":"365","author":"Howick","year":"2019","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nbt.1597","article-title":"Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum","volume":"28","author":"Hu","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpara.2007.07.018","article-title":"Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes","volume":"38","author":"Iyer","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02732-19","article-title":"Identification of Fis1 Interactors in Toxoplasma gondii Reveals a Novel Protein Required for Peripheral Distribution of the Mitochondrion","volume":"11","author":"Jacobs","year":"2020","journal-title":"mBio"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00248","article-title":"The Complexity of Piroplasms Life Cycles","volume":"8","author":"Jalovecka","year":"2018","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/cr.2010.88","article-title":"Metamorphosis of the malaria parasite in the liver is associated with organelle clearance","volume":"20","author":"Jayabalasingham","year":"2010","journal-title":"Cell Res."},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00047-16","article-title":"Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development","volume":"81","author":"Jeffers","year":"2017","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B92","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/pathogens8020047","article-title":"ApiAP2 Transcription Factors in Apicomplexan Parasites","volume":"8","author":"Jeninga","year":"2019","journal-title":"Pathogens"},{"key":"B93","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.chom.2015.05.009","article-title":"A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression","volume":"17","author":"Josling","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B94","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1126\/science.1165740","article-title":"Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells","volume":"323","author":"Kafsack","year":"2009","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1084\/jem.20022100","article-title":"Transformation of sporozoites into early exoerythrocytic malaria parasites does not require host cells","volume":"197","author":"Kaiser","year":"2003","journal-title":"J. Exp. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"11249","DOI":"10.1038\/s41598-018-29590-5","article-title":"Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei","volume":"8","author":"Kehrer","year":"2018","journal-title":"Sci. Rep."},{"key":"B97","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41467-020-20216-x","article-title":"TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii","volume":"12","author":"Khelifa","year":"2021","journal-title":"Nat. Commun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1146\/annurev-micro-090817-062741","article-title":"The Epigenome, Cell Cycle, and Development in Toxoplasma","volume":"72","author":"Kim","year":"2018","journal-title":"Annu. Rev. Microbiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1093\/molbev\/mss081","article-title":"Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite","volume":"29","author":"Kono","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1242\/jcs.181230","article-title":"Pellicle formation in the malaria parasite","volume":"129","author":"Kono","year":"2016","journal-title":"J. Cell Sci"},{"key":"B101","doi-asserted-by":"publisher","first-page":"R589","DOI":"10.1016\/j.cub.2020.02.021","article-title":"Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes","volume":"30","author":"Kops","year":"2020","journal-title":"Curr. Biol."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz4137","article-title":"A helical inner scaffold provides a structural basis for centriole cohesion","volume":"6","author":"Le Guennec","year":"2020","journal-title":"Sci. Adv."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1126\/science.1087025","article-title":"Discovery of gene function by expression profiling of the malaria parasite life cycle","volume":"301","author":"Le Roch","year":"2003","journal-title":"Science"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1101\/gad.1829209","article-title":"Endoreplication: polyploidy with purpose","volume":"23","author":"Lee","year":"2009","journal-title":"Genes Dev."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky373","article-title":"Cooperative binding of ApiAP2 transcription factors is crucial for the expression of virulence genes in Toxoplasma gondii","volume":"46","author":"Lesage","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"6057","DOI":"10.1093\/nar\/gky373","article-title":"Cooperative binding of ApiAP2 transcription factors is crucial for the expression of virulence genes in Toxoplasma gondii","volume":"46","author":"Lesage","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B107","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.pt.2020.07.006","article-title":"Noncoding RNAs in Apicomplexan Parasites: An Update","volume":"36","author":"Li","year":"2020","journal-title":"Trends Parasitol."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002410","article-title":"Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity","volume":"7","author":"Lige","year":"2011","journal-title":"PloS Pathog."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012302","article-title":"A Toxoplasma MORN1 Null Mutant Undergoes Repeated Divisions but Is Defective in Basal Assembly, Apicoplast Division and Cytokinesis","volume":"5","author":"Lorestani","year":"2010","journal-title":"PloS One"},{"key":"B110","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijpara.2008.09.013","article-title":"Intracellular survival of apicomplexan parasites and host cell modification","volume":"39","author":"Luder","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"31871","DOI":"10.1074\/jbc.M800028200","article-title":"Centrins, cell cycle regulation proteins in human malaria parasite Plasmodium falciparum","volume":"283","author":"Mahajan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B112","doi-asserted-by":"publisher","first-page":"41240","DOI":"10.1074\/jbc.M205056200","article-title":"Proteolytic Processing of TgIMC1 during Maturation of the Membrane Skeleton of Toxoplasma gondii","volume":"277","author":"Mann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000364","article-title":"Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction","volume":"17","author":"Martorelli Di Genova","year":"2019","journal-title":"PloS Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13071-018-2800-1","article-title":"Checks and balances? DNA replication and the cell cycle in Plasmodium","volume":"11","author":"Matthews","year":"2018","journal-title":"Parasit. Vectors"},{"key":"B115","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0065-308X(08)60285-7","article-title":"The piroplasms: life cycle and sexual stages","volume":"23","author":"Mehlhorn","year":"1984","journal-title":"Adv. Parasitol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.bbrc.2005.09.131","article-title":"Expression and characterization of human malaria parasite Plasmodium falciparum origin recognition complex subunit 1","volume":"337","author":"Mehra","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B117","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1111\/j.1550-7408.1985.tb03104.x","article-title":"Fine structure of exoerythrocytic merozoite formation of Plasmodium berghei in rat liver","volume":"32","author":"Meis","year":"1985","journal-title":"J. Protozool."},{"key":"B118","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/cm.21353","article-title":"Towards a molecular architecture of the centrosome in Toxoplasma gondii","volume":"74","author":"Morlon-Guyot","year":"2017","journal-title":"Cytoskeleton (Hoboken)"},{"key":"B119","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1242\/jcs.115.5.1017","article-title":"Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii","volume":"115","author":"Morrissette","year":"2002","journal-title":"J. Cell Sci."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00579-17","article-title":"The Toxoplasma Centrocone Houses Cell Cycle Regulatory Factors","volume":"8","author":"Naumov","year":"2017","journal-title":"MBio"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1242\/jcs.021089","article-title":"Organellar dynamics during the cell cycle of Toxoplasma gondii","volume":"121","author":"Nishi","year":"2008","journal-title":"J. Cell Sci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1111\/j.1462-5822.2005.00518.x","article-title":"Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma","volume":"7","author":"Nishikawa","year":"2005","journal-title":"Cell Microbiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"8271","DOI":"10.1093\/nar\/gku500","article-title":"The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems","volume":"42","author":"Oberstaller","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-11-r108","article-title":"Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum","volume":"13","author":"Oehring","year":"2012","journal-title":"Genome Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/emboj\/21.5.1231","article-title":"A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes","volume":"21","author":"O\u2019donnell","year":"2002","journal-title":"EMBO J."},{"key":"B126","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1242\/jcs.147736","article-title":"Dynamics of the Toxoplasma gondii inner membrane complex","volume":"127","author":"Ouologuem","year":"2014","journal-title":"J. Cell Sci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2010.11.014","article-title":"The Apicomplexan AP2 family: integral factors regulating Plasmodium development","volume":"176","author":"Painter","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1016\/j.celrep.2020.01.033","article-title":"Plasmodium Condensin Core Subunits SMC2\/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission","volume":"30","author":"Pandey","year":"2020","journal-title":"Cell Rep."},{"key":"B129","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1038\/s41467-020-17306-1","article-title":"Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes","volume":"11","author":"Paul","year":"2020","journal-title":"Nat. Commun."},{"key":"B130","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/nature00946","article-title":"Golgi biogenesis in Toxoplasma gondii","volume":"418","author":"Pelletier","year":"2002","journal-title":"Nature"},{"key":"B131","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1038\/s41467-019-12136-2","article-title":"A highly dynamic F-actin network regulates transport and recycling of micronemes in Toxoplasma gondii vacuoles","volume":"10","author":"Periz","year":"2019","journal-title":"Nat. Commun."},{"key":"B133","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0166-6851(01)00284-5","article-title":"Defining the cell cycle for the tachyzoite stage of Toxoplasma gondii","volume":"115","author":"Radke","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0166-6851(03)00198-1","article-title":"A change in the premitotic period of the cell cycle is associated with bradyzoite differentiation in Toxoplasma gondii","volume":"131","author":"Radke","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.pt.2018.04.006","article-title":"Sex in Plasmodium falciparum: Silence Play between GDV1 and HP1","volume":"34","author":"Rea","year":"2018","journal-title":"Trends Parasitol."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.11.333179","article-title":"A single-cell atlas of Plasmodium falciparum transmission through the mosquito","author":"Real","year":"2020","journal-title":"BioRXiv."},{"key":"B136","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.molbiopara.2006.04.008","article-title":"Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites","volume":"149","author":"Rees-Channer","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1101\/gr.168955.113","article-title":"Genomic analysis of the causative agents of coccidiosis in domestic chickens","volume":"24","author":"Reid","year":"2014","journal-title":"Genome Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/ncomms2449","article-title":"Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes","volume":"4","author":"Riglar","year":"2013","journal-title":"Nat. Commun."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004488","article-title":"Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity","volume":"10","author":"Roiko","year":"2014","journal-title":"PloS Pathog."},{"key":"B140","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0091-679X(08)61845-2","article-title":"Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii","volume":"45","author":"Roos","year":"1994","journal-title":"Methods Cell Biol."},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005273","article-title":"Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes","volume":"11","author":"Roques","year":"2015","journal-title":"PloS Pathog."},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1242\/bio.036822","article-title":"Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation","volume":"8","author":"Roques","year":"2019","journal-title":"Biol. Open"},{"key":"B144","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1038\/s41467-019-10214-z","article-title":"An essential contractile ring protein controls cell division in Plasmodium falciparum","volume":"10","author":"Rudlaff","year":"2019","journal-title":"Nat. Commun."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008587","article-title":"Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis","volume":"16","author":"Rudlaff","year":"2020","journal-title":"PloS Pathog."},{"key":"B145","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.chom.2017.05.006","article-title":"Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor","volume":"21","author":"Santos","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B146","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1021\/acs.jproteome.6b00366","article-title":"Dynamic and Combinatorial Landscape of Histone Modifications during the Intraerythrocytic Developmental Cycle of the Malaria Parasite","volume":"15","author":"Saraf","year":"2016","journal-title":"J. Proteome Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.chom.2015.10.014","article-title":"The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions","volume":"18","author":"Silmon De Monerri","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B148","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1590\/S0074-02761996000500001","article-title":"The biology of malarial parasite in the mosquito\u2013a review","volume":"91","author":"Simonetti","year":"1996","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B149","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.mib.2020.09.009","article-title":"The RESTRICTION checkpoint: a window of opportunity governing developmental transitions in Toxoplasma gondii","volume":"58","author":"Sinai","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"4003","DOI":"10.1038\/s41598-017-04407-z","article-title":"Single-molecule analysis reveals that DNA replication dynamics vary across the course of schizogony in the malaria parasite Plasmodium falciparum","volume":"7","author":"Stanojcic","year":"2017","journal-title":"Sci. Rep."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1111\/j.1462-5822.2011.01657.x","article-title":"Organelle segregation into Plasmodium liver stage merozoites","volume":"13","author":"Stanway","year":"2011","journal-title":"Cell Microbiol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"5433","DOI":"10.1074\/jbc.M209390200","article-title":"Toxoplasma gondii Rab6 mediates a retrograde pathway for sorting of constitutively secreted proteins to the Golgi complex","volume":"278","author":"Stedman","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1083\/jcb.151.7.1423","article-title":"The plastid of Toxoplasma gondii is divided by association with the centrosomes","volume":"151","author":"Striepen","year":"2000","journal-title":"J. Cell Biol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molbiopara.2011.09.006","article-title":"Nuclear actin-related protein is required for chromosome segregation in Toxoplasma gondii","volume":"181","author":"Suvorova","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002093","article-title":"A novel bipartite centrosome coordinates the apicomplexan cell cycle","volume":"13","author":"Suvorova","year":"2015","journal-title":"PloS Biol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1073\/pnas.022554999","article-title":"Measuring tubulin content in Toxoplasma gondii: a comparison of laser-scanning confocal and wide-field fluorescence microscopy","volume":"99","author":"Swedlow","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B157","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/bfgp\/elz004","article-title":"What functional genomics has taught us about transcriptional regulation in malaria parasites","volume":"18","author":"Toenhake","year":"2019","journal-title":"Brief Funct. Genomics"},{"key":"B158","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.chom.2018.03.007","article-title":"Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development","volume":"23","author":"Toenhake","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56635.sa2","article-title":"Essential function of the alveolin network in the subpellicular microtubules and conoid assembly in Toxoplasma gondii","volume":"9","author":"Tosetti","year":"2020","journal-title":"Elife"},{"key":"B160","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1007\/s00436-014-4093-4","article-title":"Distinct temporal recruitment of Plasmodium alveolins to the subpellicular network","volume":"113","author":"Tremp","year":"2014","journal-title":"Parasitol. Res."},{"key":"B161","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1242\/jcs.02458","article-title":"Plastid segregation and cell division in the apicomplexan parasite Sarcocystis neurona","volume":"118","author":"Vaishnava","year":"2005","journal-title":"J. Cell Sci."},{"key":"B162","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1365-2958.2005.04699.x","article-title":"Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum","volume":"57","author":"Van Dooren","year":"2005","journal-title":"Mol. Microbiol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0168-9525(03)00203-8","article-title":"Scaling laws in the functional content of genomes","volume":"19","author":"Van Nimwegen","year":"2003","journal-title":"Trends Genet."},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025486","article-title":"Malaria Parasite Liver Infection and Exoerythrocytic Biology","volume":"7","author":"Vaughan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B165","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s41579-019-0306-2","article-title":"Plasmodium asexual growth and sexual development in the haematopoietic niche of the host","volume":"18","author":"Venugopal","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/BF01951885","article-title":"The biology of tissue forms and other asexual stages in mammalian plasmodia","volume":"40","author":"Verhave","year":"1984","journal-title":"Experientia"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00682-16","article-title":"Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites","volume":"7","author":"Voss","year":"2016","journal-title":"mBio"},{"key":"B168","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.cell.2019.12.013","article-title":"Identification of a Master Regulator of Differentiation in Toxoplasma","volume":"180","author":"Waldman","year":"2020","journal-title":"Cell"},{"key":"B169","doi-asserted-by":"publisher","first-page":"31127","DOI":"10.1074\/jbc.M113.486589","article-title":"Toxoplasma Transcription Factor TgAP2XI-5 Regulates the Expression of Genes Involved in Parasite Virulence and Host Invasion","volume":"288","author":"Walker","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B171","doi-asserted-by":"publisher","first-page":"e1003830","DOI":"10.1371\/journal.ppat.1003830","article-title":"Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation","volume":"10","author":"Wang","year":"2014","journal-title":"PloS Pathog."},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13291","article-title":"Internal daughter formation of Toxoplasma gondii tachyzoites is coordinated by transcription factor TgAP2IX-5","volume":"23","author":"Wang","year":"2020","journal-title":"Cell Microbiol."},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019104168","article-title":"A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium","volume":"39","author":"Wang","year":"2020","journal-title":"EMBO J."},{"key":"B173","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1111\/j.1462-5822.2011.01592.x","article-title":"3D nuclear architecture reveals coupled cell cycle dynamics of chromatin and nuclear pores in the malaria parasite Plasmodium falciparum","volume":"13","author":"Weiner","year":"2011","journal-title":"Cell Microbiol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.pt.2018.07.006","article-title":"Apicomplexa Cell Cycles: Something Old, Borrowed, Lost, and New","volume":"34","author":"White","year":"2018","journal-title":"Trends Parasitol."},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06974.033","article-title":"Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites","volume":"4","author":"Woo","year":"2015","journal-title":"Elife"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54129.sa2","article-title":"A single-parasite transcriptional atlas of Toxoplasma Gondii reveals novel control of antigen expression","volume":"9","author":"Xue","year":"2020","journal-title":"Elife"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008048","article-title":"Plasmodium kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission","volume":"15","author":"Zeeshan","year":"2019","journal-title":"PloS Pathog."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.583812","article-title":"Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites","volume":"10","author":"Zeeshan","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.245753","article-title":"Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation","volume":"134","author":"Zeeshan","year":"2020","journal-title":"J. Cell Sci."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.670049\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T16:04:33Z","timestamp":1619885073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.670049\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":179,"alternative-id":["10.3389\/fcimb.2021.670049"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2021.670049","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]},"article-number":"670049"}}