{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:13:22Z","timestamp":1793366002130,"version":"4.5.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    As the second leading etiological agent of candidemia in Turkey and the cause of severe fluconazole-non-susceptible (FNS) clonal outbreaks,\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    emerged as a major health threat at Ege University Hospital (EUH). Evaluation of microbiological and pertinent clinical profiles of candidemia patients due to\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>parapsilosis<\/jats:italic>\n                    in EUH in 2019\u20132020.\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    isolates were collected from blood samples and identified by sequencing internal transcribed spacer ribosomal DNA. Antifungal susceptibility testing was performed in accordance with CLSI M60 protocol and\n                    <jats:italic>ERG11<\/jats:italic>\n                    and HS1\/HS2-\n                    <jats:italic>FKS1<\/jats:italic>\n                    were sequenced to explore the fluconazole and echinocandin resistance, respectively. Isolates were typed using a multilocus microsatellite typing assay. Relevant clinical data were obtained for patients recruited in the current study. FNS\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>parapsilosis<\/jats:italic>\n                    isolates were recovered from 53% of the patients admitted to EUH in 2019\u20132020. Y132F was the most frequent mutation in Erg11. All patients infected with\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>parapsilosis<\/jats:italic>\n                    isolates carrying Y132F, who received fluconazole showed therapeutic failure and significantly had a higher mortality than those infected with other FNS and susceptible isolates (50%\n                    <jats:italic>vs<\/jats:italic>\n                    . 16.1%). All isolates carrying Y132F grouped into one major cluster and mainly recovered from patients admitted to chest diseases and pediatric surgery wards. The unprecedented increase in the number of Y132F\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>parapsilosis<\/jats:italic>\n                    , which corresponded with increased rates of fluconazole therapeutic failure and mortality, is worrisome and highlights the urgency for strict infection control strategies, antifungal stewardship, and environmental screening in EUH.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2021.676177","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T12:29:24Z","timestamp":1619094564000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":83,"title":["Clonal Candidemia Outbreak by Candida parapsilosis Carrying Y132F in Turkey: Evolution of a Persisting Challenge"],"prefix":"10.3389","volume":"11","author":[{"given":"Amir","family":"Arastehfar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyha","family":"Hilmio\u011flu-Polat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Daneshnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Hafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fcmr\u00fct","family":"\u015eahbudak-Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek Ye\u015fim","family":"Metin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o N. de Almeida","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macit","family":"Ilkit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Perlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/jof5040101","article-title":"Ongoing Challenges With Healthcare-Associated Candida Auris Outbreaks in Oman","volume":"5","author":"Al Maani","year":"2019","journal-title":"J. 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