{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:01:37Z","timestamp":1792904497773,"version":"4.5.0"},"reference-count":223,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013275","name":"Instituto Serrapilheira","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Malaria is a serious public health problem that affects mostly the poorest countries in the world, killing more than 400,000 people per year, mainly children under 5 years old. Among the control and prevention strategies, the differential diagnosis of the\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    \u2013infecting species is an important factor for selecting a treatment and, consequently, for preventing the spread of the disease. One of the main difficulties for the detection of a specific\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    sp is that most of the existing methods for malaria diagnosis focus on detecting\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    . Thus, in many cases, the diagnostic methods neglect the other non-falciparum species and underestimate their prevalence and severity. Traditional methods for diagnosing malaria may present low specificity or sensitivity to non-falciparum spp. Therefore, there is high demand for new alternative methods able to differentiate\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species in a faster, cheaper and easier manner to execute. This review details the classical procedures and new perspectives of diagnostic methods for malaria non-falciparum differential detection and the possibilities of their application in different circumstances.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2021.681063","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T07:02:32Z","timestamp":1623913352000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Diagnostic Methods for Non-Falciparum Malaria"],"prefix":"10.3389","volume":"11","author":[{"given":"Alba Marina","family":"Gimenez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo F.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Regiart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Youssef","family":"Bargieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"CD011431","DOI":"10.1002\/14651858.CD011431","article-title":"Rapid Diagnostic Tests for Diagnosing Uncomplicated Non-Falciparum or Plasmodium vivax Malaria in Endemic Countries","author":"Abba","year":"2014","journal-title":"Cochrane Database Syst. 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