{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:30:10Z","timestamp":1791923410856,"version":"4.3.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2018ZX10713-003-002, 2018ZX10713-001-002"],"award-info":[{"award-number":["2018ZX10713-003-002, 2018ZX10713-001-002"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>A lytic <jats:italic>Yersinia pestis<\/jats:italic> phage vB_YpP<jats:italic>-<\/jats:italic>YepMm (also named YepMm for briefly) was first isolated from the bone marrow of a <jats:italic>Marmota himalayana<\/jats:italic> who died of natural causes on the Qinghai-Tibet plateau in China. Based on its morphologic (isometric hexagonal head and short non-contractile conical tail) and genomic features, we classified it as belonging to the <jats:italic>Podoviridae<\/jats:italic> family. At the MOI of 10, YepMm reached maximum titers; and the one-step growth curve showed that the incubation period of the phage was about 10\u00a0min, the rise phase was about 80\u00a0min, and the lysis amount of the phage during the lysis period of 80\u00a0min was about 187 PFU\/cell. The genome of the bacteriophage YepMm had nucleotide-sequence similarity of 99.99% to that of the <jats:italic>Y. pestis<\/jats:italic> bacteriophage Yep-phi characterized previously. Analyses of the biological characters showed that YepMm has a short latent period, strong lysis, and a broader lysis spectrum. It could infect <jats:italic>Y. pestis<\/jats:italic>, highly pathogenic bioserotype 1B\/O:8 <jats:italic>Y. enterocolitica<\/jats:italic>, as well as serotype O:1b <jats:italic>Y. pseudotuberculosis<\/jats:italic>\u2014the ancestor of <jats:italic>Y. pestis<\/jats:italic>. It could be further developed as an important biocontrol agent in pathogenic <jats:italic>Yersinia<\/jats:italic> spp. infection.<\/jats:p>","DOI":"10.3389\/fcimb.2021.700322","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T09:30:37Z","timestamp":1625736637000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Lytic Yersina pestis Bacteriophage Obtained From the Bone Marrow of Marmota himalayana in a Plague-Focus Area in China"],"prefix":"10.3389","volume":"11","author":[{"given":"Junrong","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaokai","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiqi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/340467a0","article-title":"High Abundance of Viruses Found in Aquatic Environments","volume":"340","author":"Bergh","year":"1989","journal-title":"Nature"},{"key":"B2","first-page":"195","article-title":"Classification of Actinophages","volume":"25","author":"Berthiaume","year":"1977","journal-title":"Pathol. 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