{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:54:11Z","timestamp":1788623651866,"version":"build-2803163510"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T00:00:00Z","timestamp":1630627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM124594"],"award-info":[{"award-number":["R35GM124594"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Fungal infections are increasing in prevalence worldwide. The paucity of available antifungal drug classes, combined with the increased occurrence of multidrug resistance in fungi, has led to new clinical challenges in the treatment of fungal infections. <jats:italic>Candida auris<\/jats:italic> is a recently emerged multidrug resistant human fungal pathogen that has become a worldwide public health threat. <jats:italic>C. auris<\/jats:italic> clinical isolates are often resistant to one or more antifungal drug classes, and thus, there is a high unmet medical need for the development of new therapeutic strategies effective against <jats:italic>C. auris<\/jats:italic>. Additionally, <jats:italic>C. auris<\/jats:italic> possesses several virulence traits, including the ability to form biofilms, further contributing to its drug resistance, and complicating the treatment of <jats:italic>C. auris<\/jats:italic> infections. Here we assessed red, green, and blue visible lights alone and in combination with photosensitizing compounds for their efficacies against <jats:italic>C. auris<\/jats:italic> biofilms. We found that (1) blue light inhibited and disrupted <jats:italic>C. auris<\/jats:italic> biofilms on its own and that the addition of photosensitizing compounds improved its antibiofilm potential; (2) red light inhibited and disrupted <jats:italic>C. auris<\/jats:italic> biofilms, but only in combination with photosensitizing compounds; and (3) green light inhibited <jats:italic>C. auris<\/jats:italic> biofilms in combination with photosensitizing compounds, but had no effects on disrupting <jats:italic>C. auris<\/jats:italic> biofilms. Taken together, our findings suggest that photodynamic therapy could be an effective non-drug therapeutic strategy against multidrug resistant <jats:italic>C. auris<\/jats:italic> biofilm infections.<\/jats:p>","DOI":"10.3389\/fcimb.2021.713092","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T10:44:29Z","timestamp":1630752269000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Photodynamic Therapy Is Effective Against Candida auris Biofilms"],"prefix":"10.3389","volume":"11","author":[{"given":"Priyanka S.","family":"Bapat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa J.","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/BJ20150942","article-title":"New Photosensitizers for Photodynamic Therapy","volume":"473","author":"Abrahamse","year":"2016","journal-title":"Biochem. 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