{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:34:53Z","timestamp":1792503293594,"version":"4.5.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Extended-spectrum \u03b2-lactamases producing <jats:italic>Escherichia coli<\/jats:italic> (ESBL-EC) lend resistance to most \u03b2-lactam antibiotics. Because of limited treatment options, ESBL-EC infections are generally more difficult to treat, leading to higher hospital costs, reduced rates of microbiological and clinical responses, and a threat to the patient\u2019s life. This study aimed to determine the antibiotic resistance pattern of ESBL-EC isolated from patients with urinary tract infection in Morocco. This retrospective laboratory-based study was conducted at Cheikh Khalifa International University Hospital, Casablanca, from January 2016 to June 2019. A total of 670 urine samples were collected from urinary tract infection patients and processed by standard microbiological methods. <jats:italic>In vitro<\/jats:italic> susceptibility testing to different antibiotics of all identified isolates of <jats:italic>Escherichia coli (E. coli)<\/jats:italic> was performed following Kirby\u2013Bauer\u2019s disc diffusion method on Mueller\u2013Hinton Agar according to the EUCAST standards. The reviewing of ESBL-EC was confirmed by the appearance of a characteristically shaped zone referred to as a \u201cchampagne cork\u201d using the Combined Disk Test. Among a total of 438 <jats:italic>E. coli<\/jats:italic> isolated from nonrepetitive urine samples, two hundred fifty-nine (59%) were ESBL-EC, of which 200 (77%) were isolated from adult patients (over the age of 50) and the majority were female. All ESBL-EC isolates were resistant to third-generation cephalosporin and quinolones and sensitive to carbapenem and fosfomycin. Knowledge of antimicrobial resistance patterns in ESBL-EC, the major pathogen associated with urinary tract infection, is indispensable as a guide in choosing empirical antimicrobial treatment.<\/jats:p>","DOI":"10.3389\/fcimb.2021.720701","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T05:04:52Z","timestamp":1629263092000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Antibiotic Resistance Pattern of Extended Spectrum Beta Lactamase Producing Escherichia coli Isolated From Patients With Urinary Tract Infection in Morocco"],"prefix":"10.3389","volume":"11","author":[{"given":"Mohamed","family":"Kettani Halabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Azzahra","family":"Lahlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idrissa","family":"Diawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younes","family":"El Adouzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabiaa","family":"Marnaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Benmessaoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Smyej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"916","DOI":"10.17179\/excli2015-207","article-title":"Original Article: The Erratic Antibiotic Susceptibility Patterns of Bacterial Pathogens Causing","volume":"14","author":"Ahmed","year":"2015","journal-title":"EXCLI J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s10393-019-01404-8","article-title":"Virulence and Antibiotic Resistance Patterns in E. 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