{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:11:51Z","timestamp":1787026311883,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Diutina catenulata<\/jats:italic>\n                    (\n                    <jats:italic>Candida catenulata<\/jats:italic>\n                    ) is an ascomycete yeast species widely used in environmental and industrial research and capable of causing infections in humans and animals. At present, there are only a few studies on\n                    <jats:italic>D. catenulata<\/jats:italic>\n                    , and further research is required for its more in-depth characterization and analysis. Eleven strains of\n                    <jats:italic>D. catenulata<\/jats:italic>\n                    collected from China Hospital Invasive Fungal Surveillance Net (CHIF-NET) and the CHIF-NET North China Program were identified using matrix-assisted laser desorption ionization\u2013time of flight mass spectrometry and internal transcribed spacer sequencing. The antifungal susceptibility of the\n                    <jats:italic>Diutina catenulata<\/jats:italic>\n                    strains was tested using the Clinical and Laboratory Standards Institute broth microdilution method and Sensititre YeastOne\u2122. Furthermore, ERG11 and FKS1 were sequenced to determine any mutations related to azole and echinocandin resistance in\n                    <jats:italic>D. catenulata<\/jats:italic>\n                    . All isolates exhibited low minimum inhibitory concentration (MIC) values for itraconazole (0.06\u20130.12 \u03bcg\/ml), posaconazole (0.06\u20130.12 \u03bcg\/ml), amphotericin B (0.25\u20131 \u03bcg\/ml), and 5-flucytosine (range, &amp;lt;0.06\u20130.12 \u03bcg\/ml), whereas four isolates showed high MICs (\u22654 \u03bcg\/ml) for echinocandins. Strains with high MIC values for azoles showed common\n                    <jats:italic>ERG11<\/jats:italic>\n                    mutations, namely, F126L\/K143R. In addition, L139R mutations may be linked to high MICs of fluconazole. Two amino acid alterations reported to correspond to high MIC values of echinocandin, namely, F621I (F641) and S625L (S645), were found in the hot spot 1 region of\n                    <jats:italic>FKS1<\/jats:italic>\n                    . In addition, one new amino acid alteration, I1348S (I1368), was found outside of the\n                    <jats:italic>FKS1<\/jats:italic>\n                    hot spot 2 region, and its contribution to echinocandin resistance requires future investigation.\n                    <jats:italic>Diutina catenulata<\/jats:italic>\n                    mainly infects patients with a weak immune system, and the high MIC values for various antifungals exhibited by these isolates may represent a challenge to clinical treatment.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2021.739496","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T02:12:28Z","timestamp":1635473548000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Antifungal Susceptibility Profiles and Resistance Mechanisms of Clinical Diutina catenulata Isolates With High MIC Values"],"prefix":"10.3389","volume":"11","author":[{"given":"Xin-Fei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Gui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Fei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/jac\/dkaa419","article-title":"Genetically Related Micafungin-Resistant Candida parapsilosis Blood Isolates Harbouring Novel Mutation R658G in Hotspot 1 of Fks1p: A New Challenge","volume":"76","author":"Arastehfar","year":"2021","journal-title":"J. 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