{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:59:57Z","timestamp":1767830397233,"version":"3.49.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060373, 81760369, 81360251"],"award-info":[{"award-number":["82060373, 81760369, 81360251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by infection with the larvae of <jats:italic>Echinococcus granulosus sensu lato<\/jats:italic> (<jats:italic>s.l.<\/jats:italic>) cluster. It is urgent to identify novel drug targets and develop new drug candidates against CE. Glucose transporter 1 (GLUT1) is mainly responsible for the transmembrane transport of glucose to maintain its constant cellular availability and is a recent research hotspot as a drug target in various diseases. However, the role of GLUT1 in <jats:italic>E. granulosus s.l.<\/jats:italic> (EgGLUT1) was unknown. In this study, we cloned a conserved GLUT1 homology gene (named EgGLUT1-ss) from <jats:italic>E. granulosus sensu stricto<\/jats:italic> (<jats:italic>s.s.<\/jats:italic>) and found EgGLUT1-ss was crucial for glucose uptake and viability by the protoscoleces of <jats:italic>E. granulosus s.s.<\/jats:italic> WZB117, a GLUT1 inhibitor, inhibited glucose uptake by <jats:italic>E. granulosus s.s.<\/jats:italic> and the viability of the metacestode <jats:italic>in vitro<\/jats:italic>. In addition, WZB117 showed significant therapeutic activity in <jats:italic>E. granulosus s.s.<\/jats:italic>-infected mice: a 10 mg\/kg dose of WZB117 significantly reduced the number and weight of parasite cysts (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) as efficiently as the reference drug, albendazole. Our results demonstrate that EgGLUT1-ss is crucial for glucose uptake by the protoscoleces of <jats:italic>E. granulosus s.s.<\/jats:italic>, and its inhibitor WZB117 has a therapeutic effect on CE.<\/jats:p>","DOI":"10.3389\/fcimb.2021.747739","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T10:13:13Z","timestamp":1636625593000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["EgGLUT1 Is Crucial for the Viability of Echinococcus granulosus sensu stricto Metacestode: A New Therapeutic Target?"],"prefix":"10.3389","volume":"11","author":[{"given":"Kuerbannisha","family":"Amahong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique A.","family":"Vuitton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renyong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1128\/jcm.02420-15","article-title":"Cystic Echinococcosis","volume":"54","author":"Agudelo Higuita","year":"2016","journal-title":"J. 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