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Cell. Infect. Microbiol."],"abstract":"<jats:p>This prospective study aimed to investigate the clinical and microbiological characteristics of different <jats:italic>Aeromonas<\/jats:italic> species. Clinical isolates of <jats:italic>Aeromonas<\/jats:italic> species between 2016 to 2018 were collected in a university hospital in southern Taiwan. The species was determined by <jats:italic>rpoD<\/jats:italic> or <jats:italic>gyrB<\/jats:italic> sequencing. A total of 222 <jats:italic>Aeromonas<\/jats:italic> isolates from 160 patients in 164 episodes were identified. The crude in-hospital mortality was 17.2%. The most frequently isolated species was <jats:italic>Aeromonas veronii<\/jats:italic> (30.6%), followed by <jats:italic>A. caviae<\/jats:italic> (24.8%), <jats:italic>A. hydrophila<\/jats:italic> (23%), and <jats:italic>A. dhakensis<\/jats:italic> (16.7%). The major clinical manifestations were primary bacteremia (31.1%), skin and soft tissue infection (22.6%), and biliary tract infection (18.3%). The most common underlying diseases were malignancy (45.1%), diabetes mellitus (27.4%), and liver cirrhosis or chronic hepatitis (26.2%). <jats:italic>A. hydrophila<\/jats:italic> and <jats:italic>A. dhakensis<\/jats:italic> predominated in the skin and soft tissue infection (p&amp;lt;0.0001), whereas <jats:italic>A. vernoii<\/jats:italic> and <jats:italic>A. caviae<\/jats:italic> prevailed in primary bacteremia and biliary tract infections (p=0.012). Pneumonia, malignancy, and <jats:italic>ascF-ascG<\/jats:italic> genotype were independent factors associated with mortality. Ertapenem susceptibility was decreased in <jats:italic>A. sobria<\/jats:italic> (42.9%), <jats:italic>A. veronii<\/jats:italic> (66.7%), <jats:italic>A. dhakensis<\/jats:italic> (73%), and <jats:italic>A. hydrophila<\/jats:italic> (84.3%). Cefotaxime resistance was found in 30.9% of <jats:italic>A. caviae<\/jats:italic> and 18.9% of <jats:italic>A. dhakensis<\/jats:italic> isolates, much more prevalent than the other species. The metallo-\u03b2-lactamase <jats:italic>bla<jats:sub>CphA<\/jats:sub><\/jats:italic> was almost invariably present in <jats:italic>A. dhakensis<\/jats:italic>, <jats:italic>A. hydrophila<\/jats:italic>, and <jats:italic>A. veronii<\/jats:italic> (100%, 100% and 89.9%, respectively). Amp-C \u03b2-lactamases such as <jats:italic>bla<jats:sub>MOX<\/jats:sub><\/jats:italic> and <jats:italic>bla<jats:sub>AQU-1<\/jats:sub><\/jats:italic> were identified in all <jats:italic>A.\u00a0caviae<\/jats:italic> and 91.9% of <jats:italic>A. dhakensis<\/jats:italic> isolates. Cefepime, fluoroquinolones and tigecycline showed good <jats:italic>in vitro<\/jats:italic> activity against aeromonads.<\/jats:p>","DOI":"10.3389\/fcimb.2021.749269","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T20:38:15Z","timestamp":1634762295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Pancreaticobiliary Cancers and Aeromonas Isolates Carrying Type \u2162 Secretion System Genes ascF-ascG Are Associated With Increased Mortality: An Analysis of 164 Aeromonas Infection Episodes in Southern Taiwan"],"prefix":"10.3389","volume":"11","author":[{"given":"Ying-Wen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Shiang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lung","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Shan","family":"Syue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Chi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1128\/JCM.00472-11","article-title":"Aeromonas Aquariorum is Widely Distributed in Clinical and Environmental Specimens and can be Misidentified as Aeromonas Hydrophila","volume":"49","author":"Aravena-Rom\u00e1n","year":"2011","journal-title":"J. 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