{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:46:34Z","timestamp":1773287194814,"version":"3.50.1"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Clonorchiasis is recognized as an important zoonotic parasitic disease worldwide. However, the roles of host long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in the response to <jats:italic>Clonorchis sinensis<\/jats:italic> (<jats:italic>C. sinensis<\/jats:italic>) infection remain unknown. Here we compared the expression of lncRNAs and mRNAs in the liver tissue of mice infected with <jats:italic>C. sinensis<\/jats:italic>, in order to further understand the molecular mechanisms of clonorchiasis. A total of 388 lncRNAs and 1,172 mRNAs were found to be differentially expressed with absolute value of fold change (FC) \u2265 2.0 and <jats:italic>p<\/jats:italic> &amp;lt; 0.05 by microarray. Compared with controls, <jats:italic>Gm6135<\/jats:italic> and <jats:italic>4930581F22Rik<\/jats:italic> were the most over- and under-expressed lncRNAs; flavin-containing monooxygenase 3 (<jats:italic>Fmo3<\/jats:italic>) and deleted in malignant brain tumors 1 (<jats:italic>Dmbt1<\/jats:italic>) were the most over- and under-expressed mRNAs. Moreover, functional annotation showed that the significantly different mRNAs were related with \u201cFOXO signaling pathway\u201d, \u201cWnt signaling pathway\u201d, and \u201cAMPK signaling pathway\u201d. Remarkably, lncRNA <jats:italic>Gm8801<\/jats:italic> were significantly correlated with mRNA glycerol-3-phosphate acyltransferase mitochondrial (<jats:italic>Gpam<\/jats:italic>), insulin receptor substrate 2 (<jats:italic>Irs2<\/jats:italic>), and tumor necrosis factor receptor superfamily member 19 (<jats:italic>Tnfrsf19<\/jats:italic>) in ceRNA networks. These results showed that the expression profiles of lncRNAs and mRNAs in the liver changed after <jats:italic>C. sinensis<\/jats:italic> infection. Our results provided valuable insights into the lncRNAs and mRNAs involved in clonorchiasis pathogenesis, which may be useful for future control strategies.<\/jats:p>","DOI":"10.3389\/fcimb.2021.754224","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T05:05:39Z","timestamp":1642568739000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Long Non-Coding RNA and mRNA Expression Analysis in Liver of Mice With Clonorchis sinensis Infection"],"prefix":"10.3389","volume":"11","author":[{"given":"Su","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jiao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Shan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei-Bei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Nan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12005","DOI":"10.1074\/jbc.C300557200","article-title":"AMP-Activated Protein Kinase Plays a Role in the Control of Food Intake","volume":"279","author":"Andersson","year":"2004","journal-title":"J. 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