{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:22:05Z","timestamp":1792725725150,"version":"4.5.0"},"reference-count":239,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Recent advances have identified significant associations between the composition and function of the gut microbiota and various disorders in organ systems other than the digestive tract. Utilizing next-generation sequencing and multiomics approaches, the microbial community that possibly impacts ocular disease has been identified. This review provides an overview of the literature on approaches to microbiota analysis and the roles of commensal microbes in ophthalmic diseases, including autoimmune uveitis, age-related macular degeneration, glaucoma, and other ocular disorders. In addition, this review discusses the hypothesis of the \u201cgut-eye axis\u201d and evaluates the therapeutic potential of targeting commensal microbiota to alleviate ocular inflammation.<\/jats:p>","DOI":"10.3389\/fcimb.2021.759333","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T01:23:27Z","timestamp":1634779407000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["Microbiota and Ocular Diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Wei","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41564-017-0084-4","article-title":"Metatranscriptome of Human Faecal Microbial Communities in a Cohort of Adult Men","volume":"3","author":"Abu-Ali","year":"2018","journal-title":"Nat. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41586-019-0965-1","article-title":"A New Genomic Blueprint of the Human Gut Microbiota","volume":"568","author":"Almeida","year":"2019","journal-title":"Nature"},{"key":"B3","first-page":"184","article-title":"Bacterial Keratitis: Perspective on Epidemiology, Clinico-Pathogenesis, Diagnosis and Treatment","volume":"9","author":"Al-Mujaini","year":"2009","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.immuni.2005.07.005","article-title":"The Cellular Mechanism of AIRE Control of T Cell Tolerance","volume":"23","author":"Anderson","year":"2005","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1126\/science.1075958","article-title":"Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein","volume":"298","author":"Anderson","year":"2002","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jtos.2020.09.003","article-title":"Ocular Surface Microbiota in Patients With Aqueous Tear-Deficient Dry Eye","volume":"19","author":"Andersson","year":"2021","journal-title":"Ocul. Surf."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.15252\/emmm.201606531","article-title":"Gut Microbiota Influences Pathological Angiogenesis in Obesity-Driven Choroidal Neovascularization","volume":"8","author":"Andriessen","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12974-019-1494-4","article-title":"Antibiotics, Gut Microbiota, and Alzheimer's Disease","volume":"16","author":"Angelucci","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/nrneph.2015.191","article-title":"The Gut Microbiome, Diet, and Links to Cardiometabolic and Chronic Disorders","volume":"12","author":"Aron-Wisnewsky","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.chom.2016.04.014","article-title":"Human Microbiota-Associated Mice: A Model With Challenges","volume":"19","author":"Arrieta","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/art.39681","article-title":"Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis","volume":"68","author":"Asquith","year":"2016","journal-title":"Arthritis. Rheumatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e104416","DOI":"10.1371\/journal.pone.0104416","article-title":"Oral Microbiome Link to Neurodegeneration in Glaucoma","volume":"9","author":"Astafurov","year":"2014","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species","volume":"331","author":"Atarashi","year":"2011","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41586-019-1608-2","article-title":"The Fungal Mycobiome Promotes Pancreatic Oncogenesis via Activation of MBL","volume":"574","author":"Aykut","year":"2019","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The Gut Microbiota as an Environmental Factor That Regulates Fat Storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature16468","article-title":"The Functional Diversity of Retinal Ganglion Cells in the Mouse","volume":"529","author":"Baden","year":"2016","journal-title":"Nature"},{"key":"B17","first-page":"295","article-title":"A Novel Model of Bacterially-Induced Acute Anterior Uveitis in Rats and the Lack of Effect From HLA-B27 Expression","volume":"45","author":"Baggia","year":"1997","journal-title":"J. Investig. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1177\/1535370218813616","article-title":"The Microbiome and Ophthalmic Disease","volume":"244","author":"Baim","year":"2019","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"B19","doi-asserted-by":"publisher","first-page":"10719","DOI":"10.1073\/pnas.1711233114","article-title":"Gut Microbiota From Multiple Sclerosis Patients Enables Spontaneous Autoimmune Encephalomyelitis in Mice","volume":"114","author":"Berer","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000481401","article-title":"Gut Microbiome in Inflammatory Bowel Disease and Other Chronic Immune-Mediated Inflammatory Diseases","volume":"2","author":"Bernstein","year":"2017","journal-title":"Inflamm. Intest. Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jbspin.2014.07.011","article-title":"Essential Role for CD103+ Cells in the Pathogenesis of Spondyloarthritides","volume":"82","author":"Berthelot","year":"2015","journal-title":"Joint Bone Spine"},{"key":"B22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-1-4939-8546-3_2","article-title":"Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases","volume":"1802","author":"Bodis","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"191","DOI":"10.7150\/ijms.17718","article-title":"Reviewing Primary Sj\u00f6gren's Syndrome: Beyond the Dryness - From Pathophysiology to Diagnosis and Treatment","volume":"14","author":"Both","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/hel.12403","article-title":"Epidemiology of Helicobacter Pylori Infection","volume":"22","author":"Burucoa","year":"2017","journal-title":"Helicobacter"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.3390\/ijms19061689","article-title":"Microbiome-Gut-Brain Axis and Toll-Like Receptors in Parkinson's Disease","volume":"19","author":"Caputi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1172\/JCI42440","article-title":"A Look at Autoimmunity and Inflammation in the Eye","volume":"120","author":"Caspi","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.2147\/OPTH.S166547","article-title":"Effect of Clinical Parameters on the Ocular Surface Microbiome in Children and Adults","volume":"12","author":"Cavuoto","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1167\/iovs.06-0807","article-title":"Changes in Toll-Like Receptor (TLR)-2 and TLR4 Expression and Function But Not Polymorphisms are Associated With Acute Anterior Uveitis","volume":"48","author":"Chang","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/ceo.13343","article-title":"Role of Diet and Food Intake in Age-Related Macular Degeneration: A Systematic Review","volume":"47","author":"Chapman","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1038\/s41467-018-05681-9","article-title":"Commensal Microflora-Induced T Cell Responses Mediate Progressive Neurodegeneration in Glaucoma","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s40168-017-0375-2","article-title":"MetaLab: An Automated Pipeline for Metaproteomic Data Analysis","volume":"5","author":"Cheng","year":"2017","journal-title":"Microbiome"},{"key":"B32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1001\/jama.2015.9677","article-title":"Effect of Omega-3 Fatty Acids, Lutein\/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial","volume":"314","author":"Chew","year":"2015","journal-title":"Jama"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.3390\/nu11102375","article-title":"The Gut Microbiota in Celiac Disease and Probiotics","volume":"11","author":"Chibbar","year":"2019","journal-title":"Nutrients"},{"key":"B34","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2174\/1574884712666170704145046","article-title":"Aging Eye Microbiota in Dry Eye Syndrome in Patients Treated With Enterococcus Faecium and Saccharomyces Boulardii","volume":"12","author":"Chisari","year":"2017","journal-title":"Curr. Clin. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1478-405X.2006.00422.x","article-title":"Inflammation, Immunity, Vaccines for Helicobacter Infection","volume":"11","author":"Chmiela","year":"2006","journal-title":"Helicobacter"},{"key":"B36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1167\/iovs.61.3.42","article-title":"IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model","volume":"61","author":"Choi","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/1471-2164-8-215","article-title":"Transcriptome Profiling of the Small Intestinal Epithelium in Germfree Versus Conventional Piglets","volume":"8","author":"Chowdhury","year":"2007","journal-title":"BMC Genom."},{"key":"B38","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1128\/CMR.17.4.840-862.2004","article-title":"Impact of 16S rRNA Gene Sequence Analysis for Identification of Bacteria on Clinical Microbiology and Infectious Diseases","volume":"17","author":"Clarridge","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1053\/j.gastro.2020.06.042","article-title":"Altered Gut Archaea Composition and Interaction With Bacteria are Associated With Colorectal Cancer","volume":"159","author":"Coker","year":"2020","journal-title":"Gastroenterology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1128\/CMR.17.2.348-369.2004","article-title":"HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations","volume":"17","author":"Colmegna","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e201301007","DOI":"10.5936\/csbj.201301007","article-title":"Untargeted Metabolomics: An Emerging Approach to Determine the Composition of Herbal Products","volume":"4","author":"Commisso","year":"2013","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"B42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4137\/OED.S2858","article-title":"Anterior Chamber-Associated Immune Deviation (ACAID): An Acute Response to Ocular Insult Protects From Future Immune-Mediated Damage","volume":"1","author":"Cone","year":"2009","journal-title":"Ophthalmol. Eye Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3928\/1542-8877-19981001-04","article-title":"Microbial Keratitis Resulting in Loss of the Eye","volume":"29","author":"Cruz","year":"1998","journal-title":"Ophthalmic Surg. Lasers"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"199","DOI":"10.12938\/bmfh.2020-001","article-title":"Influence of Fermented Soy Protein Consumption on Hypertension and Gut Microbial Modulation in Spontaneous Hypertensive Rats","volume":"39","author":"Daliri","year":"2020","journal-title":"Biosci. Microbiota Food Health"},{"key":"B46","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3390\/biom11020300","article-title":"Challenges and Perspective in Integrated Multi-Omics in Gut Microbiota Studies","volume":"11","author":"Daliri","year":"2021","journal-title":"Biomolecules"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.1080\/10408398.2016.1220913","article-title":"The Human Microbiome and Metabolomics: Current Concepts and Applications","volume":"57","author":"Daliri","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0120826","DOI":"10.1371\/journal.pone.0120826","article-title":"Viable Bacteria Associated With Red Blood Cells and Plasma in Freshly Drawn Blood Donations","volume":"10","author":"Damgaard","year":"2015","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/ICU.0b013e32834372ec","article-title":"Neuroprotection in Glaucoma: Recent and Future Directions","volume":"22","author":"Danesh-Meyer","year":"2011","journal-title":"Curr. Opin. Ophthalmol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41421-021-00245-6","article-title":"Identification of an Intraocular Microbiota","volume":"7","author":"Deng","year":"2021","journal-title":"Cell Discov"},{"key":"B51","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3945\/ajcn.116.140012","article-title":"Probiotics (Lactobacillus Gasseri KS-13, Bifidobacterium Bifidum G9-1, and Bifidobacterium Longum MM-2) Improve Rhinoconjunctivitis-Specific Quality of Life in Individuals With Seasonal Allergies: A Double-Blind, Placebo-Controlled, Randomized Trial","volume":"105","author":"Dennis-Wall","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"B52","doi-asserted-by":"publisher","first-page":"23561","DOI":"10.1038\/srep23561","article-title":"Altered Mucosal Microbiome Diversity and Disease Severity in Sj\u00f6gren Syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1097\/IJG.0b013e318166f00b","article-title":"Helicobacter Pylori IgG Antibodies in Aqueous Humor and Serum of Subjects With Primary Open Angle and Pseudo-Exfoliation Glaucoma in a South Indian Population","volume":"17","author":"Deshpande","year":"2008","journal-title":"J. Glaucoma"},{"key":"B54","doi-asserted-by":"publisher","first-page":"eaba1590","DOI":"10.1126\/sciadv.aba1590","article-title":"Bioinorganic Hybrid Bacteriophage for Modulation of Intestinal Microbiota to Remodel Tumor-Immune Microenvironment Against Colorectal Cancer","volume":"6","author":"Dong","year":"2020","journal-title":"Sci. Adv."},{"key":"B55","doi-asserted-by":"publisher","first-page":"4774","DOI":"10.1167\/iovs.19-27719","article-title":"Composition and Diversity of Bacterial Community on the Ocular Surface of Patients With Meibomian Gland Dysfunction","volume":"60","author":"Dong","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1097\/MEG.0000000000000581","article-title":"Persisting Changes of Intestinal Microbiota After Bowel Lavage and Colonoscopy","volume":"28","author":"Drago","year":"2016","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"B57","first-page":"56","article-title":"Gut Microbiota and Mucosal Immunity in the Neonate","volume":"6","author":"Dzidic","year":"2018","journal-title":"Med. Sci. (Basel)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1074\/mcp.RA118.001240","article-title":"Metaquantome: An Integrated, Quantitative Metaproteomics Approach Reveals Connections Between Taxonomy and Protein Function in Complex Microbiomes","volume":"18","author":"Easterly","year":"2019","journal-title":"Mol. Cell. Proteom."},{"key":"B59","doi-asserted-by":"publisher","first-page":"S46","DOI":"10.1097\/ICO.0000000000001338","article-title":"Diagnostic Approach to Ocular Infections Using Various Techniques From Conventional Culture to Next-Generation Sequencing Analysis","volume":"36","author":"Eguchi","year":"2017","journal-title":"Cornea"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e9310","DOI":"10.1097\/MD.0000000000009310","article-title":"Acute Keratoconjunctivitis Due to Contamination of Contact Lens Care Solution With Histamine-Producing Raoultella Species: A Case Report","volume":"96","author":"Eguchi","year":"2017","journal-title":"Med. (Baltimore)"},{"key":"B61","doi-asserted-by":"publisher","first-page":"26R","DOI":"10.1203\/PDR.0b013e31819e76c7","article-title":"The T(reg)\/Th17 Cell Balance: A New Paradigm for Autoimmunity","volume":"65","author":"Eisenstein","year":"2009","journal-title":"Pediatr. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s40168-017-0285-3","article-title":"Schr\u00f6dinger's Microbes: Tools for Distinguishing the Living From the Dead in Microbial Ecosystems","volume":"5","author":"Emerson","year":"2017","journal-title":"Microbiome"},{"key":"B63","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/ilar\/ilv021","article-title":"Manipulating the Gut Microbiota: Methods and Challenges","volume":"56","author":"Ericsson","year":"2015","journal-title":"Ilar J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/eye.2009.218","article-title":"The Conjunctival Bacterial Pattern of Diabetics Undergoing Cataract Surgery","volume":"24","author":"Fern\u00e1ndez-Rubio","year":"2010","journal-title":"Eye (London)"},{"key":"B65","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41577-018-0063-x","article-title":"Bacteria-Primed T Cells Identified as Culprit in Glaucoma","volume":"18","author":"Flemming","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3109\/08830185.2012.747524","article-title":"Uveitis in Mouse and Man","volume":"32","author":"Forrester","year":"2013","journal-title":"Int. Rev. Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nature15766","article-title":"Disentangling Type 2 Diabetes and Metformin Treatment Signatures in the Human Gut Microbiota","volume":"528","author":"Forslund","year":"2015","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","first-page":"E2329","DOI":"10.1073\/pnas.1319284111","article-title":"Relating the Metatranscriptome and Metagenome of the Human Gut","volume":"111","author":"Franzosa","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B69","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.immuni.2009.08.020","article-title":"The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses","volume":"31","author":"Gaboriau-Routhiau","year":"2009","journal-title":"Immunity"},{"key":"B70","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/S0161-6420(03)00093-9","article-title":"Helicobacter Pylori Infection and the Risk for Open-Angle Glaucoma","volume":"110","author":"Galloway","year":"2003","journal-title":"Ophthalmology"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.2337\/dc18-0777","article-title":"Intestinal Metaproteomics Reveals Host-Microbiota Interactions in Subjects at Risk for Type 1 Diabetes","volume":"41","author":"Gavin","year":"2018","journal-title":"Diabetes Care"},{"key":"B72","doi-asserted-by":"publisher","first-page":"102535","DOI":"10.1016\/j.autrev.2020.102535","article-title":"Glaucoma is an Autoimmune Disease","volume":"19","author":"Geyer","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.pharmthera.2015.11.012","article-title":"Gut Microbiome in Health and Disease: Linking the Microbiome-Gut-Brain Axis and Environmental Factors in the Pathogenesis of Systemic and Neurodegenerative Diseases","volume":"158","author":"Ghaisas","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"B74","doi-asserted-by":"publisher","first-page":"107921","DOI":"10.1016\/j.exer.2020.107921","article-title":"Gut Microbiota Compositional Profile and Serum Metabolic Phenotype in Patients With Primary Open-Angle Glaucoma","volume":"191","author":"Gong","year":"2020","journal-title":"Exp. Eye Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e55817","DOI":"10.1371\/journal.pone.0055817","article-title":"Alterations in the Colonic Microbiota in Response to Osmotic Diarrhea","volume":"8","author":"Gorkiewicz","year":"2013","journal-title":"PLoS One"},{"key":"B76","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1167\/iovs.07-0588","article-title":"Ocular Pathogen or Commensal: A PCR-Based Study of Surface Bacterial Flora in Normal and Dry Eyes","volume":"48","author":"Graham","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.3390\/microorganisms8111811","article-title":"Duodenal Metatranscriptomics to Define Human and Microbial Functional Alterations Associated With Severe Obesity: A Pilot Study","volume":"8","author":"Granata","year":"2020","journal-title":"Microorganisms"},{"key":"B78","doi-asserted-by":"publisher","first-page":"18193","DOI":"10.1073\/pnas.0709160104","article-title":"Danger-Free Autoimmune Disease in AIRE-Deficient Mice","volume":"104","author":"Gray","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/jam.13095","article-title":"Ruminococcus Gnavus E1 Modulates Mucin Expression and Intestinal Glycosylation","volume":"120","author":"Graziani","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.chom.2020.08.003","article-title":"The Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut","volume":"28","author":"Gregory","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B81","doi-asserted-by":"publisher","first-page":"eaan2306","DOI":"10.1126\/scitranslmed.aan2306","article-title":"Commensal Orthologs of the Human Autoantigen Ro60 as Triggers of Autoimmunity in Lupus","volume":"10","author":"Greiling","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"B82","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ophtha.2003.06.014","article-title":"Incidence and Prevalence of Uveitis in Northern California; the Northern California Epidemiology of Uveitis Study","volume":"111","author":"Gritz","year":"2004","journal-title":"Ophthalmology"},{"key":"B83","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s00417-014-2619-1","article-title":"Plasma Metabonomics Study of the Patients With Acute Anterior Uveitis Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry","volume":"252","author":"Guo","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.1038\/s41467-019-11262-1","article-title":"A Systems Biology Approach Towards Understanding and Treating non-Neovascular Age-Related Macular Degeneration","volume":"10","author":"Handa","year":"2019","journal-title":"Nat. Commun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"6826","DOI":"10.1523\/JNEUROSCI.1856-04.2004","article-title":"Promotion of Axon Regeneration by Myelin-Associated Glycoprotein and Nogo Through Divergent Signals Downstream of Gi\/G","volume":"24","author":"Hasegawa","year":"2004","journal-title":"J. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"16180","DOI":"10.1038\/nmicrobiol.2016.180","article-title":"Integrated Multi-Omics of the Human Gut Microbiome in a Case Study of Familial Type 1 Diabetes","volume":"2","author":"Heintz-Buschart","year":"2016","journal-title":"Nat. Microbiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"12672","DOI":"10.1073\/pnas.1904099116","article-title":"Ruminococcus Gnavus, a Member of the Human Gut Microbiome Associated With Crohn's Disease, Produces an Inflammatory Polysaccharide","volume":"116","author":"Henke","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B88","first-page":"532","article-title":"Endotoxin-Induced Uveitis in the Rat. The Significance of Intraocular Interleukin-6","volume":"33","author":"Hoekzema","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00232","article-title":"Microbiome and Autoimmune Uveitis","volume":"10","author":"Horai","year":"2019","journal-title":"Front. Immunol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jaut.2013.06.003","article-title":"Breakdown of Immune Privilege and Spontaneous Autoimmunity in Mice Expressing a Transgenic T Cell Receptor Specific for a Retinal Autoantigen","volume":"44","author":"Horai","year":"2013","journal-title":"J. Autoimmun."},{"key":"B91","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.immuni.2015.07.014","article-title":"Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site","volume":"43","author":"Horai","year":"2015","journal-title":"Immunity"},{"key":"B92","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/j.ajo.2008.06.003","article-title":"Bacteriologic Profile of the Conjunctiva in the Patients With Dry Eye","volume":"146","author":"Hori","year":"2008","journal-title":"Am. J. Ophthalmol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1136\/gutjnl-2015-310027","article-title":"Real Friends: Faecalibacterium Prausnitzii Supports Mucosal Immune Homeostasis","volume":"65","author":"Hornef","year":"2016","journal-title":"Gut"},{"key":"B94","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.chom.2019.05.001","article-title":"Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model","volume":"25","author":"Hsu","year":"2019","journal-title":"Cell Host Microbe"},{"key":"B95","doi-asserted-by":"publisher","first-page":"643.e647","DOI":"10.1016\/j.cmi.2016.04.008","article-title":"Defining the Normal Core Microbiome of Conjunctival Microbial Communities","volume":"22","author":"Huang","year":"2016","journal-title":"Clin. Microbiol. Infect."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1167\/iovs.17-22677","article-title":"Gut Microbiota Composition and Fecal Metabolic Phenotype in Patients With Acute Anterior Uveitis","volume":"59","author":"Huang","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B98","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","article-title":"Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International Workshop","volume":"140","author":"Jabs","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1002\/pmic.201500074","article-title":"Metaproteomic Analysis Using the Galaxy Framework","volume":"15","author":"Jagtap","year":"2015","journal-title":"Proteomics"},{"key":"B100","doi-asserted-by":"publisher","first-page":"12015","DOI":"10.1038\/ncomms12015","article-title":"Alterations of the Human Gut Microbiome in Multiple Sclerosis","volume":"7","author":"Jangi","year":"2016","journal-title":"Nat. Commun."},{"key":"B101","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1167\/iovs.18-24813","article-title":"Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis","volume":"60","author":"Janowitz","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"e00208","DOI":"10.1128\/mSystems.00208-18","article-title":"Rare Taxa Exhibit Disproportionate Cell-Level Metabolic Activity in Enriched Anaerobic Digestion Microbial Communities","volume":"4","author":"Jia","year":"2019","journal-title":"mSystems"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.2147\/IDR.S162135","article-title":"Pathogens in the Meibomian Gland and Conjunctival Sac: Microbiome of Normal Subjects and Patients With Meibomian Gland Dysfunction","volume":"11","author":"Jiang","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s40168-015-0146-x","article-title":"Metatranscriptomic Analysis of Diverse Microbial Communities Reveals Core Metabolic Pathways and Microbiome-Specific Functionality","volume":"4","author":"Jiang","year":"2016","journal-title":"Microbiome"},{"key":"B105","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1479-5876-1-8","article-title":"Polymorphism in Clinical Immunology - From HLA Typing to Immunogenetic Profiling","volume":"1","author":"Jin","year":"2003","journal-title":"J. Transl. Med."},{"key":"B106","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12088-018-0746-9","article-title":"Dysbiosis in the Gut Bacterial Microbiome of Patients With Uveitis, an Inflammatory Disease of the Eye","volume":"58","author":"Kalyana Chakravarthy","year":"2018","journal-title":"Indian J. Microbiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the Gut Microbiota in Immunity and Inflammatory Disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature12198","article-title":"Gut Metagenome in European Women With Normal, Impaired and Diabetic Glucose Control","volume":"498","author":"Karlsson","year":"2013","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"179","DOI":"10.12688\/f1000research.6709.2","article-title":"Individuality, Phenotypic Differentiation, Dormancy and 'Persistence' in Culturable Bacterial Systems: Commonalities Shared by Environmental, Laboratory, and Clinical Microbiology","volume":"4","author":"Kell","year":"2015","journal-title":"F1000Res"},{"key":"B110","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/RHU.0b013e3181637a38","article-title":"HLA-B27 and its Pathogenic Role","volume":"14","author":"Khan","year":"2008","journal-title":"J. Clin. Rheumatol."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01835","article-title":"The Human Gut Microbiome - a Potential Controller of Wellness and Disease","volume":"9","author":"Kho","year":"2018","journal-title":"Front. Microbiol."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111166","article-title":"Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye","volume":"9","author":"Kim","year":"2017","journal-title":"Nutrients"},{"key":"B113","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.exer.2004.07.008","article-title":"Growth Factors in the Anterior Segment: Role in Tissue Maintenance, Wound Healing and Ocular Pathology","volume":"79","author":"Klenkler","year":"2004","journal-title":"Exp. Eye Res."},{"key":"B114","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000099252","article-title":"Anatomy and Immunology of the Ocular Surface","volume":"92","author":"Knop","year":"2007","journal-title":"Chem. Immunol. Allergy"},{"key":"B115","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12886-015-0035-x","article-title":"Systematic Review and Mixed Treatment Comparison of Intravitreal Aflibercept With Other Therapies for Diabetic Macular Edema (DME)","volume":"15","author":"Korobelnik","year":"2015","journal-title":"BMC Ophthalmol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0161-6420(00)00598-4","article-title":"Relationship Between Helicobacter Pylori Infection and Glaucoma","volume":"108","author":"Kountouras","year":"2001","journal-title":"Ophthalmology"},{"key":"B117","doi-asserted-by":"publisher","first-page":"e1005855","DOI":"10.1371\/journal.ppat.1005855","article-title":"Impact of Microbiota on Resistance to Ocular Pseudomonas Aeruginosa-Induced Keratitis","volume":"12","author":"Kugadas","year":"2016","journal-title":"PLoS Pathog."},{"key":"B118","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1167\/iovs.17-22119","article-title":"Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA","volume":"58","author":"Kugadas","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.clim.2017.04.017","article-title":"Sjogren's Syndrome From the Perspective of Ophthalmology","volume":"182","author":"Kuklinski","year":"2017","journal-title":"Clin. Immunol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1097\/IJG.0b013e31815a34ac","article-title":"No Association Between Helicobacter Pylori Infection or CagA-Bearing Strains and Glaucoma","volume":"17","author":"Kurtz","year":"2008","journal-title":"J. Glaucoma"},{"key":"B121","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00281-014-0433-9","article-title":"Autoimmune and Autoinflammatory Mechanisms in Uveitis","volume":"36","author":"Lee","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.1167\/iovs.12-9922","article-title":"Comparative Ocular Microbial Communities in Humans With and Without Blepharitis","volume":"53","author":"Lee","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1128\/JB.182.11.3037-3044.2000","article-title":"mRNA Composition and Control of Bacterial Gene Expression","volume":"182","author":"Liang","year":"2000","journal-title":"J. Bacteriol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1017\/S0952523805225130","article-title":"Inherited Glaucoma in DBA\/2J Mice: Pertinent Disease Features for Studying the Neurodegeneration","volume":"22","author":"Libby","year":"2005","journal-title":"Vis. Neurosci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/ICU.0000000000000465","article-title":"The Role of the Intestinal Microbiome in Ocular Inflammatory Disease","volume":"29","author":"Lin","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/ceo.13493","article-title":"Importance of the Intestinal Microbiota in Ocular Inflammatory Diseases: A Review","volume":"47","author":"Lin","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609765","article-title":"Ocular Microbiota and Intraocular Inflammation","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/S1130-1473(08)70215-X","article-title":"Historical Vignette of Cajal's Work \"Degeneration and Regeneration of the Nervous System\" With a Reflection of the Author","volume":"19","author":"Lobato","year":"2008","journal-title":"Neurocirugia"},{"key":"B129","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41522-020-0123-4","article-title":"Metaproteomics Characterizes Human Gut Microbiome Function in Colorectal Cancer","volume":"6","author":"Long","year":"2020","journal-title":"NPJ Biofilms Microbiomes"},{"key":"B130","doi-asserted-by":"publisher","first-page":"e021037","DOI":"10.1136\/bmjopen-2017-021037","article-title":"Clinical and Multi-Omics Cross-Phenotyping of Patients With Autoimmune and Autoinflammatory Diseases: The Observational TRANSIMMUNOM Protocol","volume":"8","author":"Lorenzon","year":"2018","journal-title":"BMJ Open"},{"key":"B131","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1053\/j.gastro.2016.07.008","article-title":"Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair","volume":"151","author":"Luissint","year":"2016","journal-title":"Gastroenterology"},{"key":"B132","first-page":"325","article-title":"Human Microbiota and Ophthalmic Disease","volume":"89","author":"Lu","year":"2016","journal-title":"Yale J. Biol. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"180","DOI":"10.5694\/mja2.50020","article-title":"Current Management of Glaucoma","volume":"210","author":"Lusthaus","year":"2019","journal-title":"Med. J. Aust."},{"key":"B134","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/ni.3400","article-title":"Gut Microbiome-Derived Metabolites Modulate Intestinal Epithelial Cell Damage and Mitigate Graft-Versus-Host Disease","volume":"17","author":"Mathewson","year":"2016","journal-title":"Nat. Commun."},{"key":"B135","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2012.10.052","article-title":"Xenobiotics Shape the Physiology and Gene Expression of the Active Human Gut Microbiome","volume":"152","author":"Maurice","year":"2013","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1021\/acs.jproteome.6b00938","article-title":"Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression From a Mouse Model of Inflammatory Bowel Disease","volume":"16","author":"Mayers","year":"2017","journal-title":"J. Proteome Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12934-020-01348-7","article-title":"Gut Microbial Dysbiosis in Individuals With Sj\u00f6gren's Syndrome","volume":"19","author":"Mendez","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1093\/bioinformatics\/btw039","article-title":"Unipept Web Services for Metaproteomics Analysis","volume":"32","author":"Mesuere","year":"2016","journal-title":"Bioinformatics"},{"key":"B139","doi-asserted-by":"publisher","first-page":"3612015","DOI":"10.1155\/2017\/3612015","article-title":"In Vivo Studies on the Influence of Bacteriophage Preparations on the Autoimmune Inflammatory Process","volume":"2017","author":"Mi\u0119dzybrodzki","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"B140","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1097\/ACI.0b013e3283303e1b","article-title":"The Role of Microbial Flora on the Ocular Surface","volume":"9","author":"Miller","year":"2009","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"12595","DOI":"10.1038\/s41598-020-69554-2","article-title":"Presence of Acanthamoeba and Diversified Bacterial Flora in Poorly Maintained Contact Lens Cases","volume":"10","author":"Miyazaki","year":"2020","journal-title":"Sci. Rep."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e0229029","DOI":"10.1371\/journal.pone.0229029","article-title":"Gut Dysbiosis is Prevailing in Sj\u00f6gren's Syndrome and is Related to Dry Eye Severity","volume":"15","author":"Moon","year":"2020","journal-title":"PLoS One"},{"key":"B143","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The Gut Microbiota-Brain Axis in Behaviour and Brain Disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.18632\/aging.101583","article-title":"Long-Term Intake of Lactobacillus Paracasei KW3110 Prevents Age-Related Chronic Inflammation and Retinal Cell Loss in Physiologically Aged Mice","volume":"10","author":"Morita","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"B145","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/1471-2415-13-71","article-title":"External Ocular Surface Bacterial Isolates and Their Antimicrobial Susceptibility Patterns Among Pre-Operative Cataract Patients at Mulago National Hospital in Kampala, Uganda","volume":"13","author":"Mshangila","year":"2013","journal-title":"BMC Ophthalmol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1021\/acs.analchem.7b03544","article-title":"MPA Portable: A Stand-Alone Software Package for Analyzing Metaproteome Samples on the Go","volume":"90","author":"Muth","year":"2018","journal-title":"Anal. Chem."},{"key":"B147","first-page":"34","article-title":"High Throughput RNA Sequencing of Mice Retina Reveals Metabolic Pathways Involved in the Gut-Retina Axis","volume":"3","author":"Nadeem","year":"2020","journal-title":"bioRxiv"},{"key":"B148","doi-asserted-by":"publisher","first-page":"4042","DOI":"10.1038\/s41598-019-40182-9","article-title":"Effects of Bowel Preparation on the Human Gut Microbiome and Metabolome","volume":"9","author":"Nagata","year":"2019","journal-title":"Sci. Rep."},{"key":"B149","doi-asserted-by":"publisher","first-page":"102950","DOI":"10.1016\/j.ebiom.2020.102950","article-title":"Gut Mycobiome and its Interaction With Diet, Gut Bacteria and Alzheimer's Disease Markers in Subjects With Mild Cognitive Impairment: A Pilot Study","volume":"59","author":"Nagpal","year":"2020","journal-title":"EBioMedicine"},{"key":"B150","doi-asserted-by":"publisher","first-page":"11745","DOI":"10.1038\/s41598-017-12163-3","article-title":"Short Chain Fatty Acids Ameliorate Immune-Mediated Uveitis Partially by Altering Migration of Lymphocytes From the Intestine","volume":"7","author":"Nakamura","year":"2017","journal-title":"Sci. Rep."},{"key":"B151","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1167\/iovs.16-19733","article-title":"Gut Microbial Alterations Associated With Protection From Autoimmune Uveitis","volume":"57","author":"Nakamura","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1080\/07853890.2021.1925150","article-title":"Influence of Gut Microbiota on Eye Diseases: An Overview","volume":"53","author":"Napolitano","year":"2021","journal-title":"Ann. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The Human Tumor Microbiome is Composed of Tumor Type-Specific Intracellular Bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"B154","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and Regulatory T Cell Balance in Autoimmune and Inflammatory Diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1128\/IAI.00358-15","article-title":"Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus Aureus Bloodstream Infection","volume":"83","author":"O'Keeffe","year":"2015","journal-title":"Infect. Immun."},{"key":"B156","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1136\/gutjnl-2014-306931","article-title":"The HLA-DQ2 Genotype Selects for Early Intestinal Microbiota Composition in Infants at High Risk of Developing Coeliac Disease","volume":"64","author":"Olivares","year":"2015","journal-title":"Gut"},{"key":"B157","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3109\/09273949609079638","article-title":"Calprotectin is Raised in Endogenous Posterior Uveitis","volume":"4","author":"Olson","year":"1996","journal-title":"Ocul. Immunol. Inflamm."},{"key":"B158","doi-asserted-by":"publisher","first-page":"9880","DOI":"10.1038\/s41598-017-10494-9","article-title":"Temporal Stability and Composition of the Ocular Surface Microbiome","volume":"7","author":"Ozkan","year":"2017","journal-title":"Sci. Rep."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/trf.13477","article-title":"Comprehensive Description of Blood Microbiome From Healthy Donors Assessed by 16S Targeted Metagenomic Sequencing","volume":"56","author":"Paisse","year":"2016","journal-title":"Transfusion"},{"key":"B160","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2019.01.001","article-title":"Extensive Unexplored Human Microbiome Diversity Revealed by Over 150,000 Genomes From Metagenomes Spanning Age, Geography, and Lifestyle","volume":"176","author":"Pasolli","year":"2019","journal-title":"Cell"},{"key":"B161","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1007\/s13238-015-0185-x","article-title":"Functional Metabolomics: From Biomarker Discovery to Metabolome Reprogramming","volume":"6","author":"Peng","year":"2015","journal-title":"Protein Cell"},{"key":"B162","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1172\/JCI93450","article-title":"Two Rheumatoid Arthritis-Specific Autoantigens Correlate Microbial Immunity With Autoimmune Responses in Joints","volume":"127","author":"Pianta","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00297","article-title":"Conjunctival Microbiome-Host Responses Are Associated With Impaired Epithelial Cell Health in Both Early and Late Stages of Trachoma","volume":"9","author":"Pickering","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.ophtha.2004.12.024","article-title":"Detection of Virulence Factors in a Corneal Isolate of Klebsiella Pneumoniae","volume":"112","author":"Pinna","year":"2005","journal-title":"Ophthalmology"},{"key":"B165","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s41586-020-2095-1","article-title":"Microbiome Analyses of Blood and Tissues Suggest Cancer Diagnostic Approach","volume":"579","author":"Poore","year":"2020","journal-title":"Nature"},{"key":"B166","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/femsre\/fuv013","article-title":"The Dormant Blood Microbiome in Chronic, Inflammatory Diseases","volume":"39","author":"Potgieter","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"B167","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1172\/JCI84440","article-title":"LYN- and AIRE-Mediated Tolerance Checkpoint Defects Synergize to Trigger Organ-Specific Autoimmunity","volume":"126","author":"Proekt","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B168","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.coi.2017.10.003","article-title":"Insights Into Immune Tolerance From AIRE Deficiency","volume":"49","author":"Proekt","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The Number of People With Glaucoma Worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/ajg.2014.427","article-title":"Intestinal Microbiota and Diet in IBS: Causes, Consequences, or Epiphenomena","volume":"110","author":"Rajili\u0107-Stojanovi\u0107","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jneuroim.2010.04.014","article-title":"Antigen-Specific Therapy of EAE via Intranasal Delivery of Filamentous Phage Displaying a Myelin Immunodominant Epitope","volume":"225","author":"Rakover","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s40168-019-0743-1","article-title":"Comparative Analysis of Amplicon and Metagenomic Sequencing Methods Reveals Key Features in the Evolution of Animal Metaorganisms","volume":"7","author":"Rausch","year":"2019","journal-title":"Microbiome"},{"key":"B173","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3389\/fmicb.2016.00979","article-title":"Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut","volume":"7","author":"Rivi\u00e8re","year":"2016","journal-title":"Front. Microbiol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jaut.2018.10.012","article-title":"Molecular Mimicry and Autoimmunity","volume":"95","author":"Rojas","year":"2018","journal-title":"J. Autoimmun."},{"key":"B175","doi-asserted-by":"publisher","first-page":"e37172","DOI":"10.7554\/eLife.37172","article-title":"A Bacterial Immunomodulatory Protein With Lipocalin-Like Domains Facilitates Host-Bacteria Mutualism in Larval Zebrafish","volume":"7","author":"Rolig","year":"2018","journal-title":"Elife"},{"key":"B176","first-page":"792","article-title":"Characterization of Uveitis Associated With Spondyloarthritis","volume":"16","author":"Rosenbaum","year":"1989","journal-title":"J. Rheumatol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41584-018-0097-2","article-title":"The Microbiome and HLA-B27-Associated Acute Anterior Uveitis","volume":"14","author":"Rosenbaum","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"E4472","DOI":"10.1073\/pnas.1702302114","article-title":"Involvement of a Gut-Retina Axis in Protection Against Dietary Glycemia-Induced Age-Related Macular Degeneration","volume":"114","author":"Rowan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.2460\/ajvr.72.8.1079","article-title":"Isolation and Characterization of Two Bacteriophages With Strong In Vitro Antimicrobial Activity Against Pseudomonas Aeruginosa Isolated From Dogs With Ocular Infections","volume":"72","author":"Santos","year":"2011","journal-title":"Am. J. Vet. Res."},{"key":"B180","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1128\/aem.42.6.996-1001.1981","article-title":"Transit Time of Epithelial Cells in the Small Intestines of Germfree Mice and Ex-Germfree Mice Associated With Indigenous Microorganisms","volume":"42","author":"Savage","year":"1981","journal-title":"Appl. Environ. Microbiol."},{"key":"B181","first-page":"1164","article-title":"16s rDNA-Based Identification of Bacteria From Conjunctival Swabs by PCR and DGGE Fingerprinting","volume":"42","author":"Schabereiter-Gurtner","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B182","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39259","article-title":"Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases","volume":"68","author":"Scher","year":"2016","journal-title":"Arthritis. Rheumatol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1136\/gutjnl-2018-316227","article-title":"Circulating Microbiome in Blood of Different Circulatory Compartments","volume":"68","author":"Schierwagen","year":"2019","journal-title":"Gut"},{"key":"B184","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1128\/MMBR.68.4.686-691.2004","article-title":"Status of the Microbial Census","volume":"68","author":"Schloss","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B185","first-page":"225","article-title":"The Diagnosis and Treatment of Glaucoma","volume":"117","author":"Schuster","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/j.chembiol.2015.09.015","article-title":"Host-Microbe Protein Interactions During Bacterial Infection","volume":"22","author":"Schweppe","year":"2015","journal-title":"Chem. Biol."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00904","article-title":"Advances and Challenges in Metatranscriptomic Analysis","volume":"10","author":"Shakya","year":"2019","journal-title":"Front. Genet."},{"key":"B188","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00535-015-1064-1","article-title":"The Microbiota in Inflammatory Bowel Disease","volume":"50","author":"Sheehan","year":"2015","journal-title":"J. Gastroenterol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jconrel.2017.11.028","article-title":"RNA Nanoparticle Distribution and Clearance in the Eye After Subconjunctival Injection With and Without Thermosensitive Hydrogels","volume":"270","author":"Shi","year":"2018","journal-title":"J.\u00a0Control Release"},{"key":"B190","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1038\/ctg.2015.54","article-title":"The Effects of Bowel Preparation on Microbiota-Related Metrics Differ in Health and in Inflammatory Bowel Disease and for the Mucosal and Luminal Microbiota Compartments","volume":"7","author":"Shobar","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1128\/AAC.00126-14","article-title":"Intravitreal Injection of the Chimeric Phage Endolysin Ply187 Protects Mice From Staphylococcus Aureus Endophthalmitis","volume":"58","author":"Singh","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"B192","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1097\/IJG.0000000000001025","article-title":"Butyrate, a Gut Bacterial Metabolite, Lowers Intraocular Pressure in Normotensive But Not in Hypertensive Rats","volume":"27","author":"Skrzypecki","year":"2018","journal-title":"J.\u00a0Glaucoma"},{"key":"B193","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s10792-020-01587-y","article-title":"Glaucoma Patients Have an Increased Level of Trimethylamine, a Toxic Product of Gut Bacteria, in the Aqueous Humor: A Pilot Study","volume":"41","author":"Skrzypecki","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1126\/science.1241165","article-title":"The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis","volume":"341","author":"Smith","year":"2013","journal-title":"Science"},{"key":"B195","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.ajo.2007.06.037","article-title":"Relationship Between Climate, Disease Severity, and Causative Organism for Contact Lens-Associated Microbial Keratitis in Australia","volume":"144","author":"Stapleton","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.it.2008.08.002","article-title":"Immune Regulation and the Eye","volume":"29","author":"Stein-Streilein","year":"2008","journal-title":"Trends Immunol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.immuni.2017.06.014","article-title":"An Ocular Commensal Protects Against Corneal Infection by Driving an Interleukin-17 Response From Mucosal \u03b3\u03b4 T Cells","volume":"47","author":"St Leger","year":"2017","journal-title":"Immunity"},{"key":"B198","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbi.2020.11.032","article-title":"Antibiotic-Induced Microbiome Depletion in Adult Mice Disrupts Blood-Brain Barrier and Facilitates Brain Infiltration of Monocytes After Bone-Marrow Transplantation","volume":"92","author":"Sun","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"B199","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00535-016-1242-9","article-title":"Microbiota Metabolite Short Chain Fatty Acids, GPCR, and Inflammatory Bowel Diseases","volume":"52","author":"Sun","year":"2017","journal-title":"J. Gastroenterol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.02.004","article-title":"T Cell Epitope Mimicry Between Sj\u00f6gren's Syndrome Antigen A (SSA)\/Ro60 and Oral, Gut, Skin and Vaginal Bacteria","volume":"152","author":"Szymula","year":"2014","journal-title":"Clin. Immunol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4103\/2008-322X.150799","article-title":"Choroidal Neovascularization Induces Retinal Edema and its Treatment Addresses This Problem","volume":"9","author":"Tadayoni","year":"2014","journal-title":"J. Ophthalmic. Vis. Res."},{"key":"B202","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11154-015-9309-0","article-title":"The Role of Gut Microbiota in the Development of Type 1, Type 2 Diabetes Mellitus and Obesity","volume":"16","author":"Tai","year":"2015","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"B203","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1084\/jem.180.6.2359","article-title":"The Germfree State Prevents Development of Gut and Joint Inflammatory Disease in HLA-B27 Transgenic Rats","volume":"180","author":"Taurog","year":"1994","journal-title":"J. Exp. Med."},{"key":"B204","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, Function and Diversity of the Healthy Human Microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"key":"B205","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10384-018-0630-5","article-title":"Genetic Diversity and Persistent Colonization of Enterococcus Faecalis on Ocular Surfaces","volume":"62","author":"Todokoro","year":"2018","journal-title":"Jpn J. Ophthalmol."},{"key":"B206","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.jtos.2019.10.006","article-title":"The Gut-Eye-Lacrimal Gland-Microbiome Axis in Sj\u00f6gren Syndrome","volume":"18","author":"Trujillo-Vargas","year":"2020","journal-title":"Ocul. Surf."},{"key":"B207","doi-asserted-by":"publisher","first-page":"6ra14","DOI":"10.1126\/scitranslmed.3000322","article-title":"The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice","volume":"1","author":"Turnbaugh","year":"2009","journal-title":"Sci. Transl. Med."},{"key":"B208","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.coi.2021.06.002","article-title":"Microbiota and Human Allergic Diseases: The Company We Keep","volume":"72","author":"Vercelli","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aar7201","article-title":"Translocation of a Gut Pathobiont Drives Autoimmunity in Mice and Humans","volume":"359","author":"Vieira","year":"2018","journal-title":"Science"},{"key":"B210","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/anie.201804736","article-title":"High-Throughput Metabolomics by 1D NMR","volume":"58","author":"Vignoli","year":"2019","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"B211","doi-asserted-by":"crossref","first-page":"eaaf9655","DOI":"10.1126\/scitranslmed.aaf9655","article-title":"IgA-Coated E. Coli Enriched in Crohn's Disease Spondyloarthritis Promote T(H)17-Dependent Inflammation","volume":"9","author":"Viladomiu","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B212","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/0039-6257(91)90005-Z","article-title":"Acute Anterior Uveitis and HLA-B27","volume":"36","author":"Wakefield","year":"1991","journal-title":"Surv. Ophthalmol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.cell.2019.12.025","article-title":"Establishing or Exaggerating Causality for the Gut Microbiome: Lessons From Human Microbiota-Associated Rodents","volume":"180","author":"Walter","year":"2020","journal-title":"Cell"},{"key":"B214","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1111\/1462-2920.12923","article-title":"Phage-Bacteria Interaction Network in Human Oral Microbiome","volume":"18","author":"Wang","year":"2016","journal-title":"Environ. Microbiol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"565","DOI":"10.3390\/ijms19020565","article-title":"Sj\u00f6gren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B216","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.femsre.2003.08.001","article-title":"Ecology of Prokaryotic Viruses","volume":"28","author":"Weinbauer","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"B217","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/ICU.0000000000000466","article-title":"Cytokines in Uveitis","volume":"29","author":"Weinstein","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1167\/iovs.17-22957","article-title":"The Influence of Age and Sex on Ocular Surface Microbiota in Healthy Adults","volume":"58","author":"Wen","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B219","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1076\/ceyr.26.1.33.14253","article-title":"Molecular Analysis of the Pediatric Ocular Surface for Fungi","volume":"26","author":"Wu","year":"2003","journal-title":"Curr. Eye Res."},{"key":"B220","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1021\/pr500936p","article-title":"Development of an Enhanced Metaproteomic Approach for Deepening the Microbiome Characterization of the Human Infant Gut","volume":"14","author":"Xiong","year":"2015","journal-title":"J. Proteome Res."},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145091","article-title":"Lactobacillus Paracasei KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans","volume":"21","author":"Yamazaki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B222","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.3390\/ijms19103241","article-title":"Outer Membrane Protein of Gut Commensal Microorganism Induces Autoantibody Production and Extra-Intestinal Gland Inflammation in Mice","volume":"19","author":"Yanagisawa","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B223","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/bjophthalmol-2016-309499","article-title":"Clinical Features of HLA-B27-Positive Acute Anterior Uveitis With or Without Ankylosing Spondylitis in a Chinese Cohort","volume":"102","author":"Yang","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/19490976.2019.1700754","article-title":"Altered Gut Microbiome Composition in Patients With Vogt-Koyanagi-Harada Disease","volume":"11","author":"Ye","year":"2020","journal-title":"Gut Microbes"},{"key":"B225","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s40168-018-0520-6","article-title":"A Metagenomic Study of the Gut Microbiome in Behcet's Disease","volume":"6","author":"Ye","year":"2018","journal-title":"Microbiome"},{"key":"B226","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.3390\/ijms22094616","article-title":"Advances in Regeneration of Retinal Ganglion Cells and Optic Nerves","volume":"22","author":"Yuan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B227","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1167\/iovs.18-23795","article-title":"Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis","volume":"59","author":"Zaidi","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B228","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.it.2014.08.003","article-title":"Metabolic Control of Regulatory T Cell Development and Function","volume":"36","author":"Zeng","year":"2015","journal-title":"Trends Immunol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1167\/iovs.15-17059","article-title":"The Relationship Between Helicobacter Pylori Infection and Open-Angle Glaucoma: A Meta-Analysis","volume":"56","author":"Zeng","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B230","doi-asserted-by":"publisher","first-page":"dmm032698","DOI":"10.1242\/dmm.032698","article-title":"Pgc-1\u03b1 Repression and High-Fat Diet Induce Age-Related Macular Degeneration-Like Phenotypes in Mice","volume":"11","author":"Zhang","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"B231","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1038\/s41467-018-05357-4","article-title":"Metaproteomics Reveals Associations Between Microbiome and Intestinal Extracellular Vesicle Proteins in Pediatric Inflammatory Bowel Disease","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"B232","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s40168-019-0767-6","article-title":"Advancing Functional and Translational Microbiome Research Using Meta-Omics Approaches","volume":"7","author":"Zhang","year":"2019","journal-title":"Microbiome"},{"key":"B233","doi-asserted-by":"publisher","first-page":"113856","DOI":"10.1016\/j.addr.2021.113856","article-title":"Bacteriophage-Mediated Modulation of Microbiota for Diseases Treatment","volume":"5","author":"Zhang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B234","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1167\/iovs.61.8.22","article-title":"Metagenomic Profiling of Ocular Surface Microbiome Changes in Meibomian Gland Dysfunction","volume":"61","author":"Zhao","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B235","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13073-014-0099-x","article-title":"The Conjunctival Microbiome in Health and Trachomatous Disease: A Case Control Study","volume":"6","author":"Zhou","year":"2014","journal-title":"Genome Med."},{"key":"B236","doi-asserted-by":"publisher","first-page":"114108","DOI":"10.1016\/j.bcp.2020.114108","article-title":"A Combination of Inhibiting Microglia Activity and Remodeling Gut Microenvironment Suppresses the Development and Progression of Experimental Autoimmune Uveitis","volume":"180","author":"Zhou","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"B237","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jtos.2020.07.007","article-title":"Assessing the Ocular Surface Microbiome in Severe Ocular Surface Diseases","volume":"18","author":"Zilliox","year":"2020","journal-title":"Ocul. Surf."},{"key":"B238","doi-asserted-by":"publisher","first-page":"40826","DOI":"10.1038\/srep40826","article-title":"Association of the Intestinal Microbiome With the Development of Neovascular Age-Related Macular Degeneration","volume":"7","author":"Zinkernagel","year":"2017","journal-title":"Sci. Rep."},{"key":"B239","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.62.10.8","article-title":"Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome","volume":"62","author":"Zysset-Burri","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.759333\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T01:23:44Z","timestamp":1634779424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.759333\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":239,"alternative-id":["10.3389\/fcimb.2021.759333"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2021.759333","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]},"article-number":"759333"}}