{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:53:13Z","timestamp":1791816793036,"version":"4.3.4"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016966","name":"Bethune Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the correlation between serum immunoglobulin E (IgE) levels and the complications in children with\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      pneumonia (MPP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of MPP patients hospitalized from May 2019 to July 2021 was performed. We analyzed the clinical manifestations, complications, laboratory findings, and treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 275 patients who met the inclusion criteria were enrolled in the study. We divided patients into two groups based on whether there were complications. Complications occurred in 147 patients, of which pulmonary complications were more common than extrapulmonary complications. The IgE level in the complication group was higher than that in the non-complication group with\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041. Patients with complications of necrotizing pneumonitis, pneumothorax, skin rash, or bronchiolitis obliterans had higher IgE levels. There was no statistically significant difference in IgE levels between pulmonary complications and extrapulmonary complications. The older the age, the greater the probability of complications (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). The group with complications was more likely to have chest pain (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000), while the group without complications was more likely to have wheezing (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.017). The use of bronchoscopy and glucocorticoids was higher in the complication group than in the non-complication group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      MPP patients with higher IgE levels had more severe clinical symptoms and complications. We speculated that IgE might be a biomarker for complications after\n                      <jats:italic>MP<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2021.783635","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:05:28Z","timestamp":1638295528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children"],"prefix":"10.3389","volume":"11","author":[{"given":"Lili","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhufei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e590","DOI":"10.5546\/aap.2018.e590","article-title":"Mycoplasma Pneumoniae: Neurologic Manifestations and Diagnostic Controversies. A Case Report","volume":"116","author":"Arighi","year":"2018","journal-title":"Archivos Argentinos Pediatria"},{"key":"B2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/1348-0421.12267","article-title":"Pathogenesis and Association of Mycoplasma Pneumoniae Infection With Cardiac and Hepatic Damage","volume":"59","author":"Fan","year":"2015","journal-title":"Microbiol. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e24894","DOI":"10.1097\/MD.0000000000024894","article-title":"The Risk Factors of Children Acquiring Refractory Mycoplasma Pneumoniae Pneumonia: A Meta-Analysis","volume":"100","author":"Gong","year":"2021","journal-title":"Medicine"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.563693","article-title":"Mycoplasma Pneumoniaelncrna MALAT1 Affects Pneumonia via NF-\u03bab Regulation","volume":"8","author":"Gu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.21037\/tp-20-471","article-title":"Mycoplasma Pneumoniaethe Clinical Characteristics of Pneumonia and its Relationship Between Hypokalemia in West China","volume":"10","author":"Han","year":"2021","journal-title":"Transl. Pediatr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.2500\/aap.2014.35.3734","article-title":"Selective IgE Deficiency, Immune Dysregulation, and Autoimmunity","volume":"35","author":"Magen","year":"2014","journal-title":"Allergy Asthma Proc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e24316","DOI":"10.1097\/MD.0000000000024316","article-title":"Arthritis Associated With Mycoplasma Pneumoniae in a Pediatric Patient: A Case Report","volume":"100","author":"M\u0103rginean","year":"2021","journal-title":"Medicine"},{"key":"B8","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13052-014-0104-4","article-title":"Mycoplasma Pneumoniae as a Causative Agent of Community-Acquired Pneumonia in Children: Clinical Features and Laboratory Diagnosis","volume":"40","author":"Medjo","year":"2014","journal-title":"Ital. J. Pediatr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/QCO.0000000000000063","article-title":"Mycoplasma Pneumoniae in Children: Carriage, Pathogenesis, and Antibiotic Resistance","volume":"27","author":"Meyer","year":"2014","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s10156-010-0044-X","article-title":"Pathogenesis of Extrapulmonary Manifestations of Mycoplasma Pneumoniae Infection With Special Reference to Pneumonia","volume":"16","author":"Narita","year":"2010","journal-title":"J.\u00a0Infection Chemother."},{"key":"B11","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1097\/BOR.0000000000000494","article-title":"Extra-Pulmonary Diseases Related to Mycoplasma Pneumoniae in Children: Recent Insights Into the Pathogenesis","volume":"30","author":"Poddighe","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"6596596","DOI":"10.1155\/2021\/6596596","article-title":"Mycoplasma Pneumoniae Seroprevalence and Total IgE Levels in Patients With Juvenile Idiopathic Arthritis","volume":"2021","author":"Poddighe","year":"2021","journal-title":"J. Immunol. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"490","DOI":"10.18502\/ijaai.v17i5.307","article-title":"Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma Pneumoniae-Related Extra-Pulmonary Diseases","volume":"17","author":"Poddighe","year":"2018","journal-title":"Iranian J.\u00a0Allergy Asthma Immunol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4081\/pr.2016.6395","article-title":"Is There Any Relationship Between Extra-Pulmonary Manifestations of Mycoplasma Pneumoniae Infection and Atopy\/Respiratory Allergy in Children","volume":"8","author":"Poddighe","year":"2016","journal-title":"Pediatr. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1097\/ICO.0000000000001985","article-title":"Ophthalmic Manifestations of Mycoplasma-Induced Rash and Mucositis","volume":"38","author":"Shah","year":"2019","journal-title":"Cornea"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7147","DOI":"10.1038\/s41598-019-43451-9","article-title":"Immunosuppression Reduces Lung Injury Caused by Mycoplasma Pneumoniae Infection","volume":"9","author":"Shi","year":"2019","journal-title":"Sci. Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2174\/1871526517666161121151544","article-title":"Detection of the M. Pneumonia in Synovial Fluid of Children With Negative Culture Arthritis: A Cross Sectional Study in Tehran, Iran","volume":"17","author":"Shokrollahi","year":"2017","journal-title":"Infect. Disord. Drug Targets"},{"key":"B18","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","article-title":"Mycoplasma Pneumoniae and its Role as a Human Pathogen","volume":"17","author":"Waites","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211016376","article-title":"Mutations in Domain V of Mycoplasma Pneumoniae 23S rRNA and Clinical Characteristics of Pediatric M. Pneumoniae Pneumonia in Nanjing, China","volume":"49","author":"Xu","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/ppul.24327","article-title":"Molecular and Clinical Characteristics of Severe Mycoplasma Pneumoniae Pneumonia in Children","volume":"54","author":"Yan","year":"2019","journal-title":"Pediatr. Pulmonol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.anai.2018.03.014","article-title":"Mycoplasma Pneumoniae Induces Allergy by Producing P1-Specific Immunoglobulin E","volume":"121","author":"Ye","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"986527","DOI":"10.1155\/2014\/986527","article-title":"Mycoplasma Pneumoniae Infection in Children is a Risk Factor for Developing Allergic Diseases","volume":"2014","author":"Ye","year":"2014","journal-title":"TheScientificWorldJournal"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.687391","article-title":"Mycoplasma Pneumoniaethe Level of D-Dimer Is Positively Correlated With the Severity of Pneumonia in Children","volume":"11","author":"Zheng","year":"2021","journal-title":"Front. Cell. Infection Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"19061","DOI":"10.1038\/s41598-020-76083-5","article-title":"Early Prediction of Necrotizing Pneumonia From Mycoplasma Pneumoniae Pneumonia With Large Pulmonary Lesions in Children","volume":"10","author":"Zhou","year":"2020","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1128\/AAC.01806-13","article-title":"More Complications Occur in Macrolide-Resistant Than in Macrolide-Sensitive Mycoplasma Pneumoniae Pneumonia","volume":"58","author":"Zhou","year":"2014","journal-title":"Antimicrobial Agents Chemother."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.783635\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T06:23:50Z","timestamp":1641882230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2021.783635\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":25,"alternative-id":["10.3389\/fcimb.2021.783635"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2021.783635","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"article-number":"783635"}}