{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:14:28Z","timestamp":1790223268058,"version":"4.1.0"},"reference-count":94,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Methamphetamine use disorder (MUD) is a major public health problem worldwide with limited effective treatment options. Previous studies have reported methamphetamine-associated alterations in gut microbiota. A potential role of gut microbiota in regulating methamphetamine-induced brain dysfunction through interactions with the host immune system has been proposed, but evidence for this hypothesis is limited. The present study aimed to investigate the alterations in the fecal microbiota and explore its relationship with systemic inflammation in MUD. Fecal samples were obtained from 26 male subjects with MUD and 17 sex- and age- matched healthy controls. Fecal microbial profiles were analyzed by 16S rRNA sequencing. Plasma inflammatory markers were measured using enzyme-linked immunosorbent assay. Associations between fecal microbiota, systemic inflammatory markers and clinical characteristics were examined by Spearman partial correlation analysis while controlling for possible confounders. Compared with healthy controls, individuals with MUD showed no difference in fecal microbial diversity, but exhibited differences in the relative abundance of several microbial taxa. At the genus level, a higher abundance of\n                    <jats:italic>Collinsella<\/jats:italic>\n                    ,\n                    <jats:italic>Odoribacter<\/jats:italic>\n                    and\n                    <jats:italic>Megasphaera<\/jats:italic>\n                    and lower levels of\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Blautia<\/jats:italic>\n                    ,\n                    <jats:italic>Dorea<\/jats:italic>\n                    and\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    were detected in subjects with MUD. More importantly, altered fecal microbiota was found to be correlated with plasma levels of CRP, IL-2, IL-6 and IL-10. The order\n                    <jats:italic>Lactobacillales<\/jats:italic>\n                    , exhibiting lower abundance in participants with MUD, was positively related to the duration of methamphetamine abstinence and the plasma level of anti-inflammatory cytokine IL-10. This study is the first to provide evidence for a link between altered fecal microbiota and systemic inflammation in MUD. Further elucidation of interactions between gut microbiota and the host immune system may be beneficial for the development of novel therapeutic approaches for MUD.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2021.783917","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T04:47:52Z","timestamp":1637210872000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Altered Fecal Microbiota Correlated With Systemic Inflammation in Male Subjects With Methamphetamine Use Disorder"],"prefix":"10.3389","volume":"11","author":[{"given":"Di","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1016\/j.cell.2021.03.022","article-title":"SnapShot: The Microbiota-Gut-Brain Axis","volume":"184","author":"Agirman","year":"2021","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.ebiom.2019.05.064","article-title":"Gut Microbiota in Parkinson\u2019s Disease: Temporal Stability and Relations to Disease Progression","volume":"44","author":"Aho","year":"2019","journal-title":"EBioMedicine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1080\/19490976.2020.1758010","article-title":"Longitudinal Gut Microbiome Changes in Alcohol Use Disorder are Influenced by Abstinence and Drinking Quantity","volume":"11","author":"Ames","year":"2020","journal-title":"Gut Microbes"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0227774","article-title":"Differential Effects of Synthetic Psychoactive Cathinones and Amphetamine Stimulants on the Gut Microbiome in Mice","volume":"15","author":"Angoa-P\u00e9rez","year":"2020","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1080\/19490976.2019.1681861","article-title":"Lower Gut Microbiome Diversity and Higher Abundance of Proinflammatory Genus Collinsella are Associated With Biopsy-Proven Nonalcoholic Steatohepatitis","volume":"11","author":"Astbury","year":"2020","journal-title":"Gut Microbes"},{"key":"B6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.pnpbp.2015.09.001","article-title":"Opposing Effects of Alcohol on the Immune System","volume":"65","author":"Barr","year":"2016","journal-title":"Prog. 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