{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:14:32Z","timestamp":1790738072310,"version":"4.1.0"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Blocking malaria transmission is critical to malaria control programs but remains a major challenge especially in endemic regions with high levels of asymptomatic infections. New strategies targeting the transmissible sexual stages of the parasite, called gametocytes, are needed. This review focuses on\u00a0<jats:italic>P. falciparum<\/jats:italic>\u00a0gametocytogenesis<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>. Highlighting advances made elucidating genes required for gametocyte production and identifying key questions that remain unanswered such as the factors and regulatory mechanisms that contribute to gametocyte induction, and the mechanism of sequestration. Tools available to begin to address these issues are also described to facilitate advances in our understanding of this important stage of the life cycle.<\/jats:p>","DOI":"10.3389\/fcimb.2021.790067","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T10:25:30Z","timestamp":1638440730000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Stressed Out About Plasmodium falciparum Gametocytogenesis"],"prefix":"10.3389","volume":"11","author":[{"given":"Miho","family":"Usui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim C.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1182\/blood-2013-08-520767","article-title":"Molecular Evidence for the Localization of Plasmodium Falciparum Immature Gametocytes in Bone Marrow","volume":"123","author":"Aguilar","year":"2014","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/j.1462-5822.2012.01786.x","article-title":"Host Cell Deformability Is Linked to Transmission in the Human Malaria Parasite Plasmodium Falciparum","volume":"14","author":"Aingaran","year":"2012","journal-title":"Cell. 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