{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:00:43Z","timestamp":1790413243584,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Disseminated coccidioidomycosis (DCM), often a severe and refractory disease leading to poor outcomes, is a risk for people with certain primary immunodeficiencies (PID). Several DCM-associated PID (STAT4, STAT3, IFN\u03b3, and Dectin-1) are modeled in mice. To determine if vaccination could provide these mice protection, mice with mutations in <jats:italic>Stat4<\/jats:italic>, <jats:italic>Stat3<\/jats:italic>, <jats:italic>Ifngr1<\/jats:italic>, <jats:italic>Clec7a<\/jats:italic> (Dectin-1), and Rag-1 (T- and B-cell deficient) knockout (KO) mice were vaccinated with the live, avirulent, \u0394<jats:italic>cps1<\/jats:italic> vaccine strain and subsequently challenged intranasally with pathogenic <jats:italic>Coccidioides posadasii<\/jats:italic> Silveira strain. Two weeks post-infection, vaccinated mice of all strains except Rag-1 KO had significantly reduced lung and spleen fungal burdens (p&amp;lt;0.05) compared to unvaccinated control mice. Splenic dissemination was prevented in most vaccinated immunodeficient mice while all unvaccinated B6 mice and the Rag-1 KO mice displayed disseminated disease. The mitigation of DCM by \u0394<jats:italic>cps1<\/jats:italic> vaccination in these mice suggests that it could also benefit humans with immunogenetic risks of severe disease.<\/jats:p>","DOI":"10.3389\/fcimb.2021.790488","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T06:46:24Z","timestamp":1641537984000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Daniel A.","family":"Powell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D.","family":"Butkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien T.","family":"Trinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Frelinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Galgiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa F.","family":"Shubitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1189\/jlb.5RI0315-096R","article-title":"Trained Innate Immunity as Underlying Mechanism for the Long-Term, Nonspecific Effects of Vaccines","volume":"98","author":"Blok","year":"2015","journal-title":"J. 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