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Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Triatomines have evolved salivary glands that produce versatile molecules with various biological functions, including those leading their interactions with vertebrate hosts\u2019 hemostatic and immunological systems. Here, using high-throughput transcriptomics and\u00a0proteomics, we report the first sialome study on the synanthropic triatomine\n                    <jats:italic>Triatoma sordida<\/jats:italic>\n                    . As a result, 57,645,372 reads were assembled into 26,670 coding sequences (CDS). From these, a total of 16,683 were successfully annotated. The sialotranscriptomic profile shows Lipocalin as the most abundant protein family within putative secreted transcripts. Trialysins and Kazal-type protease inhibitors have high transcript levels followed by ubiquitous protein families and enzyme classes. Interestingly, abundant trialysin and Kazal-type members are highlighted in this triatomine sialotranscriptome. Furthermore, we identified 132 proteins in\n                    <jats:italic>T. sordida<\/jats:italic>\n                    salivary gland soluble extract through LC-MS\/MS spectrometry. Lipocalins, Hemiptera specific families, CRISP\/Antigen-5 and Kazal-type protein inhibitors proteins were identified. Our study provides a comprehensive description of the transcript and protein compositions of the salivary glands of\n                    <jats:italic>T. sordida<\/jats:italic>\n                    . It significantly enhances the information in the Triatominae sialome databanks reported so far, improving the understanding of the vector\u2019s biology, the hematophagous behaviour, and the Triatominae subfamily\u2019s evolution.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2021.798924","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T02:43:11Z","timestamp":1641177791000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["An Integrative Sialomic Analysis Reveals Molecules From Triatoma sordida (Hemiptera: Reduviidae)"],"prefix":"10.3389","volume":"11","author":[{"given":"Yanna Reis","family":"Pra\u00e7a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Beatriz","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Charneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Coelho","family":"Mandacaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela Marques Dourado","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaio Lu\u00eds da Silva","family":"Bentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Marcelino Martins","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldeyr Mendes Cordeiro","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionizete Garcia","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Valle","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Maria de Almeida","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Marcos Chaves","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Martins","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Nunes","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: A New Generation of Protein Database Search Programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000547","article-title":"The Function and Three-Dimensional Structure of a Thromboxane A2\/Cysteinyl Leukotriene-Binding Protein From the Saliva of a Mosquito Vector of the Malaria Parasite","volume":"8","author":"Alvarenga","year":"2010","journal-title":"PloS. 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