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Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    The association between periodontal disease and systemic disease has become a research hotspot.\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    (\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    ), a crucial periodontal pathogen, affects the development of systemic diseases. The pathogenicity of\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    is largely linked to interference with the host\u2019s immunity. This review aims to discover the role of\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    in the modulation of the host\u2019s adaptive immune system through a large number of virulence factors and the manipulation of cellular immunological responses (mainly mediated by T cells). These factors may affect the cause of large numbers of systemic diseases, such as atherosclerosis, hypertension, adverse pregnancy outcomes, inflammatory bowel disease, diabetes mellitus, non-alcoholic fatty liver disease, rheumatoid arthritis, and Alzheimer\u2019s disease. The point of view of adaptive immunity may provide a new idea for treating periodontitis and related systemic diseases.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.1026457","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:47:58Z","timestamp":1668646078000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["Association between Porphyromonas Gingivalis and systemic diseases: Focus on T cells-mediated adaptive immunity"],"prefix":"10.3389","volume":"12","author":[{"given":"Cheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.dsx.2016.12.007","article-title":"Cytokine ratios in chronic periodontitis and type 2 diabetes mellitus","volume":"11","author":"Acharya","year":"2017","journal-title":"Diabetes Metab. 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