{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:59:40Z","timestamp":1792612780009,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of chronic psychological stress on hepatitis and liver fibrosis is concerned. However, its mechanism remains unclear. We investigated the effect and mechanism of chronic psychological stress in promoting liver injury and fibrosis through gut.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty male SD rats were randomly assigned to 6 groups. Rat models of chronic psychological stress (4 weeks) and liver fibrosis (8 weeks) were established. The diversity of gut microbiota in intestinal feces, permeability of intestinal mucosa, pathologies of intestinal and liver tissues, collagen fibers, protein expressions of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa \u03b2 (NF-\u03ba\u03b2), tumor necrosis factor \u03b1 (TNF-\u03b1) and interleukin 1 (IL-1) in liver tissue, liver function and coagulation function in blood and lipopolysaccharide (LPS) in portal vein blood were detected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diversities and abundances of gut microbiota were significant differences in rats among each group. The pathological lesions of intestinal and liver tissues, decreased expression of occludin protein in intestinal mucosa, deposition of collagen fibers and increased protein expression of TLR4, MyD88, NF-\u03ba\u03b2, TNF-\u03b1 and IL-1 in liver tissue, increased LPS level in portal vein blood, and abnormalities of liver function and coagulation function, were observed in rats exposed to chronic psychological stress or liver fibrosis. There were significant differences with normal rats. When the dual intervention factors of chronic psychological stress and liver fibrosis were superimposed, the above indicators were further aggravated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic psychological stress promotes liver injury and fibrosis, depending on changes in the diversity of gut microbiota and increased intestinal permeability caused by psychological stress, LPS that enters liver and acts on TLR4, and active LPS-TLR4 pathway depend on MyD88. It demonstrates the possibility of existence of brain-gut-liver axis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcimb.2022.1040749","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T06:39:55Z","timestamp":1670827195000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Brain-gut-liver axis: Chronic psychological stress promotes liver injury and fibrosis via gut in rats"],"prefix":"10.3389","volume":"12","author":[{"given":"Meng-Yang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can-Can","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Han","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/s1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/brain\/awaa096","article-title":"Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates","volume":"143","author":"Arotcarena","year":"2020","journal-title":"Brain"},{"key":"B3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","article-title":"Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation","volume":"25","author":"Bailey","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2017.38","article-title":"Mindfulness-based stress reduction therapy improves patient and caregiver-reported outcomes in cirrhosis","volume":"8","author":"Bajaj","year":"2017","journal-title":"Clin. Transl. Gastroenterol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.jhep.2013.12.019","article-title":"Altered profile of human gut microbiome is associated with cirrhosis and its complications","volume":"60","author":"Bajaj","year":"2014","journal-title":"J. Hepatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41467-020-20422-7","article-title":"Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma","volume":"12","author":"Behary","year":"2021","journal-title":"Nat. Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1136\/gutjnl-2018-316723","article-title":"Human gut microbiome: hopes, threats and promises","volume":"67","author":"Cani","year":"2018","journal-title":"Gut"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1016\/j.celrep.2019.10.042","article-title":"Intestinal IL-17R signaling constrains IL-18-Driven liver inflammation by the regulation of microbiome-derived products","volume":"29","author":"Castillo-Dela Cruz","year":"2019","journal-title":"Cell Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/hep.26494","article-title":"Microbiota-liver axis in hepatic disease","volume":"59","author":"Chassaing","year":"2014","journal-title":"Hepatology"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.947382","article-title":"The gut microbiota: A novel player in autoimmune hepatitis","volume":"12","author":"Cheng","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1002\/hep.20158","article-title":"Electric foot shock stress-induced exacerbation of alpha-galactosylceramide-triggered apoptosis in mouse liver","volume":"39","author":"Chida","year":"2004","journal-title":"Hepatology"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095173","article-title":"Continuous ingestion of lacticaseibacillus rhamnosus JB-1 during chronic stress ensures neurometabolic and behavioural stability in rats","volume":"23","author":"Chudzik","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.aat0835","article-title":"Intestinal barriers protect against disease","volume":"359","author":"Citi","year":"2018","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12970-016-0155-6","article-title":"Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes","volume":"13","author":"Clark","year":"2016","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"B15","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s12916-021-02106-1","article-title":"Understanding the impact of exposure to adverse socioeconomic conditions on chronic stress from a complexity science perspective","volume":"19","author":"Crielaard","year":"2021","journal-title":"BMC Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1080\/19490976.2018.1562268","article-title":"Exercise influence on the microbiome-gut-brain axis","volume":"10","author":"Dalton","year":"2019","journal-title":"Gut Microbes"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1869501","article-title":"Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain","volume":"13","author":"Deng","year":"2021","journal-title":"Gut Microbes"},{"key":"B18","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.bbi.2016.08.021","article-title":"Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice","volume":"59","author":"de Sousa Rodrigues","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020662","article-title":"The intestinal barrier and its dysfunction in patients with metabolic diseases and non-alcoholic fatty liver disease","volume":"23","author":"Forlano","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12916-016-0604-8","article-title":"Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis","volume":"14","author":"Forsythe","year":"2016","journal-title":"BMC Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.jhep.2012.01.019","article-title":"Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease","volume":"56","author":"Fouts","year":"2012","journal-title":"J. Hepatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1089\/scd.2013.0345","article-title":"LPS-stimulated inflammatory environment inhibits BMP-2-induced osteoblastic differentiation through crosstalk between TLR4\/MyD88\/NF-kappaB and BMP\/Smad signaling","volume":"23","author":"Huang","year":"2014","journal-title":"Stem Cells Dev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/j.1440-1746.2007.04896.x","article-title":"Expression of toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury","volume":"22","author":"Hua","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s00535-019-01649-8","article-title":"Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives","volume":"55","author":"Hu","year":"2020","journal-title":"J. Gastroenterol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax6328","article-title":"Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication","volume":"6","author":"Hulme","year":"2020","journal-title":"Sci. Adv."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110030","article-title":"The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease","volume":"37","author":"Hu","year":"2021","journal-title":"Cell Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000488378","article-title":"Psychosocial-stress, liver regeneration and weight gain: a conspicuous pathophysiological triad","volume":"46","author":"Ishtiaq","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.14309\/ajg.0000000000000281","article-title":"Psychobiotics: Shaping the mind with gut bacteria","volume":"114","author":"Jacobs","year":"2019","journal-title":"Am. J. Gastroenterol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"13897","DOI":"10.1038\/s41598-018-31764-0","article-title":"Immobilization stress-induced escherichia coli causes anxiety by inducing NF-kappaB activation through gut microbiota disturbance","volume":"8","author":"Jang","year":"2018","journal-title":"Sci. Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bbi.2009.08.006","article-title":"Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors","volume":"24","author":"Kiank","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.dci.2005.02.002","article-title":"Expression and function of toll-like receptors in chicken heterophils","volume":"29","author":"Kogut","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/j.ajpath.2017.01.021","article-title":"Toll-like receptor 4-independent carbon tetrachloride-induced fibrosis and lipopolysaccharide-induced acute liver injury in mice: Role of hepatic stellate cells","volume":"187","author":"Kumar","year":"2017","journal-title":"Am. J. Pathol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.207","article-title":"Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression","volume":"49","author":"Lee","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4982","DOI":"10.1038\/s41467-020-18754-5","article-title":"Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.881071","article-title":"Crosstalk between the gut and brain: Importance of the fecal microbiota in patient with brain tumors","volume":"12","author":"Li","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/ajg.2015.313","article-title":"Clinical and pathophysiological consequences of alterations in the microbiome in cirrhosis","volume":"110","author":"Macnaughtan","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"100","DOI":"10.21037\/hbsn.2020.03.27","article-title":"The gut-liver axis as a target of liver disease management","volume":"10","author":"Mandato","year":"2021","journal-title":"Hepatob. Surg. Nutr."},{"key":"B39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jcmgh.2018.04.003","article-title":"The brain-Gut-Microbiome axis","volume":"6","author":"Martin","year":"2018","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101457","article-title":"Gut microbiota's relationship with liver disease and role in hepatoprotection by dietary natural products and probiotics","volume":"10","author":"Meng","year":"2018","journal-title":"Nutrients"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay0574","article-title":"Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production","volume":"13","author":"Metwally","year":"2020","journal-title":"Sci. Signal"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020395","article-title":"Gut-liver axis, gut microbiota, and its modulation in the management of liver diseases: A review of the literature","volume":"20","author":"Milosevic","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/hep.510270131","article-title":"Regulation of CD95 (APO-1\/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells","volume":"27","author":"Muschen","year":"1998","journal-title":"Hepatology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-8-15","article-title":"Evaluation of behavioural and antioxidant activity of cytisus scoparius link in rats exposed to chronic unpredictable mild stress","volume":"8","author":"Nirmal","year":"2008","journal-title":"BMC Complement. Altern. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin. J. Gastroenterol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1002\/hep.23917","article-title":"The role of intestinal endotoxin in liver injury: a long and evolving history","volume":"52","author":"Nolan","year":"2010","journal-title":"Hepatology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1365-2982.2009.01412.x","article-title":"Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the wistar Kyoto rat","volume":"22","author":"o'malley","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010426","article-title":"Role of microbiota-derived metabolites in alcoholic and non-alcoholic fatty liver diseases","volume":"23","author":"Park","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00660","article-title":"Hypothalamus-Pituitary-Adrenal dysfunction in cholestatic liver disease","volume":"9","author":"Petrescu","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8030335","article-title":"Digestive ability, physiological characteristics, and rumen bacterial community of Holstein finishing steers in response to three nutrient density diets as fattening phases advanced","volume":"8","author":"Qiu","year":"2020","journal-title":"Microorganisms"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1927633","article-title":"Gut akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of l-aspartate via gut-liver axis","volume":"13","author":"Rao","year":"2021","journal-title":"Gut Microbes"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00496","article-title":"Chronic psychosocial stress in mice is associated with increased acid sphingomyelinase activity in liver and serum and with hepatic C16:0-ceramide accumulation","volume":"9","author":"Reichel","year":"2018","journal-title":"Front. Psychiatry"},{"key":"B54","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nrgastro.2009.35","article-title":"Principles and clinical implications of the brain-gut-enteric microbiota axis","volume":"6","author":"Rhee","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/jgh.12019","article-title":"Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis","author":"Roh","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/s12276-020-0438-5","article-title":"Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease","volume":"52","author":"Shim","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1186\/s12916-020-01713-8","article-title":"Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches","volume":"18","author":"Soto-Angona","year":"2020","journal-title":"BMC Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1007\/s00535-012-0627-7","article-title":"Altered neuro-endocrine-immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model","volume":"47","author":"Stasi","year":"2012","journal-title":"J. Gastroenterol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bbi.2017.05.009","article-title":"The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease","volume":"66","author":"Sundman","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1053\/j.gastro.2014.10.042","article-title":"Gut-liver axis in alcoholic liver disease","volume":"148","author":"Szabo","year":"2015","journal-title":"Gastroenterology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/gutjnl-2019-320490","article-title":"Liver tissue microbiome in NAFLD: next step in understanding the gut-liver axis","volume":"69","author":"Tilg","year":"2020","journal-title":"Gut"},{"key":"B64","doi-asserted-by":"publisher","first-page":"345","DOI":"10.21037\/hbsn.2019.10.34","article-title":"Gut microbiota and hepatocellular carcinoma","volume":"9","author":"Wang","year":"2020","journal-title":"Hepatob. Surg. Nutr."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.936815","article-title":"Circadian rhythms coordinated with gut microbiota partially account for individual differences in hepatitis b-related cirrhosis","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01658","article-title":"Evolutionary implications of anoxygenic phototrophy in the bacterial phylum candidatus eremiobacterota (WPS-2)","volume":"10","author":"Ward","year":"2019","journal-title":"Front. Microbiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"ra59","DOI":"10.1126\/scisignal.aaa2155","article-title":"Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation","volume":"8","author":"Xue","year":"2015","journal-title":"Sci. Signal"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.7150\/ijbs.46405","article-title":"The gut-liver axis in immune remodeling: New insight into liver diseases","volume":"16","author":"Yang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba8555","article-title":"Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders","volume":"6","author":"Yang","year":"2020","journal-title":"Sci. Adv."},{"key":"B70","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.jcmgh.2020.10.011","article-title":"Hepatic autophagy deficiency remodels gut microbiota for adaptive protection via FGF15-FGFR4 signaling","volume":"11","author":"Yan","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/BF03326435","article-title":"Brain-gut axis of the liver: the role of central neuropeptides","author":"Yoneda","year":"2002","journal-title":"J. Gastroenterol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.1040749\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T06:39:58Z","timestamp":1670827198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.1040749\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":71,"alternative-id":["10.3389\/fcimb.2022.1040749"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.1040749","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"article-number":"1040749"}}