{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:43:50Z","timestamp":1791654230386,"version":"4.3.4"},"reference-count":153,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Understanding the targets and interactions of long non-coding RNAs (lncRNAs) related to the retinoic acid-inducible gene-I (RIG-I) signaling pathway is essential for developing interventions, which would enable directing the host inflammatory response regulation toward protective immunity. In the RIG-I signaling pathway, lncRNAs are involved in the important processes of ubiquitination, phosphorylation, and glycolysis, thus promoting the transport of the interferon regulatory factors 3 and 7 (IRF3 and IRF7) and the nuclear factor kappa B (NF-\u03baB) into the nucleus, and activating recruitment of type I interferons (IFN-I) and inflammatory factors to the antiviral action site. In addition, the RIG-I signaling pathway has recently been reported to contain the targets of coronavirus disease-19 (COVID-19)-related lncRNAs. The molecules in the RIG-I signaling pathway are directly regulated by the lncRNA\u2013microRNAs (miRNAs)\u2013messenger\u00a0RNA\u00a0(mRNA) axis. Therefore, targeting this axis has become a novel strategy for the diagnosis and treatment of cancer. In this paper, the studies on the regulation of the RIG-I signaling pathway by lncRNAs during viral infections and cancer are comprehensively analyzed. The aim is to provide a solid foundation of information for conducting further detailed studies on lncRNAs and RIG-I in the future and also contribute to clinical drug development.<\/jats:p>","DOI":"10.3389\/fcimb.2022.1041682","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T01:36:45Z","timestamp":1667957805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["The lncRNAs involved in regulating the RIG-I signaling pathway"],"prefix":"10.3389","volume":"12","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengwang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ccr.2013.11.011","article-title":"Hepatic RIG-I predicts survival and interferon-\u03b1 therapeutic response in hepatocellular carcinoma","volume":"25","author":"Hou","year":"2014","journal-title":"Cancer Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"9042","DOI":"10.1073\/pnas.1920393117","article-title":"MaIL1Noncoding RNA is an integral component of the TLR4-TRIF pathway","volume":"117","author":"Aznaourova","year":"2020","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.534705","article-title":"Haemonchus contortusRIG-I has a role in immunity against , a gastrointestinal parasite in: A novel report","volume":"11","author":"Banerjee","year":"2020","journal-title":"Front. Immunol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00655","article-title":"Long non-coding RNA BST2\/BISPR is induced by IFN and regulates the expression of the antiviral factor tetherin","volume":"5","author":"Barriocanal","year":"2014","journal-title":"Front. Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1158\/0008-5472.can-16-2634","article-title":"Long noncoding RNA and cancer: A new paradigm","volume":"77","author":"Bhan","year":"2017","journal-title":"Cancer Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/s41577-018-0018-2","article-title":"Reigning in RIG-I","volume":"18","author":"Bird","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe2550","article-title":"OAS1\/RNase l executes RIG-I ligand-dependent tumor cell apoptosis","volume":"6","author":"Boehmer","year":"2021","journal-title":"Sci. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"104192","DOI":"10.1016\/j.phrs.2019.03.001","article-title":"Harnessing the immune system to fight cancer with toll-like receptor and RIG-i-like receptor agonists","volume":"154","author":"Bourquin","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1158\/0008-5472.Can-20-4172","article-title":"Being small and intronic: miRNAs that count","volume":"81","author":"Calin","year":"2021","journal-title":"Cancer Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.15252\/embr.201541763","article-title":"Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication","volume":"17","author":"Carnero","year":"2016","journal-title":"EMBO Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e00539","DOI":"10.1128\/jvi.00539-18","article-title":"Lnc-ISG20 inhibits influenza a virus replication by enhancing ISG20 expression","volume":"92","author":"Chai","year":"2018","journal-title":"J. Virol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/ijms19051310","article-title":"Noncoding RNA: RNA regulatory networks in cancer","volume":"19","author":"Chan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.932","article-title":"LncRNAs harbouring regulatory motifs within repeat elements modulate immune response towards COVID-19 disease severity and clinical outcomes","volume":"12","author":"Chattopadhyay","year":"2022","journal-title":"Clin. Trans. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.chom.2019.02.013","article-title":"NLRP12 regulates anti-viral RIG-I activation via interaction with TRIM25","volume":"25","author":"Chen","year":"2019","journal-title":"Cell Host Microbe"},{"key":"B15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/s41556-019-0299-0","article-title":"Extracellular vesicle-packaged HIF-1\u03b1-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells","volume":"21","author":"Chen","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.cell.2013.01.011","article-title":"Induction of siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation","volume":"152","author":"Chen","year":"2013","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.672165","article-title":"RDUR, a lncRNA, promotes innate antiviral responses and provides feedback control of NF-\u03baB activation","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/v13010047","article-title":"SARS-CoV-2 nucleocapsid protein interacts with RIG-I and represses RIG-mediated IFN-\u03b2 production","volume":"13","author":"Chen","year":"2020","journal-title":"Viruses"},{"key":"B19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12943-019-0947-9","article-title":"Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143\/HK2 axis in gallbladder cancer","volume":"18","author":"Chen","year":"2019","journal-title":"Mol. Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.virusres.2018.08.018","article-title":"LncRNA, miRNA and lncRNA-miRNA interaction in viral infection","volume":"257","author":"Chen","year":"2018","journal-title":"Virus Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.cytogfr.2014.06.005","article-title":"Regulation of RIG-i-like receptor signaling by host and viral proteins","volume":"25","author":"Chiang","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"B22","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1588","article-title":"TRIM25 and its emerging RNA-binding roles in antiviral defense","volume":"11","author":"Choudhury","year":"2020","journal-title":"WIREs RNA"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008670","article-title":"Long noncoding RNA MARL regulates antiviral responses through suppression miR-122-dependent MAVS downregulation in lower vertebrates","volume":"16","author":"Chu","year":"2020","journal-title":"PLoS Pathog."},{"key":"B24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cmet.2020.07.007","article-title":"Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1\u03b1\/Glycolysis-Dependent axis","volume":"32","author":"Codo","year":"2020","journal-title":"Cell Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/cdd.2017.17","article-title":"The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways","volume":"24","author":"Cohen","year":"2017","journal-title":"Cell Death differentiation"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.13.21257152","article-title":"Distinct mucoinflammatory phenotype and the immunomodulatory long noncoding transcripts associated with SARS-CoV-2 airway infection","author":"Devadoss","year":"2021","journal-title":"medRxiv: preprint server Health Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202152450","article-title":"Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection","volume":"22","author":"Ding","year":"2021","journal-title":"EMBO Rep."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00990","article-title":"RIG-1-Like receptor activation synergizes with intratumoral alpha radiation to induce pancreatic tumor rejection, triple-negative breast metastases clearance, and antitumor immune memory in mice","volume":"10","author":"Domankevich","year":"2020","journal-title":"Front. Oncol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13046-021-02018-1","article-title":"Long non-coding RNA DLEU2 drives EMT and glycolysis in endometrial cancer through HK2 by competitively binding with miR-455 and by modulating the EZH2\/miR-181a pathway","volume":"40","author":"Dong","year":"2021","journal-title":"J. Exp. Clin. Cancer research: CR"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2012.12.009","article-title":"Regulation of the MIR155 host gene in physiological and pathological processes","volume":"532","author":"Elton","year":"2013","journal-title":"Gene"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01711","article-title":"A human long non-coding RNA LncATV promotes virus replication through restricting RIG-I-Mediated innate immunity","volume":"10","author":"Fan","year":"2019","journal-title":"Front. Immunol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006720","article-title":"MAVS activates TBK1 and IKK\u03f5 through TRAFs in NEMO dependent and independent manner","volume":"13","author":"Fang","year":"2017","journal-title":"PLoS Pathog."},{"key":"B33","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1158\/2159-8290.cd-19-0608","article-title":"Type I interferon regulates a coordinated gene network to enhance cytotoxic T cell-mediated tumor killing","volume":"10","author":"Fan","year":"2020","journal-title":"Cancer Discovery"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02314","article-title":"Regulatory NLRs control the RLR-mediated type I interferon and inflammatory responses in human dendritic cells","volume":"9","author":"Fekete","year":"2018","journal-title":"Front. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s13238-012-2088-4","article-title":"Structural and biochemical studies of RIG-I antiviral signaling","volume":"4","author":"Feng","year":"2013","journal-title":"Protein Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"16743","DOI":"10.1073\/pnas.0804947105","article-title":"Roles of RIG-I n-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction","volume":"105","author":"Gack","year":"2008","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3220","DOI":"10.1128\/jvi.02241-09","article-title":"Phosphorylation-mediated negative regulation of RIG-I antiviral activity","volume":"84","author":"Gack","year":"2010","journal-title":"J. Virol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1038\/s41467-021-21456-1","article-title":"E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3","volume":"12","author":"Gao","year":"2021","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.molcel.2018.06.026","article-title":"UntRIG(er)ing lncRNAs","volume":"71","author":"Garcin","year":"2018","journal-title":"Mol. Cell"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.696820","article-title":"The impact of lncRNAs and miRNAs in regulation of function of cancer stem cells and progression of cancer","volume":"9","author":"Ghafouri-Fard","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1002\/eji.201545794","article-title":"Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses","volume":"45","author":"Goubau","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1038\/s41467-021-23219-4","article-title":"USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS","volume":"12","author":"Hou","year":"2021","journal-title":"Nat. Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41422-020-0362-1","article-title":"A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I\/MDA5 for degradation during viral infection","volume":"31","author":"Hou","year":"2021","journal-title":"Cell Res."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003721","article-title":"Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression","volume":"10","author":"Hwang","year":"2022","journal-title":"J. immunotherapy Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2014.01.009","article-title":"Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli","volume":"53","author":"Imamura","year":"2014","journal-title":"Mol. Cell"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113158","article-title":"The innate immune signalling pathways: Turning RIG-I sensor activation against cancer","volume":"12","author":"Iurescia","year":"2020","journal-title":"Cancers"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202050051","article-title":"Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response","volume":"21","author":"Jena","year":"2020","journal-title":"EMBO Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.immuni.2012.03.022","article-title":"Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response","volume":"36","author":"Jiang","year":"2012","journal-title":"Immunity"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104607","article-title":"LncNSPL facilitates influenza a viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination","volume":"25","author":"Jiang","year":"2022","journal-title":"iScience"},{"key":"B51","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.cell.2018.03.064","article-title":"Self-recognition of an inducible host lncRNA by RIG-I feedback restricts innate immune response","volume":"173","author":"Jiang","year":"2018","journal-title":"Cell"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02805","article-title":"Zebrafish TRIM25 promotes innate immune response to RGNNV infection by targeting 2CARD and RD regions of RIG-I for K63-linked ubiquitination","volume":"10","author":"Jin","year":"2019","journal-title":"Front. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.cell.2021.08.004","article-title":"The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function","author":"Johnson","year":"2021","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bbrc.2011.10.015","article-title":"55 amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation","volume":"415","author":"Kageyama","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"10668","DOI":"10.1093\/nar\/gku713","article-title":"Negative regulation of the interferon response by an interferon-induced long non-coding RNA","volume":"42","author":"Kambara","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Functional classification and experimental dissection of long noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.cell.2011.09.039","article-title":"Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA","volume":"147","author":"Kowalinski","year":"2011","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1158\/0008-5472.can-20-1406","article-title":"FTXSystematic analysis of intronic miRNAs reveals cooperativity within the multicomponent locus to promote colon cancer development","volume":"81","author":"Kwok","year":"2021","journal-title":"Cancer Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.fsi.2018.11.070","article-title":"RNF135 is a positive regulator of IFN expression and involved in RIG-I signaling pathway by targeting RIG-I","volume":"86","author":"Lai","year":"2019","journal-title":"Fish shellfish Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1038\/s41418-021-00791-2","article-title":"Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a","volume":"28","author":"Lai","year":"2021","journal-title":"Cell Death Differ"},{"key":"B63","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12967-021-03023-w","article-title":"Knockdown of long noncoding RNA GAS5 reduces vascular smooth muscle cell apoptosis by inactivating EZH2-mediated RIG-I signaling pathway in abdominal aortic aneurysm","volume":"19","author":"Le","year":"2021","journal-title":"J. Trans. Med."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147688","article-title":"Roles of PRR-mediated signaling pathways in the regulation of oxidative stress and inflammatory diseases","volume":"22","author":"Li","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"6693","DOI":"10.1007\/s11033-022-07268-6","article-title":"Viral long non-coding RNA regulates virus life-cycle and pathogenicity","volume":"49","author":"Li","year":"2022","journal-title":"Mol. Biol. Rep"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00786-19","article-title":"Long noncoding RNA lnc-MxA inhibits beta interferon transcription by forming RNA-DNA triplexes at its promoter","volume":"93","author":"Li","year":"2019","journal-title":"J. Virol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41590-019-0379-0","article-title":"The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response","volume":"20","author":"Lin","year":"2019","journal-title":"Nat. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/hep.29462","article-title":"Taurine up-regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma","volume":"67","author":"Lin","year":"2018","journal-title":"Hepatol. (Baltimore Md)"},{"key":"B69","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1266\/ggs.18-00036","article-title":"Transcriptome sequencing in a 6-hydroxydopamine rat model of parkinson's disease","volume":"94","author":"Li","year":"2019","journal-title":"Genes Genet. Syst."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"25350","DOI":"10.18632\/oncotarget.8129","article-title":"Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1002\/hep.30266","article-title":"A novel lncRNA regulates HCV infection through IFI6","volume":"69","author":"Liu","year":"2018","journal-title":"Hepatology"},{"key":"B73","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41591-018-0302-5","article-title":"Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss","volume":"25","author":"Liu","year":"2019","journal-title":"Nat. Med."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24425","article-title":"Cyclophilin a-regulated ubiquitination is critical for RIG-i-mediated antiviral immune responses","volume":"6","author":"Liu","year":"2017","journal-title":"eLife"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27562","article-title":"Dysregulation of FTX\/miR-545 signaling pathway downregulates Tim-3 and is responsible for the abnormal activation of macrophage in cirrhosis","author":"Liu","year":"2018","journal-title":"J. Cell. Biochem"},{"key":"B76","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2016.06.020","article-title":"Post-translational modification control of innate immunity","volume":"45","author":"Liu","year":"2016","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02335-21","article-title":"SARS-CoV-2 Nsp5 demonstrates two distinct mechanisms targeting RIG-I and MAVS to evade the innate immune response","volume":"12","author":"Liu","year":"2021","journal-title":"mBio"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abg8744","article-title":"SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response","volume":"15","author":"Liu","year":"2022","journal-title":"Sci. Signaling"},{"key":"B79","doi-asserted-by":"publisher","first-page":"113149","DOI":"10.1016\/j.yexcr.2022.113149","article-title":"METTL3-stabilized lncRNA SNHG7 accelerates glycolysis in prostate cancer via SRSF1\/c-myc axis","volume":"416","author":"Liu","year":"2022","journal-title":"Exp. Cell Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal transduction targeted Ther."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040711","article-title":"The role of mitophagy in viral infection","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"key":"B82","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12943-021-01318-6","article-title":"Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer","volume":"20","author":"Long","year":"2021","journal-title":"Mol. Cancer"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13036","article-title":"Identification of lncRNA-155 encoded by MIR155HG as a novel regulator of innate immunity against influenza a virus infection","volume":"21","author":"Maarouf","year":"2019","journal-title":"Cell Microbiol."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02250-16","article-title":"The long noncoding RNA NEAT1 exerts antihantaviral effects by acting as positive feedback for RIG-I signaling","volume":"91","author":"Ma","year":"2017","journal-title":"J. Virol."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00100","article-title":"The long non-coding RNA NRIR drives IFN-response in monocytes: Implication for systemic sclerosis","volume":"10","author":"Mariotti","year":"2019","journal-title":"Front. Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/j.omtn.2022.02.008","article-title":"RIG-i-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection","volume":"27","author":"Marx","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1128\/jvi.02647-13","article-title":"Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I\/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation","volume":"88","author":"Matthys","year":"2014","journal-title":"J. Virol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.canlet.2018.01.008","article-title":"Membrane-lipid associated lncRNA: A new regulator in cancer signaling","volume":"419","author":"Ma","year":"2018","journal-title":"Cancer Lett."},{"key":"B89","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1186\/s12864-019-6156-5","article-title":"Identification and analysis of long non-coding RNAs that are involved in inflammatory process in response to transmissible gastroenteritis virus infection","volume":"20","author":"Ma","year":"2019","journal-title":"BMC Genomics"},{"key":"B90","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-3-030-35582-1_5","article-title":"Toll-like receptors signaling in the tumor microenvironment","volume":"1223","author":"McCall","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1056\/NEJMcibr1603785","article-title":"Targeting a long noncoding RNA in breast cancer","volume":"374","author":"Mendell","year":"2016","journal-title":"New Engl. J. Med."},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat6912","article-title":"DGCR5The long noncoding RNA may regulate expression of several schizophrenia-related genes","volume":"10","author":"Meng","year":"2018","journal-title":"Sci. Trans. Med."},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.590870","article-title":"The neat dance of COVID-19: NEAT1, DANCR, and Co-modulated cholinergic RNAs link to inflammation","volume":"11","author":"Meydan","year":"2020","journal-title":"Front. Immunol."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188519","article-title":"Long non-coding RNAs and cancer metastasis: Molecular basis and therapeutic implications","volume":"1875","author":"Ming","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"B95","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.1111\/jcmm.16596","article-title":"Interplay between SARS-CoV-2 and human long non-coding RNAs","volume":"25","author":"Moazzam-Jazi","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"4012","DOI":"10.1021\/acs.accounts.1c00521","article-title":"In VitroImmunogenicity of -transcribed RNA","volume":"54","author":"Mu","year":"2021","journal-title":"Accounts Chem. Res."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3390\/v13030402","article-title":"mRNA-lncRNA Co-expression network analysis reveals the role of lncRNAs in immune dysfunction during severe SARS-CoV-2 infection","volume":"13","author":"Mukherjee","year":"2021","journal-title":"Viruses"},{"key":"B98","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.freeradbiomed.2014.04.028","article-title":"The glutaredoxin\/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with s-glutathionylation of nuclear factor \u03baB family proteins","volume":"73","author":"Nolin","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01942","article-title":"Regulation of RIG-I activation by K63-linked polyubiquitination","volume":"8","author":"Okamoto","year":"2017","journal-title":"Front. Immunol."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00200","article-title":"Accessory factors of cytoplasmic viral RNA sensors required for antiviral innate immune response","volume":"7","author":"Oshiumi","year":"2016","journal-title":"Front. Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.celrep.2015.04.047","article-title":"DDX60 is involved in RIG-I-Dependent and independent antiviral responses, and its function is attenuated by virus-induced EGFR activation","volume":"11","author":"Oshiumi","year":"2015","journal-title":"Cell Rep."},{"key":"B102","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/wrna.1321","article-title":"lncRNAs regulate the innate immune response to viral infection","volume":"7","author":"Ouyang","year":"2016","journal-title":"Wiley Interdiscip Rev. RNA"},{"key":"B103","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.chom.2014.10.001","article-title":"NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription","volume":"16","author":"Ouyang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205118","article-title":"Identification of an interferon-stimulated long noncoding RNA (LncRNA ISR) involved in regulation of influenza a virus replication","volume":"20","author":"Pan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature13140","article-title":"Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I","volume":"509","author":"Peisley","year":"2014","journal-title":"Nature"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12187","article-title":"Robust delivery of RIG-I agonists using extracellular vesicles for anti-cancer immunotherapy","volume":"11","author":"Peng","year":"2022","journal-title":"J. extracellular vesicles"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1128\/mcb.01098-15","article-title":"lncRHOXF1, a long noncoding RNA from the X chromosome that suppresses viral response genes during development of the early human placenta","volume":"36","author":"Penkala","year":"2016","journal-title":"Mol. Cell Biol."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.606001","article-title":"Human cancer cells sense cytosolic nucleic acids through the RIG-I-MAVS pathway and cGAS-STING pathway","volume":"8","author":"Qiao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/eji.201646484","article-title":"Negative regulators of the RIG-i-like receptor signaling pathway","volume":"47","author":"Quicke","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1111\/mmi.14841","article-title":"Cytosolic detection of phagosomal bacteria-mechanisms underlying PAMP exodus from the phagosome into the cytosol","volume":"116","author":"Ragland","year":"2021","journal-title":"Mol. Microbiol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41577-020-0288-3","article-title":"RIG-i-like receptors: their regulation and roles in RNA sensing","volume":"20","author":"Rehwinkel","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.807737","article-title":"The triangle relationship between long noncoding RNA, RIG-i-like receptor signaling pathway, and glycolysis","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Microbiol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1146\/annurev-biochem-062917-012708","article-title":"Long noncoding RNAs: Molecular modalities to organismal functions","volume":"89","author":"Rinn","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"B114","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nm.4479","article-title":"Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA","volume":"24","author":"Sallam","year":"2018","journal-title":"Nat. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta stone of a hidden RNA language","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1089\/ars.2021.0167","article-title":"The MAVS immune recognition pathway in viral infection and sepsis","volume":"35","author":"Sharma","year":"2021","journal-title":"Antioxidants Redox Signaling"},{"key":"B117","doi-asserted-by":"publisher","first-page":"17022","DOI":"10.1038\/nmicrobiol.2017.22","article-title":"Systems-based analysis of RIG-i-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation","volume":"2","author":"Soonthornvacharin","year":"2017","journal-title":"Nat. Microbiol."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176447","article-title":"LncRNAs in the type I interferon antiviral response","volume":"21","author":"Suarez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.cell.2018.01.009","article-title":"CD10GPR77 cancer-associated fibroblasts promote cancer formation and chemoresistance by sustaining cancer stemness","volume":"172","author":"Su","year":"2018","journal-title":"Cell"},{"key":"B120","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.tig.2017.11.005","article-title":"Nuclear long noncoding RNAs: Key regulators of gene expression","volume":"34","author":"Sun","year":"2018","journal-title":"Trends Genet. TIG"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1128\/jvi.01734-10","article-title":"Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response","volume":"85","author":"Sun","year":"2011","journal-title":"J. Virol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1016\/j.cell.2021.07.026","article-title":"Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death","volume":"189","author":"Taft","year":"2021","journal-title":"Cell"},{"key":"B123","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1093\/intimm\/dxz034","article-title":"Regulation of signaling mediated by nucleic acid sensors for innate interferon-mediated responses during viral infection","volume":"31","author":"Takaoka","year":"2019","journal-title":"Int. Immunol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000493967","article-title":"lncRNA AFAP1-AS1 promotes migration and invasion of non-small cell lung cancer via up-regulating IRF7 and the RIG-I-Like receptor signaling pathway","volume":"50","author":"Tang","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.cmet.2014.03.009","article-title":"Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication","volume":"19","author":"Thai","year":"2014","journal-title":"Cell Metab."},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114760","article-title":"Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential","volume":"193","author":"Tzeng","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.molcel.2016.04.021","article-title":"Structural analysis of dsRNA binding to anti-viral pattern recognition receptors LGP2 and MDA5","volume":"62","author":"Uchikawa","year":"2016","journal-title":"Mol. Cell"},{"key":"B128","doi-asserted-by":"publisher","first-page":"eabh2624","DOI":"10.1126\/scitranslmed.abh2624","article-title":"Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19","volume":"13","author":"van der Wijst","year":"2021","journal-title":"Sci. Trans. Med"},{"key":"B129","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"key":"B130","doi-asserted-by":"publisher","first-page":"9407","DOI":"10.7150\/thno.48520","article-title":"Roles of long non-coding RNAs and emerging RNA-binding proteins in innate antiviral responses","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.immuni.2020.11.010","article-title":"Decreased expression of the host long-noncoding RNA-GM facilitates viral escape by inhibiting the kinase activity TBK1 via s-glutathionylation","volume":"53","author":"Wang","year":"2020","journal-title":"Immunity"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119484","article-title":"Critical role of microRNAs in host and influenza a (H1N1) virus interactions","volume":"277","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.immuni.2019.01.004","article-title":"Survival of single positive thymocytes depends upon developmental control of RIPK1 kinase signaling by the IKK complex independent of NF-\u03baB","volume":"50","author":"Webb","year":"2019","journal-title":"Immunity"},{"key":"B134","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.immuni.2012.11.018","article-title":"Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling","volume":"38","author":"Wies","year":"2013","journal-title":"Immunity"},{"key":"B135","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/mmi.14837","article-title":"Fc-conjugated c-type lectin receptors: Tools for understanding host-pathogen interactions","volume":"117","author":"Willment","year":"2022","journal-title":"Mol. Microbiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.trsl.2017.08.004","article-title":"The anticancer functions of RIG-i-like receptors, RIG-I and MDA5, and their applications in cancer therapy","volume":"190","author":"Wu","year":"2017","journal-title":"Trans. Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"7991","DOI":"10.1038\/s41598-021-86134-0","article-title":"A study of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood","volume":"11","author":"Wu","year":"2021","journal-title":"Sci. Rep."},{"key":"B138","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/s41590-021-00942-0","article-title":"RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells","volume":"22","author":"Yamada","year":"2021","journal-title":"Nat. Immunol."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.700184","article-title":"Long noncoding RNAs as emerging regulators of COVID-19","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Immunol."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73737","article-title":"Correction: RTN3 inhibits RIG-i-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination","volume":"10","author":"Yang","year":"2021","journal-title":"eLife"},{"key":"B141","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s12943-017-0722-8","article-title":"Overexpression of lncRNA IGFBP4-1 reprograms energy metabolism to promote lung cancer progression","volume":"16","author":"Yang","year":"2017","journal-title":"Mol. Cancer"},{"key":"B142","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1002\/1873-3468.13564","article-title":"Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I","volume":"593","author":"Yong","year":"2019","journal-title":"FEBS Lett."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1111\/liv.15281","article-title":"Hepatic exosomes with declined MiR-27b-3p trigger RIG-I\/TBK1 signal pathway in macrophages","volume":"42","author":"You","year":"2022","journal-title":"Liver Int"},{"key":"B144","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/s41419-022-04797-7","article-title":"Cooperative effects of RIG-i-like receptor signaling and IRF1 on DNA damage-induced cell death","volume":"13","author":"Zander","year":"2022","journal-title":"Cell Death Dis."},{"key":"B145","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s13277-015-3860-x","article-title":"AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis","volume":"37","author":"Zeng","year":"2016","journal-title":"Tumour Biol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 years of NF-\u03baB: A blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"key":"B147","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.cell.2019.05.003","article-title":"Lactate is a natural suppressor of RLR signaling by targeting MAVS","volume":"178","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"B148","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41392-021-00742-w","article-title":"A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal transduction targeted Ther."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00878-3","article-title":"SARS-CoV-2 NSP5 and n protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules","volume":"7","author":"Zheng","year":"2022","journal-title":"Signal transduction targeted Ther."},{"key":"B150","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41392-020-00438-7","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I\/MDA-5 signaling","volume":"5","author":"Zheng","year":"2020","journal-title":"Signal transduction targeted Ther."},{"key":"B151","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/s41467-020-20316-8","article-title":"Hepatitis b virus rigs the cellular metabolome to avoid innate immune recognition","volume":"12","author":"Zhou","year":"2021","journal-title":"Nat. Commun."},{"key":"B152","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41422-019-0193-0","article-title":"Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation","volume":"29","author":"Zhou","year":"2019","journal-title":"Cell Res."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.immuni.2021.04.001","article-title":"Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection","volume":"54","author":"Zhu","year":"2021","journal-title":"Immunity"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.1041682\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T01:36:48Z","timestamp":1667957808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.1041682\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":153,"alternative-id":["10.3389\/fcimb.2022.1041682"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.1041682","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]},"article-number":"1041682"}}