{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:41:02Z","timestamp":1792683662726,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902263, 31870917"],"award-info":[{"award-number":["31902263, 31870917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004943","name":"Nanyang Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Streptococcus agalactiae<\/jats:italic> infections may lead to clinical or subclinical mastitis in dairy animals when it invades the mammary gland. In this study, 51 <jats:italic>S. agalactiae<\/jats:italic> strains were isolated from 305 milk samples that were collected from goats with mastitis in 13 provinces of China. The antimicrobial resistance of <jats:italic>S<\/jats:italic>. <jats:italic>agalactiae<\/jats:italic> was determined by disk diffusion methods against 18 antibiotics from six classes. In addition, multilocus sequence typing (MLST), and the presence of resistance and virulence genes was determined by PCR analysis. Seven sequence types in five clonal complexes were identified according to MLST; CC103 and CC67 strains were predominant, with rates of 45.1% and 39.2%, respectively. All isolates (100%) were multiresistant to three or more antimicrobial agents. <jats:italic>S<\/jats:italic>. <jats:italic>agalactiae<\/jats:italic> isolates had a 100% resistance rate to penicillin, oxacillin, and amoxicillin, followed by doxycycline (82.4%), tetracycline (76.5%), and amikacin (74.5%). The lowest resistance was observed for ciprofloxacin (29.4%), which varied in five different regions. The detection rates of six classes of antimicrobial-related genes were calculated as follows: 33 (64.7%) for \u03b2-lactam-related resistance gene, 12 (23.5%) for tetracyclines, 11 (21.6%) for quinolone-related resistance genes, 10 (19.6%) for aminoglycosides, 7 (13.7%) for macrolides (<jats:italic>ermA<\/jats:italic>, <jats:italic>ermB<\/jats:italic>, and <jats:italic>mefA<\/jats:italic>), and 3 (5.9%) for lincosamide (<jats:italic>lnu(B)<\/jats:italic>). Regarding virulence genes, profile 1 (<jats:italic>bca cfb<\/jats:italic>-<jats:italic>cspA<\/jats:italic>-<jats:italic>cylE-hylB-bibA-pavA-fbsA-fbsB<\/jats:italic>) was the most prevalent, with a detection rate of 54.9%. This work provides a primary source related to the molecular epidemiology of <jats:italic>S. agalactiae<\/jats:italic> in dairy goat herds in China and will aid in the clinical treatment, prevention, and control of mastitis.<\/jats:p>","DOI":"10.3389\/fcimb.2022.1049167","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T08:25:22Z","timestamp":1673252722000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular epidemiology, drug resistance, and virulence gene analysis of Streptococcus agalactiae isolates from dairy goats in backyard farms in China"],"prefix":"10.3389","volume":"12","author":[{"given":"Hongfei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunguang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.5455\/javar.2022.i573","article-title":"Prevalence, antimicrobial susceptibility, and genotyping of streptococcus agalactiae in tilapia fish (Oreochromis niloticus) in Egypt","volume":"9","author":"Alazab","year":"2022","journal-title":"J. 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