{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T11:42:48Z","timestamp":1774006968885,"version":"3.50.1"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>DEAD\/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp\/His). Current evidence indicates that DEAD\/H-box helicases regulate RNA metabolism and innate immune responses. In recent years, DEAD\/H-box helicases have been reported to participate in the development of a variety of diseases, including hepatitis B virus (HBV) infection, which is a significant risk factor for hepatic fibrosis, cirrhosis, and liver cancer. Furthermore, emerging evidence suggests that different DEAD\/H-box helicases play vital roles in the regulation of viral replication, based on the interaction of DEAD\/H-box helicases with HBV and the modulation of innate signaling pathways mediated by DEAD\/H-box helicases. Besides these, HBV can alter the expression and activity of DEAD\/H-box helicases to facilitate its biosynthesis. More importantly, current investigation suggests that targeting DEAD\/H-box helicases with appropriate compounds is an attractive treatment strategy for the virus infection. In this review, we delineate recent advances in molecular mechanisms relevant to the interplay of DEAD\/H-box helicase and HBV and the potential of targeting DEAD\/H-box helicase to eliminate HBV infection.<\/jats:p>","DOI":"10.3389\/fcimb.2022.1062553","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T05:44:03Z","timestamp":1669355043000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The emerging role of DEAD\/H-box helicases in hepatitis B virus infection"],"prefix":"10.3389","volume":"12","author":[{"given":"Hongjuan","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiucheng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuiyang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanyun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renxian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15958","DOI":"10.1074\/jbc.M116.724641","article-title":"RNA Exosome complex regulates stability of the hepatitis b virus X-mRNA transcript in a non-stop-mediated (NSD) RNA quality control mechanism","volume":"291","author":"Aly","year":"2016","journal-title":"J. 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