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In this study, we identified a schistosome miRNA (named Sja-miR-71a) through screening of 57 <jats:italic>Schistosoma japonicum<\/jats:italic> miRNAs that exerts antitumor activity <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> models. We demonstrated presence of this parasite miRNA in liver cells during infection. We showed that Sja-miR-71a arrested cell cycle at G0\/G1 phase of hepatoma cell lines and inhibited cell proliferation <jats:italic>in vitro<\/jats:italic>. The HepG2 transfected with Sja-miR-71a mimics displayed significant reduction of migration and colony formation. Further, growth of the tumor cells transfected with the Sja-miR-71a mimics was obviously suppressed in a xenograft mouse model. Mechanically, we found the antitumor activity of Sja-miR-71a was through targeting a host gene encoding Frizzled Class Receptor 4 (FZD4), as <jats:italic>FZD4<\/jats:italic> small interfering RNAs (siRNAs) generated a similar inhibitory effect on the tumor. These data indicated that Sja-miR-71a is a tumor suppressor miRNA and suggested this parasite-derived miRNA as a potential therapeutic target for cancer.<\/jats:p>","DOI":"10.3389\/fcimb.2022.786543","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T16:33:52Z","timestamp":1643646832000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification of a Schistosoma japonicum MicroRNA That Suppresses Hepatoma Cell Growth and Migration by Targeting Host FZD4 Gene"],"prefix":"10.3389","volume":"12","author":[{"given":"Pengyue","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1111\/j.1440-1746.2011.06903.x","article-title":"MicroRNA, Hypoxic Stress and Hepatocellular Carcinoma: Future Directions","volume":"26","author":"Ang","year":"2011","journal-title":"J. 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