{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:58:06Z","timestamp":1793026686034,"version":"4.5.0"},"reference-count":166,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    is a common oral opportunistic bacterium that can cause different infections. In recent years, studies have shown that\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    is enriched in lesions in periodontal diseases, halitosis, dental pulp infection, oral cancer, and systemic diseases. Hence, it can promote the development and\/or progression of these conditions. The current study aimed to assess research progress in the epidemiological evidence, possible pathogenic mechanisms, and treatment methods of\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    in oral and systemic diseases. Novel viewpoints obtained in recent studies can provide knowledge about the role of\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    in hosts and a basis for identifying new methods for the diagnosis and treatment of\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    -related diseases.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.815318","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T03:35:47Z","timestamp":1643859347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":133,"title":["More Than Just a Periodontal Pathogen \u2013the Research Progress on Fusobacterium nucleatum"],"prefix":"10.3389","volume":"12","author":[{"given":"Yuanxin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Ziebolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schmalz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/jre.12546","article-title":"Potential Role of Periodontal Pathogens in Compromising Epithelial Barrier Function by Inducing Epithelial-Mesenchymal Transition","volume":"53","author":"Abdulkareem","year":"2018","journal-title":"J.\u00a0Periodontal. 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