{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:11:26Z","timestamp":1787026286604,"version":"build-2736575974"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015390","name":"Universit\u00e9 de Franche-Comt\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011773","name":"Conseil r\u00e9gional de Bourgogne-Franche-Comt\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>The protein kinase B or Akt is a central regulator of survival, metabolism, growth and proliferation of the cells and is known to be targeted by various viral pathogens, including HIV-1. The central role of Akt makes it a critical player in HIV-1 pathogenesis, notably by affecting viral entry, latency and reactivation, cell survival, viral spread and immune response to the infection. Several HIV proteins activate the PI3K\/Akt pathway, to fuel the progression of the infection. Targeting Akt could help control HIV-1 entry, viral latency\/replication, cell survival of infected cells, HIV spread from cell-to-cell, and the immune microenvironment which could ultimately allow to curtail the size of the HIV reservoir. Beside the \u201cshock and kill\u201d and \u201cblock and lock\u201d strategies, the use of Akt inhibitors in combination with latency inducing agents, could favor the clearance of infected cells and be part of new therapeutic strategies with the goal to \u201cblock and clear\u201d HIV.<\/jats:p>","DOI":"10.3389\/fcimb.2022.827717","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T01:35:50Z","timestamp":1643938550000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["CounterAKTing HIV: Toward a \u201cBlock and Clear\u201d Strategy?"],"prefix":"10.3389","volume":"12","author":[{"given":"S\u00e9bastien","family":"Pasquereau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Herbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.3390\/v7041578","article-title":"Eradication of HIV-1 From the Macrophage Reservoir: An Uncertain Goal","volume":"7","author":"Abbas","year":"2015","journal-title":"Viruses"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.03060","article-title":"Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs","volume":"10","author":"Ait-Ammar","year":"2020","journal-title":"Front. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00355","article-title":"IL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells","volume":"6","author":"Ali","year":"2015","journal-title":"Front. Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/sj.cdd.4401580","article-title":"In Vitro and In Vivo Effects of HIV Protease Inhibitors on Apoptosis","volume":"12","author":"Badley","year":"2005","journal-title":"Cell Death Differ"},{"key":"B5","doi-asserted-by":"publisher","first-page":"E665","DOI":"10.3390\/v12060665","article-title":"Extracellular Vesicle Activation of Latent HIV-1 Is Driven by EV-Associated C-Src and Cellular SRC-1 via the PI3K\/AKT\/mTOR Pathway","volume":"12","author":"Barclay","year":"2020","journal-title":"Viruses"},{"key":"B6","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s41580-019-0129-z","article-title":"PI3K Isoforms in Cell Signalling and Vesicle Trafficking","volume":"20","author":"Bilanges","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1002\/eji.1830271110","article-title":"Extracellular HIV-1 Tat Protein Activates Phosphatidylinositol 3- and Akt\/PKB Kinases in CD4+ T Lymphoblastoid Jurkat Cells","volume":"27","author":"Borgatti","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"16934","DOI":"10.1073\/pnas.1002894107","article-title":"Establishment of HIV-1 Latency in Resting CD4+ T Cells Depends on Chemokine-Induced Changes in the Actin Cytoskeleton","volume":"107","author":"Cameron","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005018","article-title":"Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy Through Transcription Factor EB Sequestration","volume":"11","author":"Campbell","year":"2015","journal-title":"PloS Pathog."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-020-02761-x","article-title":"SMAC Mimetics Induce Autophagy-Dependent Apoptosis of HIV-1-Infected Macrophages","volume":"11","author":"Campbell","year":"2020","journal-title":"Cell Death Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/annonc\/mdv615","article-title":"Regulation of PD-L1: A Novel Role of Pro-Survival Signalling in Cancer","volume":"27","author":"Chen","year":"2016","journal-title":"Ann. Oncol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"12655","DOI":"10.1073\/pnas.1220136110","article-title":"CTIP2 is a Negative Regulator of P-TEFb","volume":"110","author":"Cherrier","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1371\/journal.ppat.0030146","article-title":"HMBA Releases P-TEFb From HEXIM1 and 7SK snRNA via PI3K\/Akt and Activates HIV Transcription","volume":"3","author":"Contreras","year":"2007","journal-title":"PloS Pathog."},{"key":"B14","doi-asserted-by":"publisher","first-page":"898","DOI":"10.4049\/jimmunol.180.2.898","article-title":"Transcription Factor FOXO3A Mediates Apoptosis in HIV-1-Infected Macrophages","volume":"180","author":"Cui","year":"2008","journal-title":"J. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-1-4419-1599-3_11","article-title":"New Insights for FOXO and Cell-Fate Decision in HIV Infection and HIV Associated Neurocognitive Disorder","volume":"665","author":"Cui","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.it.2016.12.003","article-title":"HIV Latency: Should We Shock or Lock","volume":"38","author":"Darcis","year":"2017","journal-title":"Trends Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"20752","DOI":"10.18632\/oncotarget.5123","article-title":"Autophagy Restricts HIV-1 Infection","volume":"6","author":"Daussy","year":"2015","journal-title":"Oncotarget"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.3390\/v5123192","article-title":"Make Yourself at Home: Viral Hijacking of the PI3K\/Akt Signaling Pathway","volume":"5","author":"Diehl","year":"2013","journal-title":"Viruses"},{"key":"B19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/icb.2014.88","article-title":"Roles of Autophagy in HIV Infection","volume":"93","author":"Dinkins","year":"2015","journal-title":"Immunol. Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1365-2125.2010.03735.x","article-title":"Potential Use of Rapamycin in HIV Infection","volume":"70","author":"Donia","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.1128\/AAC.48.10.3905-3911.2004","article-title":"Human Immunodeficiency Virus Type 1 Protease Inhibitors Block Toll-Like Receptor 2 (TLR2)- and TLR4-Induced NF-kappaB Activation","volume":"48","author":"Equils","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068378","article-title":"Transiently Reduced PI3K\/Akt Activity Drives the Development of Regulatory Function in Antigen-Stimulated Na\u00efve T-Cells","volume":"8","author":"Etemire","year":"2013","journal-title":"PloS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/82_2010_58","article-title":"Protein Kinase B (PKB\/Akt), a Key Mediator of the PI3K Signaling Pathway","volume":"346","author":"Fayard","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B24","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.4049\/jimmunol.161.11.6433","article-title":"Natural Killer Cells From HIV-1+ Patients Produce C-C Chemokines and Inhibit HIV-1 Infection","volume":"161","author":"Fehniger","year":"1998","journal-title":"J. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1128\/jvi.77.4.2539-2549.2003","article-title":"Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication Following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages","volume":"77","author":"Fran\u00e7ois","year":"2003","journal-title":"J. Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"9824","DOI":"10.1128\/JVI.05170-11","article-title":"Spinoculation Triggers Dynamic Actin and Cofilin Activity That Facilitates HIV-1 Infection of Transformed and Resting CD4 T Cells","volume":"85","author":"Guo","year":"2011","journal-title":"J. Virol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1248\/bpb.b18-00801","article-title":"The Phosphatidylinositol 3-Kinase P110\u03b1\/PTEN Signaling Pathway Is Crucial for HIV-1 Entry","volume":"42","author":"Hamada","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102906","article-title":"Shock and Kill, But Don\u2019t Miss the Target","volume":"58","author":"Herbein","year":"2020","journal-title":"EBioMedicine"},{"key":"B29","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/s12026-008-8037-x","article-title":"Foxp3 and Treg Cells in HIV-1 Infection and Immuno-Pathogenesis","volume":"41","author":"Holmes","year":"2008","journal-title":"Immunol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2014.10.008","article-title":"Role of the Immune System in HIV-Associated Neuroinflammation and Neurocognitive Implications","volume":"45","author":"Hong","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.4049\/jimmunol.177.4.2304","article-title":"TRAIL-Mediated Apoptosis in HIV-1-Infected Macrophages Is Dependent on the Inhibition of Akt-1 Phosphorylation","volume":"177","author":"Huang","year":"2006","journal-title":"J. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1128\/JVI.67.7.4050-4055.1993","article-title":"Partial Inhibition of the Human Immunodeficiency Virus Type 1 Protease Results in Aberrant Virus Assembly and the Formation of Noninfectious Particles","volume":"67","author":"Kaplan","year":"1993","journal-title":"J. Virol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/imr.12080","article-title":"The Immunological Synapse: The Gateway to the HIV Reservoir","volume":"254","author":"Kulpa","year":"2013","journal-title":"Immunol. Rev."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/srep38313","article-title":"Limited HIV-1 Reactivation in Resting CD4(+) T Cells From Aviremic Patients Under Protease Inhibitors","volume":"6","author":"Kumar","year":"2016","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/srep24090","article-title":"Tuning of AKT-Pathway by Nef and its Blockade by Protease Inhibitors Results in Limited Recovery in Latently HIV Infected T-Cell Line","volume":"6","author":"Kumar","year":"2016","journal-title":"Sci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1189\/jlb.0105056","article-title":"HIV-1 Gp120-Induced TNF-{Alpha} Production by Primary Human Macrophages is Mediated by Phosphatidylinositol-3 (PI-3) Kinase and Mitogen-Activated Protein (MAP) Kinase Pathways","volume":"78","author":"Lee","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3390\/v8060152","article-title":"Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway","volume":"8","author":"Le Sage","year":"2016","journal-title":"Viruses"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00228","article-title":"Akt and mTOR in B Cell Activation and Differentiation","volume":"3","author":"Limon","year":"2012","journal-title":"Front. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"9114","DOI":"10.1128\/JVI.00175-11","article-title":"Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, Through the Akt Pathway","volume":"85","author":"Lin","year":"2011","journal-title":"J. Virol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1742-4690-10-60","article-title":"Critical Roles for Akt Kinase in Controlling HIV Envelope-Mediated Depletion of CD4 T Cells","volume":"10","author":"Li","year":"2013","journal-title":"Retrovirology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013121","article-title":"Targeting the PI3K\/Akt Cell Survival Pathway to Induce Cell Death of HIV-1 Infected Macrophages With Alkylphospholipid Compounds","volume":"5","author":"Lucas","year":"2010","journal-title":"PloS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.chom.2008.04.008","article-title":"HIV-1 Accessory Proteins\u2013Ensuring Viral Survival in a Hostile Environment","volume":"3","author":"Malim","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.662232","article-title":"AKT Inhibitors: New Weapons in the Fight Against Breast Cancer","volume":"12","author":"Martorana","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009581","article-title":"Biogenesis of P-TEFb in CD4+ T Cells to Reverse HIV Latency is Mediated by Protein Kinase C (PKC)-Independent Signaling Pathways","volume":"17","author":"Mbonye","year":"2021","journal-title":"PloS Pathog."},{"key":"B45","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1684\/ecn.2010.0198","article-title":"IL-15 in HIV Infection: Pathogenic or Therapeutic Potential","volume":"21","author":"Mueller","year":"2010","journal-title":"Eur. Cytokine Netw."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.4049\/jimmunol.1100594","article-title":"HIV-Mediated Phosphatidylinositol 3-Kinase\/Serine\u2013Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells","volume":"187","author":"Muthumani","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1074\/jbc.M312591200","article-title":"Phosphoinositide 3-Kinase-Mediated Activation of Cofilin Phosphatase Slingshot and Its Role for Insulin-Induced Membrane Protrusion","volume":"279","author":"Nishita","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B48","first-page":"5230","article-title":"The Human Immunodeficiency Virus (HIV)-1 Protease Inhibitor Saquinavir Inhibits Proteasome Function and Causes Apoptosis and Radiosensitization in non-HIV-Associated Human Cancer Cells","volume":"62","author":"Pajonk","year":"2002","journal-title":"Cancer Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/v9040064","article-title":"Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: From Immune Activation to Viral Reservoirs","volume":"10","author":"Pasquereau","year":"2017","journal-title":"Viruses"},{"key":"B50","doi-asserted-by":"publisher","first-page":"14496","DOI":"10.1038\/s41598-018-32316-2","article-title":"Serum Deprivation\/Starvation Leads to Reactivation of HIV-1 in Latently Infected Monocytes via Activating ERK\/JNK Pathway","volume":"8","author":"Raja","year":"2018","journal-title":"Sci. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1042\/BCJ20160825","article-title":"HIV-1 Tat Potently Stabilises Mdm2 and Enhances Viral Replication","volume":"474","author":"Raja","year":"2017","journal-title":"Biochem. J."},{"key":"B52","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1128\/JVI.02174-14","article-title":"Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4+ T Lymphocytes","volume":"89","author":"Sagnier","year":"2014","journal-title":"J. Virol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"7797","DOI":"10.1073\/pnas.0800928105","article-title":"T Cell Receptor Signaling Controls Foxp3 Expression via PI3K, Akt, and mTOR","volume":"105","author":"Sauer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B54","doi-asserted-by":"publisher","first-page":"6264","DOI":"10.1128\/JVI.00563-15","article-title":"In Vivo Activation of Human NK Cells by Treatment With an Interleukin-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized Mice","volume":"89","author":"Seay","year":"2015","journal-title":"J. Virol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1742-4690-10-79","article-title":"Ubiquitin Conjugation to Gag is Essential for ESCRT-Mediated HIV-1 Budding","volume":"10","author":"Sette","year":"2013","journal-title":"Retrovirology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1042\/BJ20112092","article-title":"PI3K Signalling in B- and T-Lymphocytes: New Developments and Therapeutic Advances","volume":"442","author":"So","year":"2012","journal-title":"Biochem. J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.chom.2009.06.004","article-title":"HIV-1 Nef Interferes With Host Cell Motility by Deregulation of Cofilin","volume":"6","author":"Stolp","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B58","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/1742-4690-10-161","article-title":"Protease Inhibitors Effectively Block Cell-to-Cell Spread of HIV-1 Between T Cells","volume":"10","author":"Titanji","year":"2013","journal-title":"Retrovirology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1874357901004010157","article-title":"CXCR4 Tropic HIV-1 Gp120 Inhibition of SDF-1\u03b1-Induced Chemotaxis Requires Lck and is Associated With Cofilin Phosphorylation","volume":"4","author":"Trushin","year":"2010","journal-title":"Open Virol. J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.ebiom.2019.02.014","article-title":"Dendritic Cells Potently Purge Latent HIV-1 Beyond TCR-Stimulation, Activating the PI3K-Akt-mTOR Pathway","volume":"42","author":"van Montfort","year":"2019","journal-title":"EBioMedicine"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","article-title":"Akt Signaling Pathway in Macrophage Activation and M1\/M2 Polarization","volume":"198","author":"Vergadi","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"556.6","DOI":"10.1096\/fasebj.27.1_supplement.556.6","article-title":"The ESCRT Machinery Regulates Akt Signaling Mediated by the G Protein-Coupled Receptor CXCR4","volume":"27","author":"Verma","year":"2013","journal-title":"FASEB J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"12554","DOI":"10.1074\/jbc.M110.182238","article-title":"LIM Kinase 1 Modulates Cortical Actin and CXCR4 Cycling and is Activated by HIV-1 to Initiate Viral Infection","volume":"286","author":"Vorster","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B64","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1600-065X.2012.01152.x","article-title":"mTOR, Metabolism, and the Regulation of T-Cell Differentiation and Function","volume":"249","author":"Waickman","year":"2012","journal-title":"Immunol. Rev."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00362","article-title":"Microglial Cells: The Main HIV-1 Reservoir in the Brain","volume":"9","author":"Wallet","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/aps.2015.71","article-title":"PI3K Isoform-Selective Inhibitors: Next-Generation Targeted Cancer Therapies","volume":"36","author":"Wang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"B67","doi-asserted-by":"publisher","first-page":"35455","DOI":"10.1074\/jbc.M112.362400","article-title":"A Dichotomy in Cortical Actin and Chemotactic Actin Activity Between Human Memory and Naive T Cells Contributes to Their Differential Susceptibility to HIV-1 Infection","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/s0960-9822(99)80192-4","article-title":"Akt\/PKB Localisation and 3\u2019 Phosphoinositide Generation at Sites of Epithelial Cell-Matrix and Cell-Cell Interaction","volume":"9","author":"Watton","year":"1999","journal-title":"Curr. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/nm1101-1217","article-title":"HIV-1 Nef Associated PAK and PI3-Kinases Stimulate Akt-Independent Bad-Phosphorylation to Induce Anti-Apoptotic Signals","volume":"7","author":"Wolf","year":"2001","journal-title":"Nat. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/1742-4690-5-95","article-title":"Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study","volume":"5","author":"Wu","year":"2008","journal-title":"Retrovirology"},{"key":"B71","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1016\/j.febslet.2015.11.033","article-title":"EZH2 Phosphorylation Regulates Tat-Induced HIV-1 Transactivation","volume":"589","author":"Zhang","year":"2015","journal-title":"via ROS\/Akt Signaling Pathway. FEBS Lett."},{"key":"B72","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.abb.2010.10.018","article-title":"Akt\/Nox2\/NF-\u03bab Signaling Pathway is Involved in Tat-Induced HIV-1 Long Terminal Repeat (LTR) Transactivation","volume":"505","author":"Zhang","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.bbamcr.2011.03.010","article-title":"Akt, FoxO and Regulation of Apoptosis. Biochimica Et Biophysica Acta (BBA)","volume":"1813","author":"Zhang","year":"2011","journal-title":"Mol. Cell Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12974-019-1466-8","article-title":"HIV-1 Tat Enhances Purinergic P2Y4 Receptor Signaling to Mediate Inflammatory Cytokine Production and Neuronal Damage via PI3K\/Akt and ERK MAPK Pathways","volume":"16","author":"Zhou","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"B75","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.chom.2008.10.004","article-title":"Genome-Scale RNAi Screen for Host Factors Required for HIV Replication","volume":"4","author":"Zhou","year":"2008","journal-title":"Cell Host Microbe"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.827717\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T15:33:14Z","timestamp":1674660794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.827717\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":75,"alternative-id":["10.3389\/fcimb.2022.827717"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.827717","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]},"article-number":"827717"}}