{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:22:00Z","timestamp":1792167720355,"version":"4.4.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Background<\/jats:title>\n \n Since the outbreak of COVID-19, a series of preventive and control measures in China have been used to effectively curb the spread of COVID-19. This study aimed to analyze the epidemiological characteristics of\n Mycoplasma pneumoniae<\/jats:italic>\n (\n MP<\/jats:italic>\n ) and\n Chlamydia pneumoniae<\/jats:italic>\n (\n CP<\/jats:italic>\n ) in hospitalized children with acute respiratory tract infection during the COVID-19 pandemic.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n MP<\/jats:italic>\n IgM antibody and\n CP<\/jats:italic>\n IgM antibody were detected in all hospitalized children due to acute respiratory tract infection in the Children\u2019s Hospital Affiliated to Zhejiang University from January 2019 to December 2020. These data were compared between 2019 and 2020 based on age and month.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The overall detection rate of\n MP<\/jats:italic>\n and\n CP<\/jats:italic>\n in 2020 was significantly lower than that in 2019 (\n MP<\/jats:italic>\n : 21.5% vs 32.9%,\n P<\/jats:italic>\n &lt;0.001;\n CP<\/jats:italic>\n : 0.3% vs 0.9%,\n P<\/jats:italic>\n &lt;0.001). This study found a 4-fold reduction in the number of children positive for\n MP<\/jats:italic>\n and a 7.5-fold reduction in the number of children positive for\n CP<\/jats:italic>\n from 2019 to 2020. The positive cases were concentrated in children aged &gt;1 year old. In 2019, the positive rate of\n MP<\/jats:italic>\n was detected more commonly in children 3 years of age or older than in younger children. In 2020, the higher positive rate of\n MP<\/jats:italic>\n reached a peak in the 3- to 6-year age group (35.3%).\n CP<\/jats:italic>\n was detected predominantly in children aged 6 years older in 2019 and 2020, with positive rates of 4.8% and 2.6%, respectively. Meanwhile, the positive rates of\n MP<\/jats:italic>\n in 2019 were detected more commonly in July, August and September, with 47.2%, 46.7% and 46.3%, respectively. Nevertheless, the positive rates of\n MP<\/jats:italic>\n from February to December 2020 apparently decreased compared to those in 2019. The positive rates of\n CP<\/jats:italic>\n were evenly distributed throughout the year, with 0.5%-1.6% in 2019 and 0.0%-2.1% in 2020.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n A series of preventive and control measures for SARS-CoV-2 during the COVID-19 pandemic can not only contain the spread of SARS-CoV-2 but also sharply improve the infection of other atypical pathogens, including\n MP<\/jats:italic>\n and\n CP<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2022.843463","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T17:32:49Z","timestamp":1647970369000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Epidemiological Study on Mycoplasma pneumoniae and Chlamydia pneumoniae Infection of Hospitalized Children in a Single Center During the COVID-19 Pandemic"],"prefix":"10.3389","volume":"12","author":[{"given":"Fengqing","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jmii.2013.03.015","article-title":"Comparison of Real-Time Polymerase Chain Reaction and Serological Tests for the Confirmation of Mycoplasma Pneumoniae Infection in Children with Clinical Diagnosis of Atypical Pneumonia","volume":"47","author":"Chang","year":"2020","journal-title":"J Microbiol. 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