{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:12:14Z","timestamp":1792213934011,"version":"4.4.0"},"reference-count":127,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Several strains of lactic acid bacteria are potent probiotics and can cure a variety of diseases using different modes of actions. These bacteria produce antimicrobial peptides, bacteriocins, which inhibit or kill generally closely related bacterial strains and other pathogenic bacteria such as\n                    <jats:italic>Listeria, Clostridium<\/jats:italic>\n                    , and\n                    <jats:italic>Salmonella<\/jats:italic>\n                    . Bacteriocins are cationic peptides that kill the target cells by pore formation and the dissipation of cytosolic contents, leading to cell death. Bacteriocins are also known to modulate native microbiota and host immunity, affecting several health-promoting functions of the host. In this review, we have discussed the ability of bacteriocin-producing probiotic lactic acid bacteria in the modulation of gut microbiota correcting dysbiosis and treatment\/maintenance of a few important human disorders such as chronic infections, inflammatory bowel diseases, obesity, and cancer.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.851140","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T02:23:31Z","timestamp":1652667811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":248,"title":["Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota"],"prefix":"10.3389","volume":"12","author":[{"family":"Anjana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104998","article-title":"Interesting Probiotic Traits of Mother\u2019s Milk Lactobacillus Isolates; From Bacteriocin to Inflammatory Bowel Disease Improvement","volume":"158","author":"Abdi","year":"2021","journal-title":"Microb. Pathog."},{"key":"B2","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/ajmg.b.32567","article-title":"Microbiome, Inflammation, Epigenetic Alterations, and Mental Diseases","volume":"174","author":"Alam","year":"2017","journal-title":"Am. J. Med. Genet. B: Neuropsychiatr. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12602-014-9162-6","article-title":"Antiviral Potential of Lactic Acid Bacteria and Their Bacteriocins","volume":"6","author":"Al Kassaa","year":"2014","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-019-1494-4","article-title":"Antibiotics, Gut Microbiota, and Alzheimer\u2019s Disease","volume":"16","author":"Angelucci","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/9478630","article-title":"Probiotic Species in the Modulation of Gut Microbiota: An Overview","volume":"2018","author":"Azad","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1189\/jlb.0108017","article-title":"Commensal Bacteria Trigger a Full Dendritic Cell Maturation Program That Promotes the Expansion of Non-Tr1 Suppressor T Cells","volume":"84","author":"Baba","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13205-020-02317-y","article-title":"Bacteriocin PJ4 From Probiotic Lactobacillus Reduced Adipokine and Inflammasome in High Fat Diet Induced Obesity 3","volume":"10","author":"Bai","year":"2020","journal-title":"Biotech"},{"key":"B8","doi-asserted-by":"publisher","first-page":"10393","DOI":"10.1007\/s00253-018-9420-8","article-title":"Bacteriocins: Perspective for the Development of Novel Anticancer Drugs","volume":"102","author":"Baindara","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.15171\/mejdd.2017.66","article-title":"Effects of Probiotic and Prebiotic Supplementation on Leptin, Adiponectin, and Glycemic Parameters in Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial","volume":"9","author":"Behrouz","year":"2017","journal-title":"Middle East J. Dig. Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.fm.2006.05.006","article-title":"Reduction of Escherichia Coli Population Following Treatment With Bacteriocins From Lactic Acid Bacteria and Chelators","volume":"24","author":"Belfiore","year":"2007","journal-title":"Food Microbiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01662","article-title":"Criteria to Qualify Microorganisms as \u201cProbiotic\u201d Foods Dietary Supplement","volume":"11","author":"Binda","year":"2020","journal-title":"Front. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3934\/microbiol.2018.4.665","article-title":"Lactic Acid Bacteria as Starter Cultures: An Update in Their Metabolism and Genetics","volume":"4","author":"Bintsis","year":"2018","journal-title":"AIMS Microbiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1128\/aem.01597-09","article-title":"Molecular and Genetic Characterization of a Novel Bacteriocin Locus in Enterococcus Avium Isolates From Infants","volume":"76","author":"Birri","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10787-019-00595-4","article-title":"A Randomised, Double-Blind, Placebo-Controlled Trial of a Multi-Strain Probiotic in Patients With Asymptomatic Ulcerative Colitis and Crohn\u2019s Disease","volume":"27","author":"Bjarnason","year":"2019","journal-title":"Inflammopharmacology"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00049","article-title":"The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis","volume":"12","author":"Bonaz","year":"2018","journal-title":"Front. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/978-1-4939-0897-4_17","article-title":"The Impact of Microbiota on Brain and Behavior: Mechanisms and Therapeutic Potential","volume":"2014","author":"Borre","year":"2014","journal-title":"Microbial Endocrinol.: Microbiota-Gut-Brain Axis Health Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1128\/AEM.01173-10","article-title":"Characterization of Garvicin ML, a Novel Circular Bacteriocin Produced by Lactococcus Garvieae DCC43, Isolated From Mallard Ducks (Anas Platyrhynchos)","volume":"77","author":"Borrero","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1007\/s00415-018-8943-3","article-title":"Can Epilepsy be Treated by Antibiotics","volume":"265","author":"Braakman","year":"2018","journal-title":"J. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu10050591","article-title":"Dietary Neurotransmitters: A Narrative Review on Current Knowledge","volume":"10","author":"Briguglio","year":"2018","journal-title":"Nutrients"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.26191","article-title":"Dysbiosis of the Gut Microbiota in Disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ijantimicag.2017.04.020","article-title":"Inhibition of Herpes Simplex Virus 1 (HSV-1) and Poliovirus (PV-1) by Bacteriocins From Lactococcus Lactis Subsp. Lactis and Enterococcus Durans Strains Isolated From Goat Milk","volume":"51","author":"Cavicchioli","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B22","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3322\/caac.20038","article-title":"Worldwide Variations in Colorectal Cancer: CA Cancer","volume":"59","author":"Center","year":"2009","journal-title":"J. Clin."},{"key":"B23","doi-asserted-by":"publisher","first-page":"M72","DOI":"10.1111\/j.1750-3841.2010.01965.x","article-title":"Growth Inhibition of Foodborne Pathogens by Kimchi Prepared With Bacteriocin-Producing Starter Culture","volume":"76","author":"Chang","year":"2011","journal-title":"J. Food Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s00284-017-1375-y","article-title":"Synergistic Antimicrobial Activity Between the Broad Spectrum Bacteriocin Garvicin KS and Nisin, Farnesol and Polymyxin B Against Gram-Positive and Gram-Negative Bacteria","volume":"75","author":"Chi","year":"2018","journal-title":"Curr. Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/j.crohns.2014.08.006","article-title":"Fecal Microbiota Transplantation as Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis","volume":"8","author":"Colman","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"B26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s13311-017-0598-8","article-title":"Microbiota Signaling Pathways That Influence Neurologic Disease","volume":"15","author":"Cox","year":"2018","journal-title":"Neurotherapeutics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ijfoodmicro.2009.05.005","article-title":"In Vivo Study on the Effectiveness of Pediocin PA-1 and Pediococcus Acidilactici UL5 at Inhibiting Listeria Monocytogenes","volume":"133","author":"Dabour","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00223-017-0331-y","article-title":"Gut Microbiota, Immune System, and Bone","volume":"102","author":"D\u2019amelio","year":"2018","journal-title":"Calcif. Tissue Int."},{"key":"B29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1472-765X.2008.02488.x","article-title":"Nisin F in the Treatment of Respiratory Tract Infections Caused by Staphylococcus Aureus. Lett","volume":"48","author":"De Kwaadsteniet","year":"2009","journal-title":"Appl. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1128\/AEM.00436-06","article-title":"Bacteriocin T8, a Novel Class IIa Sec-Dependent Bacteriocin Produced by Enterococcus Faecium T8, Isolated From Vaginal Secretions of Children Infected With Human Immunodeficiency Virus","volume":"72","author":"De Kwaadsteniet","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"37","DOI":"10.21775\/cimb.010.037","article-title":"Immunomodulatory Effects of Probiotics in the Intestinal Tract","volume":"10","author":"Delcenserie","year":"2008","journal-title":"Curr. Issues Mol. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.15302\/J-FASE-2021397","article-title":"Antiviral Effects of Bacteriocin Against Animal-to-Human Transmittable Mutated Sars-Cov-2: A Systematic Review","volume":"8","author":"Dey","year":"2021","journal-title":"Front. Agr. Sci. Eng."},{"key":"B33","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.gtc.2016.09.007","article-title":"The Microbiome-Gut-Brain Axis in Health and Disease","volume":"46","author":"Dinan","year":"2017","journal-title":"Gastroenterol. Clin. North Am."},{"key":"B34","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.bbamem.2015.10.018","article-title":"Molecular Mechanisms of Membrane Targeting Antibiotics","volume":"1858","author":"Epand","year":"2016","journal-title":"Biochim. Biophys. Acta \u2013 Biomembr."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e313","DOI":"10.1371\/journal.pone.0000313","article-title":"A Key Role of Dendritic Cells in Probiotic Functionality","volume":"2","author":"Foligne","year":"2007","journal-title":"PloSone"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1038\/s41388-020-1341-1","article-title":"Gut Microbiota Modulation: A Novel Strategy for Prevention and Treatment of Colorectal Cancer","volume":"39","author":"Fong","year":"2020","journal-title":"Oncogene"},{"key":"B37","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1136\/gut.2004.044834","article-title":"Synbiotic Therapy (Bifidobacterium Longum\/Synergy 1) Initiates Resolution of Inflammation in Patients With Active Ulcerative Colitis: A Randomised Controlled Pilot Trial","volume":"54","author":"Furrie","year":"2005","journal-title":"Gut"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1089\/jmf.2014.7000","article-title":"The Gut Microbiome and the Brain","volume":"17","author":"Galland","year":"2014","journal-title":"J. Med. Food"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jcm8111915","article-title":"Anorexia Nervosa and the Immune System\u2014a Narrative Review","volume":"8","author":"Gibson","year":"2019","journal-title":"J. Clin. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00253-008-1726-5","article-title":"The Dual Role of Bacteriocins as Anti-and Probiotics","volume":"81","author":"Gillor","year":"2008","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/jac\/42.2.277","article-title":"Activity of Nisin Against Streptococcus Pneumoniae, In Vitro, and in a Mouse Infection Model","volume":"42","author":"Goldstein","year":"1998","journal-title":"J. Antimicrob. Chemother."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1007\/s13197-018-3298-4","article-title":"Purification and Characterization of a Broad Spectrum Bacteriocin Produced by a Selected Lactococcus Lactis Strain 63 Isolated From Indian Dairy Products","volume":"55","author":"Goyal","year":"2018","journal-title":"J. Food Sci. Technol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4315\/0362-028X-52.6.384","article-title":"Antimicrobial Activity of Lactic Acid Bacteria Against Listeria Monocytogenes","volume":"52","author":"Harris","year":"1989","journal-title":"J. Food Prot."},{"key":"B44","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1080\/19490976.2018.1534513","article-title":"Lactobacillus Plantarum Bacteriocin Is Associated With Intestinal and Systemic Improvements in Diet-Induced Obese Mice and Maintains Epithelial Barrier Integrity In Vitro","volume":"10","author":"Heeney","year":"2019","journal-title":"Gut Microbes"},{"key":"B45","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41579-021-00569-w","article-title":"The Microbiome-Shaping Roles of Bacteriocins","volume":"19","author":"Heilbronner","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ani11040979","article-title":"Bacteriocins From Lactic Acid Bacteria. A Powerful Alternative as Antimicrobials, Probiotics, and Immunomodulators in Veterinary Medicine","volume":"11","author":"Hernandez-Gonzalez","year":"2021","journal-title":"Animals"},{"key":"B47","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jaci.2005.10.043","article-title":"Supernatant of Bifidobacterium Breve Induces Dendritic Cell Maturation, Activation, and Survival Through a Toll-Like Receptor 2 Pathway","volume":"117","author":"Hoarau","year":"2006","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/5518825","article-title":"Bacteriocins: Potential for Human Health","volume":"212","author":"Huang","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01666","article-title":"Secretome of Intestinal Bacilli: A Natural Guard Against Pathologies","volume":"8","author":"Ilinskaya","year":"2017","journal-title":"Front. Microbiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.micpath.2018.04.005","article-title":"Effect of Nisin on Microbiome-Brain-Gut Axis Neurochemicals by Escherichia Coli-Induced Diarrhea in Mice","volume":"119","author":"Jia","year":"2018","journal-title":"Microb. Pathog."},{"key":"B51","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41579-018-0014-3","article-title":"Why Does the Microbiome Affect Behaviour","volume":"16","author":"Johnson","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00272","article-title":"Bacteriocins as Potential Anticancer Agents","volume":"6","author":"Kaur","year":"2015","journal-title":"Front. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41586-019-1501-z","article-title":"Microbiota-Derived Lantibiotic Restores Resistance Against Vancomycin-Resistant Enterococcus","volume":"572","author":"Kim","year":"2019","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1126\/science.aaa4690","article-title":"Targeting DnaN for Tuberculosis Therapy Using Novel Griselimycins","volume":"348","author":"Kling","year":"2015","journal-title":"Science"},{"key":"B55","first-page":"35","article-title":"Prebiotic and Synbiotic Treatment Before Colorectal Surgery-Randomised Double Blind Trial","volume":"40","author":"Krebs","year":"2016","journal-title":"Coll. Antropol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"05","DOI":"10.3920\/BM2014.0063","article-title":"The Impact of Oral Consumption of Lactobacillus Plantarum P-8 on Faecal Bacteria Revealed by Pyrosequencing","volume":"64","author":"Kwok","year":"2015","journal-title":"Benef Microbes"},{"key":"B57","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1159\/000443360","article-title":"Effects of Antibiotics on Gut Microbiota","volume":"34","author":"Lange","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12560-013-9135-z","article-title":"Antiviral Potential of Selected Starter Cultures, Bacteriocins and D, L-Lactic Acid","volume":"6","author":"Lange-Starke","year":"2014","journal-title":"Food Environ. Virol."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103163","article-title":"Role of Probiotics in Stimulating the Immune System in Viral Respiratory Tract Infections: A Narrative Review","volume":"12","author":"Lehtoranta","year":"2020","journal-title":"Nutrients"},{"key":"B60","doi-asserted-by":"publisher","first-page":"178ra41","DOI":"10.1126\/scitranslmed.3005687","article-title":"Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity","volume":"5","author":"Liou","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s00726-017-2410-9","article-title":"L-Glutamine and L-Arginine Protect Against Enterotoxigenic Escherichia Coli Infection via Intestinal Innate Immunity in Mice","volume":"49","author":"Liu","year":"2017","journal-title":"Amino Acids"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12934-020-1289-4","article-title":"Surface Components and Metabolites of Probiotics for Regulation of Intestinal Epithelial Barrier","volume":"19","author":"Liu","year":"2020","journal-title":"Microb. Cell Factories"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.625210","article-title":"Gut Microbiota and Diarrhea: An Updated Review","volume":"11","author":"Li","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"132009","DOI":"10.1016\/j.foodchem.2021.132009","article-title":"Synergistic Antibacterial Activity and Mechanism of Action of Nisin\/Carvacrol Combination Against Staphylococcus Aureus and Their Application in the Infecting Pasteurized Milk","volume":"380","author":"Li","year":"2022","journal-title":"Food Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1365-2567.2005.02159.x","article-title":"Immune Responses That Adapt the Intestinal Mucosa to Commensal Intestinal Bacteria","volume":"115","author":"Macpherson","year":"2005","journal-title":"Immunology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1091334","article-title":"Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria","volume":"303","author":"Macpherson","year":"2004","journal-title":"Sci. (New York N.Y.)"},{"key":"B67","doi-asserted-by":"publisher","first-page":"4756","DOI":"10.1128\/AEM.00817-08","article-title":"Isolation and Characterization of Carnocyclin A, a Novel Circular Bacteriocin Produced by Carnobacterium Maltaromaticum UAL307","volume":"74","author":"Martin-Visscher","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020258","article-title":"Probiotics: How Effective Are They in the Fight Against Obesity","volume":"11","author":"Mazloom","year":"2019","journal-title":"Nutrients"},{"key":"B69","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nature07008","article-title":"A Microbial Symbiosis Factor Prevents Intestinal Inflammatory Disease","volume":"453","author":"Mazmanian","year":"2008","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/628157","article-title":"Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut","volume":"2015","author":"Michielan","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e7056","DOI":"10.1371\/journal.pone.0007056","article-title":"Comparison of the Immunomodulatory Properties of Three Probiotic Strains of Lactobacilli Using Complex Culture Systems: Prediction for In Vivo Efficacy","volume":"4","author":"Mileti","year":"2009","journal-title":"PloSone"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1128\/AEM.02150-07","article-title":"Capacity of Human Nisin and Pediocin-Producing Lactic Acid Bacteria to Reduce Intestinal Colonization by Vancomycin-Resistant Enterococci","volume":"74","author":"Millette","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/1469-0691.12172","article-title":"Gut Bacterial Microbiota and Obesity","volume":"19","author":"Million","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3390\/molecules22081255","article-title":"Lactic Acid Bacteria and Their Bacteriocins: Classification, Biosynthesis and Applications Against Uropathogens: A Mini-Review","volume":"22","author":"Mokoena","year":"2017","journal-title":"Molecules"},{"key":"B75","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3233\/NHA-170030","article-title":"Gut Microbiome and Aging: Physiological and Mechanistic Insights","volume":"4","author":"Nagpal","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/4374891","article-title":"Current Applications of Bacteriocin","volume":"2020","author":"Negash","year":"2020","journal-title":"Int. J. Microbiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4265\/bio.17.1","article-title":"Antibacterial Peptide Bacteriocin. An Overview of Their Diverse Characteristics and Applications","volume":"1","author":"Nishei","year":"2012","journal-title":"Biocontrol Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.micpath.2018.07.006","article-title":"Nisin, a Potent Bacteriocin and Anti-Bacterial Peptide, Attenuates Expression of Metastatic Genes in Colorectal Cancer Cell Lines","volume":"123","author":"Norouzi","year":"2018","journal-title":"Microb. Pathog."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00925","article-title":"Bifidobacteria and Their Role as Members of the Human Gut Microbiota","volume":"7","author":"O\u2019Callaghan","year":"2016","journal-title":"Front. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-30271-6","article-title":"The Potency of the Broad Spectrum Bacteriocin, Bactofencin A, Against Staphylococci Is Highly Dependent on Primary Structure, N-Terminal Charge and Disulphide Formation","volume":"8","author":"O\u2019 Connor","year":"2018","journal-title":"Sci. Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1574-695X.1999.tb01262.x","article-title":"Evaluation of Immunomodulatory Effects of Nisin-Containing Diets on Mice","volume":"24","author":"Pablo","year":"1999","journal-title":"FEMS Microbiol. Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"018","DOI":"10.1055\/s-2007-970196","article-title":"Bacterial Colitis","volume":"20","author":"Papaconstantinou","year":"2007","journal-title":"Clin. Colon Rectal Surg."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-13-S1-S3","article-title":"Novel Bacteriocins From Lactic Acid Bacteria (LAB): Various Structures and Applications","volume":"13","author":"Perez","year":"2014","journal-title":"Microb. Cell Fact"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.3390\/microorganisms9102107","article-title":"Current Knowledge of the Mode of Action and Immunity Mechanisms of LAB-Bacteriocins","volume":"9","author":"P\u00e9rez-Ramos","year":"2021","journal-title":"Microorganisms"},{"key":"B85","doi-asserted-by":"publisher","first-page":"8301","DOI":"10.1007\/s13277-015-3571-3","article-title":"Effect of Nisin and Doxorubicin on DMBA-Induced Skin Carcinogenesis\u2014a Possible Adjunct Therapy","volume":"36","author":"Preet","year":"2015","journal-title":"Tumor Biol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11910-017-0802-6","article-title":"Microbiota-Brain-Gut Axis and Neurodegenerative Diseases","volume":"17","author":"Quigley","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"B87","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1099\/jmm.0.47085-0","article-title":"Antimicrobial Activity of Lacticin 3147 Against Clinical Clostridium Difficile Strains","volume":"56","author":"Rea","year":"2007","journal-title":"J. Med. Microbiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"9352","DOI":"10.1073\/pnas.0913554107","article-title":"Thuricin CD, a Posttranslationally Modified Bacteriocin With a Narrow Spectrum of Activity Against Clostridium Difficile","volume":"107","author":"Rea","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0031113","article-title":"Effect of Lactobacillus Salivarius Bacteriocin Abp118 on the Mouse and Pig Intestinal Microbiota","volume":"7","author":"Riboulet-Bisson","year":"2012","journal-title":"PloS One"},{"key":"B90","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/gastroent12010006","article-title":"Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs)","volume":"12","author":"Ryma","year":"2021","journal-title":"Gastroenterol. Insights"},{"key":"B91","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3889\/oamjms.2020.5483","article-title":"The Effectiveness of Probiotics Against Viral Infections: A Rapid Review With Focus on SARS-CoV-2 Infection","volume":"8","author":"Salman","year":"2020","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1089\/fpd.2011.0972","article-title":"Enterocin CRL35 Inhibits Listeria Monocytogenes in a Murine Model","volume":"9","author":"Salvucci","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"key":"B93","doi-asserted-by":"publisher","first-page":"127","DOI":"10.4161\/gmic.2.3.16174","article-title":"Health Claims Substantiation for Probiotic and Prebiotic Products","volume":"2","author":"Sanders","year":"2011","journal-title":"Gut Microbes"},{"key":"B94","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nature20557","article-title":"Microcins Mediate Competition Among Enterobacteriaceae in the Inflamed Gut","volume":"540","author":"Sassone-Corsi","year":"2016","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1023\/A:1013204612762","article-title":"Physical and Psychological Stress in Rats Enhances Colonic Epithelial Permeability via Peripheral CRH","volume":"47","author":"Saunders","year":"2002","journal-title":"Dig. Dis. Sci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/435268","article-title":"Gut Microbial Flora, Prebiotics, and Probiotics in IBD: Their Current Usage and Utility","volume":"2010","author":"Scaldaferri","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1128\/IAI.01563-06","article-title":"Induction of Human \u03b2-Defensin 2 by the Probiotic Escherichia Coli Nissle 1917 Is Mediated Through Flagellin","volume":"75","author":"Schlee","year":"2007","journal-title":"Infect. Immun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"215","DOI":"10.4166\/kjg.2015.65.4.215","article-title":"Effects of Probiotics on Gut Microbiota in Patients With Inflammatory Bowel Disease: A Double-Blind, Placebo-Controlled Clinical Trial","volume":"65","author":"Shadnoush","year":"2015","journal-title":"Korean J. Gastroenterol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s12602-020-09708-w","article-title":"Synergistically-Acting Enterocin LD3 and Plantaricin LD4 Against Gram-Positive and Gram-Negative Pathogenic Bacteria","volume":"13","author":"Sheoran","year":"2021","journal-title":"Probiotics Antimicro. Prot."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1111\/jam.13033","article-title":"Biomedical Applications of Nisin","volume":"120","author":"Shin","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"B101","first-page":"206","article-title":"The Gut Microbiome","volume":"46","author":"Sidhu","year":"2017","journal-title":"Aust. Fam. Physician"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2020.12.014","article-title":"Probiotics: A Potential Immunomodulator in COVID-19 Infection Management","volume":"87","author":"Singh","year":"2021","journal-title":"Nutr. Res."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117754","article-title":"Bacteriotherapy in Gastrointestinal Cancer","volume":"254","author":"Soleimanpour","year":"2020","journal-title":"Life Sci."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa039","article-title":"Bacteriocins as a New Generation of Antimicrobials: Toxicity Aspects and Regulations","volume":"45","author":"Soltani","year":"2021","journal-title":"FEMS Microbiol. Rev."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01018-16","article-title":"Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome","volume":"7","author":"Sze","year":"2016","journal-title":"MBio"},{"key":"B106","doi-asserted-by":"publisher","first-page":"364","DOI":"10.5114\/pg.2021.109622","article-title":"Anticancer Properties of Colicin E7 Against Colon Cancer","volume":"16","author":"Taherikalani","year":"2021","journal-title":"Prz. Gastroenterol."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01877","article-title":"Probiotics at War Against Viruses: What Is Missing From the Picture","volume":"11","author":"Tiwari","year":"2020","journal-title":"Front. Microbiol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.fm.2010.05.001","article-title":"Characterisation of an Antiviral Pediocin-Like Bacteriocin Produced by Enterococcus Faecium","volume":"27","author":"Todorov","year":"2010","journal-title":"Food Microbiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-Induced Obesity Is Linked to Marked But Reversible Alterations in the Mouse Distal Gut Microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0164036","article-title":"The Potential of Class II Bacteriocins to Modify Gut Microbiota to Improve Host Health","volume":"11","author":"Umu","year":"2016","journal-title":"PloS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/16512235.2017.1348886","article-title":"Modulation of the Gut Microbiota by Prebiotic Fibres and Bacteriocins","volume":"28","author":"Umu","year":"2017","journal-title":"Microb. Ecol. Health Dis."},{"key":"B112","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.tim.2011.04.004","article-title":"Structure and Genetics of Circular Bacteriocins","volume":"19","author":"Van-Belkum","year":"2011","journal-title":"Trends Microbiol."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00125","article-title":"Nutrition, Immunity and Viral Infections","volume":"125","author":"Villena","year":"2020","journal-title":"Front. Nutr."},{"key":"B114","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0924-8579(99)00078-3","article-title":"Antiviral Activity of Enterocin CRL35 Against Herpesviruses","volume":"12","author":"Wachsman","year":"1999","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B115","doi-asserted-by":"publisher","first-page":"4985","DOI":"10.1128\/AEM.00753-08","article-title":"Ecological Role of Lactobacilli in the Gastrointestinal Tract: Implications for Fundamental and Biomedical Research","volume":"74","author":"Walter","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.4103\/0366-6999.190667","article-title":"Gut Microbiota-Brain Axis","volume":"129","author":"Wang","year":"2016","journal-title":"Chin. Med. J."},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8081148","article-title":"Probiotics for the Treatment of Overweight and Obesity in Humans\u2014A Review of Clinical Trials","volume":"8","author":"Wici\u0144ski","year":"2020","journal-title":"Microorganisms"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-5-22","article-title":"Probiotic Lactobacillus Rhamnosus GG Mono-Association Suppresses Human Rotavirus-Induced Autophagy in the Gnotobiotic Piglet Intestine","volume":"5","author":"Wu","year":"2013","journal-title":"Gut Pathog."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep45176","article-title":"Probiotics may Delay the Progression of Nonalcoholic Fatty Liver Disease by Restoring the Gut Microbiota Structure and Improving Intestinal Endotoxemia","volume":"7","author":"Xue","year":"2017","journal-title":"Sci. Rep."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00241","article-title":"Antibacterial Activities of Bacteriocins: Application in Foods and Pharmaceuticals","volume":"5","author":"Yang","year":"2014","journal-title":"Front. Microbiol."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2020.100794","article-title":"Action Mode of Bacteriocin BM1829 Against Escherichia Coli and Staphylococcus Aureus","volume":"39","author":"Yan","year":"2021","journal-title":"Food Biosci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.3168\/jds.2014-7921","article-title":"Lactobacillus Acidophilus Modulates the Virulence of Clostridium Difficile","volume":"97","author":"Yun","year":"2014","journal-title":"J. Dairy Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.apcbee.2012.06.010","article-title":"Bacteriocins Produced by Lactic Acid Bacteria a Review Article","volume":"2","author":"Zacharof","year":"2012","journal-title":"Apcbee Proc."},{"key":"B124","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1365-2567.2007.02800.x","article-title":"Toll-Like Receptor 2 and Nucleotide Binding Oligomerization Domain-2 Play Divergent Roles in the Recognition of Gut-Derived Lactobacilli and Bifidobacteria in Dendritic Cells","volume":"124","author":"Zeuthen","year":"2008","journal-title":"Immunology"},{"key":"B125","doi-asserted-by":"publisher","first-page":"7493","DOI":"10.3390\/ijms16047493","article-title":"Impacts of Gut Bacteria on Human Health and Disease","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.7939\/r3-egnz-m294","article-title":"A Taxonomic Note on the Genus Lactobacillus: Description of 23 Novel Genera, Emended Description of the Genus Lactobacillus Beijerinck 1901, and Union of Lactobacillaceae and Leuconostocaceae","volume":"70","author":"Zheng","year":"2020","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"7878","DOI":"10.3748\/wjg.v20.i24.7878","article-title":"Emerging Roles of Lactic Acid Bacteria in Protection Against Colorectal Cancer","volume":"20","author":"Zhong","year":"2014","journal-title":"World J. Gastroenterol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.851140\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T02:23:36Z","timestamp":1652667816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.851140\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":127,"alternative-id":["10.3389\/fcimb.2022.851140"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.851140","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742177758.793594806","asserted-by":"object"}]},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]},"article-number":"851140"}}