{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:47:19Z","timestamp":1753890439051,"version":"3.41.2"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Neisseria<\/jats:italic> pathogens express a Macrophage Infectivity Potentiator Protein (MIP), which belongs to the FK506 binding protein (FKBP) family of proteins that exhibit peptidyl-prolyl cis\/trans isomerase (PPIase) activity. <jats:italic>Neisseria<\/jats:italic> MIP proteins are potential candidates for inclusion into vaccines for gonorrhoea caused by <jats:italic>N. gonorrhoeae<\/jats:italic> infection, and meningitis\/sepsis caused by <jats:italic>M. meningitidis<\/jats:italic> infection. <jats:italic>Neisseria<\/jats:italic> MIP proteins are also potential targets for directed drug treatments, although this remains relatively unexplored. In this mini-review, we provide an update into the vaccine potential of <jats:italic>Neisseria<\/jats:italic> MIP and the few published drug targeting studies, and explore further the diversity of this protein amongst both pathogenic and commensal <jats:italic>Neisseria<\/jats:italic> spp.<\/jats:p>","DOI":"10.3389\/fcimb.2022.861489","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T16:50:18Z","timestamp":1648486218000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Update on the Neisseria Macrophage Infectivity Potentiator-Like PPIase Protein"],"prefix":"10.3389","volume":"12","author":[{"given":"Myron","family":"Christodoulides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1128\/IAI.01815-14","article-title":"Recombinant Protein Truncation Strategy for Inducing Bactericidal Antibodies to the Macrophage Infectivity Potentiator Protein of Neisseria Meningitidis and Circumventing Potential Cross-Reactivity With Human FK506-Binding Proteins","volume":"83","author":"Bielecka","year":"2015","journal-title":"Infect. 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