{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:44:32Z","timestamp":1792014272890,"version":"4.4.0"},"reference-count":233,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis. Taking into account the metabolic effects in the patient\u2019s body, tick-borne diseases are a significant problem from an epidemiological and clinical point of view. Inflammation and oxidative stress are key elements in the pathogenesis of infectious diseases, including tick-borne diseases. In consequence, this leads to oxidative modifications of the structure and function of phospholipids and proteins and results in qualitative and quantitative changes at the level of lipid mediators arising in both reactive oxygen species (ROS) and ROS enzyme\u2013dependent reactions. These types of metabolic modifications affect the functioning of the cells and the host organism. Therefore, links between the severity of the disease state and redox imbalance and the level of phospholipid metabolites are being searched, hoping to find unambiguous diagnostic biomarkers. Assessment of molecular effects of oxidative stress may also enable the monitoring of the disease process and treatment efficacy.<\/jats:p>","DOI":"10.3389\/fcimb.2022.870398","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:51:35Z","timestamp":1658479895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases"],"prefix":"10.3389","volume":"12","author":[{"given":"Monika","family":"Groth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Skrzydlewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Dobrzy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Pancewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Moniuszko-Malinowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/imb.12098","article-title":"Transcriptional Activation of Antioxidants may Compensate for Selenoprotein Deficiencies in Amblyomma Maculatum (Acari: Ixodidae) Injected With selK- or selM-dsRNA","volume":"23","author":"Adamson","year":"2014","journal-title":"Insect Mol. Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1042\/EBC20190096","article-title":"Moving Forward With Isoprostanes, Neuroprostanes and Phytoprostanes: Where are We Now","volume":"64","author":"Ahmed","year":"2020","journal-title":"Essays Biochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"13236","DOI":"10.1038\/s41598-019-49766-x","article-title":"The Redox Metabolic Pathways Function to Limit Anaplasma Phagocytophilum Infection and Multiplication While Preserving Fitness in Tick Vector Cells","volume":"9","author":"Alberdi","year":"2019","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.tips.2014.03.001","article-title":"COX-2-Derived Endocannabinoid Metabolites as Novel Inflammatory Mediators","volume":"35","author":"Alhouayek","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1096\/fba.2018-00066","article-title":"Glutathione Increase by the N-Butanoyl Glutathione Derivative (GSH-C4) Inhibits Viral Replication and Induces a Predominant Th1 Immune Profile in Old Mice Infected With Influenza Virus","volume":"1","author":"Amatore","year":"2019","journal-title":"FASEB Bioadv."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.4161\/hv.23802","article-title":"Epidemiology of Tick-Borne Encephalitis (TBE) in Europe and its Prevention by Available Vaccines","volume":"9","author":"Amicizia","year":"2013","journal-title":"Hum. Vaccines Immunother."},{"key":"B7","doi-asserted-by":"publisher","first-page":"pp.770","DOI":"10.1002\/med.21712","article-title":"Mitochondria and Lipid Peroxidation in the Mechanism of Neurodegeneration: Finding Ways for Prevention","volume":"41","author":"Angelova","year":"2021","journal-title":"Med. Res. Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"35133","DOI":"10.18632\/oncotarget.6032","article-title":"Longistatin in Tick-Saliva Targets RAGE","volume":"6","author":"Anisuzzaman","year":"2015","journal-title":"Oncotarget"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583845","article-title":"Tick Salivary Compounds for Targeted Immunomodulatory Therapy","volume":"11","author":"Aounallah","year":"2020","journal-title":"Front. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"pp.65","DOI":"10.1080\/03602532.2019.1574303","article-title":"Cannabinoids and Bone Regeneration","volume":"51","author":"Apostu","year":"2019","journal-title":"Drug Metab. Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/360438","article-title":"Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"pp.358","DOI":"10.1016\/j.biotechadv.2017.12.012","article-title":"Nrf2 as Regulator of Innate Immunity: A Molecular Swiss Army Knife","volume":"36","author":"Battino","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"B13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12929-015-0194-3","article-title":"T Cells and Reactive Oxygen Species","volume":"22","author":"Belikov","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.pt.2019.12.017","article-title":"Skin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis","volume":"36","author":"Bernard","year":"2020","journal-title":"Trends Parasitol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098614","article-title":"Knockdown of the Rhipicephalus Microplus Cytochrome C Oxidase Subunit III Gene is Associated With a Failure of Anaplasma Marginale Transmission","volume":"9","author":"Bifano","year":"2014","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ttbdis.2018.10.006","article-title":"Inter- and Intraspecies-Specific Adhesion of Lyme Borreliae to Human Keratinocytes","volume":"10","author":"Bigelmayr","year":"2019","journal-title":"Ticks Tick Borne Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"21599","DOI":"10.1074\/jbc.M109.003822","article-title":"Lipidomic Analysis of Dynamic Eicosanoid Responses During the Induction and Resolution of Lyme Arthritis","volume":"284","author":"Blaho","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5644","DOI":"10.4049\/jimmunol.0901499","article-title":"Cyclooxygenase-1 Orchestrates Germinal Center Formation and Antibody Class-Switch via Regulation of IL-17","volume":"183","author":"Blaho","year":"2009","journal-title":"J. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.idc.2018.10.010","article-title":"The Rickettsioses: A Practical Update","volume":"33","author":"Blanton","year":"2019","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B20","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s13071-018-2882-9","article-title":"Shifts in Borrelia Burgdorferi (s.L.) Geno-Species Infections in Ixodes Ricinus Over a 10-Year Surveillance Period in the City of Hanover (Germany) and Borrelia Miyamotoi-Specific Reverse Line Blot Detection","volume":"11","author":"Blazejak","year":"2018","journal-title":"Parasit. Vectors"},{"key":"B21","doi-asserted-by":"publisher","first-page":"p.e0009072","DOI":"10.1371\/journal.pntd.0009072","article-title":"Relevance of Oxidative Stress in Inhibition of Eif2 Alpha Phosphorylation and Stress Granules Formation During Usutu Virus Infection","volume":"15","author":"Bl\u00e1zquez","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i5.430","article-title":"Tick-Borne Encephalitis: A Review of Epidemiology, Clinical Characteristics, and Management","volume":"3","author":"Bogovic","year":"2015","journal-title":"World J. Clin. cases"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/351289","article-title":"Oxidative Stress Control by Apicomplexan Parasites","volume":"2015","author":"Bosch","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"B24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.medmal.2019.01.007","article-title":"Ticks and Tick-Borne Diseases","volume":"49","author":"Boulanger","year":"2019","journal-title":"M\u00e9d. Mal. Infect."},{"key":"B25","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.biochi.2017.06.010","article-title":"Borrelia Burgdorferi Infection Induces Lipid Mediator Production During Lyme Arthritis","volume":"141","author":"Brown","year":"2017","journal-title":"Biochimie"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1194\/jlr.R900004-JLR200","article-title":"Thematic Review Series: Proteomics. An Integrated Omics Analysis of Eicosanoid Biology","volume":"50","author":"Buczynski","year":"2009","journal-title":"J. Lipid Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ibmb.2017.07.00","article-title":"Amblyomma Maculatum SECIS Binding Protein 2 and Putative Selenoprotein P are Indispensable for Pathogen Replication and Tick Fecundity","volume":"88","author":"Budachetri","year":"2017","journal-title":"Insect Biochem. Mol. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/imb.12184","article-title":"An Insight Into the Functional Role of Thioredoxin Reductase, a Selenoprotein, in Maintaining Normal Native Microbiota in the Gulf Coast Tick (Amblyomma Maculatum)","volume":"24","author":"Budachetri","year":"2015","journal-title":"Insect Mol. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s40168-018-0524-2","article-title":"The Tick Endosymbiont Candidatus Midichloria Mitochondrii and Selenoproteins are Essential for the Growth of Rickettsia Parkeri in the Gulf Coast Tick Vector","volume":"6","author":"Budachetri","year":"2018","journal-title":"Microbiome"},{"key":"B30","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/imb.12304","article-title":"Catalase is a Determinant of the Colonization and Transovarial Transmission of Rickettsia Parkeri in the Gulf Coast Tick Amblyomma Maculatum","volume":"26","author":"Budachetri","year":"2017","journal-title":"Insect Mol. Biol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00023","article-title":"Anaplasma Phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes Scapularis","volume":"7","author":"Cabezas-Cruz","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10096-018-3417-1","article-title":"Clinical Spectrum of Lyme Disease","volume":"38","author":"Cardenas-de la Garza","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1124\/pr.120.019422","article-title":"On the Clinical Pharmacology of Reactive Oxygen Species","volume":"72","author":"Casas","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170961","article-title":"MicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected With Borrelia Burgdorferi","volume":"12","author":"Casselli","year":"2017","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.3390\/molecules14124892","article-title":"Phospholipids: Key Players in Apoptosis and Immune Regulation","volume":"14","author":"Chaurio","year":"2009","journal-title":"Molecules"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3390\/nu11081952","article-title":"Role of Glutathionylation in Infection and Inflammation","volume":"11","author":"Checconi","year":"2019","journal-title":"Nutrients"},{"key":"B37","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.freeradbiomed.2014.04.018","article-title":"A Novel Immunomodulatory Effect of Ugonin U in Human Neutrophils via Stimulation of Phospholipase C","volume":"72","author":"Chen","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1128\/IAI.01679-14","article-title":"The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation During Anaplasma Phagocytophilum Infection","volume":"82","author":"Chen","year":"2014","journal-title":"Infect. Immun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nature11042","article-title":"Infection Regulates Pro-Resolving Mediators That Lower Antibiotic Requirements","volume":"484","author":"Chiang","year":"2012","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","first-page":"12768","DOI":"10.1038\/s41598-020-69566-y","article-title":"Plasma Sphingosine 1-Phosphate Concentrations and Cardiovascular Autonomic Neuropathy in Individuals With Type 2 Diabetes","volume":"10","author":"Chung","year":"2020","journal-title":"Sci. Rep."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084980","article-title":"Borrelia Burgdorferi Elicited-IL-10 Suppresses the Production of Inflammatory Mediators, Phagocytosis, and Expression of Co-Stimulatory Receptors by Murine Macrophages and\/or Dendritic Cells","volume":"8","author":"Chung","year":"2013","journal-title":"PLoS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/bph.15461","article-title":"Dual Inhibition of CB 1 Receptors and iNOS, as a Potential Novel Approach to the Pharmacological Management of Acute and Long COVID-19","author":"Cinar","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/ACI.0b013e3283624560","article-title":"Tick Bites and Red Meat Allergy","volume":"13","author":"Commins","year":"2013","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.freeradbiomed.2004.06.007","article-title":"Plasma F2-Isoprostanes are Elevated in Newborns and Inversely Correlated to Gestational Age","volume":"37","author":"Comporti","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bcp.2008.09.014","article-title":"A Role for CB2 Receptors in Anandamide Signalling Pathways Involved in the Regulation of IL-12 and IL-23 in Microglial Cells","volume":"77","author":"Correa","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jprot.2013.10.033","article-title":"Differential Expression of Ixodes Ricinus Salivary Gland Proteins in the Presence of the Borrelia Burgdorferi Sensu Lato Complex","volume":"96","author":"Cott\u00e9","year":"2014","journal-title":"J. Proteomics"},{"key":"B47","first-page":"554","article-title":"Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity Through Induction of Type I Interferon and Apoptosis in Macrophages","volume-title":"Immunity","author":"Coulombe","year":"2014"},{"key":"B48","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/384083a0","article-title":"Molecular Characterization of an Enzyme That Degrades Neuromodulatory Fatty-Acid Amides","volume":"384","author":"Cravatt","year":"1996","journal-title":"Nature"},{"key":"B49","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13071-016-1579-1","article-title":"Rickettsia Parkeri Colonization in Amblyomma Maculatum: The Role of Superoxide Dismutases","volume":"9","author":"Crispell","year":"2016","journal-title":"Parasit. Vectors"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01056","article-title":"Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy","volume":"10","author":"Crispell","year":"2019","journal-title":"Front. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic Targeting of the NRF2 and KEAP1 Partnership in Chronic Diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1160","article-title":"Evaluation of NSE and S100B in Patients With Tick-Borne Encephalitis","volume":"8","author":"Czupryna","year":"2018","journal-title":"Brain Behav."},{"key":"B53","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s10096-018-03447-1","article-title":"Assessment of the Tau Protein Concentration in Patients With Tick-Borne Encephalitis","volume":"38","author":"Czupryna","year":"2019","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1038\/cdd.2013.138","article-title":"Cell Death and Diseases Related to Oxidative Stress:4-Hydroxynonenal (HNE) in the Balance","volume":"20","author":"Dalleau","year":"2013","journal-title":"Cell Death Differ."},{"key":"B55","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.13652826.2008.01689.x","article-title":"A Saturated N-Acylethanolamine Other Than N-Palmitoyl Ethanolamine With Anti-Inflammatory Properties: A Neglected Story","volume":"20","author":"Dalle Carbonare","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s11250-011-9938-6","article-title":"Correlations Among Anaplasma Marginale Parasitemia and Markers of Oxidative Stress in Crossbred Calves","volume":"44","author":"De","year":"2012","journal-title":"Trop. Anim. Health Prod."},{"key":"B57","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.ygeno.2007.08.009","article-title":"Functional Genomic Studies of Tick Cells in Response to Infection With the Cattle Pathogen, Anaplasma Marginale","volume":"90","author":"de la Fuente","year":"2007","journal-title":"Genomics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid Storm in Infection and Inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.medmal.2013.02.004","article-title":"Regulation of Oxidative Stress by Nrf2 in the Pathophysiology of Infectious Diseases","volume":"43","author":"Deramaudt","year":"2013","journal-title":"M\u00e9d. Mal. Infect."},{"key":"B60","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1042\/bj3580249","article-title":"Palmitoylethanolamide Inhibits the Expression of Fatty Acid Amide Hydrolase and Enhances the Anti-Proliferative Effect of Anandamide in Human Breast Cancer Cells","volume":"358","author":"Di Marzo","year":"2001","journal-title":"Biochem. J."},{"key":"B61","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ttbdis.2013.01.002","article-title":"Hepatic Oxidative Stress in Mongolian Gerbils Experimentally Infected With Babesia Divergens","volume":"4","author":"Dkhil","year":"2013","journal-title":"Ticks Tick Borne Dis."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101614","article-title":"Time-Dependent Replicative Senescence vs. Disturbed Flow-Induced Pre-Mature Aging in Atherosclerosis","volume":"37","author":"Dominic","year":"2020","journal-title":"Redox Biol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009172","article-title":"Insights Into the Molecular Basis of Tick-Borne Encephalitis From Multiplatform Metabolomics","volume":"15","author":"Du","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020021","article-title":"Comparative Genomics of Emerging Human Ehrlichiosis Agents","volume":"2","author":"Dunning Hotopp","year":"2006","journal-title":"PLoS Genet."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2021.e01073","article-title":"Severe Anaplasmosis Presenting as Possible Cva: Case Report and 3-Year Anaplasma Infection Diagnosis Data is Based on Pcr Testing and Serology","volume":"24","author":"Eldaour","year":"2021","journal-title":"IDCases"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/297512","article-title":"Triggers and Effectors of Oxidative Stress at Blood-Brain Barrier Level: Relevance for Brain Ageing and Neurodegeneration","volume":"2013","author":"Enciu","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.micpath.2018.07.039","article-title":"Evaluation of Oxidative Stress and Antioxidant Status, Serum Trace Mineral Levels and Cholinesterases Activity in Cattle Infected With Anaplasma Marginale","volume":"123","author":"Esmaeilnejad","year":"2018","journal-title":"Microbial pathogenesis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1080\/10715762.2018.1475733","article-title":"The Role of Oxidative Stress in Anxiety Disorder:Cause or Consequence","volume":"52","author":"Fedoce","year":"2018","journal-title":"Free Radic. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"pp.610","DOI":"10.1021\/acs.jproteome.9b00470","article-title":"Host Metabolic Response in Early Lyme Disease","volume":"19","author":"Fitzgerald","year":"2020","journal-title":"J. Proteome Res."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00371-21","article-title":"Nitric Oxide Inhibition of Rickettsia Rickettsii","volume":"89","author":"Fitzsimmons","year":"2021","journal-title":"Infect. Immun."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.628054","article-title":"Tick Immune System: What Is Known, the Interconnections, the Gaps, and the Challenges","volume":"12","author":"Foga\u00e7a","year":"2021","journal-title":"Front. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4366","DOI":"10.1128\/JVI.0313413","article-title":"Vaccinia Virus Requires Glutamine But Not Glucose for Efficient Replication","volume":"88","author":"Fontaine","year":"2014","journal-title":"J. Virol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ttbdis.2012.06.007","article-title":"Exploring Gaps in Our Knowledge on Lyme Borreliosis Spirochaetes \u2013 Updates on Complex Heterogeneity, Ecology, and Pathogenicity","volume":"4","author":"Franke","year":"2013","journal-title":"Ticks Tick Borne Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"7676","DOI":"10.1016\/j.vaccine.2010.09.033","article-title":"The Increase in Intra-Macrophage Thiols Induced by New Pro-GSH Molecules Directs the Th1 Skewing in Ovalbumin Immunized Mice","volume":"28","author":"Fraternale","year":"2010","journal-title":"Vaccine"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073603","article-title":"Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection","volume":"22","author":"Fraternale","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"pp.46","DOI":"10.1016\/j.chemphyslip.2019.03.011","article-title":"Biological Effect of Protein Modifications by Lipid Peroxidation Products","volume":"221","author":"G\u0119gotek","year":"2019","journal-title":"Chem. Phys. Lipids"},{"key":"B77","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.plipres.2017.09.004","article-title":"Isoprostanes, Neuroprostanes and Phytoprostanes: An Overview of 25 Years of Research in Chemistry and Biology","volume":"68","author":"Galano","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/5315816","article-title":"New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress","volume":"2018","author":"Georgescu","year":"2018","journal-title":"J. Immunol. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.redox.2017.01.023","article-title":"Redox Regulation in Metabolic Programming and Inflammation","volume":"12","author":"Griffiths","year":"2017","journal-title":"Redox Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1128\/IAI.73.6.3242-3250.2005","article-title":"\u03b22 Integrins Control the Severity of Murine Lyme Carditis","volume":"73","author":"Guerau-de-Arellano","year":"2005","journal-title":"Infect. Immun."},{"key":"B81","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.virol.2014.10.037","article-title":"Oxidative Stress Influences Positive Strand RNA Virus Genome Synthesis and Capping","volume":"475","author":"Gullberg","year":"2015","journal-title":"Virology"},{"key":"B82","doi-asserted-by":"publisher","first-page":"26","DOI":"10.2119\/molmed.2014.00219","article-title":"A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated With Borrelia Seropositivity","volume":"21","author":"Hammer","year":"2015","journal-title":"Mol. Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1093\/cvr\/cvp240","article-title":"CB1 and CB2 Cannabinoid Receptors Differentially Regulate the Production of Reactive Oxygen Species by Macrophages","volume":"84","author":"Han","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1242\/bio.201410900","article-title":"Apolipoprotein CIII Regulates Lipoprotein-Associated Phospholipase A2 Expression via the MAPK and Nf\u03bab Pathways","volume":"4","author":"Han","year":"2015","journal-title":"Biol. Open"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/nu12102963","article-title":"Therapeutic Potential of \u03b2-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications","volume":"12","author":"Hashiesh","year":"2020","journal-title":"Nutrients"},{"key":"B86","doi-asserted-by":"publisher","first-page":"19683","DOI":"10.1074\/jbc.REV119.006217","article-title":"Detection, Identification, and Quantification of Oxidative Protein Modifications","volume":"294","author":"Hawkins","year":"2019","journal-title":"J. Biol. Chem."},{"key":"B87","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.tim.2011.03.007","article-title":"Multifaceted Roles for Lipids in Viral Infection","volume":"19","author":"Heaton","year":"2011","journal-title":"Trends in microbiology"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105763","article-title":"An Ixodes Scapularis Glutathione S-Transferase Plays a Role in Cell Survival and Viability During Langat Virus Infection of a Tick Cell Line","volume":"214","author":"Hernandez","year":"2021","journal-title":"Acta Trop."},{"key":"B89","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/17843286.2018.1461754","article-title":"Cannabinoid Receptor 2: A Potential Novel Therapeutic Target for Sepsis","volume":"74","author":"He","year":"2019","journal-title":"Acta Clin. Belg."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.4049\/jimmunol.1801179","article-title":"Treatment Ofborrelia Burgdorferi\u2013Infected Mice With Apoptotic Cells Attenuates Lyme Arthritis via PPAR-\u03b3","volume":"202","author":"Hilliard","year":"2019","journal-title":"J. Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.virol.2016.12.019","article-title":"Nrf2-Dependent Induction of Innate Host Defense via Heme Oxygenase-1 Inhibits Zika Virus Replication","volume":"503","author":"Huang","year":"2017","journal-title":"Virology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.plipres.2016.02.002","article-title":"Endocannabinoids and Endocannabinoid-Related Mediators: Targets, Metabolism and Role in Neurological Disorders","volume":"62","author":"Iannotti","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"B93","volume-title":"Regulation of Oxidoreductase Enzymes During Inflammation. A Thesis Submitted to the University of Brighton and the University of Sussex for a Programme of Study Undertaken at the Brighton and Sussex Medical School for the Degree of Doctor of Philosophy","author":"Ingram","year":"2018"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/3496043","article-title":"Oxidative Stress in Infection and Consequent Disease","volume":"2017","author":"Ivanov","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B95","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/mmi.12882","article-title":"Stage-Specific Global Alterations in the Transcriptomes of Lyme Disease Spirochetes During Tick Feeding and Following Mammalian Host Adaptation","volume":"95","author":"Iyer","year":"2015","journal-title":"Mol. Microbiol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9111151","article-title":"The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies","volume":"9","author":"Jaganjac","year":"2020","journal-title":"Antioxidants"},{"key":"B97","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00011-018-1180-5","article-title":"Metabolites of Prostaglandin Synthases as Potential Biomarkers of Lyme Disease Severity and Symptom Resolution","volume":"68","author":"Jarosz","year":"2018","journal-title":"Inflamm. Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"pp.265","DOI":"10.1016\/j.phrs.2016.08.035","article-title":"Celastrol Modulates Inflammation Through Inhibition of the Catalytic Activity of Mediators of Arachidonic Acid Pathway: Secretory Phospholipase A 2 Group IIA, 5-Lipoxygenase and Cyclooxygenase-2","volume":"113","author":"Joshi","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B99","doi-asserted-by":"publisher","first-page":"277","DOI":"10.17219\/acem\/63006","article-title":"Serum Carnitine and Acyl-Carnitine in Patients With Meningitis Due to Tick-Borne Encephalitis Virus Infection","volume":"26","author":"K\u0119pka","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.idc.2008.03.013","article-title":"Tick-Borne Encephalitis","volume":"22","author":"Kaiser","year":"2008","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B101","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1186\/s13071-017-2575-9","article-title":"Immune-Related Redox Metabolism of Embryonic Cells of the Tick Rhipicephalus Microplus (BME26) in Response to Infection With Anaplasma Marginale","volume":"10","author":"Kalil","year":"2017","journal-title":"Parasit. Vectors"},{"key":"B102","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-387680-5.00004-5","article-title":"RNA Interference in Ticks: A Functional Genomics Tool for the Study of Physiology","volume-title":"Small RNAs: Their Diversity, Roles, and Practical Uses","author":"Karim","year":"2012"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12830","article-title":"Recent Advances in Understanding Tick and Rickettsiae Interactions","volume":"43","author":"Karim","year":"2021","journal-title":"Parasit. Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"154","DOI":"10.2174\/1874255601103010154","article-title":"Oxidants and Antioxidants in the Pathogenesis of HIV\/AIDS","volume":"3","author":"Kashou","year":"2011","journal-title":"Open Reprod. Sci. J."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00339","article-title":"Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface","volume":"7","author":"Kazim\u00edrov\u00e1","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00106-17","article-title":"Tick-Borne Flaviviruses, With a Focus on Powassan Virus","volume":"32","author":"Kemenesi","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"B107","doi-asserted-by":"publisher","first-page":"101386","DOI":"10.1016\/j.ttbdis.2020.101386","article-title":"Borrelia Burgdorferi Hijacks Cellular Metabolism of Immune Cells: Consequences for Host Defense","volume":"11","author":"Kerstholt","year":"2020","journal-title":"Ticks Tick Borne Dis."},{"key":"B108","doi-asserted-by":"publisher","first-page":"E2320","DOI":"10.1073\/pnas.1720833115","article-title":"Role of Glutathione Metabolism in Host Defense Against Borrelia Burgdorferi Infection","volume":"115","author":"Kerstholt","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3390\/v10080392","article-title":"Redox Biology of Respiratory Viral Infections","volume":"10","author":"Khomich","year":"2018","journal-title":"Viruses"},{"key":"B110","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.bpj.2014.01.015","article-title":"Modeling of Eicosanoid Fluxes Reveals Functional Coupling Between Cyclooxygenases and Terminal Synthases","volume":"106","author":"Kihara","year":"2014","journal-title":"Biophys. J."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9110866","article-title":"Geographical Distribution of Borrelia Burgdorferi Sensu Lato in Ticks Collected From Wild Rodents in the Republic of Korea","volume":"9","author":"Kim","year":"2020","journal-title":"Pathogens"},{"key":"B112","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12864-021-07429-0","article-title":"Borrelia Burgdorferi Infection Modifies Protein Content in Saliva of Ixodes Scapularis Nymphs","volume":"22","author":"Kim","year":"2021","journal-title":"BMC Genomics"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00176","article-title":"Ixodes Immune Responses Against Lyme Disease Pathogens","volume":"8","author":"Kitsou","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-9-42","article-title":"Silencing of Genes Involved in Anaplasma Marginale-Tick Interactions Affects the Pathogen Developmental Cycle in Dermacentor Variabilis","volume":"9","author":"Kocan","year":"2009","journal-title":"BMC Dev. Biol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1000141","DOI":"10.4172\/2153-0645.1000141","article-title":"Respiratory Viral Infections and Subversion of Cellular Antioxidant Defenses","volume":"5","author":"Komaravelli","year":"2014","journal-title":"J. Pharmacogenomics Pharmacoproteomics"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101198","article-title":"Metabolic Programming of Macrophage Functions and Pathogens Control","volume":"24","author":"Koo","year":"2019","journal-title":"Redox Biol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.apjtb.2016.12.010","article-title":"A Lipidomic Concept in Infectious Diseases","volume":"7","author":"Koriem","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"B118","first-page":"90","article-title":"The Effects of Babesiosis on Oxidative Stress and DNA Damage in Anatolian Black Goats Naturally Infected With Babesia Ovis","volume":"9","author":"Kucukkurt","year":"2014","journal-title":"Iran. J. Parasitol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"616","DOI":"10.3201\/eid2702.202731","article-title":"Estimating the Frequency of Lyme Disease Diagnoses, United States 2010\u20132018","volume":"27","author":"Kugeler","year":"2021","journal-title":"Emerg. Infect. Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12974-014-0193-4","article-title":"Increased Levels of Sphingosine-1-Phosphate in Cerebrospinal Fluid of Patients Diagnosed With Tick-Borne Encephalitis","volume":"11","author":"Ku\u0142akowska","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"B121","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/imb.12218","article-title":"Assessment of Tick Antioxidant Responses to Exogenous Oxidative Stressors and Insight Into the Role of Catalase in the Reproductive Fitness of the Gulf Coast Tick, Amblyomma Maculatum","volume":"25","author":"Kumar","year":"2016","journal-title":"Insect Mol. Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s13071-019-3548-y","article-title":"Is Selenoprotein K Required for Borrelia Burgdorferi Infection Within the Tick Vector Ixodes Scapularis","volume":"12","author":"Kumar","year":"2019","journal-title":"Parasit. Vectors"},{"key":"B123","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/s41579-020-0400-5","article-title":"Interactions Between Borrelia Burgdorferi and Ticks","volume":"18","author":"Kurokawa","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00007","article-title":"A Peroxiredoxin From the Haemaphysalis Longicornis Tick Affects Langat Virus Replication in a Hamster Cell Line","volume":"10","author":"Kusakisako","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1128\/IAI.69.1.575-578.2001","article-title":"Tick Salivary Gland Extract Inhibits Killing of Borrelia Afzelii Spirochetes by Mouse Macrophages","volume":"69","author":"Kuthejlov\u00e1","year":"2001","journal-title":"Infect. Immun."},{"key":"B126","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000452160","article-title":"Nonstructural Protein 1 of Tick-Borne Encephalitis Virus Induces Oxidative Stress and Activates Antioxidant Defense by the Nrf2\/ARE Pathway","volume":"59","author":"Kuzmenko","year":"2016","journal-title":"Intervirology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/6208067","article-title":"Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway","volume":"2018","author":"Lee","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B128","doi-asserted-by":"publisher","first-page":"101056","DOI":"10.1016\/j.redox.2018.11.014","article-title":"Redox Regulation of Cell State and Fate","volume":"25","author":"Lee","year":"2019","journal-title":"Redox Biol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/946813","article-title":"Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases","volume":"2012","author":"Lima","year":"2012","journal-title":"Mediators Inflamm."},{"key":"B130","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/s41419-019-2192-y","article-title":"The Impact of Oncogenic RAS on Redox Balance and Implications for Cancer Development","volume":"10","author":"Lim","year":"2019","journal-title":"Cell Death Dis."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/S0140-6736(08)60800-4","article-title":"Tick-Borne Encephalitis","volume":"371","author":"Lindquist","year":"2008","journal-title":"Lancet"},{"key":"B132","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cotox.2017.11.002","article-title":"NF-\u03bab in Oxidative Stress","volume":"7","author":"Lingappan","year":"2018","journal-title":"Curr. Opin. Toxicol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-\u03b1 Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide","volume":"67","author":"Lo Verme","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1080\/03602532.2021.1895204","article-title":"In Quest of a New Therapeutic Approach in COVID-19: The Endocannabinoid System","volume":"53","author":"Lucaciu","year":"2021","journal-title":"Drug Metab. Rev."},{"key":"B135","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s11745-016-4212-3","article-title":"Phospholipidomic Analysis Reveals Changes in Sphingomyelin and Lysophosphatidylcholine Profiles in Plasma From Patients With Neuroborreliosis","volume":"52","author":"\u0141uczaj","year":"2017","journal-title":"Lipids"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/00365513.2015.1084040","article-title":"Tick-Borne Encephalitis \u2013 Lipid Peroxidation and its Consequences","volume":"76","author":"\u0141uczaj","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"B137","doi-asserted-by":"publisher","first-page":"433","DOI":"10.5604\/12321966.1167708","article-title":"Peroxidative Metabolism of Arachidonic Acid in the Course of Lyme Arthritis","volume":"22","author":"\u0141uczaj","year":"2015","journal-title":"Ann. Agric. Environ. Med."},{"key":"B138","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An Introduction to the Endogenous Cannabinoid System","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"B139","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.bpsc.2020.07.016","article-title":"Review of the Endocannabinoid System","volume":"6","author":"Lu","year":"2021","journal-title":"Biol. Psychiatry: Cogn. Neurosci. Neuroimaging"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ttbdis.2020.101623","article-title":"Evaluation of Enzymatic Activity of Babesia Microti Thioredoxin Reductase (Bmi TrxR)-Mutants and Screening of its Potential Inhibitors","volume":"12","author":"Lu","year":"2021","journal-title":"Ticks Tick Borne Dis."},{"key":"B141","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s40169-018-0182-9","article-title":"Lipidomics Unveils the Complexity of the Lipidome in Metabolic Diseases","volume":"7","author":"Lydic","year":"2018","journal-title":"Clin. Trans. Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of Nrf2 in Oxidative Stress and Toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00083-18","article-title":"Emerging Tick-Borne Diseases","volume":"33","author":"Madison-Antenucci","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"B144","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1093\/infdis\/jix563","article-title":"Transcriptome Assessment of Erythema Migrans Skin Lesions in Patients With Early Lyme Disease Reveals Predominant Interferon Signaling","volume":"217","author":"Marques","year":"2017","journal-title":"J. Infect. Dis."},{"key":"B145","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1186\/s13071-019-3852-6","article-title":"A Review on the Eco-Epidemiology and Clinical Management of Human Granulocytic Anaplasmosis and its Agent in Europe","volume":"12","author":"Matei","year":"2019","journal-title":"Parasit. Vectors"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133876","article-title":"Functional Role of NRF2 in Cervical Carcinogenesis","volume":"10","author":"Ma","year":"2015","journal-title":"PLoS One"},{"key":"B147","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/imr.12249","article-title":"Cytokine and Lipid Mediator Networks in Tuberculosis","volume":"264","author":"Mayer-Barber","year":"2015","journal-title":"Immunol. Rev."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/572491","article-title":"Isoprostanes and Neuroprostanes as Biomarkers of Oxidative Stress in Neurodegenerative Diseases","volume":"2014","author":"Miller","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B149","doi-asserted-by":"publisher","first-page":"p.740","DOI":"10.3390\/jcm9030740","article-title":"The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders","volume":"9","author":"Missiroli","year":"2020","journal-title":"J. Clin. Med."},{"key":"B150","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/iub.2008","article-title":"Vitamin E: Regulatory Redox Interactions","volume":"71","author":"Miyazawa","year":"2019","journal-title":"IUBMB Life"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.biopha.2018.10.019","article-title":"Crosstalk of Toll-Like Receptors Signaling and Nrf2 Pathway for Regulation of Inflammation","volume":"108","author":"Mohan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B152","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.freeradbiomed.2016.04.032","article-title":"Lipid Peroxidation in the Pathogenesis of Neuroborreliosis","volume":"96","author":"Moniuszko-Malinowska","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.15252\/embr.201744331","article-title":"Lipids at Membrane Contact Sites: Cell Signaling and Ion Transport","volume":"18","author":"Muallem","year":"2017","journal-title":"EMBO Rep."},{"key":"B154","doi-asserted-by":"publisher","first-page":"78","DOI":"10.11604\/pamj.2020.37.78.25100","article-title":"An Elevated 8-Isoprostaglandin F2 Alpha (8-Iso-PGF2\u03b1) in COVID-19 Subjects Co-Infected With Malaria","volume":"37","author":"Muhammad","year":"2020","journal-title":"Pan Afr. Med. J."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2019.12.022","article-title":"How the Redox State Regulates Immunity","volume":"157","author":"Mullen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1002\/1521-4141(2002010)32:10<2866::AID-IMMU2866>3.0.CO;2-V","article-title":"IFN-Gamma and Pro-Inflammatory Cytokine Production by Antigen-Presenting Cells is Dictated by Intracellular Thiol Redox Status Regulated by Oxygen Tension","volume":"32","author":"Murata","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/s1567-5769(01)00212-0","article-title":"The Skewing to Th1 Induced by Lentinan is Directed Through the Distinctive Cytokine Production by Macrophages With Elevated Intracellular Glutathione Content","volume":"2","author":"Murata","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.chom.2007.06.001","article-title":"A Tick Antioxidant Facilitates the Lyme Disease Agent's Successful Migration From the Mammalian Host to the Arthropod Vector","volume":"2","author":"Narasimhan","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B159","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond Oxidative Stress: An Immunologist\u2019s Guide to Reactive Oxygen Species","volume":"13","author":"Nathan","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1089\/can.2018.0073","article-title":"Immune Responses Regulated by Cannabidiol","volume":"5","author":"Nichols","year":"2020","journal-title":"Cannabis Cannabinoid Res"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.bbamem.2017.04.013","article-title":"Membrane Lipid Replacement for Chronic Illnesses, Aging and Cancer Using Oral Glycerolphospholipid Formulations With Fructooligosaccharides to Restore Phospholipid Function in Cellular Membranes, Organelles, Cells and Tissues","volume":"1859","author":"Nicolson","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Biomembr."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8159562","article-title":"Oxidative Stress in Microbial Diseases: Pathogen, Host, and Therapeutics","volume":"2019","author":"Novaes","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B163","doi-asserted-by":"publisher","first-page":"3506","DOI":"10.1038\/s41467-018-05861-7","article-title":"Nrf2 Negatively Regulates STING Indicating a Link Between Antiviral Sensing and Metabolic Reprogramming","volume":"9","author":"Olagnier","year":"2018","journal-title":"Nat. Commun."},{"key":"B164","doi-asserted-by":"publisher","first-page":"5419","DOI":"10.1038\/s41467-020-18764-3","article-title":"SARS-CoV2-Mediated Suppression of NRF2-Signaling Reveals Potent Antiviral and Anti-Inflammatory Activity of 4-Octyl-Itaconate and Dimethyl Fumarate","volume":"11","author":"Olagnier","year":"2020","journal-title":"Nat. Commun."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1111\/bph.13497","article-title":"An Update on PPAR Activation by Cannabinoids","volume":"173","author":"O\u2019Sullivan","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1124\/pr.58.3.2","article-title":"The Endocannabinoid System as an Emerging Target of Pharmacotherapy","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006928","article-title":"ROS and Trypanosoma Cruzi: Fuel to Infection, Poison to the Heart","volume":"14","author":"Paiva","year":"2018","journal-title":"PLoS Pathog."},{"key":"B168","first-page":"1230","article-title":"Role of Reactive Oxygen Species (ROS) in Patients With Erythema Migrans, an Early Manifestation of Lyme Borreliosis","volume":"7","author":"Pancewicz","year":"2001","journal-title":"Med. Sci. Monit."},{"key":"B169","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.redox.2015.03.002","article-title":"New Insights Into Lyme Disease","volume":"5","author":"Peacock","year":"2015","journal-title":"Redox Biol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12223-013-0239-5","article-title":"Role of Oxidative Stress in Infectious Diseases. A Review","volume":"58","author":"Pohanka","year":"2013","journal-title":"Folia Microbiol."},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24244545","article-title":"The Role of Phosphatidylethanolamine Adducts in Modification of the Activity of Membrane Proteins Under Oxidative Stress","volume":"24","author":"Pohl","year":"2019","journal-title":"Molecules"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00069","article-title":"The Role of Eicosanoids in Experimental Lyme Arthritis","volume":"4","author":"Pratt","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B173","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.98236","article-title":"Modulations in Oxidative Stress of Erythrocytes During Bacterial and Viral Infections","volume-title":"Erythrocyte - A Peripheral Biomarker For Infection and Inflammation","author":"Rajashekaraiah","year":"2021"},{"key":"B174","doi-asserted-by":"publisher","first-page":"BC24","DOI":"10.7860\/JCDR\/2017\/28478.10473","article-title":"Oxidative Stress Markers in Tuberculosis and HIV\/TB Co-Infection","volume":"11","author":"Rajopadhye","year":"2017","journal-title":"J. Clin. Diagn. Res"},{"key":"B175","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12974-017-0806-9","article-title":"Effects of Dexamethasone and Meloxicam on Borrelia Burgdorferi-Induced Inflammation in Glial and Neuronal Cells of the Central Nervous System","volume":"14","author":"Ramesh","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"B176","doi-asserted-by":"publisher","first-page":"6031","DOI":"10.4049\/jimmunol.1302795","article-title":"The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response Against Influenza Virus: A New Class of Adjuvant","volume":"193","author":"Ramon","year":"2014","journal-title":"J. Immunol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S0165-5728(02)00187-X","article-title":"Borrelia Burgdorferi Induces Inflammatory Mediator Production by Murine Microglia","volume":"130","author":"Rasley","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"B178","first-page":"26","article-title":"Evaluation of Serum Levels of Nitric Oxide and its Biomarkers in Patients With Lyme Borreliosis","volume":"3","author":"Ratajczak-Wrona","year":"2013","journal-title":"Prog. Health Sci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.3390\/ph3061873","article-title":"Cannabinoids and Viral Infections","volume":"3","author":"Reiss","year":"2010","journal-title":"Pharmaceuticals"},{"key":"B180","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejim.2019.01.004","article-title":"Tick-Borne Encephalitis in Europe: A Brief Update on Epidemiology, Diagnosis, Prevention, and Treatment","volume":"62","author":"Riccardi","year":"2019","journal-title":"Eur. J. Internal Med."},{"key":"B181","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and Inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s42238-021-00068-y","article-title":"Involvement of the Endocannabinoid System in the Inhibition of Sindbis Virus Replication: A Preliminary Study","volume":"3","author":"Rodriguez","year":"2021","journal-title":"J. Cannabis Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1089\/ars.2013.5745","article-title":"Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"B184","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s11481-013-9445-9","article-title":"Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation","volume":"8","author":"Rom","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B185","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1093\/jmedent\/42.1.36","article-title":"Differential Expression of Ixodes Ricinus Tick Genes Induced by Blood Feeding or Borrelia Burgdorferi Infection","volume":"42","author":"Rudenko","year":"2005","journal-title":"J. Med. Entomol."},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.22456\/1679-9216.94819","article-title":"Control of Redox Homeostasis in Tick Blood Feeding","volume":"47","author":"Sabadin","year":"2019","journal-title":"Acta Sci. Vet."},{"key":"B187","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev-pathmechdis-012418-012800","article-title":"Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection","volume":"14","author":"Sahni","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ijvsm.2016.10.003","article-title":"Clinical, Hemato-Biochemical Alterations and Oxidant\u2013Antioxidant Biomarkers in Babesia-Infected Calves","volume":"4","author":"Salem","year":"2016","journal-title":"Int. J. Vet. Sci. Med."},{"key":"B189","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.virol.2015.02.038","article-title":"Viral Activation of Cellular Metabolism","author":"Sanchez","year":"2015","journal-title":"Virology"},{"key":"B190","volume-title":"Anaplasma Phagocytophilum and Human Granulocytic Anaplasmosis in Portugal Universidade Nova De Lisboa","author":"Santos","year":"2007"},{"key":"B191","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.1128\/iai.60.12.5113-5118.1992","article-title":"Rickettsia Rickettsii Induces Superoxide Radical and Superoxide Dismutase in Human Endothelial Cells","volume":"60","author":"Santucci","year":"1992","journal-title":"Infect. Immun."},{"key":"B192","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.redox.2015.07.0122","article-title":"Effects of N-Acetylcysteine, Oral Glutathione (GSH) and a Novel Sublingual Form of GSH on Oxidative Stress Markers: A Comparative Crossover Study","volume":"6","author":"Schmitt","year":"2015","journal-title":"Redox Biol."},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040046","article-title":"Microarray Analyses of Inflammation Response of Human Dermal Fibroblasts to Different Strains of Borrelia Burgdorferi Sensu Stricto","volume":"7","author":"Schramm","year":"2012","journal-title":"PLoS One"},{"key":"B194","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving Inflammation: Dual Anti-Inflammatory and Pro-Resolution Lipid Mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.bbalip.2014.08.006","article-title":"Protectins and Maresins: New Pro-Resolving Families of Mediators in Acute Inflammation and Resolution Bioactive Metabolome","volume":"1851","author":"Serhan","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Biol. Lipids"},{"key":"B196","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in Inflammation: Emergence of the Pro-Resolving Superfamily of Mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B197","doi-asserted-by":"publisher","first-page":"5922","DOI":"10.1021\/cr100396c","article-title":"Resolvins and Protectins in Inflammation Resolution","volume":"111","author":"Serhan","year":"2011","journal-title":"Chem. Rev."},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00310","article-title":"P62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases","volume":"11","author":"Shah","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.680264","article-title":"Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack","volume":"11","author":"Sharma","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1089\/152308604322899350","article-title":"Antioxidant Role of Glutathione S-Transferases: Protection Against Oxidant Toxicity and Regulation of Stress-Mediated Apoptosis","volume":"6","author":"Sharma","year":"2004","journal-title":"Antioxid. Redox Signal."},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7695364","article-title":"Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis","volume":"2018","author":"Shastri","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B202","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/s0006-2952(01)00586-x","article-title":"Regulation of Tnf\u03b1 and Interleukin-10 Production by Prostaglandins I2 and E2: Studies With Prostaglandin Receptor-Deficient Mice and Prostaglandin E-Receptor Subtype-Selective Synthetic Agonists","volume":"61","author":"Shinomiya","year":"2001","journal-title":"Biochem. Pharmacol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.arr.2018.06.003","article-title":"Nrf2: Molecular and Epigenetic Regulation During Aging","volume":"47","author":"Silva-Palacios","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"B204","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1128\/iai.56.12.3110-3115.1988","article-title":"Potential for Free Radical-Induced Lipid Peroxidation as a Cause of Endothelial Cell Injury in Rocky Mountain Spotted Fever","volume":"56","author":"Silverman","year":"1988","journal-title":"Infect. Immun."},{"key":"B205","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1042\/BST20150054","article-title":"Nrf2 as a Master Regulator of Tissue Damage Control and Disease Tolerance to Infection","volume":"43","author":"Soares","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165574","article-title":"Eicosanoid Pathway on Host Resistance and Inflammation During Mycobacterium Tuberculosis Infection is Comprised by LTB4 Reduction But Not PGE2 Increment","volume":"1866","author":"Sorgi","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.90","article-title":"Lyme Borreliosis","volume":"2","author":"Steere","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2021.36.005848","article-title":"Metabolic Abnormalities in Tick-Borne Encephalitis: A Mini-Review","volume":"36","author":"Sun","year":"2021","journal-title":"Biomedical Journal of Scientific & Technical Research"},{"key":"B209","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijid.2013.12.017","article-title":"Endocannabinoid System Activation Contributes to Glucose Metabolism Disorders of Hepatocytes and Promotes Hepatitis C Virus Replication","volume":"23","author":"Sun","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5080843","article-title":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B211","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jmv.24292","article-title":"Effects of Cannabinoids and Their Receptors on Viral Infections","volume":"88","author":"Tahamtan","year":"2015","journal-title":"J. Med. Virol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.smim.2013.08.006","article-title":"Lipidomic Profiling of Bioactive Lipids by Mass Spectrometry During Microbial Infections","volume":"25","author":"Tam","year":"2013","journal-title":"Semin. Immunol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1073\/pnas.1400593111","article-title":"Mapping the Innate Signaling Cascade Essential for Cytokine Storm During Influenza Virus Infection","volume":"111","author":"Teijaro","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B214","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2478\/jvetres-2021-0031","article-title":"Antioxidant Status, and Blood Zinc and Copper Concentrations in Dogs With Uncomplicated Babesiosis Due to Babesia Canis Infections","volume":"65","author":"Teodorowski","year":"2021","journal-title":"J. Vet. Res."},{"key":"B215","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox Regulation of Cell Survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137237","article-title":"Identification and Characterization of Anaplasma Phagocytophilum Proteins Involved in Infection of the Tick Vector, Ixodes Scapularis","volume":"10","author":"Villar","year":"2015","journal-title":"PLoS One"},{"key":"B217","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1186\/s13071-016-1747-3","article-title":"The Intracellular Bacterium Anaplasma Phagocytophilum Selectively Manipulates the Levels of Vertebrate Host Proteins in the Tick Vector Ixodes Scapularis","volume":"9","author":"Villar","year":"2016","journal-title":"Parasit. Vectors"},{"key":"B218","doi-asserted-by":"publisher","first-page":"20899","DOI":"10.1016\/S0021-9258(18)54795-5","article-title":"Mechanism for the Formation of Dihydro Metabolites of 12-Hydroxyeicosanoids. Conversion of Leukotriene B4 and 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid to 12-Oxo Intermediates","volume":"266","author":"Wainwright","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153683","article-title":"Arachidonic Acid Metabolism and Kidney Inflammation","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B220","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting Molecular Cross-Talk Between Nrf2 and NF-\u03bab Response Pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9050275","article-title":"Effect of Borrelia Burgdorferi Outer Membrane Vesicles on Host Oxidative Stress Response","volume":"9","author":"Wawrzeniak","year":"2020","journal-title":"Antibiotics"},{"key":"B222","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1086\/432935","article-title":"Prospective Clinical Evaluation of Patients From Missouri and New York With Erythema Migrans\u2013Like Skin Lesions","volume":"41","author":"Wormser","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"B223","doi-asserted-by":"publisher","first-page":"16606","DOI":"10.1074\/jbc.M109.094615","article-title":"Two Immunoregulatory Peptides With Antioxidant Activity From Tick Salivary Glands","volume":"285","author":"Wu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12894-z","article-title":"Single-Cell RNA-Sequencing of Herpes Simplex Virus 1-Infected Cells Connects NRF2 Activation to an Antiviral Program","volume":"10","author":"Wyler","year":"2019","journal-title":"Nat. Commun."},{"key":"B225","doi-asserted-by":"publisher","first-page":"12813","DOI":"10.1074\/jbc.M113.538272","article-title":"A Dityrosine Network Mediated by Dual Oxidase and Peroxidase Influences the Persistence of Lyme Disease Pathogens Within the Vector","volume":"289","author":"Yang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B226","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-3-540-88955-7_2","article-title":"Endocannabinoid Receptor Pharmacology","volume-title":"Behavioral Neurobiology of the Endocannabinoid System","author":"Yao","year":"2009"},{"key":"B227","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.bbagen.2014.11.010","article-title":"Oxidative Stress, Redox Regulation and Diseases of Cellular Differentiation","volume":"1850","author":"Ye","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) - Gen. Subj."},{"key":"B228","doi-asserted-by":"publisher","first-page":"pp.65","DOI":"10.1093\/jb\/mvu078","article-title":"Two Distinct Leukotriene B4 Receptors, BLT1 and BLT2","volume":"157","author":"Yokomizo","year":"2015","journal-title":"J. Biochem."},{"key":"B229","doi-asserted-by":"publisher","first-page":"18128","DOI":"10.1016\/S0021-9258(17)46820-7","article-title":"Enzymatic Inactivation of Leukotriene B4 by a Novel Enzyme Found in the Porcine Kidney. Purification and Properties of Leukotriene B4 12-Hydroxydehydrogenase","volume":"268","author":"Yokomizo","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B230","doi-asserted-by":"publisher","first-page":"7995","DOI":"10.2147\/IJGM.S331374","article-title":"Serum Metabolomics of Tick-Borne Encephalitis Based on Orbitrap-Mass Spectrometry","volume":"14","author":"Zhang","year":"2021","journal-title":"Int. J. Gen. Med."},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1409582","article-title":"Flaviviridae Viruses and Oxidative Stress: Implications for Viral Pathogenesis","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B232","doi-asserted-by":"publisher","first-page":"pp.30","DOI":"10.1016\/j.ijid.2014.02.011","article-title":"Antioxidants: Potential Antiviral Agents for Japanese Encephalitis Virus Infection","volume":"24","author":"Zhang","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.633442","article-title":"Serum 8-Iso-PGF2\u03b1 Predicts the Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study","volume":"8","author":"Zheng","year":"2021","journal-title":"Front. Med."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.870398\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:51:49Z","timestamp":1658479909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.870398\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":233,"alternative-id":["10.3389\/fcimb.2022.870398"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.870398","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"870398"}}