{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:30:00Z","timestamp":1772767800759,"version":"3.50.1"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>BCL6A is a transcriptional repressor implicated in the development and survival of B and T lymphoctyes, which is also highly expressed in many non-Hodgkin\u2019s lymphomas, such as diffuse large B cell lymphoma and follicular lymphoma. Roles in other cell types, including macrophages and non-hematopoietic cells, have also been suggested but require further investigation. This study sought to identify and characterize zebrafish BCL6A and investigate its role in immune cell development and function, with a focus on early macrophages. Bioinformatics analysis identified a homologue for BCL6A (<jats:italic>bcl6aa<\/jats:italic>), as well as an additional fish-specific duplicate (<jats:italic>bcl6ab<\/jats:italic>) and a homologue for the closely-related BCL6B (<jats:italic>bcl6b<\/jats:italic>). The human BCL6A and zebrafish Bcl6aa proteins were highly conserved across the constituent BTB\/POZ, PEST and zinc finger domains. Expression of <jats:italic>bcl6aa<\/jats:italic> during early zebrafish embryogenesis was observed in the lateral plate mesoderm, a site of early myeloid cell development, with later expression seen in the brain, eye and thymus. Homozygous <jats:italic>bcl6aa<\/jats:italic> mutants developed normally until around 14 days post fertilization (dpf), after which their subsequent growth and maturation was severely impacted along with their relative survival, with heterozygous <jats:italic>bcl6aa<\/jats:italic> mutants showing an intermediate phenotype. Analysis of immune cell development revealed significantly decreased lymphoid and macrophage cells in both homozygous and heterozygous <jats:italic>bcl6aa<\/jats:italic> mutants, being exacerbated in homozygous mutants. In contrast, the number of neutrophils was unaffected. Only the homozygous <jats:italic>bcl6aa<\/jats:italic> mutants showed decreased macrophage mobility in response to wounding and reduced ability to contain bacterial infection. Collectively, this suggests strong conservation of BCL6A across evolution, including a role in macrophage biology.<\/jats:p>","DOI":"10.3389\/fcimb.2022.887278","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T07:00:21Z","timestamp":1666940421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["B cell lymphoma 6A regulates immune development and function in zebrafish"],"prefix":"10.3389","volume":"12","author":[{"given":"Farooq L. 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