{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:58:13Z","timestamp":1791867493100,"version":"4.3.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    is a common pathogen of nosocomial pneumonia worldwide and community-acquired pneumonia (CAP) in Asia. Previous studies have shown that\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    bacteremic CAP is associated with high mortality. We aimed to revisit\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    bacteremic pneumonia in the current era and determine the risk factors associated with 28-day mortality. Between January 2014 and August 2020, adult patients with\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    bacteremic pneumonia in a medical center in Taiwan were identified. Clinical and microbiological characteristics were compared between CAP and nosocomial pneumonia. Risk factors for 28-day mortality were analyzed using multivariate logistic regression. Among 150 patients with\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    bacteremic pneumonia, 52 had CAP and 98 had nosocomial pneumonia. The 28-day mortality was 52% for all patients, 36.5% for CAP, and 60.2% for nosocomial pneumonia. Hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    was more prevalent in CAP (61.5%) than in nosocomial pneumonia (16.3%). Carbapenem-resistant\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    was more prevalent in nosocomial pneumonia (58.2%) than in CAP (5.8%). Nosocomial pneumonia, a higher Severe Organ Failure Assessment score, and not receiving appropriate definitive therapy were independent risk factors for 28-day mortality. In conclusion, revisiting\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    bacteremic pneumonia in the current era showed a high mortality rate. Host factors, disease severity, and timely effective therapy affect the treatment outcomes of these patients.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.903682","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T02:33:10Z","timestamp":1655951590000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Clinical and Microbiological Characteristics of Bacteremic Pneumonia Caused by Klebsiella pneumoniae"],"prefix":"10.3389","volume":"12","author":[{"given":"I-Ren","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Neng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ni","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Hua","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Der","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tsung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"B1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2022"},{"key":"B2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.chest.2019.10.006","article-title":"Rate and Predictors of Bacteremia in Afebrile Community-Acquired Pneumonia","volume":"157","author":"Forstner","year":"2020","journal-title":"Chest."},{"key":"B3","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S1473-3099(17)30228-1","article-title":"Effect of Appropriate Combination Therapy on Mortality of Patients With Bloodstream Infections Due to Carbapenemase-Producing Enterobacteriaceae (INCREMENT): A Retrospective Cohort Study","volume":"17","author":"Guti\u00e9rrez-Guti\u00e9rrez","year":"2017","journal-title":"Lancet Infect. 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