{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:49:01Z","timestamp":1792756141263,"version":"4.5.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP2003848"],"award-info":[{"award-number":["APP2003848"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Many individuals diagnosed with autism spectrum disorder (ASD) experience gastrointestinal (GI) dysfunction and show microbial dysbiosis. Variation in gut microbial populations is associated with increased risk for GI symptoms such as chronic constipation and diarrhoea, which decrease quality of life. Several preclinical models of autism also demonstrate microbial dysbiosis. Given that much pre-clinical research is conducted in mouse models, it is important to understand the similarities and differences between the gut microbiome in humans and these models in the context of autism. We conducted a systematic review of the literature using PubMed, ProQuest and Scopus databases to compare microbiome profiles of patients with autism and transgenic (NL3<jats:sup>R451C<\/jats:sup>, Shank3 KO, 15q dup), phenotype-first (BTBR) and environmental (Poly I:C, Maternal Inflammation Activation (MIA), valproate) mouse models of autism. Overall, we report changes in fecal microbial communities relevant to ASD based on both clinical and preclinical studies. Here, we identify an overlapping cluster of genera that are modified in both fecal samples from individuals with ASD and mouse models of autism. Specifically, we describe an increased abundance of <jats:italic>Bilophila<\/jats:italic>, <jats:italic>Clostridium<\/jats:italic>, <jats:italic>Dorea<\/jats:italic> and <jats:italic>Lactobacillus<\/jats:italic> and a decrease in <jats:italic>Blautia<\/jats:italic> genera in both humans and rodents relevant to this disorder. Studies in both humans and mice highlighted multidirectional changes in abundance (i.e. in some cases increased abundance whereas other reports showed decreases) for several genera including <jats:italic>Akkermansia<\/jats:italic>, <jats:italic>Bacteroides<\/jats:italic>, <jats:italic>Bifidobacterium<\/jats:italic>, <jats:italic>Parabacteroides<\/jats:italic> and <jats:italic>Prevotella<\/jats:italic>, suggesting that these genera may be susceptible to modification in autism. Identification of these microbial profiles may assist in characterising underlying biological mechanisms involving host-microbe interactions and provide future therapeutic targets for improving gut health in autism.<\/jats:p>","DOI":"10.3389\/fcimb.2022.905841","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T05:52:46Z","timestamp":1656654766000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review"],"prefix":"10.3389","volume":"12","author":[{"given":"Mohammed U.","family":"Alamoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Hosie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya E.","family":"Shindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley E.","family":"Franks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa L.","family":"Hill-Yardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-22","article-title":"Gastrointestinal Flora and Gastrointestinal Status in Children With Autism \u2013 Comparisons to Typical Children and Correlation With Autism Severity","volume":"11","author":"Adams","year":"2011","journal-title":"BMC Gastroenterol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41586-019-0965-1","article-title":"A New Genomic Blueprint of the Human Gut Microbiota","volume":"568","author":"Almeida","year":"2019","journal-title":"Nature"},{"key":"B3","volume-title":"Diagnostic and Statistical Manual of Mental Disorders: DSM-5. 5th Edn","year":"2013"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/medsci6020029","article-title":"Clostridium Bacteria and Autism Spectrum Conditions: A Systematic Review and Hypothetical Contribution of Environmental Glyphosate Levels","volume":"6","author":"Argou-Cardozo","year":"2018","journal-title":"Med. 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