{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:43:45Z","timestamp":1791863025939,"version":"4.3.4"},"reference-count":134,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>The biofilm community of microorganisms has been identified as the dominant mode of microbial growth in nature and a common characteristic of different microorganisms such as Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. The biofilm structure helps in the protection from environmental threats including host immune system and antimicrobial agents. Thus, the biofilm community has led to a higher prevalence of multidrug-resistant (MDR) strains in recent years. In this regard, the use of a new class of antibiotics, natural compounds, and anti-biofilm enzymes has been considered for the destruction of the microbial biofilm. However, different drawbacks such as low penetration, high susceptibility to degradation, instability, and poor solubility in aqueous solutions limit the use of anti-biofilm agents (ABAs) in a clinical setting. As such, recent studies have been using poly lactic-<jats:italic>co<\/jats:italic>-glycolic acid (PLGA)-based nanoplatforms (PLGA NPFs) for delivery of ABAs that have reported promising results. These particles, due to proper drug loading and release kinetics, could suppress microbial attachment, colonization, and biofilm formation for a long time. Additionally, PLGA NPFs, because of the high drug-loading efficiencies, hydrophilic surface, negative charge, and electrostatic interaction, lead to effective penetration of antibiotics to the deeper layer of the biofilm, thereby eliminating the microbial biofilm. Thus, PLGA NPFs could be considered as a potential candidate for coating catheters and other medical material surfaces for inhibition and destruction of the microbial biofilm. However, the exact interaction of PLGA NPFs and the microbial biofilm should be evaluated in animal studies. Additionally, a future goal will be to develop PLGA formulations as systems that can be used for the treatment of the MDR microbial biofilm, since the exact interactions of PLGA NPFs and these biofilm structures are not elucidated. In the present review article, we have discussed various aspects of PLGA usage for inhibition and destruction of the microbial biofilm along with different methods and procedures that have been used for improving PLGA NPF efficacy against the microbial biofilm.<\/jats:p>","DOI":"10.3389\/fcimb.2022.926363","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:31:58Z","timestamp":1655785918000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":80,"title":["PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm"],"prefix":"10.3389","volume":"12","author":[{"given":"Aref","family":"Shariati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Chegini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsanollah","family":"Ghaznavi-Rad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan Nazarzadeh","family":"Zare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mostafa","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4053","DOI":"10.2147\/IJN.S34341","article-title":"Gentamicin-Loaded Nanoparticles Show Improved Antimicrobial Effects Towards Pseudomonas Aeruginosa Infection","volume":"7","author":"Abdelghany","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"B2","doi-asserted-by":"publisher","first-page":"111894","DOI":"10.1016\/j.msec.2021.111894","article-title":"Formulation of pH-Sensitive Chlorhexidine-Loaded\/Mesoporous Silica Nanoparticles Modified Experimental Dentin Adhesive","volume":"122","author":"Akram","year":"2021","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1166\/jbn.2020.2881","article-title":"PLGA Based Nanoparticles for the Monocyte-Mediated Anti-Tumor Drug Delivery System","volume":"16","author":"Allavena","year":"2020","journal-title":"J. Biomed. Nanotech."},{"key":"B4","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3390\/cancers12010242","article-title":"Nano-Therapies for Glioblastoma Treatment","volume":"12","author":"Alphand\u00e9ry","year":"2020","journal-title":"Cancers"},{"key":"B5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jconrel.2014.03.053","article-title":"An Overview of Clinical and Commercial Impact of Drug Delivery Systems","volume":"190","author":"Anselmo","year":"2014","journal-title":"J. Controlled Release"},{"key":"B6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1080\/10717544.2019.1701140","article-title":"Preparation of PLGA-Chitosan Based Nanocarriers for Enhancing Antibacterial Effect of Ciprofloxacin in Root Canal Infection","volume":"27","author":"Arafa","year":"2020","journal-title":"Drug Delivery"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1007\/s10856-006-0602-z","article-title":"Innovation in Multifunctional Bioabsorbable Osteoconductive Drug-Releasing Hard Tissue Fixation Devices","volume":"17","author":"Ashammakhi","year":"2006","journal-title":"J. Mater Sci. Mater Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"E6919","DOI":"10.1073\/pnas.1613722113","article-title":"Polymeric Nanofiber Coating With Tunable Combinatorial Antibiotic Delivery Prevents Biofilm-Associated Infection In Vivo","volume":"113","author":"Ashbaugh","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1163\/156856206775997322","article-title":"Synthesis and Characterization of PLGA Nanoparticles","volume":"17","author":"Astete","year":"2006","journal-title":"J. biomat. science polymer edition"},{"key":"B10","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jconrel.2015.04.028","article-title":"Disassembling Bacterial Extracellular Matrix With DNase-Coated Nanoparticles to Enhance Antibiotic Delivery in Biofilm Infections","volume":"209","author":"Baelo","year":"2015","journal-title":"J. Controlled Release"},{"key":"B11","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2147\/IDR.S188527","article-title":"Molecular Characterization of the Pils2 Gene and Its Association With the Frequency of Pseudomonas Aeruginosa Plasmid Pklc102 and PAPI-1 Pathogenicity Island","volume":"12","author":"Bahramian","year":"2019","journal-title":"Infection Drug resistance"},{"key":"B12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/17425255.2019.1621289","article-title":"Solid Lipid Matrix Mediated Nanoarchitectonics for Improved Oral Bioavailability of Drugs","volume":"15","author":"Banerjee","year":"2019","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.carbpol.2019.05.067","article-title":"Review of Polysaccharide Particle-Based Functional Drug Delivery","volume":"221","author":"Barclay","year":"2019","journal-title":"Carbohydr. polymers"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-021-00851-2","article-title":"Synthesis and Self-Assembly of Curcumin-Modified Amphiphilic Polymeric Micelles With Antibacterial Activity","volume":"19","author":"Barros","year":"2021","journal-title":"J. nanobiotech."},{"key":"B15","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s10856-013-5125-9","article-title":"A Controlled Release of Antibiotics From Calcium Phosphate-Coated Poly(Lactic-Co-Glycolic Acid) Particles and Their In Vitro Efficacy Against Staphylococcus Aureus Biofilm","volume":"25","author":"Bastari","year":"2014","journal-title":"J. Mater Sci. Mater Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"7933","DOI":"10.1016\/j.biomaterials.2012.07.027","article-title":"Diazeniumdiolate-Doped Poly(Lactic-Co-Glycolic Acid)-Based Nitric Oxide Releasing Films as Antibiofilm Coatings","volume":"33","author":"Cai","year":"2012","journal-title":"Biomaterials"},{"key":"B17","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s12272-014-0516-0","article-title":"Chemical Composition and Anti-Biofilm Activity of Thymus Sipyleus BOISS. Subsp. Sipyleus BOISS. Var. Davisianus RONNIGER Essential Oil","volume":"38","author":"Ceylan","year":"2015","journal-title":"Arch. pharmacal. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1080\/21691401.2017.1396997","article-title":"Osteogenic and Antibacterial Properties of Vancomycin-Laden Mesoporous Bioglass\/PLGA Composite Scaffolds for Bone Regeneration in Infected Bone Defects","volume":"46","author":"Cheng","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.22203\/eCM.v024a17","article-title":"Multifunctional Surfaces With Biomimetic Nanofibres and Drug-Eluting Micro-Patterns for Infection Control and Bone Tissue Formation","volume":"24","author":"Chen","year":"2012","journal-title":"Eur. Cell Mater"},{"key":"B20","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1166\/jbn.2010.1116","article-title":"Antibacterial Efficacy of Inhalable Antibiotic-Encapsulated Biodegradable Polymeric Nanoparticles Against E. Coli Biofilm Cells","volume":"6","author":"Cheow","year":"2010","journal-title":"J. BioMed. Nanotechnol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s11095-010-0142-6","article-title":"Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Polymeric Nanoparticles Against E. Coli Biofilm Cells: The Effect of Antibiotic Release Profile","volume":"27","author":"Cheow","year":"2010","journal-title":"Pharm. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.3390\/pharmaceutics13071042","article-title":"PLGA-Based Nanoparticles for Neuroprotective Drug Delivery in Neurodegenerative Diseases","volume":"13","author":"Cunha","year":"2021","journal-title":"Pharmaceutics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.colsurfb.2015.08.027","article-title":"Overcoming Barriers in Pseudomonas Aeruginosa Lung Infections: Engineered Nanoparticles for Local Delivery of a Cationic Antimicrobial Peptide","volume":"135","author":"D'angelo","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"key":"B24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-Based Nanoparticles: An Overview of Biomedical Applications","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Controlled release"},{"key":"B25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1021\/acsabm.9b00850","article-title":"Co-Delivery of Diverse Therapeutic Compounds Using PEG\u2013PLGA Nanoparticle Cargo Against Drug-Resistant Bacteria: An Improved Anti-Biofilm Strategy","volume":"3","author":"Deepika","year":"2019","journal-title":"ACS Appl. Bio Materials"},{"key":"B26","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1021\/acsabm.9b00850","article-title":"Co-Delivery of Diverse Therapeutic Compounds Using PEG-PLGA Nanoparticle Cargo Against Drug-Resistant Bacteria: An Improved Anti-Biofilm Strategy","volume":"3","author":"Deepika","year":"2020","journal-title":"ACS Appl. Bio Mater"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-019-1576-8","article-title":"Encapsulation of Red Propolis in Polymer Nanoparticles for the Destruction of Pathogenic Biofilms","volume":"21","author":"De M\u00e9lo Silva","year":"2020","journal-title":"AAPS Pharmscitech"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.msec.2017.12.036","article-title":"Recent Advances of PLGA Micro\/Nanoparticles for the Delivery of Biomacromolecular Therapeutics","volume":"92","author":"Ding","year":"2018","journal-title":"Materials Sci. Engineering: C"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-05301-z","article-title":"Receptor-Targeted Nanoparticles Modulate Cannabinoid Anticancer Activity Through Delayed Cell Internalization","volume":"12","author":"Dur\u00e1n-Lobato","year":"2022","journal-title":"Sci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"823","DOI":"10.3390\/polym12040823","article-title":"Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications","volume":"12","author":"Duskey","year":"2020","journal-title":"Polymers"},{"key":"B31","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ejpb.2018.07.025","article-title":"Polyester-Based Particles to Overcome the Obstacles of Mucus and Biofilms in the Lung for Tobramycin Application Under Static and Dynamic Fluidic Conditions","volume":"131","author":"Ernst","year":"2018","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"B32","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ijpharm.2018.09.066","article-title":"AgCa-PLGA Submicron Particles Inhibit the Growth and Colonization of E. Faecalis and P. Gingivalis on Dentin Through Infiltration Into Dentinal Tubules","volume":"552","author":"Fan","year":"2018","journal-title":"Int. J. Pharm."},{"key":"B33","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3390\/nano8090633","article-title":"Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite","volume":"8","author":"Ficai","year":"2018","journal-title":"Nanomat. (Basel)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e050","DOI":"10.1590\/1807-3107bor-2020.vol34.0050","article-title":"Antibiofilm Efficacy of Tea Tree Oil and of its Main Component Terpinen-4-Ol Against Candida Albicans","volume":"34","author":"Francisconi","year":"2020","journal-title":"Braz. Oral. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/omi.12155","article-title":"A Bacterial-Biofilm-Induced Oral Osteolytic Infection can be Successfully Treated by Immuno-Targeting an Extracellular Nucleoid-Associated Protein","volume":"32","author":"Freire","year":"2017","journal-title":"Mol. Oral. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.3390\/ijms15033640","article-title":"An Overview of Poly(Lactic-Co-Glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering","volume":"15","author":"Gentile","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.3390\/polym13152457","article-title":"In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated With Antibiofilm Compounds","volume":"13","author":"Geremias","year":"2021","journal-title":"Polymers (Basel)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.3390\/pathogens10121638","article-title":"\u03b2-Lactam Resistance in Pseudomonas Aeruginosa: Current Status, Future Prospects","volume":"10","author":"Glen","year":"2021","journal-title":"Pathogens"},{"key":"B39","doi-asserted-by":"publisher","first-page":"5013","DOI":"10.3390\/molecules19045013","article-title":"Biocompatible Fe3O4 Increases the Efficacy of Amoxicillin Delivery Against Gram-Positive and Gram-Negative Bacteria","volume":"19","author":"Grumezescu","year":"2014","journal-title":"Molecules"},{"key":"B40","doi-asserted-by":"publisher","first-page":"035002","DOI":"10.1088\/1758-5082\/6\/3\/035002","article-title":"Usnic Acid-Loaded Biocompatible Magnetic PLGA-PVA Microsphere Thin Films Fabricated by MAPLE With Increased Resistance to Staphylococcal Colonization","volume":"6","author":"Grumezescu","year":"2014","journal-title":"Biofabrication"},{"key":"B41","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.actbio.2011.08.006","article-title":"Inkjet Printed Antibiotic- and Calcium-Eluting Bioresorbable Nanocomposite Micropatterns for Orthopedic Implants","volume":"8","author":"Gu","year":"2012","journal-title":"Acta Biomater"},{"key":"B42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jbiotec.2020.04.009","article-title":"The Battle Against Biofilm Infections: Juglone Loaded Nanoparticles as an Anticandidal Agent","volume":"316","author":"Gumus","year":"2020","journal-title":"J. Biotechnol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-021-00980-8","article-title":"Elaboration on the Architecture of pH-Sensitive Surface Charge-Adaptive Micelles With Enhanced Penetration and Bactericidal Activity in Biofilms","volume":"19","author":"Guo","year":"2021","journal-title":"J. nanobiotech."},{"key":"B44","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3109\/1061186X.2013.878944","article-title":"Inhalable Microspheres Embedding Chitosan-Coated PLGA Nanoparticles for 2-Methoxyestradiol","volume":"22","author":"Guo","year":"2014","journal-title":"J. Drug Targeting"},{"key":"B45","doi-asserted-by":"publisher","first-page":"110512","DOI":"10.1016\/j.colsurfb.2019.110512","article-title":"Enzyme-Encapsulating Polymeric Nanoparticles: A Potential Adjunctive Therapy in Pseudomonas Aeruginosa Biofilm-Associated Infection Treatment","volume":"184","author":"Han","year":"2019","journal-title":"Colloids Surfaces B: Biointerfaces"},{"key":"B46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1515\/ntrev-2016-0054","article-title":"Recent Developments in the Use of Nanoparticles for Treatment of Biofilms","volume":"6","author":"Han","year":"2017","journal-title":"Nanotech. Rev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"109741","DOI":"10.1016\/j.msec.2019.109741","article-title":"PEI\/NONOates-Doped PLGA Nanoparticles for Eradicating Methicillin-Resistant Staphylococcus Aureus Biofilm in Diabetic Wounds via Binding to the Biofilm Matrix","volume":"103","author":"Hasan","year":"2019","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1039\/C6TB03290G","article-title":"Biodegradable Nitric Oxide Precursor-Loaded Micro- and Nanoparticles for the Treatment of Staphylococcus Aureus Biofilms","volume":"5","author":"Hasan","year":"2017","journal-title":"J. Mater Chem. B"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13756-019-0504-8","article-title":"Doxycycline-Encapsulated Solid Lipid Nanoparticles as Promising Tool Against Brucella Melitensis Enclosed in Macrophage: A Pharmacodynamics Study on J774A. 1 Cell Line","volume":"8","author":"Hosseini","year":"2019","journal-title":"Antimicrobial Resistance Infection Control"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12941-019-0333-x","article-title":"Doxycycline-Encapsulated Solid Lipid Nanoparticles for the Enhanced Antibacterial Potential to Treat the Chronic Brucellosis and Preventing its Relapse: In Vivo Study","volume":"18","author":"Hosseini","year":"2019","journal-title":"Ann. Clin. Microbiol. Antimicrobials"},{"key":"B51","doi-asserted-by":"publisher","first-page":"112609","DOI":"10.1016\/j.biopha.2021.112609","article-title":"Nano Drug Delivery in Intracellular Bacterial Infection Treatments","volume":"146","author":"Hosseini","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B52","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jcis.2020.05.067","article-title":"Synthesis of Carbon Quantum Dot-Poly Lactic-Co-Glycolic Acid Hybrid Nanoparticles for Chemo-Photothermal Therapy Against Bacterial Biofilms","volume":"577","author":"Huang","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114271","article-title":"Externally Controlled Triggered-Release of Drug From PLGA Micro and Nanoparticles","volume":"9","author":"Hua","year":"2014","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"3715481","DOI":"10.1155\/2019\/3715481","article-title":"In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles Against Candida Albicans","volume":"2019","author":"Iadnut","year":"2019","journal-title":"Evid Based Complement Alternat Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.3390\/ijms12085039","article-title":"Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-Lactide-Co-Glycolide) (PLGA) Nanoparticles Against Microbial Biofilm","volume":"12","author":"Iannitelli","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.3390\/ijms12085039","article-title":"Potential Antibacterial Activity of Carvacrol-Loaded Poly (DL-Lactide-Co-Glycolide)(PLGA) Nanoparticles Against Microbial Biofilm","volume":"12","author":"Iannitelli","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1016\/S0142-9612(00)00115-0","article-title":"The Manufacturing Techniques of Various Drug Loaded Biodegradable Poly (Lactide-Co-Glycolide)(PLGA) Devices","volume":"21","author":"Jain","year":"2000","journal-title":"Biomaterials"},{"key":"B58","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1002\/jps.24298","article-title":"Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy","volume":"104","author":"Kalhapure","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.2147\/IJN.S139178","article-title":"Peptide-Modified Nanoparticles Inhibit Formation of Porphyromonas Gingivalis Biofilms With Streptococcus Gordonii","volume":"12","author":"Kalia","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"7686","DOI":"10.1021\/acsami.8b18301","article-title":"Calcium-Binding Polymer-Coated Poly (Lactide-Co-Glycolide) Microparticles for Sustained Release of Quorum Sensing Inhibitors to Prevent Biofilm Formation on Hydroxyapatite Surfaces","volume":"11","author":"Kang","year":"2019","journal-title":"ACS Appl. materials interfaces"},{"key":"B62","doi-asserted-by":"publisher","first-page":"36377","DOI":"10.1038\/srep36377","article-title":"Essential Oils and Eugenols Inhibit Biofilm Formation and the Virulence of Escherichia Coli O157:H7","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ijfoodmicro.2014.11.028","article-title":"Cinnamon Bark Oil and its Components Inhibit Biofilm Formation and Toxin Production","volume":"195","author":"Kim","year":"2015","journal-title":"Int. J. Food Microbiol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.jcis.2019.08.006","article-title":"Utilizing Nanoparticles for Improving Anti-Biofilm Effects of Azithromycin: A Head-to-Head Comparison of Modified Hyaluronic Acid Nanogels and Coated Poly (Lactic-Co-Glycolic Acid) Nanoparticles","volume":"555","author":"K\u0142odzi\u0144ska","year":"2019","journal-title":"J. colloid Interface Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s40204-020-00139-y","article-title":"Recent Advances in the Formulation of PLGA Microparticles for Controlled Drug Delivery","volume":"9","author":"Lagreca","year":"2020","journal-title":"Prog. Biomater"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.3390\/molecules22101637","article-title":"Fabrication of Antimicrobial Peptide-Loaded PLGA\/Chitosan Composite Microspheres for Long-Acting Bacterial Resistance","volume":"22","author":"Li","year":"2017","journal-title":"Molecules"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1021\/acs.bioconjchem.0c00121","article-title":"Platensimycin-Encapsulated Poly(lactic-Co-Glycolic Acid) and Poly(amidoamine) Dendrimers Nanoparticles With Enhanced Anti-Staphylococcal Activity in Vivo","volume":"31","author":"Liu","year":"2020","journal-title":"Bioconjug Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"594","DOI":"10.4161\/cbt.8.7.7790","article-title":"RNA Interference of MBD1 in BxPC-3 Human Pancreatic Cancer Cells Delivered by PLGA-Poloxamer Nanoparticles","volume":"8","author":"Luo","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e1000354","DOI":"10.1371\/journal.ppat.1000354","article-title":"Assembly and Development of the Pseudomonas Aeruginosa Biofilm Matrix","volume":"5","author":"Ma","year":"2009","journal-title":"PLoS Pathog."},{"key":"B70","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12951-018-0396-4","article-title":"BAR-Encapsulated Nanoparticles for the Inhibition and Disruption of Porphyromonas Gingivalis-Streptococcus Gordonii Biofilms","volume":"16","author":"Mahmoud","year":"2018","journal-title":"J. Nanobiotech."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00926","article-title":"Rapid Release Polymeric Fibers for Inhibition of Porphyromonas Gingivalis Adherence to Streptococcus Gordonii","volume":"7","author":"Mahmoud","year":"2019","journal-title":"Front. Chem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jconrel.2019.01.036","article-title":"Functional Assessment of Peptide-Modified PLGA Nanoparticles Against Oral Biofilms in a Murine Model of Periodontitis","volume":"297","author":"Mahmoud","year":"2019","journal-title":"J. Control Release"},{"key":"B73","doi-asserted-by":"publisher","first-page":"13775","DOI":"10.1038\/srep13775","article-title":"Bacterial Inhibition Potential of 3D Rapid-Prototyped Magnesium-Based Porous Composite Scaffolds\u2013an In Vitro Efficacy Study","volume":"5","author":"Ma","year":"2015","journal-title":"Sci. Rep."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00368","article-title":"Osteoinductivity and Antibacterial Properties of Strontium Ranelate-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres With Assembled Silver and Hydroxyapatite Nanoparticles","volume":"9","author":"Mao","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12938-020-0755-x","article-title":"In Vitro Antibacterial Activity and Cytocompatibility of Magnesium-Incorporated Poly(Lactide-Co-Glycolic Acid) Scaffolds","volume":"19","author":"Ma","year":"2020","journal-title":"BioMed. Eng. Online"},{"key":"B76","doi-asserted-by":"publisher","first-page":"015015","DOI":"10.1088\/1758-5090\/ab4053","article-title":"Integration of an Ultra-Strong Poly (Lactic-Co-Glycolic Acid)(PLGA) Knitted Mesh Into a Thermally Induced Phase Separation (TIPS) PLGA Porous Structure to Yield a Thin Biphasic Scaffold Suitable for Dermal Tissue Engineering","volume":"12","author":"Mckenna","year":"2019","journal-title":"Biofabrication"},{"key":"B77","doi-asserted-by":"publisher","first-page":"549","DOI":"10.2174\/1566524020666201203165649","article-title":"Helicobacter Pylori Biofilm and New Strategies to Combat it","volume":"21","author":"Moghadam","year":"2021","journal-title":"Curr. Mol. Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.3390\/ijms23031404","article-title":"Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases","volume":"23","author":"Mohamed","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jconrel.2020.01.028","article-title":"Polyester Based Polymeric Nano and Microparticles for Pharmaceutical Purposes: A Review on Formulation Approaches","volume":"320","author":"Molavi","year":"2020","journal-title":"J. Controlled Release"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1080\/10717544.2019.1693708","article-title":"Synthesis and Evaluation of Polymeric Micelle Containing Piperacillin\/Tazobactam for Enhanced Antibacterial Activity","volume":"26","author":"Morteza","year":"2019","journal-title":"Drug delivery"},{"key":"B81","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jconrel.2007.09.013","article-title":"Nano\/micro Technologies for Delivering Macromolecular Therapeutics Using Poly (D, L-Lactide-Co-Glycolide) and its Derivatives","volume":"125","author":"Mundargi","year":"2008","journal-title":"J. Controlled Release"},{"key":"B82","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2174\/2211738508666201214103010","article-title":"A Review on Designing Poly (Lactic-Co-Glycolic Acid) Nanoparticles as Drug Delivery Systems","volume":"9","author":"Naskar","year":"2021","journal-title":"Pharm. Nanotech."},{"key":"B83","first-page":"1","article-title":"An Introduction to Nanotechnology","volume-title":"Interface Science and Technology","author":"Nasrollahzadeh","year":"2019"},{"key":"B84","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/jbm.b.30414","article-title":"Ciprofloxacin-Releasing Bioabsorbable Polymer is Superior to Titanium in Preventing Staphylococcus Epidermidis Attachment and Biofilm Formation In Vitro","volume":"76","author":"Niemel\u00e4","year":"2006","journal-title":"J. BioMed. Mater Res. B Appl. Biomater"},{"key":"B85","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1097\/01.scs.0000231621.02888.46","article-title":"Self-Reinforced Ciprofloxacin-Releasing Polylactide-Co-Glycolide 80\/20 Inhibits Attachment and Biofilm Formation by Staphylococcus Epidermidis: An In Vitro Study","volume":"17","author":"Niemel\u00e4","year":"2006","journal-title":"J. Craniofac Surg."},{"key":"B86","doi-asserted-by":"publisher","first-page":"120807","DOI":"10.1016\/j.ijpharm.2021.120807","article-title":"PLGA-Based Nanomedicines Manufacturing: Technologies Overview and Challenges in Industrial Scale-Up","volume":"605","author":"Operti","year":"2021","journal-title":"Int. J. Pharmaceutics"},{"key":"B87","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.ijpharm.2018.08.044","article-title":"A Comparative Assessment of Continuous Production Techniques to Generate Sub-Micron Size PLGA Particles","volume":"550","author":"Operti","year":"2018","journal-title":"Int. J. pharmaceutics"},{"key":"B88","doi-asserted-by":"publisher","first-page":"100059","DOI":"10.1016\/j.bioflm.2021.100059","article-title":"SagS and its Unorthodox Contributions to Pseudomonas Aeruginosa Biofilm Development","volume":"3","author":"Park","year":"2021","journal-title":"Biofilm"},{"key":"B89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano Based Drug Delivery Systems: Recent Developments and Future Prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. nanobiotech."},{"key":"B90","doi-asserted-by":"publisher","first-page":"100047","DOI":"10.1016\/j.ijpx.2020.100047","article-title":"Bacterially Sensitive Nanoparticle-Based Dissolving Microneedles of Doxycycline for Enhanced Treatment of Bacterial Biofilm Skin Infection: A Proof of Concept Study","volume":"2","author":"Permana","year":"2020","journal-title":"Int. J. Pharm. X"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1021\/acsinfecdis.8b00091","article-title":"Terpyridine-Micelles for Inhibiting Bacterial Biofilm Development","volume":"4","author":"Qiao","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"B92","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1080\/21691401.2019.1581792","article-title":"Preparation, In Vitro Release and Antibacterial Activity Evaluation of Rifampicin and Moxifloxacin-Loaded Poly(D,L-Lactide-Co-Glycolide) Microspheres","volume":"47","author":"Qiao","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.2147\/DDDT.S105367","article-title":"Development and In Vitro Characterization of Poly(Lactide-Co-Glycolide) Microspheres Loaded With an Antibacterial Natural Drug for the Treatment of Long-Term Bacterial Infections","volume":"10","author":"Reinbold","year":"2016","journal-title":"Drug Des. Devel Ther."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.3390\/molecules22091570","article-title":"Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures","volume":"22","author":"Reinbold","year":"2017","journal-title":"Molecules"},{"key":"B95","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00248-011-9844-5","article-title":"Differential Habitat Use and Niche Partitioning by Pseudomonas Species in Human Homes","volume":"62","author":"Remold","year":"2011","journal-title":"Microbial Ecol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1007\/s40265-021-01635-6","article-title":"The Epidemiology and Pathogenesis and Treatment of Pseudomonas Aeruginosa Infections: An Update","volume":"81","author":"Reynolds","year":"2021","journal-title":"Drugs"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2001341","DOI":"10.1002\/adhm.202001341","article-title":"Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery","volume":"10","author":"Rizzo","year":"2021","journal-title":"Advanced Healthcare Materials"},{"key":"B98","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.3390\/ijms23042034","article-title":"PLGA-Based Composites for Various Biomedical Applications","volume":"23","author":"Rocha","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.idc.2008.10.001","article-title":"Coagulase-Negative Staphylococcal Infections","volume":"23","author":"Rogers","year":"2009","journal-title":"Infect. Dis. Clin. North Am."},{"key":"B100","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1099\/jmm.0.000430","article-title":"Improved Effect of Amikacin-Loaded Poly (D, L-Lactide-Co-Glycolide) Nanoparticles Against Planktonic and Biofilm Cells of Pseudomonas Aeruginosa","volume":"66","author":"Sabaeifard","year":"2017","journal-title":"J. Med. Microbiol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"747","DOI":"10.2147\/IJN.S40579","article-title":"Concepts and Practices Used to Develop Functional PLGA-Based Nanoparticulate Systems","volume":"8","author":"Sah","year":"2013","journal-title":"Int. J. nanomedicine"},{"key":"B102","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejpb.2011.03.002","article-title":"Antimicrobial PLGA Ultrafine Fibers: Interaction With Wound Bacteria","volume":"79","author":"Said","year":"2011","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.physrep.2021.07.002","article-title":"Recent Advances on the Fundamental Physical Phenomena Behind Stability, Dynamic Motion, Thermophysical Properties, Heat Transport, Applications, and Challenges of Nanofluids","volume":"946","author":"Said","year":"2022","journal-title":"Phys. Rep"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1097\/01.mlg.0000221954.05467.54","article-title":"Bacterial Biofilms on the Sinus Mucosa of Human Subjects With Chronic Rhinosinusitis","volume":"116","author":"Sanderson","year":"2006","journal-title":"Laryngoscope"},{"key":"B105","doi-asserted-by":"publisher","first-page":"936438","DOI":"10.1155\/2011\/936438","article-title":"Nanocarriers for Nitric Oxide Delivery","volume":"2011","author":"Saraiva","year":"2011","journal-title":"J. Drug delivery"},{"key":"B106","doi-asserted-by":"publisher","first-page":"104586","DOI":"10.1016\/j.archoralbio.2019.104586","article-title":"Anti-Acidogenic, Anti-Biofilm and Slow Release Properties of Dodonaea Viscosa Var. Angustifolia Flavone Stabilized Polymeric Nanoparticles","volume":"109","author":"Sebelemetja","year":"2020","journal-title":"Arch. Oral. Biol."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00381","article-title":"PLGA-Based Drug Delivery Systems for Remotely Triggered Cancer Therapeutic and Diagnostic Applications","volume":"8","author":"Shen","year":"2020","journal-title":"Front. Bioengineering Biotechnol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.3390\/molecules24112070","article-title":"Anti-Candida Biofilm Activity of Pterostilbene or Crude Extract From Non-Fermented Grape Pomace Entrapped in Biopolymeric Nanoparticles","volume":"24","author":"Simonetti","year":"2019","journal-title":"Molecules"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.3390\/antibiotics10111377","article-title":"New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing","volume":"10","author":"Simonetti","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-019-0068-3","article-title":"Targeted Therapy in Chronic Diseases Using Nanomaterial-Based Drug Delivery Vehicles","volume":"4","author":"Singh","year":"2019","journal-title":"Signal transduction targeted Ther."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.2174\/1567201818666210510165938","article-title":"Effect of Modifications in Poly (Lactide-Co-Glycolide) (PLGA) on Drug Release and Degradation Characteristics: A Mini Review","volume":"18","author":"Singh","year":"2021","journal-title":"Curr. Drug Delivery"},{"key":"B112","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/anie.200802453","article-title":"Drug Delivery by Soft Matter: Matrix and Vesicular Carriers","volume":"48","author":"Soussan","year":"2009","journal-title":"Angewandte Chemie Int. Edition"},{"key":"B113","doi-asserted-by":"publisher","first-page":"6746","DOI":"10.1128\/JB.183.23.6746-6751.2001","article-title":"Biofilms and Planktonic Cells of Pseudomonas Aeruginosa Have Similar Resistance to Killing by Antimicrobials","volume":"183","author":"Spoering","year":"2001","journal-title":"J. bacteriol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0140-6736(01)05321-1","article-title":"Antibiotic Resistance of Bacteria in Biofilms","volume":"358","author":"Stewart","year":"2001","journal-title":"Lancet"},{"key":"B115","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.actbio.2018.04.006","article-title":"Customizing Poly(Lactic-Co-Glycolic Acid) Particles for Biomedical Applications","volume":"73","author":"Swider","year":"2018","journal-title":"Acta Biomater"},{"key":"B116","first-page":"180","article-title":"Application of a Spray Drying Technique in the Production of TRH-Containing Injectable Sustained-Release Microparticles of Biodegradable Polymers","volume":"49","author":"Takada","year":"1995","journal-title":"PDA J. Pharm. Sci. Technol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.msec.2018.11.079","article-title":"Optimization of Ionic Liquid-Incorporated PLGA Nanoparticles for Treatment of Biofilm Infections","volume":"97","author":"Takahashi","year":"2019","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B118","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.msec.2016.11.051","article-title":"Visualization of Silver-Decorated Poly (DL-Lactide-Co-Glycolide) Nanoparticles and Their Efficacy Against Staphylococcus Epidermidis","volume":"72","author":"Takahashi","year":"2017","journal-title":"Mater Sci. Eng. C Mater Biol. Appl."},{"key":"B119","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/jmicro\/dfv010","article-title":"Observation of Antibacterial Effect of Biodegradable Polymeric Nanoparticles on Staphylococcus Epidermidis Biofilm Using FE-SEM With an Ionic Liquid","volume":"64","author":"Takahashi","year":"2015","journal-title":"Microscopy (Oxf)"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1021\/acsinfecdis.0c00774","article-title":"Lipid-Polymer Hybrid Nanoparticles Enhance the Potency of Ampicillin Against Enterococcus Faecalis in a Protozoa Infection Model","volume":"7","author":"Tan","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"B121","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1126\/science.321.5887.356","article-title":"The Bacteria Fight Back","volume":"321","author":"Taubes","year":"2008","journal-title":"Science"},{"key":"B122","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.ijantimicag.2016.11.023","article-title":"Screening a Repurposing Library for Potentiators of Antibiotics Against Staphylococcus Aureus Biofilms","volume":"49","author":"Van Den Driessche","year":"2017","journal-title":"Int. J. antimicrobial Agents"},{"key":"B123","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1021\/acsami.9b19644","article-title":"Ultrasmall TPGS\u2013PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics Into Pseudomonas Aeruginosa Biofilms in Lungs","volume":"12","author":"Wan","year":"2019","journal-title":"ACS Appl. materials interfaces"},{"key":"B124","doi-asserted-by":"publisher","first-page":"2002047","DOI":"10.1002\/adma.202002047","article-title":"Trends in Micro-\/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications","volume":"33","author":"Wang","year":"2021","journal-title":"Advanced Materials"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s11095-014-1299-1","article-title":"One-Step Production of Protein-Loaded PLGA Microparticles via Spray Drying Using 3-Fluid Nozzle","volume":"31","author":"Wan","year":"2014","journal-title":"Pharm. Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1021\/acsinfecdis.7b00170","article-title":"New Perspectives in Biofilm Eradication","volume":"4","author":"Wolfmeier","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"B127","doi-asserted-by":"publisher","first-page":"2005930","DOI":"10.1002\/adma.202005930","article-title":"Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases","volume":"33","author":"Won","year":"2021","journal-title":"Advanced Materials"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.3390\/antibiotics10121555","article-title":"The Role of Staphylococcus Aureus YycFG in Gene Regulation, Biofilm Organization and Drug Resistance","volume":"10","author":"Wu","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"B129","doi-asserted-by":"publisher","first-page":"20200065","DOI":"10.1002\/VIW.20200065","article-title":"Recent Development of Nanomedicine for the Treatment of Bacterial Biofilm Infections","volume":"2","author":"Xiu","year":"2021","journal-title":"View"},{"key":"B130","doi-asserted-by":"publisher","first-page":"e02022","DOI":"10.1128\/AAC.02022-18","article-title":"Synergistic Antifungal Effect of Amphotericin B-Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles and Ultrasound Against Candida Albicans Biofilms","volume":"63","author":"Yang","year":"2019","journal-title":"Antimicrobial Agents chemother."},{"key":"B131","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1021\/acsami.9b19435","article-title":"Metal-Based Nanostructures\/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications","volume":"12","author":"Zare","year":"2020","journal-title":"ACS Appl. Mater Interfaces"},{"key":"B132","doi-asserted-by":"publisher","first-page":"111560","DOI":"10.1016\/j.colsurfb.2021.111560","article-title":"Polymeric non-Spherical Coarse Microparticles Fabricated by Double Emulsion-Solvent Evaporation for Simvastatin Delivery","volume":"199","author":"Zhang","year":"2021","journal-title":"Colloids Surfaces B: Biointerfaces"},{"key":"B133","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/pharmaceutics10040263","article-title":"A Comprehensive Map of FDA-Approved Pharmaceutical Products","volume":"10","author":"Zhong","year":"2018","journal-title":"Pharmaceutics"},{"key":"B134","doi-asserted-by":"publisher","first-page":"13993","DOI":"10.1021\/la303286v","article-title":"Biodegradable Polymer (PLGA) Coatings Featuring Cinnamaldehyde and Carvacrol Mitigate Biofilm Formation","volume":"28","author":"Zodrow","year":"2012","journal-title":"Langmuir"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.926363\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:32:07Z","timestamp":1655785927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.926363\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":134,"alternative-id":["10.3389\/fcimb.2022.926363"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.926363","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,21]]},"article-number":"926363"}}