{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:01:50Z","timestamp":1784664110689,"version":"3.55.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Mycoplasma hyopneumoniae<\/jats:italic> is a highly contagious pathogen causing porcine enzootic pneumonia, which elicits prolonged inflammatory response modulated by pattern recognition receptors (PRRs). Although significant advances have been achieved in understanding the Toll-Like receptors that recognize <jats:italic>M. hyopneumoniae<\/jats:italic>, the role of nucleotide-binding oligomerization domain 1 (NOD1) in <jats:italic>M. hyopneumoniae<\/jats:italic> infected cells remains poorly understood. This study revealed that <jats:italic>M. hyopneumoniae<\/jats:italic> activates the NOD1-RIP2 pathway and is co-localized with host NOD1 during infection. siRNA knockdown of NOD1 significantly impaired the TRIF and MYD88 pathway and blocked the activation of TNF-\u03b1. In contrast, NOD1 overexpression significantly suppressed <jats:italic>M. hyopneumoniae<\/jats:italic> proliferation. Furthermore, we for the first time investigated the interaction between <jats:italic>M. hyopneumoniae<\/jats:italic> mhp390 and NOD1 receptor, and the results suggested that mhp390 and NOD1 are possibly involved in the recognition of <jats:italic>M. hyopneumoniae.<\/jats:italic> These findings may improve our understanding of the interaction between PRRs and <jats:italic>M. hyopneumoniae<\/jats:italic> and the function of NOD1 in host defense against <jats:italic>M. hyopneumoniae<\/jats:italic> infection.<\/jats:p>","DOI":"10.3389\/fcimb.2022.927840","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T06:38:53Z","timestamp":1657262333000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Mycoplasma hyopneumoniae Infection Activates the NOD1 Signaling Pathway to Modulate Inflammation"],"prefix":"10.3389","volume":"12","author":[{"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.vetimm.2013.07.004","article-title":"Mycoplasma Hyopneumoniae-Derived Lipid-Associated Membrane Proteins Induce Apoptosis in Porcine Alveolar Macrophage via Increasing Nitric Oxide Production, Oxidative Stress, and Caspase-3 Activation","volume":"155","author":"Bai","year":"2013","journal-title":"Vet. 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