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These chemical compounds can be modulated by the gut microbiota, which may affect maternal mental health during the perinatal period <jats:italic>via<\/jats:italic> the gut-brain-axis. Recent studies suggest that nutritional and dietary interventions (vitamin D, \u03c9-3 fatty acids, iron, and fiber) effectively prevent or mitigate maternal depression and anxiety, but their efficacy is confounded by various factors, including the gut microbiota. Probiotics are efficacious in maintaining microbiota homeostasis, and thus, have the potential to modulate the development of perinatal mood disorders, despite no evidence in human. Therefore, clinical trials are warranted to investigate the role of probiotic supplementation in perinatal depression and behavioral changes. This article reviews the interplay between nutrition, gut microbiota and mood and cognition, and the evidence suggesting that probiotics affect the onset and development of perinatal depression.<\/jats:p>","DOI":"10.3389\/fcimb.2022.932309","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T09:35:33Z","timestamp":1661506533000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Gut microbiota: Linking nutrition and perinatal depression"],"prefix":"10.3389","volume":"12","author":[{"given":"Jia","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongde","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.psyneuen.2017.02.014","article-title":"Probiotic treatment reduces depressive-like behaviour in rats independently of diet","volume":"79","author":"Abildgaard","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.3109\/00365529709011218","article-title":"Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status","volume":"32","author":"Addolorato","year":"1997","journal-title":"Scand J. 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