{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:55:20Z","timestamp":1788972920550,"version":"build-2803163510"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    There is increasing evidence showing that microbial dysbiosis impacts the health and cancer risk of the host. An association between adherent\u2013invasive\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (AIEC) and colorectal cancer (CRC) has been revealed. Cyclomodulins (CMs) have been receiving increasing attention for carcinogenic changes. In this study, the incidence and features of intracellular AIEC and cyclomodulin-encoding genes were investigated and the phylogenetic grouping and genetic relatedness were evaluated.\n                    <jats:italic>E. coli<\/jats:italic>\n                    strains were isolated from the colorectal biopsies. Adhesion and invasion assays and intramacrophage cell survival test were performed to separate the AIEC isolates. Virulence genotyping for the genes\n                    <jats:italic>htrA<\/jats:italic>\n                    ,\n                    <jats:italic>dsbA<\/jats:italic>\n                    ,\n                    <jats:italic>chuA<\/jats:italic>\n                    , and\n                    <jats:italic>lpfA<\/jats:italic>\n                    and the cyclomodulin toxins was also conducted. In addition, phylogenetic grouping of the isolates was determined. Subsequently, repetitive element sequence-based PCR (rep-PCR) fingerprinting was performed. A total of 24 AIEC pathovars were isolated from 150 patients. The prevalence rates of\n                    <jats:italic>htr<\/jats:italic>\n                    ,\n                    <jats:italic>dsbA<\/jats:italic>\n                    , and\n                    <jats:italic>lpfA<\/jats:italic>\n                    were 70.83% and that of\n                    <jats:italic>chuA<\/jats:italic>\n                    was 91.66%. The frequencies of the cyclomodulin toxins were as follows:\n                    <jats:italic>cnf1<\/jats:italic>\n                    , 29.2%;\n                    <jats:italic>cnf2<\/jats:italic>\n                    , 25%; colibactin, 29.2%; and\n                    <jats:italic>cdt<\/jats:italic>\n                    , 4.2%;\n                    <jats:italic>cif<\/jats:italic>\n                    was not found. Among the AIEC isolates, 4.2%, 4.2%, 54.2%, 29.2%, and 8.3% with phylotypes A or C, B1, B2, D, and E were identified, respectively. Left-sided colon carcinoma and adenocarcinoma T\u22651 stage (CRC2) were colonized by B2 phylogroup AIEC-producing CMs more often than the samples from the other groups. Close genetic relatedness was observed in AIEC isolates with rep-PCR.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.938477","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:55:06Z","timestamp":1657500906000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Phenotypicand Genotypic Characterization of Clinical Isolates of Intracellular Adherent\u2013Invasive Escherichia coli Among Different Stages, Family History, and Treated Colorectal Cancer Patients in Iran"],"prefix":"10.3389","volume":"12","author":[{"given":"Razie","family":"Kamali Dolatabadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Fazeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hassan","family":"Emami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajihe","family":"Karbasizade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Maghool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojatollah","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"104233","DOI":"10.1016\/j.micpath.2020.104233","article-title":"Virulence Determinants and Genetic Diversity of Adherent-Invasive Escherichia Coli (AIEC) Strains Isolated From Patients With Crohn's Disease","volume":"145","author":"Abdelhalim","year":"2020","journal-title":"Microbial. Pathogene."},{"key":"B2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.5114\/pg.2020.93235","article-title":"The Role of Major Virulence Factors and Pathogenicity of Adherent-Invasive Escherichia Coli in Patients With Crohn\u2019s Disease","volume":"15","author":"Abdelhalim","year":"2020","journal-title":"Przegla\u031cd. Gastroenterol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13206","article-title":"The Gut Microbiota can Orchestrate the Signaling Pathways in Colorectal Cancer","volume":"130","author":"Bennedsen","year":"2022","journal-title":"APMIS"},{"key":"B4","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1158\/1078-0432","article-title":"Colonization of the Human Gut by E. Coli and Colorectal Cancer Risk","volume":"20","author":"Bonnet","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-30055-y","article-title":"AIEC Infection Triggers Modification of Gut Microbiota Composition in Genetically Predisposed Mice, Contributing to Intestinal Inflammation","volume":"8","author":"Bretin","year":"2018","journal-title":"Sci. Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1128\/IAI.73.2.712-721.2005","article-title":"HtrA Stress Protein is Involved in Intramacrophagic Replication of Adherent and Invasive Escherichia Coli Strain LF82 Isolated From a Patient With Crohn's Disease","volume":"73","author":"Bringer","year":"2005","journal-title":"Infect. Immun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4860","DOI":"10.1128\/JB.00233-07","article-title":"The Oxidoreductase DsbA Plays a Key Role in the Ability of the Crohn's Disease-Associated Adherent-Invasive Escherichia Coli Strain LF82 to Resist Macrophage Killing","volume":"189","author":"Bringer","year":"2007","journal-title":"J. Bacteriol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056964","article-title":"High Prevalence of Mucosa-Associated E. Coli Producing Cyclomodulin and Genotoxin in Colon Cancer","volume":"8","author":"Buc","year":"2013","journal-title":"PloS One"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-64894-5","article-title":"Study of a Classification Algorithm for AIEC Identification in Geographically Distinct E. Coli Strains","volume":"10","author":"Camprub\u00ed-Font","year":"2020","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00108","article-title":"Genetic and Phenotypic Features to Screen for Putative Adherent-Invasive Escherichia Coli","volume":"10","author":"Camprub\u00ed-Font","year":"2019","journal-title":"Front. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00639","article-title":"Genetic Diversity and Virulence Determinants of Escherichia Coli Strains Isolated From Patients With Crohn's Disease in Spain and Chile","volume":"8","author":"C\u00e9spedes","year":"2017","journal-title":"Front. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1172\/JCI44632","article-title":"Crohn Disease\u2013Associated Adherent-Invasive E. Coli Bacteria Target Mouse and Human Peyer\u2019s Patches via Long Polar Fimbriae","volume":"121","author":"Chassaing","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.3390\/ijms21103734","article-title":"Adherent-Invasive E. Coli: Update on the Lifestyle of a Troublemaker in Crohn\u2019s Disease","volume":"21","author":"Chervy","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/1758-2229.12019","article-title":"The C Lermont Escherichia Coli Phylo-Typing Method Revisited: Improvement of Specificity and Detection of New Phylo-Groups","volume":"5","author":"Clermont","year":"2013","journal-title":"Environ. Microbiol. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/S1470-2045(10)70186-8","article-title":"Microbial and Viral Pathogens in Colorectal Cancer","volume":"12","author":"Collins","year":"2011","journal-title":"Lancet Oncol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nrmicro2265","article-title":"Molecular Mechanisms of Escherichia Coli Pathogenicity","volume":"8","author":"Croxen","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1128\/CMR.00022-13","article-title":"Recent Advances in Understanding Enteric Pathogenic Escherichia Coli","volume":"26","author":"Croxen","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"11537","DOI":"10.1073\/pnas.1001261107","article-title":"Escherichia Coli Induces DNA Damage In Vivo and Triggers Genomic Instability in Mammalian Cells","volume":"107","author":"Cuevas-Ramos","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2180-4-18","article-title":"In Vitro Adhesion and Invasion Inhibition of Shigella Dysenteriae, Shigella Flexneri and Shigella Sonnei Clinical Strains by Human Milk Proteins","volume":"4","author":"da Motta Willer","year":"2004","journal-title":"BMC Microbiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-021-00383-w","article-title":"Host\/microbiota Interactions in Health and Diseases\u2014Time for Mucosal Microbiology","volume":"14","author":"Daniel","year":"2021","journal-title":"Mucosal Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1053\/j.gastro.2004.04.061","article-title":"High Prevalence of Adherent-Invasive Escherichia Coli Associated With Ileal Mucosa in Crohn\u2019s Disease","volume":"127","author":"Darfeuille-Michaud","year":"2004","journal-title":"Gastroenterology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1854641","article-title":"Microbiome Distinctions Between the CRC Carcinogenic Pathways","volume":"13","author":"DeDecker","year":"2021","journal-title":"Gut. Microbes"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1097\/MIB.0000000000000183","article-title":"Inflammation-Associated Adherent-Invasive Escherichia Coli Are Enriched in Pathways for Use of Propanediol and Iron and M-Cell Translocation","volume":"20","author":"Dogan","year":"2014","journal-title":"Inflamm. Bowel. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/jso.24578","article-title":"Colorectal Cancer\u2014Global Burden, Trends, and Geographical Variations","volume":"115","author":"Douaiher","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"B25","volume-title":"AJCC Cancer Staging Manual","author":"Edition","year":"2017"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023594","article-title":"Interactions With M Cells and Macrophages as Key Steps in the Pathogenesis of Enterohemorragic Escherichia Coli Infections","volume":"6","author":"Etienne-Mesmin","year":"2011","journal-title":"PloS One"},{"key":"B27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jare.2020.03.001","article-title":"Colorectal Cancer Screening: Assessment of CEACAM6, LGALS4, TSPAN8 and COL1A2 as Blood Markers in Faecal Immunochemical Test Negative Subjects","volume":"24","author":"Ferlizza","year":"2020","journal-title":"J. Adv. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1067\/msy.2002.119816","article-title":"Comparison of Microsatellite Instability and Chromosomal Instability in Predicting Survival of Patients With T3N0 Colorectal Cancer","volume":"131","author":"Gervaz","year":"2002","journal-title":"Surgery"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1128\/IAI.69.9.5529-5537.2001","article-title":"Adherent Invasive Escherichia Coli Strains From Patients With Crohn's Disease Survive and Replicate Within Macrophages Without Inducing Host Cell Death","volume":"69","author":"Glasser","year":"2001","journal-title":"Infect. Immun."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0337","article-title":"Hifts in the Fecal Microbiota Associated With Adenomatous Polyps","volume":"26","author":"Hale","year":"2017","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1172-4-22","article-title":"Familial Adenomatous Polyposis","volume":"4","author":"Half","year":"2009","journal-title":"Orphanet. J. Rare. Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2407-10-688","article-title":"Tumor Location and Patient Characteristics of Colon and Rectal Adenocarcinomas in Relation to Survival and TNM Classes","volume":"10","author":"Hemminki","year":"2010","journal-title":"BMC Cancer."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-015-0703-0","article-title":"GelJ\u2013a Tool for Analyzing DNA Fingerprint Gel Images","volume":"16","author":"Heras","year":"2015","journal-title":"BMC Bioinf."},{"key":"B34","first-page":"13","article-title":"The Comparison of Genucom and KT-1000 in the Measurement of Anterior-Posterior Displacement of the Knee","volume":"1","author":"Hsu","year":"1993","journal-title":"J. Orthopaedic. Surge."},{"key":"B35","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1111\/joim.13171","article-title":"Aspects of Colorectal Cancer Screening, Methods, Age and Gender","volume":"289","author":"Hultcrantz","year":"2021","journal-title":"J. Internal Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1128\/IAI.06181-11","article-title":"Microevolution in fimH Gene of Mucosa-Associated Escherichia Coli Strains Isolated From Pediatric Patients With Inflammatory Bowel Disease","volume":"80","author":"Iebba","year":"2012","journal-title":"Infect. Immun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/cas.15196","article-title":"Association of Escherichia Coli Containing Polyketide Synthase in the Gut Microbiota With Colorectal Neoplasia in Japan","volume":"113","author":"Iwasaki","year":"2022","journal-title":"Cancer Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1200\/JCO.2003.55.135","article-title":"Expression of CEACAM6 in Resectable Colorectal Cancer: A Factor of Independent Prognostic Significance","volume":"21","author":"Jantscheff","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.730243","article-title":"The Prevalence of Adherent-Invasive Escherichia Coli and Its Association With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis","volume":"8","author":"Kamali Dolatabadi","year":"2021","journal-title":"Front. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Nature Reviews. Microbiology","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10661-020-08635-1","article-title":"Genotypic Diversity in Multi-Drug-Resistant E. Coli Isolated From Animal Feces and Yamuna River Water, India, Using Rep-PCR Fingerprinting","volume":"192","author":"Khare","year":"2020","journal-title":"Environ. Monit. Assessment."},{"key":"B42","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3816\/CCC.2007.n.002","article-title":"Hereditary Colorectal Cancer Syndromes: An Overview","volume":"6","author":"Kwak","year":"2007","journal-title":"Clin. Colorectal. Cancer."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216165","article-title":"Characteristics and Pathogenic Role of Adherent-Invasive Escherichia Coli in Inflammatory Bowel Disease: Potential Impact on Clinical Outcomes","volume":"14","author":"Lee","year":"2019","journal-title":"PloS One"},{"key":"B44","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/nm.2143","article-title":"ERK Activation Drives Intestinal Tumorigenesis in Apcmin\/+ Mice","volume":"16","author":"Lee","year":"2010","journal-title":"Nat. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-med-080719-091604","article-title":"Microbiota Effects on Carcinogenesis: Initiation, Promotion, and Progression","volume":"72","author":"Lopez","year":"2021","journal-title":"Annu. Rev. Med."},{"key":"B46","volume-title":"Textbook of Diagnostic Microbiology-E-Book","author":"Mahon","year":"2018"},{"key":"B47","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.vetmic.2022.109337","article-title":"Characterization of Genotoxin-Encoding Escherichia Coli Isolated From Specific-Pathogen Free Cats With Impaired Fertility","volume":"1","author":"Mannion","year":"2022","journal-title":"Vet. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1053\/j.gastro.2004.03.054","article-title":"Enhanced Escherichia Coli Adherence and Invasion in Crohn\u2019s Disease and Colon Cancer","volume":"127","author":"Martin","year":"2004","journal-title":"Gastroenterology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4291\/wjgp.v5.i3.213","article-title":"Escherichia Coli in Chronic Inflammatory Bowel Diseases: An Update on Adherent Invasive Escherichia Coli Pathogenicity","volume":"5","author":"Martinez-Medina","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1001\/jamaoncol.2021.1364","article-title":"Association of Screening Lower Endoscopy With Colorectal Cancer Incidence and Mortality in Adults Older Than 75 Years","volume":"7","author":"Ma","year":"2021","journal-title":"JAMA Oncol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.1073\/pnas.1011602108","article-title":"Evolution of the Knowledge System for Agricultural Development in the Yaqui Valley, Sonora, Mexico","volume":"113","author":"McCullough","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2021.054","article-title":"Which Bacterial Toxins are Worthy of Validation as Markers in Colorectal Cancer Screening","author":"Mezerova","year":"2022","journal-title":"A. Crit. Rev."},{"key":"B53","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1126\/science.1127059","article-title":"Escherichia Coli Induces DNA Double-Strand Breaks in Eukaryotic Cells","volume":"313","author":"Nougayr\u00e8de","year":"2006","journal-title":"Science"},{"key":"B54","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The Toll-Like Receptor Pathway Establishes Commensal Gut Colonization","volume":"332","author":"Round","year":"2011","journal-title":"Sci. (New. York. NY)."},{"key":"B55","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/ibd.20818","article-title":"Dominant Genotypes in Mucosa-Associated Escherichia Coli Strains From Pediatric Patients With Inflammatory Bowel Disease","volume":"15","author":"Schippa","year":"2009","journal-title":"Inflamm. Bowel. Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejca.2017.07.016","article-title":"Understanding the Role of Primary Tumour Localisation in Colorectal Cancer Treatment and Outcomes","volume":"84","author":"Stintzing","year":"2017","journal-title":"Eur. J. Cancer."},{"key":"B57","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0016-5085(98)70194-5","article-title":"Association Between Intraepithelial Escherichia Coli and Colorectal Cancer","volume":"115","author":"Swidsinski","year":"1998","journal-title":"Gastroenterology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrmicro2298","article-title":"The Population Genetics of Commensal Escherichia Coli","volume":"8","author":"Tenaillon","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1113\/jphysiol.2009.174136","article-title":"The Core Gut Microbiome, Energy Balance and Obesity","volume":"587","author":"Turnbaugh","year":"2009","journal-title":"J. Physiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1097\/MIB.0000000000000609","article-title":"GipA Factor Supports Colonization of Peyer's Patches by Crohn's Disease-Associated Escherichia Coli","volume":"22","author":"Vazeille","year":"2016","journal-title":"Inflamm. Bowel. Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4103\/IJPM.IJPM_1398_20","article-title":"Evaluation of Microsatellite Instability in Routine Examinations of Surgical Samples","volume":"65","author":"Wlaszczuk","year":"2022","journal-title":"Indian J. Pathol. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3760\/cma.j.issn.0376-2491.2016.12.010","article-title":"Expression of Enterotoxigenic Bacteroides Fragilis and Polyketide Synthase Gene-Expressing Escherichia Coli in Colorectal Adenoma Patients","volume":"96","author":"Xie","year":"2016","journal-title":"Zhonghua. yi. xue. za. zhi."},{"key":"B63","doi-asserted-by":"publisher","first-page":"101174","DOI":"10.1016\/j.tranon.2021.101174","article-title":"Global Colorectal Cancer Burden in 2020 and Projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Trans. Oncol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nature25500","article-title":"C-MAF-Dependent Regulatory T Cells Mediate Immunological Tolerance to a Gut Pathobiont","volume":"554","author":"Xu","year":"2018","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"848","DOI":"10.7150\/ijbs.53657","article-title":"CD151 Promotes Colorectal Cancer Progression by a Crosstalk Involving CEACAM6, LGR5 and Wnt Signaling via Tgf\u03b21","volume":"17","author":"Yang","year":"2021","journal-title":"Int. J. Biol. Sci."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.938477\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:55:21Z","timestamp":1657500921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.938477\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":65,"alternative-id":["10.3389\/fcimb.2022.938477"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.938477","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"article-number":"938477"}}