{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:04:19Z","timestamp":1792649059185,"version":"4.5.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    The prevalence of\n                    <jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic>\n                    infection has exceeded 50% worldwide, and it is considered a high-risk factor for chronic gastritis, peptic ulcer, gastric adenocarcinoma, gastroesophageal reflux disease and functional dyspepsia.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    drug resistance is a common problem worldwide. In recent years, the relationship between\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection and gastrointestinal microecology has received much attention.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection changes the structure and composition of gastrointestinal microflora by regulating the gastrointestinal microecological environment, local pH value, cytokines and antimicrobial peptides, and immune response and then plays a crucial role in the occurrence and development of digestive system tumors, liver metabolism and extragastrointestinal diseases. The quadruple strategy of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication can also aggravate gastrointestinal microflora disorder. However, probiotics can reduce intestinal flora changes and imbalances through different mechanisms, thus enhancing the efficacy of\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication therapy and reducing adverse reactions caused by eradication therapy. Therefore, this paper reviews the relationship between\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection and gastrointestinal microecology and its clinical application, providing a basis for clinical treatment.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.938608","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T01:26:13Z","timestamp":1660785973000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":79,"title":["Relationship between Helicobacter pylori infection and gastrointestinal microecology"],"prefix":"10.3389","volume":"12","author":[{"given":"Wenting","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengfu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3748\/wjg.v28.i4.402","article-title":"Helicobacter pylori infection: How does age influence the inflammatory pattern","volume":"28","author":"Araujo","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00535-013-0897-8","article-title":"Roadmap to eliminate gastric cancer with helicobacter pylori eradication and consecutive surveillance in Japan","volume":"49","author":"Asaka","year":"2014","journal-title":"J. Gastroenterol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s12866-021-02315-x","article-title":"Interplay and cooperation of helicobacter pylori and gut microbiota in gastric carcinogenesis","volume":"21","author":"Bakhti","year":"2021","journal-title":"BMC Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"7535","DOI":"10.2147\/IJN.S337427","article-title":"Advancements in the pharmaceutical applications of probiotics: Dosage forms and formulation technology","volume":"16","author":"Baral","year":"2021","journal-title":"Int. J. Nanomed"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/j.jaci.2019.10.022","article-title":"The role of the changing human microbiome in the asthma pandemic","volume":"144","author":"Borbet","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.gastre.2019.01.021","article-title":"Clostridium difficile infection associated with bismuth-based quadruple therapy (Pylera((R))) for helicobacter pylori eradication","volume":"42","author":"Castro-Fernandez","year":"2019","journal-title":"Gastroenterol Y Hepatol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.2174\/1389201020666190227203107","article-title":"Role of probiotics in prophylaxis of helicobacter pylori infection","volume":"20","author":"Chakravarty","year":"2019","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12857","article-title":"The efficacy of lactobacillus acidophilus and rhamnosus in the reduction of bacterial load of helicobacter pylori and modification of gut microbiota-a double-blind, placebo-controlled, randomized trial","volume":"26","author":"Chen","year":"2021","journal-title":"Helicobacter"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1909459","article-title":"The interplay between helicobacter pylori and gastrointestinal microbiota","volume":"13","author":"Chen","year":"2021","journal-title":"Gut Microbes"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2502","DOI":"10.3390\/microorganisms9122502","article-title":"An overview of helicobacter pylori survival tactics in the hostile human stomach environment","volume":"9","author":"Cheok","year":"2021","journal-title":"Microorganisms"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218274","article-title":"Exploring the impact of helicobacter pylori on gut microbiome composition","volume":"14","author":"Dash","year":"2019","journal-title":"PloS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"117","DOI":"10.23736\/S1121-421X.19.02651-5","article-title":"Impact of a two-bacterial-strain formula, containing bifidobacterium animalis lactis BB-12 and enterococcus faecium L3, administered before and after therapy for helicobacter pylori eradication","volume":"66","author":"Di Pierro","year":"2020","journal-title":"Minerva Gastroenterol  Dietol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"S129","DOI":"10.1093\/cid\/civ085","article-title":"Risk and safety of probiotics","author":"Doron","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.3390\/microorganisms9071361","article-title":"Helicobacter pylori-related metabolic parameters and premalignant gastric mucosa histological lesions in Swiss bariatric patients","volume":"9","author":"Doulberis","year":"2021","journal-title":"Microorganisms"},{"key":"B16","doi-asserted-by":"publisher","first-page":"6263423","DOI":"10.1155\/2022\/6263423","article-title":"Role of gastric microorganisms other than helicobacter pylori in the development and treatment of gastric diseases","volume":"2022","author":"Duan","year":"2022","journal-title":"BioMed. Res. Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s10620-020-06101-z","article-title":"Microbiome and gastric cancer","volume":"65","author":"Engstrand","year":"2020","journal-title":"Digest Dis. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3390\/nu14081642","article-title":"Bacillus licheniformis reshapes the gut microbiota to alleviate the subhealth","volume":"14","author":"Feng","year":"2022","journal-title":"Nutrients"},{"key":"B19","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/gutjnl-2017-314205","article-title":"Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota","volume":"67","author":"Ferreira","year":"2018","journal-title":"Gut"},{"key":"B20","doi-asserted-by":"publisher","first-page":"8040","DOI":"10.3748\/wjg.v27.i47.8040","article-title":"Progress in elucidating the relationship between helicobacter pylori infection and intestinal diseases","volume":"27","author":"Fujimori","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"B21","first-page":"686","article-title":"Advances in Study of Probiotics in Treatment of Helicobacter pylori Infection","volume":"17","author":"Ge","year":"2012","journal-title":"Chinese journal of gastroenterology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/j.1365-2036.2006.02868.x","article-title":"Systematic review: are probiotics useful in controlling gastric colonization by helicobacter pylori","volume":"23","author":"Gotteland","year":"2006","journal-title":"Alimentary Pharmacol. Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.3390\/nu13093171","article-title":"A randomised, controlled trial: Effect of a multi-strain fermented milk on the gut microbiota recovery after helicobacter pylori therapy","volume":"13","author":"Guillemard","year":"2021","journal-title":"Nutrients"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1136\/gutjnl-2019-319696","article-title":"Effect of helicobacter pylori on gastrointestinal microbiota: a population-based study in linqu, a high-risk area of gastric cancer","volume":"69","author":"Guo","year":"2020","journal-title":"Gut"},{"key":"B25","doi-asserted-by":"publisher","first-page":"8607671","DOI":"10.1155\/2022\/8607671","article-title":"Effect of probiotic-assisted eradication of cagA+\/vacA s1m1 helicobacter pylori on intestinal flora","volume":"2022","author":"He","year":"2022","journal-title":"BioMed. Res. Int."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12590","article-title":"The eradication of helicobacter pylori restores rather than disturbs the gastrointestinal microbiota in asymptomatic young adults","volume":"24","author":"He","year":"2019","journal-title":"Helicobacter"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.881968","article-title":"Altered gut microbiota and short-chain fatty acids after vonoprazan-amoxicillin dual therapy for helicobacter pylori eradication","volume":"12","author":"Hu","year":"2022","journal-title":"Front. Cell. Infect Microbiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"6224","DOI":"10.3748\/wjg.v27.i37.6224","article-title":"Impact of helicobacter pylori infection on gut microbiota","volume":"27","author":"Iino","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/19490976.2019.1592421","article-title":"Gut bacteria signaling to mitochondria in intestinal inflammation and cancer","volume":"11","author":"Jackson","year":"2020","journal-title":"Gut Microbes"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009836","article-title":"Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome","volume":"5","author":"Jakobsson","year":"2010","journal-title":"PloS One"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.687259","article-title":"Whole-Genome-Based helicobacter pylori geographic surveillance: A visualized and expandable webtool","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-023131","article-title":"Efficacy of compound lactobacillus acidophilus tablets combined with quadruple therapy for helicobacter pylori eradication and its correlation with pH value in the stomach: a study protocol of a randomised, assessor-blinded, single-centre study","volume":"8","author":"Ji","year":"2018","journal-title":"BMJ Open"},{"key":"B33","doi-asserted-by":"publisher","first-page":"830","DOI":"10.2174\/1389200221666200514081442","article-title":"Role of genetic polymorphisms of cytochrome P450 2C19 in pantoprazole metabolism and pantoprazole-based helicobacter pylori eradication regimens","volume":"21","author":"Jonaitis","year":"2020","journal-title":"Curr. Drug Metab."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047941","article-title":"Helicobacter pylori infection-induced changes in the intestinal microbiota of 14-year-old or 15-year-old Japanese adolescents: a cross-sectional study","volume":"11","author":"Kakiuchi","year":"2021","journal-title":"BMJ Open"},{"key":"B35","doi-asserted-by":"publisher","first-page":"100904","DOI":"10.1016\/j.nmni.2021.100904","article-title":"Rescue effects of lactobacillus-containing bismuth regimens after helicobacter pylori treatment failure","volume":"42","author":"Karbalaei","year":"2021","journal-title":"New Microbes New Infect"},{"key":"B36","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1186\/s12876-021-01977-1","article-title":"Probiotics as the live microscopic fighters against helicobacter pylori gastric infections","volume":"21","author":"Keikha","year":"2021","journal-title":"BMC Gastroenterol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1038\/s41395-018-0138-0","article-title":"Probiotics in gastroenterology: How pro is the evidence in adults","volume":"113","author":"Koretz","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.jmii.2021.03.006","article-title":"Multidrug resistance: The clinical dilemma of refractory helicobacter pylori infection","volume":"54","author":"Kuo","year":"2021","journal-title":"J. Microbiol Immunol Infect"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12854","article-title":"Helicobacter pylori and the intestinal microbiome among healthy school-age children","volume":"26","author":"Lapidot","year":"2021","journal-title":"Helicobacter"},{"key":"B40","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1080\/14737159.2021.1952075","article-title":"Impact of non-antibiotic drugs on the human intestinal microbiome","volume":"21","author":"Le Bastard","year":"2021","journal-title":"Expert Rev. Mol. Diagn"},{"key":"B41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s42826-020-00073-x","article-title":"Anti-helicobacter pylori activity of acomplex mixture of lactobacillus paracasei HP7 including the extract of perilla frutescens var. acuta and glycyrrhiza glabra","volume":"36","author":"Lee","year":"2020","journal-title":"Lab. Anim. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/j.1440-1746.2009.06127.x","article-title":"Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in helicobacter pylori infection: a novel mechanism","volume":"25","author":"Lee","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"716","DOI":"10.3390\/metabo11110716","article-title":"Gut microbiota, microbial metabolites and human physical performance","volume":"11","author":"Lensu","year":"2021","journal-title":"Metabolites"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.3390\/foods11091235","article-title":"Antibacterial effects of bacteriocin PLNC8 against helicobacter pylori and its potential mechanism of action","volume":"11","author":"Liang","year":"2022","journal-title":"Foods"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1136\/gutjnl-2020-322368","article-title":"Screening and eradication of helicobacter pylori for gastric cancer prevention: the Taipei global consensus","volume":"69","author":"Liou","year":"2020","journal-title":"Gut"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.749207","article-title":"Gastrointestinal microbiota changes in patients with gastric precancerous lesions","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Cell. Infect Microbiol."},{"key":"B47","first-page":"241","article-title":"Advances in study on effects of Helicobacter pylori eradication therapy on intestinal microecology","volume":"22","author":"Li","year":"2017","journal-title":"Chinese journal of gastroenterology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"118200","DOI":"10.1016\/j.lfs.2020.118200","article-title":"Effects of choline supplementation on liver biology, gut microbiota, and inflammation in helicobacter pylori-infected mice","volume":"259","author":"Li","year":"2020","journal-title":"Life Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1097\/INF.0000000000001383","article-title":"Characterization of the gastric microbiota in a pediatric population according to helicobacter pylori status","volume":"36","author":"Llorca","year":"2017","journal-title":"Pediatr. Infect. Dis. J."},{"key":"B50","first-page":"85","article-title":"Application progress of common probiotics in Helicobacter pylori infection","volume":"23","author":"Lu","year":"2022","journal-title":"J Chronic Pathematology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000519602","article-title":"Epidemiological review of gastroesophageal junction adenocarcinoma in Asian countries","volume":"103","author":"Manabe","year":"2022","journal-title":"Digestion"},{"key":"B52","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.3390\/jcm10153258","article-title":"Gastric microenvironment-a partnership between innate immunity and gastric microbiota tricks helicobacter pylori","volume":"10","author":"Marginean","year":"2021","journal-title":"J. Clin. Med."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.712908","article-title":"Helicobacter pylori eradication therapy affect the gut microbiota and ghrelin levels","volume":"8","author":"Martin-Nunez","year":"2021","journal-title":"Front. Med."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00417","article-title":"H. pylori eradication treatment causes alterations in the gut microbiota and blood lipid levels","volume":"7","author":"Martin-Nunez","year":"2020","journal-title":"Front. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1136\/gutjnl-2021-324032","article-title":"Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community","volume":"70","author":"Megraud","year":"2021","journal-title":"Gut"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.14309\/ajg.0000000000001246","article-title":"Adverse event profile during the treatment of helicobacter pylori: A real-world experience of 22,000 patients from the European registry on h. pylori management (Hp-EuReg)","volume":"116","author":"Nyssen","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/jgh.15751","article-title":"Prevalence of helicobacter pylori infection in China: A systematic review and meta-analysis","volume":"37","author":"Ren","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01690","article-title":"Bacterial proteinaceous compounds with multiple activities toward cancers and microbial infection","volume":"10","author":"Rodrigues","year":"2019","journal-title":"Front. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1365-3083.2008.02138.x","article-title":"Effect of specific colostral antibodies and selected lactobacilli on the adhesion of helicobacter pylori on AGS cells and the helicobacter-induced IL-8 production","volume":"68","author":"Rokka","year":"2008","journal-title":"Scandinavian J. Immunol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a027953","article-title":"Targeting the mucosal barrier: How pathogens modulate the cellular polarity network","volume":"9","author":"Ruch","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12029-021-00630-0","article-title":"Helicobacter pylori infection mass screening for children and adolescents: a systematic review of observational studies","volume":"52","author":"Saito","year":"2021","journal-title":"J. Gastrointestinal Cancer"},{"key":"B62","doi-asserted-by":"publisher","first-page":"4076","DOI":"10.3748\/wjg.v26.i28.4076","article-title":"Helicobacter pylori infection: Beyond gastric manifestations","volume":"26","author":"Santos","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"B63","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12964-020-00655-1","article-title":"H. pylori modulates DC functions via T4SS\/TNFalpha\/p38-dependent SOCS3 expression","volume":"18","author":"Sarajlic","year":"2020","journal-title":"Cell Commun Signaling"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.571731","article-title":"Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes","volume":"11","author":"Scheithauer","year":"2020","journal-title":"Front. Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4070419","DOI":"10.1155\/2020\/4070419","article-title":"Molecular mechanisms contributing bacterial infections to the incidence of various types of cancer","volume":"2020","author":"Sheweita","year":"2020","journal-title":"Mediators Inflammation"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.3892\/etm.2019.7742","article-title":"Probiotic effect on helicobacter pylori attachment and inhibition of inflammation in human gastric epithelial cells","volume":"18","author":"Song","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1080\/19490976.2020.1762520","article-title":"The role of gastric microbiota in gastric cancer","volume":"11","author":"Stewart","year":"2020","journal-title":"Gut Microbes"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1136\/gutjnl-2019-319826","article-title":"Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after helicobacter pylori eradication","volume":"69","author":"Sung","year":"2020","journal-title":"Gut"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12851","article-title":"Long term impact of vonoprazan-based helicobacter pylori treatment on gut microbiota and its relation to post-treatment body weight changes","volume":"26","author":"Suzuki","year":"2021","journal-title":"Helicobacter"},{"key":"B70","doi-asserted-by":"publisher","first-page":"7490452","DOI":"10.1155\/2016\/7490452","article-title":"Effects of lactobacillus gasseri OLL2716 on helicobacter pylori-associated dyspepsia: A multicenter randomized double-blind controlled trial","volume":"2016","author":"Takagi","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"B71","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/s13577-017-0172-z","article-title":"Lactobacillus paracasei strain 06TCa19 suppresses inflammatory chemokine induced by helicobacter pylori in human gastric epithelial cells","volume":"30","author":"Takeda","year":"2017","journal-title":"Hum. Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1136\/annrheumdis-2021-221267","article-title":"Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease","volume":"81","author":"Tomofuji","year":"2022","journal-title":"Ann. Rheumatic Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S0140-6736(83)92719-8","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren","year":"1983","journal-title":"Lancet"},{"key":"B74","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s10620-021-06857-y","article-title":"Effects of proton pump inhibitors on the small bowel and stool microbiomes","volume":"67","author":"Weitsman","year":"2022","journal-title":"Digest Dis. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"101358","DOI":"10.1016\/j.psj.2021.101358","article-title":"Effects of bacillus subtilis and bacillus licheniformis on growth performance, immunity, short chain fatty acid production, antioxidant capacity, and cecal microflora in broilers","volume":"100","author":"Xu","year":"2021","journal-title":"Poultry Sci."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12502","article-title":"The \u201cthree-in-one\u201d formulation of bismuth quadruple therapy for helicobacter pylori eradication with or without probiotics supplementation: Efficacy and safety in daily clinical practice","volume":"23","author":"Zagari","year":"2018","journal-title":"Helicobacter"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-022-00591-0","article-title":"The immune microenvironment in gastric adenocarcinoma","volume":"19","author":"Zavros","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3892\/mmr.2020.11138","article-title":"Saccharomyces boulardii modulates necrotizing enterocolitis in neonatal mice by regulating the sirtuin 1\/NFkappaB pathway and the intestinal microbiota","volume":"22","author":"Zhang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12809","article-title":"Long-term changes in the gut microbiota after triple therapy, sequential therapy, bismuth quadruple therapy and concomitant therapy for helicobacter pylori eradication in Chinese children","volume":"26","author":"Zhou","year":"2021","journal-title":"Helicobacter"},{"key":"B80","doi-asserted-by":"publisher","first-page":"100474","DOI":"10.1016\/j.animal.2022.100474","article-title":"Bacillus subtilis inhibits intestinal inflammation and oxidative stress by regulating gut flora and related metabolites in laying hens","volume":"16","author":"Zou","year":"2022","journal-title":"Int. J. Anim. Biosci"},{"key":"B81","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000508330","article-title":"The protective effects of helicobacter pylori infection on allergic asthma","volume":"182","author":"Zuo","year":"2021","journal-title":"Int. Arch. Allergy Immunol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.938608\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T01:26:19Z","timestamp":1660785979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.938608\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":81,"alternative-id":["10.3389\/fcimb.2022.938608"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.938608","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,18]]},"article-number":"938608"}}