{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:50:05Z","timestamp":1777503005561,"version":"3.51.4"},"reference-count":130,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>The genus Flavivirus of the <jats:italic>Flaviviridae<\/jats:italic> family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic cells synthesize small RNA molecules that can bind specifically to sequences present in messenger RNAs to inhibit the translation process, thus regulating gene expression. These small RNAs have been named microRNAs, and they have an important impact on viral infections. In this review, we compiled the available information on miRNAs that can interact with the 3\u2019 untranslated region (3\u2019UTR) of the flavivirus genome, a conserved region that is important for viral replication and translation.<\/jats:p>","DOI":"10.3389\/fcimb.2022.976843","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T06:31:47Z","timestamp":1665642707000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Interactions of host miRNAs in the flavivirus 3\u00b4UTR genome: From bioinformatics predictions to practical approaches"],"prefix":"10.3389","volume":"12","author":[{"given":"Rodolfo Gamaliel","family":"Avila-Bonilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Santiago","family":"Salas-Benito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02050","article-title":"Aedes aegypti molecular responses to zika virus: Modulation of infection by the toll and Jak\/Stat immune pathways and virus host factors","volume":"8","author":"Angler\u00f3-Rodr\u00edguez","year":"2017","journal-title":"Front. 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