{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:33Z","timestamp":1790140413754,"version":"4.0.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    In order to evaluate the potential and safety of lactic acid bacteria (LAB) isolated from faeces samples of Ganan yak as probiotic for prevention and\/or treatment of yak diarrhea, four strains of LAB including\n                    <jats:italic>Latilactobacillus curvatus<\/jats:italic>\n                    (FY1), Weissella cibaria\u00a0(FY2),\n                    <jats:italic>Limosilactobacillus mucosae<\/jats:italic>\n                    (FY3), and\n                    <jats:italic>Lactiplantibacillus pentosus<\/jats:italic>\n                    (FY4) were isolated and identified in this study. Cell surface characteristics (hydrophobicity and cell aggregation), acid resistance and bile tolerance, compatibility, antibacterial activity and\n                    <jats:italic>in vitro<\/jats:italic>\n                    cell adhesion tests were also carried out to evaluate the probiotic potential of LAB. The results showed that the four isolates had certain acid tolerance, bile salt tolerance, hydrophobicity and cell aggregation, all of which contribute to the survival and colonization of LAB in the gastrointestinal tract. There is no compatibility between the four strains, so they can be combined into a mixed probiotic formula. Antimicrobial tests showed that the four strains were antagonistic to\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , and\n                    <jats:italic>Salmonella typhimurium<\/jats:italic>\n                    . Moreover, the\n                    <jats:italic>in vitro<\/jats:italic>\n                    safety of the four isolates were determined through hemolytic analysis, gelatinase activity, and antibacterial susceptibility experiments. The results suggest that all the four strains were considered as safe because they had no hemolytic activity, no gelatinase activity and were sensitive to most antibacterial agents. Moreover, the acute oral toxicity test of LAB had no adverse effect on body weight gain, food\u00a0utilization\u00a0and organ indices in Kunming mice. In conclusion, the four LAB isolated from yak feces have considerable potential to prevent and\/or treat yak bacterial disease-related diarrhea.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2022.984537","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T02:05:18Z","timestamp":1663293918000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["In vitro investigation on lactic\u00a0acid\u00a0bacteria\u00a0isolatedfrom Yak faeces for potential probiotics"],"prefix":"10.3389","volume":"12","author":[{"given":"Qingli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/su12031087","article-title":"Probiotics in animal husbandry: Applicability and associated risk factors","volume":"12","author":"Alayande","year":"2020","journal-title":"Sustainability"},{"key":"B2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1093\/gbe\/evv247","article-title":"Genomic and functional characterization of the unusual plock 0919 plasmid harboring the spacba pili cluster in lactobacillus casei lock 0919","volume":"8","author":"Aleksandrzak-Piekarczyk","year":"2015","journal-title":"Genome Biol. Evol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02220","article-title":"Safety and growth optimization of lactic acid bacteria isolated from feedlot cattle for probiotic formula design","volume":"9","author":"Aristimuno Ficoseco","year":"2018","journal-title":"Front. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12602-016-9209-y","article-title":"Importance of molecular methods to determine whether a probiotic is the source of lactobacillus bacteremia","volume":"8","author":"Aroutcheva","year":"2016","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.21315\/tlsr2017.28.2.8","article-title":"Lactococcus lactis strain a5 producing nisin-like bacteriocin active against gram positive and negative bacteria","volume":"28","author":"Azhar","year":"2017","journal-title":"Trop. Life Sci. Res."},{"key":"B6","unstructured":"TCSWSL016-2019 screening criteria of lactic acid bacteria for feeding aquatic animals2019"},{"key":"B7","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1007\/s12602-020-09649-4","article-title":"Properties of a new probiotic candidate and lactobacterin-tk(2) against diarrhea in calves","volume":"12","author":"Boranbayeva","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijfoodmicro.2011.12.030","article-title":"Food fermentations: Microorganisms with technological beneficial use","volume":"154","author":"Bourdichon","year":"2012","journal-title":"Int. J. Food Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1111\/j.1365-2672.2007.03543.x","article-title":"Identification of the agent from lactobacillus plantarum kfri464 that enhances bacteriocin production by leuconostoc citreum gj7","volume":"103","author":"Chang","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-021-09829-w","article-title":"Screening of Lactic Acid Bacterial Strains with Antiviral Activity Against Porcine Epidemic Diarrhea","volume":"14","author":"Chen","year":"2022","journal-title":"Probiotics and Antimicrobial Proteins"},{"key":"B11","volume-title":"Performance standards for antimicrobial susceptibility testing, M100, 28st ed","year":"2018"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8020189","article-title":"Preliminary evaluation of the safety and probiotic potential of akkermansia muciniphila dsm 22959 in comparison with lactobacillus rhamnosus gg","volume":"8","author":"Cozzolino","year":"2020","journal-title":"Microorganisms"},{"key":"B13","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1046\/j.1365-2672.2000.00845.x","article-title":"Adhesion, autoaggregation and hydrophobicity of 13 strains of bifidobacterium longum","volume":"31","author":"Del Re","year":"2000","journal-title":"Lett. Appl. Microbiol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.672149","article-title":"Genome in silico and in vitro analysis of the probiotic properties of a bacterial endophyte, bacillus paranthracis strain mhsd3","volume":"12","author":"Diale","year":"2021","journal-title":"Front. Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jff.2017.03.021","article-title":"Screening for lactic acid bacteria in traditional fermented tibetan yak milk and evaluating their probiotic and cholesterol-lowering potentials in rats fed a high-cholesterol diet","volume":"32","author":"Ding","year":"2017","journal-title":"J. Funct. Foods"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/foods9091229","article-title":"Do your kids get what you paid for? evaluation of commercially available probiotic products intended for children in the republic of the philippines and the republic of korea","volume":"9","author":"Dioso","year":"2020","journal-title":"Foods"},{"key":"B17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12602-018-9430-y","article-title":"Safety evaluation and colonisation abilities of four lactic acid bacteria as future probiotics","volume":"11","author":"Dlamini","year":"2019","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.610781","article-title":"Microbiome analysis reveals the attenuation effect of lactobacillus from yaks on diarrhea via modulation of gut microbiota","volume":"10","author":"Dong","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192978","article-title":"Selection and characterization of probiotic lactic acid bacteria and its impact on growth, nutrient digestibility, health and antioxidant status in weaned piglets","volume":"13","author":"Dowarah","year":"2018","journal-title":"PloS One"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8500","article-title":"Isolation and characterization of vaginal Lactobacillus spp. in dromedary camels (Camelus dromedarius): in vitro evaluation of probiotic potential of selected isolates","volume":"8","author":"El-Deeb","year":"2020","journal-title":"PeerJ"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.22099\/IJVR.2018.4769","article-title":"Determination of antibiotic resistance of lactic acid bacteria isolated from traditional turkish fermented dairy products","volume":"19","author":"Erginkaya Z","year":"2017","journal-title":"Iranian J. Vet. Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0307.12226","article-title":"Isolation and characterisation of lactic acid bacteria strains from raw camel milk for potential use in the production of fermented Tunisian dairy products","volume":"69","author":"Fguiri","year":"2016","journal-title":"International Journal of Dairy Technology"},{"key":"B24","article-title":"Guidelines for the evaluation of probiotics in food","volume-title":"Report ofa joint FAO\/WHO working group.Safety evaluation of certain contaminants in food","year":"2006"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/ani8090145","article-title":"Copy number variations of klf6 modulate gene transcription and growth traits in chinese datong yak (bos grunniens)","volume":"8","author":"Goshu","year":"2018","journal-title":"Animals"},{"key":"B26","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.envpol.2016.04.099","article-title":"Health risk from veterinary antimicrobial use in china's food animal production and its reduction","volume":"219","author":"Hu","year":"2016","journal-title":"Environ. pollut."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082694","article-title":"Molecular routes to specific identification of the lactobacillus casei group at the species, subspecies and strain level","volume":"21","author":"Jarocki","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/foods10092125","article-title":"Comparison of the probiotic potential between lactiplantibacillus plantarum isolated from kimchi and standard probiotic strains isolated from different sources","volume":"10","author":"Jeong","year":"2021","journal-title":"Foods"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108976","article-title":"Direct evidence of the preventive effect of milk replacer-based probiotic feeding in calves against severe diarrhea","volume":"254","author":"Kayasaki","year":"2021","journal-title":"Vet. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41467-020-20389-5","article-title":"Longitudinal evaluation of fecal microbiota transplantation for ameliorating calf diarrhea and improving growth performance","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev.micro.54.1.413","article-title":"Oral microbial communities: Biofilms, interactions, and genetic systems","volume":"54","author":"Kolenbrander","year":"2000","journal-title":"Annu. Rev. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"Mega7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00239","article-title":"Autochthonous lactic acid bacteria isolated from dairy cow feces exhibiting promising probiotic properties and in vitro antibacterial activity against foodborne pathogens in cattle","volume":"7","author":"Lin","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ani12030322","article-title":"Compound probiotics improve the diarrhea rate and intestinal microbiota of newborn calves","volume":"12","author":"Liu","year":"2022","journal-title":"Anim. (Basel)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/s0895-3988(10)60018-9","article-title":"Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketed foods and drugs","volume":"22","author":"Liu","year":"2009","journal-title":"Biomed. Environ. Sci."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.00049","article-title":"Characterization of lactic acid bacteria isolated from the gastrointestinal tract of a wild boar as potential probiotics","volume":"7","author":"Li","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12934-019-1161-6","article-title":"Probiotics isolated from yaks improves the growth performance, antioxidant activity, and cytokines related to immunity and inflammation in mice","volume":"18","author":"Li","year":"2019","journal-title":"Microb. Cell fact."},{"key":"B38","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.rvsc.2011.03.017","article-title":"Lactic acid bacteria isolated from young calves\u2013characterization and potential as probiotics","volume":"92","author":"Maldonado","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1186\/s13620-019-0154-4","article-title":"European Perspectives on efforts to reduce antimicrobial usage in food animal production","volume":"73","author":"More","year":"2020","journal-title":"Ir Vet. J."},{"key":"B40","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s12602-018-9388-9","article-title":"Evaluation of probiotic potential of bacteriocinogenic lactic acid bacteria strains isolated from meat products","volume":"10","author":"Moreno","year":"2018","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B41","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1080\/08927010903576389","article-title":"Influence of membrane surface properties on the behavior of initial bacterial adhesion and biofilm development onto nanofiltration membranes","volume":"26","author":"Myint","year":"2010","journal-title":"Biofouling"},{"key":"B42","volume-title":"Guideline for the Testing of Chemicals 423 on Acute Oral Toxicity\u2013\u2013Acute Toxic Class Method","year":"2001"},{"key":"B43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1472-765X.2006.01914.x","article-title":"Probiotic properties of vaginal lactic acid bacteria to prevent metritis in cattle","volume":"43","author":"Otero","year":"2006","journal-title":"Lett. Appl. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/j.sjbs.2020.12.040","article-title":"Insight into probiotic properties of lactic acid bacterial endosymbionts of apis mellifera l. derived from the polish apiary","volume":"28","author":"Pachla","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00058","article-title":"Discovering probiotic microorganisms: in vitro, in vivo, genetic and omics approaches","volume":"6","author":"Papadimitriou","year":"2015","journal-title":"Front. Microbiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ijfoodmicro.2014.06.001","article-title":"Virulence, antibiotic resistance and biogenic amines of bacteriocinogenic lactococci and enterococci isolated from goat milk","volume":"185","author":"Perin","year":"2014","journal-title":"Int. J. Food Microbiol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2019.106872","article-title":"Comprehensive approaches for assessing the safety of probiotic bacteria","volume":"108","author":"Pradhan","year":"2020","journal-title":"Food Control"},{"key":"B48","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/jam.14627","article-title":"Whole genome sequence analysis and in vitro probiotic characteristics of a lactobacillus strain lactobacillus paracasei zfm54","volume":"129","author":"Qureshi","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s12602-019-09610-0","article-title":"In vitro evaluation of probiotic potential and safety assessment of lactobacillus mucosae strains isolated from donkey's lactation","volume":"12","author":"Rastogi","year":"2020","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B50","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12866-019-1626-0","article-title":"Isolation, characterization, and assessment of lactic acid bacteria toward their selection as poultry probiotics","volume":"19","author":"Reuben","year":"2019","journal-title":"BMC Microbiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"396S","DOI":"10.1093\/jn\/130.2.396S","article-title":"The role of probiotic cultures in the control of gastrointestinal health","volume":"130","author":"Rolfe","year":"2000","journal-title":"J. Nutr."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7100387","article-title":"Vibrio proteases for biomedical applications: Modulating the proteolytic secretome of v Alginolyticus and v. parahaemolyticus for improved enzymes production","volume":"7","author":"Salamone","year":"2019","journal-title":"Microorganisms"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.11.062","article-title":"Identification and probiotic potential of lactic acid bacteria from camel milk","volume":"28","author":"Sharma","year":"2021","journal-title":"Saudi Journal of Biological Sciences"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/1757-4749-6-1","article-title":"Prevalence of antibiotic resistance in lactic acid bacteria isolated from the faeces of broiler chicken in malaysia","volume":"6","author":"Shazali","year":"2014","journal-title":"Gut Pathog."},{"key":"B55","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s12602-020-09674-3","article-title":"Probiotic properties of new lactobacillus strains intended to be used as feed additives for monogastric animals","volume":"13","author":"Slizewska","year":"2021","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/315819","article-title":"In vitro properties of potential probiotic indigenous lactic acid bacteria originating from traditional pickles","volume":"2015","author":"Tokatli","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"B57","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/IBPC.S73246","article-title":"Probiotics and blood pressure: current insights","volume":"9","author":"Upadrasta","year":"2016","journal-title":"Integr. Blood Press Control"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1099\/ijs.0.006163-0","article-title":"Sphingobium vermicomposti sp. nov., isolated from vermicompost","volume":"59","author":"Vaz-Moreira","year":"2009","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ijfoodmicro.2007.02.002","article-title":"Safety assessment of lactobacillus strains: Presence of putative risk factors in faecal, blood and probiotic isolates","volume":"116","author":"Vesterlund","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02987","article-title":"Probiotic potential of leuconostoc pseudomesenteroides and lactobacillus strains isolated from yaks","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Microbiol."},{"key":"B61","article-title":"Food and agricultural organization of the united nations","volume-title":"Probiotics in food: Health and nutritional properties and guidelines for evaluation","year":"2006"},{"key":"B62","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41522-021-00228-1","article-title":"Improved functionality of ligilactobacillus salivarius li01 in alleviating colonic inflammation by layer-by-layer microencapsulation","volume":"7","author":"Yao","year":"2021","journal-title":"NPJ Biofilms Microbiomes."},{"key":"B63","doi-asserted-by":"publisher","first-page":"10043","DOI":"10.1007\/s00253-016-7812-1","article-title":"Development of putative probiotics as feed additives: Validation in a porcine-specific gastrointestinal tract model","volume":"100","author":"Yeo","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.649207","article-title":"Probiotic properties of bacillus proteolyticus isolated from tibetan yaks, china","volume":"12","author":"Zeng","year":"2021","journal-title":"Front. Microbiol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1016\/j.sjbs.2020.10.022","article-title":"Probiotic characteristics of lactobacillus strains isolated from cheese and their antibacterial properties against gastrointestinal tract pathogens","volume":"27","author":"Zhang","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13177","article-title":"In vitro evaluation of probiotic properties of lactic acid bacteria isolated from the vagina of yak (bos grunniens)","volume":"10","author":"Zhang","year":"2022","journal-title":"PeerJ"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.984537\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T02:05:30Z","timestamp":1663293930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2022.984537\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":66,"alternative-id":["10.3389\/fcimb.2022.984537"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2022.984537","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,16]]},"article-number":"984537"}}