{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:21:44Z","timestamp":1788114104942,"version":"build-2803163510"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical features, diagnosis, and treatment of <jats:italic>Chlamydia psittaci<\/jats:italic> (<jats:italic>C. psittac<\/jats:italic>i) pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical data of six patients with <jats:italic>C. psittaci<\/jats:italic> pneumonia who were admitted to the Division of Pulmonary and Critical Care Medicine of the Second Hospital of Jiaxing from December 2021 to September 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients reported a fever and other accompanying symptoms, including cough (5\/6), chest tightness (1\/6), fatigue (2\/6), and headache (1\/6). Laboratory results showed that all patients had high levels of C-reactive protein (CRP\u226570 mg\/L), procalcitonin (PCT; 2 patients with PCT levels \u22650.5 ng\/L), and erythrocyte sedimentation rate (ESR). Lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels were elevated in 3\/6 and of 2\/6 patients, respectively. Chest computed tomography (CT) of most patients showed patchy, high-density shadows with partial consolidation, accompanied by air bronchogram signs and pleural effusion. Six patients were diagnosed with <jats:italic>C. psittaci<\/jats:italic> pneumonia using metagenomic next-generation sequencing (mNGS). They showed favorable outcomes following immediate adjustment of the regimen to doxycycline-based therapy and hydration, nutrition, and other follow-up treatments. In the imaging findings obtained at one-two month, the lesions were completely cleared, suggesting a favorable prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:italic>C. psittaci<\/jats:italic> pneumonia commonly present sepsis and rapidly progressing disease. Early diagnosis is critical for <jats:italic>C. psittaci<\/jats:italic> pneumonia using mNGS, which can lead to favorable prognoses <jats:italic>via<\/jats:italic> immediate adjustment therapies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcimb.2023.1084882","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T11:11:30Z","timestamp":1677237090000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Case report: A clinical case study of six patients with Chlamydia psittaci pneumonia"],"prefix":"10.3389","volume":"13","author":[{"given":"Jinmeng","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanfen","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"B7","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1136\/emj.20.4.386","article-title":"Chlamydia psittaci pneumonia presenting as acute generalised peritonism","volume":"20","author":"Bourne","year":"2003","journal-title":"Emerg. 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