{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:29:06Z","timestamp":1793309346215,"version":"4.5.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>This study was designed to investigate the occurrence and dissemination of extended-spectrum \u03b2-lactamase (ESBL) harboring <jats:italic>Klebsiella pneumoniae<\/jats:italic> in various ecological niches under the one health approach. A total of 793 samples were collected from animals, humans, and the environment. The findings of the study revealed the occurrence of <jats:italic>K. pneumoniae<\/jats:italic> as follows: animals (11.6%), humans (8.4%), and associated environments (7.0%), respectively. A high occurrence rate of ESBL genes was found in animals compared to human and environmental isolates. A total of 18 distinct sequence types (STs) and 12 clonal complexes of <jats:italic>K. pneumoniae<\/jats:italic> were observed. Overall, six STs of <jats:italic>K. pneumoniae<\/jats:italic> were identified in commercial chickens, and three were found in rural poultry. The majority of <jats:italic>K. pneumoniae<\/jats:italic> STs found in this study were positive for <jats:italic>bla<\/jats:italic>SHV, while the positivity of other ESBL-encoding genes combinations was different in different STs. The high occurrence rate of ESBL-harboring <jats:italic>K. pneumoniae<\/jats:italic> found in animals as compared to other sources is alarming and has the potential to be disseminated to the associated environment and community.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1103319","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:59:45Z","timestamp":1684828785000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Occurrence of extended- spectrum \u03b2-lactamase harboring K. pneumoniae in various sources: a one health perspective"],"prefix":"10.3389","volume":"13","author":[{"given":"Nafeesa","family":"Yasmeen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-xing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulqarnain","family":"Baloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1089\/mdr.2019.0420","article-title":"The first blaKPC harboring klebsiella pneumoniae ST258 strain isolated in Pakistan","volume":"26","author":"Aslam","year":"2020","journal-title":"Microb. 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