{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:05:34Z","timestamp":1791266734280,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Diarrhea is a severe bovine disease, globally prevalent in farm animals with a decrease in milk production and a low fertility rate. <jats:italic>Cryptosporidium<\/jats:italic> spp. are important zoonotic agents of bovine diarrhea. However, little is known about microbiota and short-chain fatty acids (SCFAs) changes in yaks infected with <jats:italic>Cryptosporidium<\/jats:italic> spp. Therefore, we performed 16S rRNA sequencing and detected the concentrations of SCFAs in <jats:italic>Cryptosporidium<\/jats:italic>-infected yaks. Results showed that over 80,000 raw and 70,000 filtered sequences were prevalent in yak samples. Shannon (<jats:italic>p<\/jats:italic>&amp;lt;0.01) and Simpson (<jats:italic>p<\/jats:italic>&amp;lt;0.01) were both significantly higher in <jats:italic>Cryptosporidium-<\/jats:italic>infected yaks. A total of 1072 amplicon sequence variants were shared in healthy and infected yaks. There were 11 phyla and 58 genera that differ significantly between the two yak groups. A total of 235 enzymes with a significant difference in abundance (<jats:italic>p<\/jats:italic>&amp;lt;0.001) were found between healthy and infected yaks. KEGG L3 analysis discovered that the abundance of 43 pathways was significantly higher, while 49 pathways were significantly lower in <jats:italic>Cryptosporidium<\/jats:italic>-infected yaks. The concentration of acetic acid (<jats:italic>p<\/jats:italic>&amp;lt;0.05), propionic acid (<jats:italic>p<\/jats:italic>&amp;lt;0.05), isobutyric acid (<jats:italic>p<\/jats:italic>&amp;lt;0.05), butyric acid (<jats:italic>p<\/jats:italic>&amp;lt;0.05), and isovaleric acid was noticeably lower in infected yaks, respectively. The findings of the study revealed that <jats:italic>Cryptosporidium<\/jats:italic> infection causes gut dysbiosis and results in a significant drop in the SCFAs concentrations in yaks with severe diarrhea, which may give new insights regarding the prevention and treatment of diarrhea in livestock.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1105126","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T04:45:50Z","timestamp":1677645950000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Intestine microbiota and SCFAs response in naturally Cryptosporidium-infected plateau yaks"],"prefix":"10.3389","volume":"13","author":[{"given":"Hailong","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiushuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fakhar-e-Alam","family":"Kulyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan Ahmad","family":"Bhutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shah","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"108983","DOI":"10.1016\/j.intimp.2022.108983","article-title":"The emerging role of microbiota-derived short-chain fatty acids in immunometabolism","volume":"110","author":"Abdalkareem Jasim","year":"2022","journal-title":"Int. IMMUNOPHARMACOL"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00427-6","article-title":"Relationships of gut microbiota, short-chain fatty acids, inflammation, and the gut barrier in parkinson\u2019s disease","volume":"16","author":"Aho","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1007\/s00284-020-02063-7","article-title":"Mycotoxin biodegradation ability of the cupriavidus genus","volume":"77","author":"AL-Nussairawi","year":"2020","journal-title":"Curr. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3855\/jidc.8418","article-title":"Acinetobacter: an underrated foodborne pathogen","volume":"11","author":"Amorim","year":"2017","journal-title":"J. Infect. Dev. Ctries"},{"key":"B5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.immuni.2019.06.002","article-title":"Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells","volume":"51","author":"Bachem","year":"2019","journal-title":"IMMUNITY"},{"key":"B6","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bpg.2013.03.005","article-title":"Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases","volume":"27","author":"Berry","year":"2013","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.jcmgh.2020.11.011","article-title":"Propionate enhances cell speed and persistence to promote intestinal epithelial turnover and repair","volume":"11","author":"Bilotta","year":"2021","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0470-z","article-title":"Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2\u2019s q2-feature-classifier plugin","volume":"6","author":"Bokulich","year":"2018","journal-title":"MICROBIOME"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-00070-7","article-title":"Total flavone of abelmoschus manihot improves colitis by promoting the growth of akkermansia in mice","volume":"11","author":"Bu","year":"2021","journal-title":"Sci. REP-UK"},{"key":"B10","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"B11","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s13668-018-0248-8","article-title":"Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health","volume":"7","author":"Chambers","year":"2018","journal-title":"Curr. Nutr. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1128\/IAI.00336-16","article-title":"Fecal indole as a biomarker of susceptibility to cryptosporidium infection","volume":"84","author":"Chappell","year":"2016","journal-title":"Infect. Immun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"111732","DOI":"10.1016\/j.ecoenv.2020.111732","article-title":"The beneficial or detrimental fluoride to gut microbiota depends on its dosages","volume":"209","author":"Chen","year":"2021","journal-title":"Ecotoxicol Environ. Saf."},{"key":"B14","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/gutjnl-2019-319101","article-title":"Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation","volume":"69","author":"Chen","year":"2020","journal-title":"GUT"},{"key":"B15","doi-asserted-by":"publisher","first-page":"533","DOI":"10.29261\/pakvetj\/2022.060","article-title":"Molecular epidemiological investigation of cryptosporidium sp., giardia duodenalis, enterocytozoon bieneusi and blastocystis sp","volume":"2022","author":"Chen","year":"2022","journal-title":"Infection Free-ranged Yaks Tibetan Pigs Plateau. Pak Vet. J."},{"key":"B16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.29261\/pakvetj\/2022.004","article-title":"RNA-Seq transcriptome analysis to unravel the gene expression profile of ovarian development in xiangxi cattle","volume":"42","author":"Cheng","year":"2022","journal-title":"Pak Vet. J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2217\/fmb.14.133","article-title":"Crohn's disease therapy with dietzia: the end of anti-inflammatory drugs","volume":"10","author":"Click","year":"2015","journal-title":"Future Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3390\/pathogens11020192","article-title":"First detection and genomic characterization of bovine norovirus from yak","volume":"11","author":"Cui","year":"2022","journal-title":"Pathogens"},{"key":"B19","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3168\/jds.2018-14807","article-title":"Effects of lipopolysaccharide dosing on bacterial community composition and fermentation in a dual-flow continuous culture system","volume":"102","author":"Dai","year":"2019","journal-title":"J. DAIRY Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"104185","DOI":"10.1016\/j.micpath.2020.104185","article-title":"Prevalence of bovine viral diarrhea virus (BVDV) in yaks between 1987 and 2019 in mainland China: A systematic review and meta-analysis","volume":"144","author":"Diao","year":"2020","journal-title":"Microb. PATHOGENESIS"},{"key":"B22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s12020-021-02721-1","article-title":"Alteration of gut microbial profile in patients with diabetic nephropathy","volume":"73","author":"Du","year":"2021","journal-title":"ENDOCRINE"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-018-0603-4","article-title":"A comparative study of the gut microbiota in immune-mediated inflammatory diseases\u2013does a common dysbiosis exist","volume":"6","author":"Forbes","year":"2018","journal-title":"MICROBIOME"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.3390\/foods10061410","article-title":"Prevalence of salmonella in free-range pigs: Risk factors and intestinal microbiota composition","volume":"10","author":"Garrido","year":"2021","journal-title":"Foods"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06432","article-title":"Study of microbiome changes in patients with ulcerative colitis in the central European part of Russia","volume":"7","author":"Gryaznova","year":"2021","journal-title":"Heliyon"},{"key":"B26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.micpath.2017.08.025","article-title":"Analysis of the intestinal microbial community in healthy and diarrheal perinatal yaks by high-throughput sequencing","volume":"111","author":"Han","year":"2017","journal-title":"Microb. PATHOGENESIS"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.619051","article-title":"APOE-\u03f54 carrier status and gut microbiota dysbiosis in patients with Alzheimer disease","volume":"15","author":"Hou","year":"2021","journal-title":"Front. NEUROSCI-SWITZ"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1021\/acs.jproteome.8b00536","article-title":"Evaluation and optimization of sample handling methods for quantification of short-chain fatty acids in human fecal samples by GC\u2013MS","volume":"5","author":"Hsu","year":"2019","journal-title":"J. Proteome Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.29261\/pakvetj\/2022.040","article-title":"Anti-parasitic applications of nanoparticles: A review","volume":"42","author":"Kandeel","year":"2022","journal-title":"PAK Vet. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"531","DOI":"10.29261\/pakvetj\/2021.078","article-title":"Biological factors associated with infectious diarrhea in calves","volume":"41","author":"Kim","year":"2021","journal-title":"PAK Vet. J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"557","DOI":"10.29261\/pakvetj\/2020.048","article-title":"Molecular investigation of important protozoal infections in yaks","volume":"41","author":"Lan","year":"2021","journal-title":"PAK Vet. J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"119008","DOI":"10.1016\/j.lfs.2020.119008","article-title":"Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats","volume":"269","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"104190","DOI":"10.1016\/j.micpath.2020.104190","article-title":"Prevalence and molecular characterization of cryptosporidium spp. in yaks (Bos grunniens) in naqu, China","volume":"144","author":"Li","year":"2020","journal-title":"Microb. Pathog."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007953","article-title":"Novel lactate dehydrogenase inhibitors with in vivo efficacy against cryptosporidium parvum","volume":"15","author":"Li","year":"2019","journal-title":"PloS Pathog."},{"key":"B36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.ijpara.2019.02.006","article-title":"Outbreak of cryptosporidiosis due to cryptosporidium parvum subtype IIdA19G1 in neonatal calves on a dairy farm in China","volume":"49","author":"Li","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1167\/iovs.63.2.21","article-title":"Enriched and decreased intestinal microbes in active VKH patients","volume":"63","author":"Li","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.805481","article-title":"Effects of short-chain fatty acid modulation on potentially diarrhea-causing pathogens in yaks through metagenomic sequencing","volume":"12","author":"Li","year":"2022","journal-title":"Front. Cell Infect. MI"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1875796","article-title":"Blautia-a new functional genus with potential probiotic properties","volume":"13","author":"Liu","year":"2021","journal-title":"Gut Microbes"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/foods10040902","article-title":"The potential role of probiotics in protection against influenza a virus infection in mice","volume":"10","author":"Lu","year":"2021","journal-title":"Foods"},{"key":"B42","doi-asserted-by":"publisher","first-page":"108696","DOI":"10.1016\/j.vetmic.2020.108696","article-title":"Treponema spp., the dominant pathogen in the lesion of bovine digital dermatitis and its characterization in dairy cattle","volume":"245","author":"Mamuad","year":"2020","journal-title":"Vet. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"27663","DOI":"10.3402\/mehd.v26.27663","article-title":"Analysis of composition of microbiomes: a novel method for studying microbial composition","volume":"26","author":"Mandal","year":"2015","journal-title":"Microbial Ecol. Health Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2111952","DOI":"10.1080\/19490976.2022.2111952","article-title":"Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era","volume":"14","author":"Martinez-Lopez","year":"2022","journal-title":"Gut Microbes"},{"key":"B45","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13028-014-0075-x","article-title":"Advances in prevention and therapy of neonatal dairy calf diarrhoea: a systematical review with emphasis on colostrum management and fluid therapy","volume":"56","author":"Meganck","year":"2014","journal-title":"Acta Vet. Scand."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2112882","article-title":"Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and paneth cells deficiency","volume":"14","author":"Mei","year":"2022","journal-title":"Gut Microbes"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82815-y","article-title":"Effects of long-acting, broad spectra anthelmintic treatments on the rumen microbial community compositions of grazing sheep","volume":"11","author":"Moon","year":"2021","journal-title":"Sci. REP-UK"},{"key":"B48","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.micpath.2017.08.021","article-title":"Probiotic characters of bifidobacterium and lactobacillus are a result of the ongoing gene acquisition and genome minimization evolutionary trends","volume":"111","author":"Papizadeh","year":"2017","journal-title":"Microb. PATHOGENESIS"},{"key":"B49","first-page":"59","article-title":"Oxigenic effect of acinetobacter baumanniiisolated from children with acute diarrhea","volume":"49","author":"Polanco","year":"2008","journal-title":"Invest. Clin."},{"key":"B50","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.annepidem.2019.09.002","article-title":"High-throughput sequencing of pooled samples to determine community-level microbiome diversity","volume":"39","author":"Ray","year":"2019","journal-title":"Ann. Epidemiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2106102","DOI":"10.1080\/19490976.2022.2106102","article-title":"Fecal metabolome and bacterial composition in severe obesity: Impact of diet and bariatric surgery","volume":"14","author":"Salazar","year":"2022","journal-title":"Gut Microbes"},{"key":"B52","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.anaerobe.2018.01.007","article-title":"Identification of clostridium species using the VITEK\u00ae MS","volume":"54","author":"Sanchez Ramos","year":"2018","journal-title":"ANAEROBE"},{"key":"B53","doi-asserted-by":"publisher","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.594778","article-title":"Biliary microbial structure of gallstone patients with a history of endoscopic sphincterotomy surgery","volume":"10","author":"Shen","year":"2021","journal-title":"Front. Cell Infect. MI"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.3390\/nu10121939","article-title":"Faecal short chain fatty acids profile is changed in polish depressive women","volume":"10","author":"Skonieczna-\u017bydecka","year":"2018","journal-title":"NUTRIENTS"},{"key":"B56","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.vetpar.2014.05.022","article-title":"Prevalence and molecular typing of cryptosporidium in dairy cattle in England and Wales and examination of potential on-farm transmission routes","volume":"204","author":"Smith","year":"2014","journal-title":"Vet. Parasitol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2478\/jvetres-2020-0002","article-title":"Non-antibiotic possibilities in prevention and treatment of calf diarrhoea","volume":"64","author":"Smulski","year":"2020","journal-title":"J. Vet. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s41586-021-03727-5","article-title":"Acetate differentially regulates IgA reactivity to commensal bacteria","volume":"595","author":"Takeuchi","year":"2021","journal-title":"NATURE"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00149","article-title":"Alterations to the lung microbiome in idiopathic pulmonary fibrosis patients","volume":"9","author":"Tong","year":"2019","journal-title":"Front. Cell Infect. MI"},{"key":"B60","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2047-217X-2-16","article-title":"EMPeror: a tool for visualizing high-throughput microbial community data","volume":"2","author":"Vazquez-Baeza","year":"2013","journal-title":"GIGASCIENCE"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.877280","article-title":"Gut fungal microbiome responses to natural cryptosporidium infection in horses","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-019-0761-z","article-title":"Ochratoxin a induces liver inflammation: involvement of intestinal microbiota","volume":"7","author":"Wang","year":"2019","journal-title":"MICROBIOME"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2020.589126","article-title":"Detection of infectious agents causing neonatal calf diarrhea on two Large dairy farms in yangxin county, Shandong province, China","volume":"7","author":"Wei","year":"2021","journal-title":"Front. Veterinary Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"420","DOI":"10.7150\/ijbs.37421","article-title":"Gut microbiota as diagnostic tools for mirroring disease progression and circulating nephrotoxin levels in chronic kidney disease: Discovery and validation study","volume":"16","author":"Wu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3892\/etm.2021.9822","article-title":"Intestinal mucosal microbiota composition of patients with acquired immune deficiency syndrome in guangzhou, China","volume":"21","author":"Xu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.615404","article-title":"Algal oil rich in n-3 PUFA alleviates DSS-induced colitis via regulation of gut microbiota and restoration of intestinal barrier","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Microbiol."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00502","article-title":"Structure and function of the fecal microbiota in diarrheic neonatal piglets","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Microbiol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.693839","article-title":"Effect of dietary Amylose\/Amylopectin ratio on intestinal health and cecal microbes\u2019 profiles of weaned pigs undergoing feed transition or challenged with escherichia coli lipopolysaccharide","volume":"12","author":"Yang","year":"2021","journal-title":"Front. Microbiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.micpath.2017.12.059","article-title":"Dysbiosis of the fecal microbiota in feedlot cattle with hemorrhagic diarrhea","volume":"115","author":"Zeineldin","year":"2018","journal-title":"Microb. PATHOGENESIS"},{"key":"B70","doi-asserted-by":"publisher","first-page":"114426","DOI":"10.1016\/j.anifeedsci.2020.114426","article-title":"The effects of benzoic acid and essential oils on growth performance, nutrient digestibility, and colonic microbiota in nursery pigs","volume":"262","author":"Zhai","year":"2020","journal-title":"Anim. FEED Sci. TECH"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.559148","article-title":"Alterations of gastric microbiota in gastric cancer and precancerous stages","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Cell Infect. MI"},{"key":"B72","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.talanta.2018.12.049","article-title":"A sensitive GC\/MS detection method for analyzing microbial metabolites short chain fatty acids in fecal and serum samples","volume":"196","author":"Zhang","year":"2019","journal-title":"TALANTA"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1105126\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T04:45:54Z","timestamp":1677645954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1105126\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":72,"alternative-id":["10.3389\/fcimb.2023.1105126"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2023.1105126","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]},"article-number":"1105126"}}