{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:01:20Z","timestamp":1793836880514,"version":"4.6.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>B<\/jats:italic>\n                    rucellosis is a common zoonotic disease that is widely spread worldwide and poses a major threat to human health. Clinically, it often presents with non-specific symptoms such as fever, excessive sweating, malaise, myalgia, arthralgia, loss of appetite, weight loss, and enlarged liver, spleen and lymph nodes. The disease has a long and recurrent course, often accumulating in multiple systems and organs. Of these, osteoarticular involvement is the most common complication, with a prevalence of approximately 2-77%, usually manifesting as spondylitis, sacroiliac arthritis and peripheral arthritis. Hepatosplenomegaly is seen in about 50% of patients with\n                    <jats:italic>b<\/jats:italic>\n                    rucellosis, and gastrointestinal disturbances such as abdominal pain, nausea, and vomiting are common. Although respiratory involvement is less common, pneumonia, pleurisy, pleural effusion, and pulmonary nodules have been reported. Besides, approximately 2-20% of cases involve infections of the male genitourinary system, mainly manifesting as unilateral epididymal-orchitis and orchitis. The most serious complication facing\n                    <jats:italic>b<\/jats:italic>\n                    rucellosis is cardiovascular involvement, and although the overall mortality rate of\n                    <jats:italic>b<\/jats:italic>\n                    rucellosis is about 1% and the incidence of\n                    <jats:italic>b<\/jats:italic>\n                    rucellosis endocarditis is less than 2%, more than 80% of deaths are associated with endocarditis. Furthermore,\n                    <jats:italic>b<\/jats:italic>\n                    rucellosis is complicated by hematologic disease, with anemia occurring in approximately 20-53% of children during the acute phase. In addition, the neurological incidence of\n                    <jats:italic>b<\/jats:italic>\n                    rucellosis is about 0.5-25%, mainly manifested as meningitis. In this study, we review the multisystem complications of brucellosis with the aim of improving early diagnosis, timely treatment and prevention of long-term complications.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2023.1136674","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T04:52:57Z","timestamp":1680238377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":139,"title":["Research progress on complications of Brucellosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Min","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingnan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00059-013-4011-z","article-title":"Myocardial infarction due to septic coronary artery embolism in the course of brucella endocarditis","volume":"40","author":"A\u00e7ar","year":"2015","journal-title":"Herz."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1111\/j.1365-4632.2010.04783.x","article-title":"Brucellosis presenting as septal panniculitis with vasculitis","volume":"51","author":"Al Jasser","year":"2012","journal-title":"Int. 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