{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:07:37Z","timestamp":1791821257846,"version":"4.3.4"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>As one of the most common oral diseases in kids, early childhood caries affects the health of children throughout the world. Clinical investigations show the copresence of <jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Streptococcus mutans<\/jats:italic> in ECC lesions, and mechanistic studies reveal co-existence of <jats:italic>C. albicans<\/jats:italic> and <jats:italic>S. mutans<\/jats:italic> affects both of their cariogenicity. Clearly a comprehensive understanding of the interkingdom interaction between these two microorganisms has important implications for ECC treatment and prevention. To this end, this review summarizes advances in our understanding of the virulence of both <jats:italic>C. albicans<\/jats:italic> and <jats:italic>S. mutans<\/jats:italic>. More importantly, the synergistic and antagonistic interactions between these two microbes are discussed.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1151532","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T05:29:32Z","timestamp":1684214972000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Roles of Streptococcus mutans-Candida albicans interaction in early childhood caries: a literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Yifei","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"B1","first-page":"81","article-title":"Policy on early childhood caries (ECC): consequences and preventive strategies","volume-title":"The reference manual of pediatric dentistry","year":"2021"},{"key":"B2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/omi.12162","article-title":"Acid-adaptive mechanisms of Streptococcus mutans-the more we know, the more we don't","volume":"32","author":"Baker","year":"2017","journal-title":"Mol. 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