{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:53:41Z","timestamp":1790783621733,"version":"4.1.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Ovine babesiosis, caused by <jats:italic>Babesia ovis<\/jats:italic>, is an acute, lethal, and endemic disease worldwide and causes a huge economic loss to animal industry. Pathogen genome sequences can be utilized for selecting diagnostic markers, drug targets, and antigens for vaccine development; however, those for <jats:italic>B. ovis<\/jats:italic> have not been available so far. In this study, we obtained a draft genome sequence for <jats:italic>B. ovis<\/jats:italic> isolated from an infected sheep in Turkey. The genome size was 7.81 Mbp with 3,419 protein-coding genes. It consisted of 41 contigs, and the N<jats:sub>50<\/jats:sub> was 526 Kbp. There were 259 orthologs identified among eight <jats:italic>Babesia<\/jats:italic> spp., <jats:italic>Plasmodium falciparum<\/jats:italic>, and <jats:italic>Toxoplasma gondii<\/jats:italic>. A phylogeny was estimated on the basis of the orthologs, which showed <jats:italic>B. ovis<\/jats:italic> to be closest to <jats:italic>B. bovis.<\/jats:italic> There were 43 <jats:italic>ves<\/jats:italic> genes identified using hmm model as well. They formed a discriminating cluster to other <jats:italic>ves<\/jats:italic> multigene family of <jats:italic>Babesia<\/jats:italic> spp. but showed certain similarities to those of <jats:italic>B. bovis<\/jats:italic>, <jats:italic>B. caballi<\/jats:italic>, and <jats:italic>Babesia<\/jats:italic> sp. Xinjiang, which is consistent with the phylogeny. Comparative genomics among <jats:italic>B. ovis<\/jats:italic> and <jats:italic>B. bovis<\/jats:italic> elucidated uniquely evolved genes in these species, which may account for the adaptation.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1194608","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T15:57:02Z","timestamp":1690905422000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Whole genome sequence and diversity in multigene families of Babesia ovis"],"prefix":"10.3389","volume":"13","author":[{"given":"Junya","family":"Yamagishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur","family":"Ceylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenan","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferda","family":"Sevinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1196\/ANNALS.1373.074","article-title":"Phylogenetic position of small-ruminant infecting piroplasms","volume":"1081","author":"Ahmed","year":"2006","journal-title":"Ann. 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